200,000+ products from a single source!
sales@angenechem.com
Home > Fluorides > 151555-47-4
151555-47-4 | Estra-1,3,5(10)-triene-3,17-diol, 11-[4-[[5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl]oxy]phenyl]-, (11β,17β)-
CAS No: 151555-47-4 Catalog No: AG001NEO MDL No:
Product Description
Catalog Number:
AG001NEO
Chemical Name:
Estra-1,3,5(10)-triene-3,17-diol, 11-[4-[[5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl]oxy]phenyl]-, (11β,17β)-
CAS Number:
151555-47-4
Molecular Formula:
C34H43F5O5S
Molecular Weight:
658.7592
IUPAC Name:
(8S,9R,11S,13S,14S,17S)-13-methyl-11-[4-[5-(4,4,5,5,5-pentafluoropentylsulfonyl)pentoxy]phenyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
InChI:
InChI=1S/C34H43F5O5S/c1-32-21-28(31-26-13-9-24(40)20-23(26)8-12-27(31)29(32)14-15-30(32)41)22-6-10-25(11-7-22)44-17-3-2-4-18-45(42,43)19-5-16-33(35,36)34(37,38)39/h6-7,9-11,13,20,27-31,40-41H,2-5,8,12,14-19,21H2,1H3/t27-,28+,29-,30-,31+,32-/m0/s1
InChI Key:
SDCUWFRXMLQNCS-LFAPAAFUSA-N
SMILES:
Oc1ccc2c(c1)CC[C@@H]1[C@@H]2[C@H](C[C@]2([C@H]1CC[C@@H]2O)C)c1ccc(cc1)OCCCCCS(=O)(=O)CCCC(C(F)(F)F)(F)F
Properties
Complexity:
1070
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
6
Defined Bond Stereocenter Count:
0
Exact Mass:
658.275g/mol
Formal Charge:
0
Heavy Atom Count:
45
Hydrogen Bond Acceptor Count:
10
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
658.765g/mol
Monoisotopic Mass:
658.275g/mol
Rotatable Bond Count:
12
Topological Polar Surface Area:
92.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
8
Literature
| Title | Journal |
|---|---|
| Coadministration of nanosystems of short silencing RNAs targeting oestrogen receptor alpha and anti-oestrogen synergistically induces tumour growth inhibition in human breast cancer xenografts. | Breast cancer research and treatment 20100701 |
| Pure antiestrogen-induced G1-arrest in myeloma cells results from the reduced kinase activity of cyclin D3/CDK6 complexes whereas apoptosis is mediated by endoplasmic reticulum-dependent caspases. | International journal of cancer 20080501 |
| Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators. | Cancer research 20071001 |
| Facilitating antidepressant-like actions of estrogens are mediated by 5-HT1A and estrogen receptors in the rat forced swimming test. | Psychoneuroendocrinology 20060901 |
| Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator. | Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20060801 |
| Improved antitumoral properties of pure antiestrogen RU 58668-loaded liposomes in multiple myeloma. | The Journal of steroid biochemistry and molecular biology 20060701 |
| Characterization of a human breast cancer cell line, MCF-7/RU58R-1, resistant to the pure antiestrogen RU 58,668. | Breast cancer research and treatment 20050501 |
| Role of the proteasome in the regulation of estrogen receptor alpha turnover and function in MCF-7 breast carcinoma cells. | The Journal of steroid biochemistry and molecular biology 20050301 |
| Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis. | Clinical cancer research : an official journal of the American Association for Cancer Research 20040501 |
| Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in female rat pituitary. | Biology of reproduction 20040301 |
| Pure antiestrogen RU 58668-loaded nanospheres: morphology, cell activity and toxicity studies. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040201 |
| Mechanisms governing the accumulation of estrogen receptor alpha in MCF-7 breast cancer cells treated with hydroxytamoxifen and related antiestrogens. | The Journal of steroid biochemistry and molecular biology 20031101 |
| Various phosphorylation pathways, depending on agonist and antagonist binding to endogenous estrogen receptor alpha (ERalpha), differentially affect ERalpha extractability, proteasome-mediated stability, and transcriptional activity in human breast cancer cells. | Molecular endocrinology (Baltimore, Md.) 20031001 |
| In vitro and in vivo biologic evaluation of long-circulating biodegradable drug carriers loaded with the pure antiestrogen RU 58668. | International journal of cancer 20030901 |
| Polyester-poly(ethylene glycol) nanoparticles loaded with the pure antiestrogen RU 58668: physicochemical and opsonization properties. | Pharmaceutical research 20030701 |
| A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice. | The Journal of clinical investigation 20030501 |
| Dexamethasone blocks antioestrogen- and oxidant-induced death of pituitary tumour cells. | The Journal of endocrinology 20010501 |
| Inhibition of volume-regulated anion channels in cultured endothelial cells by the anti-oestrogens clomiphene and nafoxidine. | British journal of pharmacology 20010101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.