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19542-67-7

19542-67-7 | (E)-3-Tosylacrylonitrile

CAS No: 19542-67-7 Catalog No: AG003C0J MDL No:MFCD00712162

Product Description

Catalog Number:
AG003C0J
Chemical Name:
(E)-3-Tosylacrylonitrile
CAS Number:
19542-67-7
Molecular Formula:
C10H9NO2S
Molecular Weight:
207.2490
MDL Number:
MFCD00712162
IUPAC Name:
(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile
InChI:
InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChI Key:
DOEWDSDBFRHVAP-KRXBUXKQSA-N
SMILES:
N#C/C=C/S(=O)(=O)c1ccc(cc1)C
UNII:
4Y5G2A4F6O

Properties

Complexity:
347  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
207.035g/mol
Formal Charge:
0
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
207.247g/mol
Monoisotopic Mass:
207.035g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
66.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.4  

Literature

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Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. The Journal of biological chemistry 20100326
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BAY 11-7082, a nuclear factor-κB inhibitor, reduces inflammation and apoptosis in a rat cardiac ischemia-reperfusion injury model. International heart journal 20100101
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Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB. The Journal of biological chemistry 20091218
Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation. Cancer research 20091215
Inhibition of constitutive and cxc-chemokine-induced NF-kappaB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells. British journal of cancer 20091103
Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI(3)K-Akt-eNOS-dependent cyclooxygenase-2 expression in endothelial cells. Toxicology letters 20091028
N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1. The Journal of biological chemistry 20091009
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Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin. Oral oncology 20090901
Role of the phosphatidylinositol 3-kinase/protein kinase B pathway in regulating alternative splicing of tissue factor mRNA in human endothelial cells. Circulation journal : official journal of the Japanese Circulation Society 20090901
Targeting NF-kappaB signaling pathway suppresses tumor growth, angiogenesis, and metastasis of human esophageal cancer. Molecular cancer therapeutics 20090901
Porphyromonas gingivalis fimbriae-dependent interleukin-6 autocrine regulation by increase of gp130 in endothelial cells. Journal of periodontal research 20090801
An unbiased chemical biology screen identifies agents that modulate uptake of oxidized LDL by macrophages. Circulation research 20090717
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Novel cytostatic activity of the trypanocidal drug Benznidazole. International immunopharmacology 20090601
Low concentration of lipopolysaccharide acts on MC3T3-E1 osteoblasts and induces proliferation via the COX-2-independent NFkappaB pathway. Cell biochemistry and function 20090601
Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. Toxicology and applied pharmacology 20090515
Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas. Journal of the National Cancer Institute 20090506
Imatinib resistance in multidrug-resistant K562 human leukemic cells. Leukemia research 20090501
IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells. Molecular endocrinology (Baltimore, Md.) 20090501
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The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death. Journal of leukocyte biology 20090101
Adiponectin upregulates ferritin heavy chain in skeletal muscle cells. Diabetes 20090101
Insulin-like growth factor-1 promotes cell cycle progression via upregulation of cyclin D1 expression through the phosphatidylinositol 3-kinase/nuclear factor-kappaB signaling pathway in FRTL thyroid cells. Acta pharmacologica Sinica 20090101
Chemosensitization in non-small cell lung cancer cells by IKK inhibitor occurs via NF-kappaB and mitochondrial cytochrome c cascade. Journal of cellular and molecular medicine 20090101
The pivotal role of p38 and NF-kappaB signal pathways in the maturation of human monocyte-derived dendritic cells stimulated by streptococcal agent OK-432. Immunobiology 20090101
Mechanistic study on growth suppression and apoptosis induction by targeting hepatoma-derived growth factor in human hepatocellular carcinoma HepG2 cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101
Triglycerides potentiate the inflammatory response in rat Kupffer cells. Antioxidants & redox signaling 20081201
TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels. Journal of neurochemistry 20081101
Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-kappaB and NFAT. Journal of immunology (Baltimore, Md. : 1950) 20081015
A nuclear factor-kappaB inhibitor BAY11-7082 inhibits interactions between human endothelial cells, T cells, and monocytes. Transplantation proceedings 20081001
BAY 11-7082 induces cell death through NF-kappaB-independent mechanisms in the Ewing's sarcoma family of tumours. Cancer letters 20080918
A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis. Rheumatology (Oxford, England) 20080901
Innate immune responses of epididymal epithelial cells to Staphylococcus aureus infection. Immunology letters 20080815
Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells. Toxicological sciences : an official journal of the Society of Toxicology 20080801
Interleukin-1beta, but not interleukin-6, enhances renal and systemic endothelin production in vivo. American journal of physiology. Renal physiology 20080801
NF-kappaB inhibitors induce lytic cytotoxicity in Epstein-Barr virus-positive nasopharyngeal carcinoma cells. Cell biology international 20080801
Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear factor-kappaB. Pharmacological research 20080701
Death receptor-4 (DR4) expression is regulated by transcription factor NF-kappaB in response to etoposide treatment. Apoptosis : an international journal on programmed cell death 20080601
Development of a cell death-based method for the screening of nuclear factor-kappaB inhibitors. Journal of immunological methods 20080601
Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells: globular adiponectin vs. high molecular weight adiponectin. Diabetes & vascular disease research 20080601
Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cells. Toxicology and applied pharmacology 20080415
Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma. Cancer research 20080415
1-Bromopropane induces macrophage activation via extracellular signal-regulated kinase 1/2 MAPK and NF-κB pathways. Cancer letters 20080408
Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation. Journal of immunology (Baltimore, Md. : 1950) 20080401
Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects. Cancer research 20080401
Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism. European journal of pharmacology 20080317
Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Experimental cell research 20080310
Decreased epithelial barrier function evoked by exposure to metabolic stress and nonpathogenic E. coli is enhanced by TNF-alpha. American journal of physiology. Gastrointestinal and liver physiology 20080301
The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes. Atherosclerosis 20080201
Mycobacterium bovis bacillus Calmette-Guerin induces CCL5 secretion via the Toll-like receptor 2-NF-kappaB and -Jun N-terminal kinase signaling pathways. Clinical and vaccine immunology : CVI 20080201
TNF alpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappa B-dependent pathways. Experimental cell research 20080201
Interferon-alpha induces transient upregulation of c-FLIP through NF-kappaB activation. Experimental cell research 20080115
Proinflammatory impact of Staphylococcus epidermidis on the nasal epithelium quantified by IL-8 and GRO-alpha responses in primary human nasal epithelial cells. International archives of allergy and immunology 20080101
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorganic & medicinal chemistry letters 20080101
Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells. International journal of oncology 20080101
Suppressive effect of hydroquinone, a benzene metabolite, on in vitro inflammatory responses mediated by macrophages, monocytes, and lymphocytes. Mediators of inflammation 20080101
[Cross-talk between nuclear factor-kappaB and P53 signal pathway in keratinocytes after ultraviolet B irradiation]. Zhonghua yi xue za zhi 20071120
Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. Journal of leukocyte biology 20071001
Bortezomib inhibits nuclear factor-kappaB dependent survival and has potent in vivo activity in mesothelioma. Clinical cancer research : an official journal of the American Association for Cancer Research 20071001
[Enhancement of Fas-mediated apoptosis in leukemic cell line HL-60 by Bay 11 - 7082]. Zhongguo shi yan xue ye xue za zhi 20071001
Inhibition of NF-kappa B during human dendritic cell differentiation generates anergy and regulatory T-cell activity for one but not two human leukocyte antigen DR mismatches. Human immunology 20070901
Modulation of tight junction barrier function by outer membrane proteins of enteropathogenic Escherichia coli: role of F-actin and junctional adhesion molecule-1. Cell biology international 20070801
High-content classification of nucleocytoplasmic import or export inhibitors. Journal of biomolecular screening 20070801
Effect of ionizing radiation on cellular procoagulability and co-ordinated gene alterations. Haematologica 20070801
Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-kappaB. Arthritis and rheumatism 20070701
Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells. Journal of cardiovascular pharmacology 20070701
NF-kappaB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene 20070614
Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-kappaB pathway. Journal of leukocyte biology 20070501
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells. International immunopharmacology 20070501
Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-kappaB and extracellular signal-regulated kinase 1/2. The Journal of endocrinology 20070501
Inflammatory effect of endosulfan via NF-kappaB activation in macrophages. Biochemical and biophysical research communications 20070420
Helicobacter pylori stimulates urokinase plasminogen activator receptor expression and cell invasiveness through reactive oxygen species and NF-kappaB signaling in human gastric carcinoma cells. International journal of molecular medicine 20070401
Activation of transcription factor IL-6 (NF-IL-6) and nuclear factor-kappaB (NF-kappaB) by lipid ozonation products is crucial to interleukin-8 gene expression in human airway epithelial cells. Environmental toxicology 20070401
The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell lines. Cancer research 20070315
Involvement of nuclear factor-kB activation through RhoA/Rho-kinase pathway in LPS-induced IL-8 production in human cervical stromal cells. Molecular human reproduction 20070301
Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes. Diabetes 20070301
Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells. Oncogene 20070222
Differential involvement of NF-kappaB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils. Journal of leukocyte biology 20070201
Ceramide induces early and late apoptosis in human papilloma virus+ cervical cancer cells by inhibiting reactive oxygen species decay, diminishing the intracellular concentration of glutathione and increasing nuclear factor-kappaB translocation. Anti-cancer drugs 20070201
NF-kappa B as a target for cancer therapy. Expert opinion on therapeutic targets 20070201
Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9. The Journal of pharmacology and experimental therapeutics 20070101
Gene expression profiling of LPS-stimulated murine macrophages and role of the NF-kappaB and PI3K/mTOR signaling pathways. Annals of the New York Academy of Sciences 20070101
Hydrogen peroxide increases [3H]-2-deoxyglucose uptake via MAPKs, cPLA2, and NF-kappaB signaling pathways in mouse embryonic stem cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
Epidermal growth factor inhibits Fas-mediated apoptosis in salivary epithelial cells of patients with primary Sjögren's syndrome. Clinical and experimental rheumatology 20070101
NF-kB inhibition as a strategy to enhance etoposide-induced apoptosis in K562 cell line. American journal of hematology 20061201
Enrichment of non-synchronized cells in the G1, S and G2 phases of the cell cycle for the study of apoptosis. Biochemical pharmacology 20061130
Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. American journal of physiology. Gastrointestinal and liver physiology 20061101
Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. The Journal of pharmacology and experimental therapeutics 20061101
Bortezomib induces different apoptotic rates in B-CLL cells according to IgVH and BCL-6 mutations. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20061101
Resistin worsens cardiac ischaemia-reperfusion injury. Biochemical and biophysical research communications 20061013
Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome. Oncogene 20061012
COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells. Toxicology letters 20060910
Raloxifene increases proliferation and up-regulates telomerase activity in human umbilical vein endothelial cells. The Journal of biological chemistry 20060825
House dust mite allergen Der p 1 elevates the release of inflammatory cytokines and expression of adhesion molecules in co-culture of human eosinophils and bronchial epithelial cells. International immunology 20060801
TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proceedings of the National Academy of Sciences of the United States of America 20060705
Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis 20060701
Serum amyloid A induces contrary immune responses via formyl peptide receptor-like 1 in human monocytes. Molecular pharmacology 20060701
An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells. Circulation research 20060623
Infectious bursal disease virus infection induces macrophage activation via p38 MAPK and NF-kappaB pathways. Virus research 20060601
Proinsulin C-peptide stimulates a PKC/IkappaB/NF-kappaB signaling pathway to activate COX-2 gene transcription in Swiss 3T3 fibroblasts. Journal of biochemistry 20060601
Nuclear Factor-kappaB controls the reaggregation of 3D neurosphere cultures in vitro. European cells & materials 20060523
Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. Regulatory peptides 20060515
Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappaB and -MAPK signaling pathways. Liver international : official journal of the International Association for the Study of the Liver 20060501
NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo. Blood 20060415
Shortcomings of protein removal prior to high performance liquid chromatographic analysis-A case study using method development for BAY 11-7082. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060413
Stereospecific and redox-sensitive increase in monocyte adhesion to endothelial cells by homocysteine. Arteriosclerosis, thrombosis, and vascular biology 20060301
Lipopolysaccharide and TNF-alpha activate the nuclear factor kappa B pathway in the human placental JEG-3 cells. Placenta 20060101
Arsenic trioxide induces apoptosis of human monocytes during macrophagic differentiation through nuclear factor-kappaB-related survival pathway down-regulation. The Journal of pharmacology and experimental therapeutics 20060101
The novel cytokine p43 induces IL-12 production in macrophages via NF-kappaB activation, leading to enhanced IFN-gamma production in CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950) 20060101
Inhibition of NF-kappaB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines. Leukemia research 20051201
Activity and function of the nuclear factor kappaB pathway in human parathyroid tumors. Endocrine-related cancer 20051201
The ACAT inhibitor VULM1457 significantly reduced production and secretion of adrenomedullin (AM) and down-regulated AM receptors on human hepatoblastic cells. General physiology and biophysics 20051201
Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction. The Biochemical journal 20051101
Enhancement of TPA-induced growth inhibition and apoptosis in myeloid leukemia cells by BAY 11-7082, an NF-kappaB inhibitor. International journal of oncology 20051001
Effects of nuclear factor-kappaB inhibitors and its implication on natural killer T-cell lymphoma cells. British journal of haematology 20051001
S100b counteracts effects of the neurotoxicant trimethyltin on astrocytes and microglia. Journal of neuroscience research 20050901
NF-kappaB activation contributes to anthracycline resistance pathway in human ovarian carcinoma cell line A2780. International journal of oncology 20050901
Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells. The Journal of biological chemistry 20050826
Methoxychlor-induced inducible nitric oxide synthase and proinflammatory cytokines expression in macrophages via NF-kappaB, ERK, and p38 mitogen-activated protein kinases. Biochemical and biophysical research communications 20050812
Proapoptotic regimes for HTLV-I-transformed cells: targeting Tax and the NF-kappaB pathway. Cell death and differentiation 20050801
Interleukin-25-induced chemokines and interleukin-6 release from eosinophils is mediated by p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappaB. American journal of respiratory cell and molecular biology 20050801
Induction of interleukin-8 production via nuclear factor-kappaB activation in human intestinal epithelial cells infected with Vibrio vulnificus. Immunology 20050801
Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation. Molecular and cellular biology 20050701
Enhancing the ratio of molecular ions to non-covalent compounds in the electrospray interface of LC-MS in quantitative analysis. Analytical and bioanalytical chemistry 20050601
Effects of mechanistically distinct NF-kappaB inhibitors on glial inducible nitric-oxide synthase expression. Nitric oxide : biology and chemistry 20050601
Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages. International immunopharmacology 20050501
Potential mechanism of blood vessel protection by resveratrol, a component of red wine. Annals of the New York Academy of Sciences 20050501
Diesel exhaust particles induce the over expression of tumor necrosis factor-alpha (TNF-alpha) gene in alveolar macrophages and failed to induce apoptosis through activation of nuclear factor-kappaB (NF-kappaB). International journal of environmental research and public health 20050501
The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices. Neuroscience letters 20050404
Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology 20050301
Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells. Biochemical pharmacology 20050101
Role of p38 MAPK and NF-kB for chemokine release in coculture of human eosinophils and bronchial epithelial cells. Clinical and experimental immunology 20050101
Interferon-gamma-dependent in vitro model for the putative keratin 17 autoimmune loop in psoriasis: exploration of pharmaco- and gene-therapeutic effects. Skin pharmacology and physiology 20050101
Inhibition of IkappaBalpha phosphorylation prevents glutamate-induced NF-kappaB activation and neuronal cell death. Acta neurochirurgica. Supplement 20050101
Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. American journal of physiology. Cell physiology 20041201
Mechanisms for macrophage-mediated HIV-1 induction. Journal of immunology (Baltimore, Md. : 1950) 20041201
Enteropathogenic Escherichia coli outer membrane proteins induce iNOS by activation of NF-kappaB and MAP kinases. Inflammation 20041201
Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. The Journal of biological chemistry 20041105
Nuclear factor kappaB activity determines the sensitivity of kidney epithelial cells to apoptosis: implications for mercury-induced renal failure. Toxicological sciences : an official journal of the Society of Toxicology 20041101
[BAY11-7082 and Lactacystein in CD154-induced NF-kappaB activation]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20041001
Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation. Free radical biology & medicine 20040815
In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. Journal of immunology (Baltimore, Md. : 1950) 20040801
T cells signaled by NF-kappa B- dendritic cells are sensitized not anergic to subsequent activation. Journal of immunology (Baltimore, Md. : 1950) 20040801
Angiotensin II stimulates the release of interleukin-6 and interleukin-8 from cultured human adipocytes by activation of NF-kappaB. Arteriosclerosis, thrombosis, and vascular biology 20040701
Glucagon-like peptide-1 prevents beta cell glucolipotoxicity. Diabetologia 20040501
Human lung fibroblasts express interleukin-6 in response to signaling after mast cell contact. American journal of respiratory cell and molecular biology 20040401
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells. Blood 20040401
Id-1 expression induces androgen-independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R). Carcinogenesis 20040401
Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 leukemia cells. Biochemical pharmacology 20040401
Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. Journal of virology 20040401
Ethanol-induced iNOS and COX-2 expression in cultured astrocytes via NF-kappa B. Neuroreport 20040322
The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells. Molecular carcinogenesis 20040101
Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors. Laboratory investigation; a journal of technical methods and pathology 20031201
The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571. Blood 20031115
Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a Toll-like receptor 2 agonist. International immunopharmacology 20031101
Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors. Free radical biology & medicine 20031101
Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. Journal of immunology (Baltimore, Md. : 1950) 20030701
Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. Journal of immunology (Baltimore, Md. : 1950) 20030615
Upregulation of expression of the chemokine receptor CCR5 by hydrogen peroxide in human monocytes. Mediators of inflammation 20030201
Characterization of the molecular events following impairment of NF-kappaB-driven transcription in neurons. Brain research. Molecular brain research 20021230
Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer research 20021201
Contributions of mitogen-activated protein kinase and nuclear factor kappa B to N-(4-hydroxyphenyl)retinamide-induced apoptosis in prostate cancer cells. Molecular carcinogenesis 20021101
Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 20020901
Expression of kinin B(1) receptor in fresh or cultured rabbit aortic smooth muscle: role of NF-kappa B. American journal of physiology. Heart and circulatory physiology 20020701
High glucose induced nuclear factor kappa B mediated inhibition of endothelial cell migration. Atherosclerosis 20020601
Further pharmacological evidence of nuclear factor-kappa B pathway involvement in bradykinin B1 receptor-sensitized responses in human umbilical vein. The Journal of pharmacology and experimental therapeutics 20020601
A nuclear factor-kappaB inhibitor BAY 11-7082 suppresses endothelin-1 production in cultured vascular endothelial cells. Japanese journal of pharmacology 20020501
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer. Oncogene 20011101
NF-kappa B-mediated chemoresistance in breast cancer cells. Surgery 20010801
CD40L induces matrix-metalloproteinase-9 but not tissue inhibitor of metalloproteinases-1 in cervical carcinoma cells: imbalance between NF-kappaB and STAT3 activation. Experimental cell research 20010715
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis. The Journal of biological chemistry 20000121
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