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146-91-8

146-91-8 | Guanosine 5'-(trihydrogen diphosphate)

CAS No: 146-91-8 Catalog No: AG001DLZ MDL No:

Product Description

Catalog Number:
AG001DLZ
Chemical Name:
Guanosine 5'-(trihydrogen diphosphate)
CAS Number:
146-91-8
Molecular Formula:
C10H15N5O11P2
Molecular Weight:
443.2005
IUPAC Name:
[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
InChI:
InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChI Key:
QGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES:
O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1nc(N)[nH]c2=O

Properties

Complexity:
760  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
443.024g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
7  
Isotope Atom Count:
0
Molecular Weight:
443.202g/mol
Monoisotopic Mass:
443.024g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
248A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-4.6  

Literature

Title Journal
A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation. The Journal of biological chemistry 20170317
Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. Chemico-biological interactions 20150605
Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. The Journal of biological chemistry 20150515
Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities. The Journal of biological chemistry 20140207
Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak. Biochimica et biophysica acta 20120901
Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis. Free radical biology & medicine 20120501
Expression, Purification, and Characterization of Ras Protein (BmRas1) from Bombyx mori. Comparative and functional genomics 20120101
Moderate exercise promotes human RBC-NOS activity, NO production and deformability through Akt kinase pathway. PloS one 20120101
Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction. Free radical research 20110901
Millimolar Mn2+ influences agonist binding to 5-HT1A receptors by inhibiting guanosine nucleotide binding to receptor-coupled G-proteins. Neurotoxicology 20110101
Safety and feasibility of long-term intravenous sodium nitrite infusion in healthy volunteers. PloS one 20110101
The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. PloS one 20110101
Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes. BMC genomics 20110101
Autocatalytic loop, amplification and diffusion: a mathematical and computational model of cell polarization in neural chemotaxis. PLoS computational biology 20090801
An Arf1 GTPase mutant with different responses to GEF inhibitors. Biochemical and biophysical research communications 20081205
Identification of a vesicular nucleotide transporter. Proceedings of the National Academy of Sciences of the United States of America 20080415
Multiplicity of cerebrospinal fluid functions: New challenges in health and disease. Cerebrospinal fluid research 20080101
Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes. Proceedings of the National Academy of Sciences of the United States of America 20070619
Direct binding of translation initiation factor eIF2gamma-G domain to its GTPase-activating and GDP-GTP exchange factors eIF5 and eIF2B epsilon. The Journal of biological chemistry 20060505
Copper and zinc inhibit Galphas function: a nucleotide-free state of Galphas induced by Cu2+ and Zn2+. The Journal of biological chemistry 20050128
Enhancement by effectors and substrate nucleotides of R1-R2 interactions in Escherichia coli class Ia ribonucleotide reductase. The Journal of biological chemistry 20040723
Specific residues of the GDP/GTP exchange factor Bud5p are involved in establishment of the cell type-specific budding pattern in yeast. The Journal of biological chemistry 20040702
nNOS is involved in estrogen mediated neuroprotection in neuroblastoma cells. Neuroreport 20040628
Arabidopsis phospholipase Dalpha1 interacts with the heterotrimeric G-protein alpha-subunit through a motif analogous to the DRY motif in G-protein-coupled receptors. The Journal of biological chemistry 20040116
Chemical modifications of alpha1,6-fucosyltransferase define amino acid residues of catalytic importance. Biochimie 20030101
PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac. Blood 20020115
The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free radical biology & medicine 20000115
ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1. The Journal of biological chemistry 19990917
The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids. Journal of virology 19990401
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel. The Journal of physiology 19970315
RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae. The Journal of biological chemistry 19950519
Preparation, characterization and crystallization of an antibody Fab fragment that recognizes RNA. Crystal structures of native Fab and three Fab-mononucleotide complexes. Journal of molecular biology 19941021
GTP cleavage by the small GTP-binding protein Rab3A is associated with exocytosis of synaptic vesicles induced by alpha-latrotoxin. The Journal of biological chemistry 19941007
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science (New York, N.Y.) 19930528
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature 19930506
Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature 19911107
Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain. Proceedings of the National Academy of Sciences of the United States of America 19900601
Guanine nucleotide regulation of [125I]beta-endorphin binding to NG108-15 and SK-N-SH cell membranes: specific cation requirements. Brain research 19890724
Inhibition of herpes simplex virus DNA polymerase by purine ribonucleoside monophosphates. The Journal of biological chemistry 19860205

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