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114084-78-5

114084-78-5 | Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-

CAS No: 114084-78-5 Catalog No: AG000AHY MDL No:MFCD00868772

Product Description

Catalog Number:
AG000AHY
Chemical Name:
Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-
CAS Number:
114084-78-5
Molecular Formula:
C9H23NO7P2
Molecular Weight:
319.2289
MDL Number:
MFCD00868772
IUPAC Name:
[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphonic acid
InChI:
InChI=1S/C9H23NO7P2/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17)
InChI Key:
MPBVHIBUJCELCL-UHFFFAOYSA-N
SMILES:
CCCCCN(CCC(P(=O)(O)O)(P(=O)(O)O)O)C
UNII:
UMD7G2653W

Properties

Complexity:
342  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
319.095g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
319.231g/mol
Monoisotopic Mass:
319.095g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
139A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-4.1  

Literature

Title Journal
Modulation of paraoxonase 1 (PON1) activity and protein N-homocysteinylation by bisphosphonates in rats. Chemico-biological interactions 20161125
Bioactivity of Ti-6Al-4V alloy implants treated with ibandronate after the formation of the nanotube TiO2 layer. Journal of biomedical materials research. Part B, Applied biomaterials 20121101
Incidence of maxillary sinusitis and oro-antral fistulae in bisphosphonate-related osteonecrosis of the jaw. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20121001
Six months of parathyroid Hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and ibandronate combination study (PICS) randomized trial. The Journal of clinical endocrinology and metabolism 20121001
The influence of ibandronate treatment on bone density and biochemical bone markers in patients with osteogenesis imperfecta. Orthopedic reviews 20120904
Oral bisphosphonate-related osteonecrosis of the jaws: Clinical characteristics of a series of 20 cases in Spain. Medicina oral, patologia oral y cirugia bucal 20120901
Efficacy of intravenously administered ibandronate in postmenopausal Korean women with insufficient response to orally administered bisphosphonates. Journal of bone and mineral metabolism 20120901
Time to onset of efficacy in fracture reduction with current anti-osteoporosis treatments. Journal of bone and mineral metabolism 20120901
Clinical trials of bisphosphonates in multiple myeloma. Clinical advances in hematology & oncology : H&O 20120901
Bisphosphonate-related osteonecrosis of the jaw in patients with oral bisphosphonate exposure: clinical course and outcomes. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120801
Prolonged administration of bisphosphonates is well-tolerated and effective for skeletal-related events in Chinese breast cancer patients with bone metastasis. Breast (Edinburgh, Scotland) 20120801
Once-monthly oral ibandronate provides significant improvement in bone mineral density in postmenopausal women treated with glucocorticoids for inflammatory rheumatic diseases: a 12-month, randomized, double-blind, placebo-controlled trial. Scandinavian journal of rheumatology 20120801
Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis. Revista brasileira de reumatologia 20120801
[Non-traumatic fractures at the end of a pregnancy: are there always of osteoporotic origin]. Praxis 20120704
Monitoring of bone turnover markers does not improve persistence with ibandronate treatment. Joint, bone, spine : revue du rhumatisme 20120701
Bisphosphonate-related osteonecrosis of the mandible secondary to postural pressure. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120701
Adherence with intravenous zoledronate and intravenous ibandronate in the United States Medicare population. Arthritis care & research 20120701
Interpreting results from oncology clinical trials: a comparison of denosumab to zoledronic acid for the prevention of skeletal-related events in cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120701
Management of osteoporosis among the elderly with other chronic medical conditions. Drugs & aging 20120701
SEOM guidelines for the treatment of bone metastases from solid tumours. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20120701
Once-monthly oral ibandronate treatment in an adolescent with recurrent fractures and inadequately low bone mass. Journal of paediatrics and child health 20120701
Efficacy and safety of monthly oral minodronate in patients with involutional osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120601
Efficacy of monthly oral ibandronate is sustained over 5 years: the MOBILE long-term extension study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120601
Long-term administration of quarterly IV ibandronate is effective and well tolerated in postmenopausal osteoporosis: 5-year data from the DIVA study long-term extension. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120601
Clinical review. Comparative effectiveness of drug treatments to prevent fragility fractures: a systematic review and network meta-analysis. The Journal of clinical endocrinology and metabolism 20120601
Gastrointestinal bleeding following intravenous ibandronate administration. Journal of pharmacy practice 20120601
Monthly ibandronate for the prevention of bone loss in patients after liver transplantation. Transplantation proceedings 20120601
Bisphosphonates in multiple myeloma: a network meta-analysis. The Cochrane database of systematic reviews 20120516
Successful treatment of calcific uraemic arteriolopathy with bisphosphonates. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20120514
Multifactorial analysis of risk factors for reduced bone mineral density among postmenopausal women. Archives of medical science : AMS 20120509
2012 update of French guidelines for the pharmacological treatment of postmenopausal osteoporosis. Joint, bone, spine : revue du rhumatisme 20120501
Persistence and compliance of medications used in the treatment of osteoporosis--analysis using a large scale, representative, longitudinal German database. International journal of clinical pharmacology and therapeutics 20120501
Summary of AHRQ's comparative effectiveness review of treatment to prevent fractures in men and women with low bone density or osteoporosis: update of the 2007 report. Journal of managed care pharmacy : JMCP 20120501
Bisphosphonates as antimyeloma drugs. Leukemia 20120401
Medication adherence and fracture risk among patients on bisphosphonate therapy in a large United States health plan. Bone 20120401
Patient-reported outcome instruments used to assess pain and functioning in studies of bisphosphonate treatment for bone metastases. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120401
[Simultaneous determination of alendronate, pamidronate, ibandronate and risedronate using ion chromatography with integrated pulsed amperometric detection]. Se pu = Chinese journal of chromatography 20120401
Effect of dosing interval duration of intermittent ibandronate treatment on the healing process of femoral osteotomy in a rat fracture model. Calcified tissue international 20120301
An evaluation of the use of oral bisphosphonates and risk of esophageal cancer. The Annals of pharmacotherapy 20120301
Primary diagnosis of metastatic breast cancer in the third trimester of pregnancy: a case report and review of the literature. The journal of obstetrics and gynaecology research 20120301
[Bisphosphonates treatment in patients with osteoporosis]. Therapeutische Umschau. Revue therapeutique 20120301
Spontaneous non-traumatic stress fractures in bilateral femoral shafts in a patient treated with bisphosphonates. The Korean journal of internal medicine 20120301
Phase I clinical study to select a novel oral formulation for ibandronate containing the excipient sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC). Die Pharmazie 20120301
Question: In postmenopausal women with osteoporosis is once monthly oral ibandronate (150 mg) therapy preferred to once weekly oral bisphosphonate therapy. The Journal of the Oklahoma State Medical Association 20120301
Ibandronate and calcitriol reduces fracture risk, reverses bone loss, and normalizes bone turnover after LTX. Transplantation 20120215
Bisphosphonates and other bone agents for breast cancer. The Cochrane database of systematic reviews 20120215
Influence of bisphosphonates on the osteoblast RANKL and OPG gene expression in vitro. Clinical oral investigations 20120201
Counting touching cell nuclei using fast ellipse detection to assess in vitro cell characteristics: a feasibility study. Clinical oral investigations 20120201
The influence of bisphosphonates on viability, migration, and apoptosis of human oral keratinocytes--in vitro study. Clinical oral investigations 20120201
Validation of the adherence evaluation of osteoporosis treatment (ADEOS) questionnaire for osteoporotic post-menopausal women. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120201
Bisphosphonate-related osteonecrosis of jaws in 3 osteoporotic patients with history of oral bisphosphonate use treated with single yearly zoledronic acid infusion. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120201
Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120201
[Pelvic pain in the athlete: not always that simple...]. Revue medicale suisse 20120125
Alendronate and atrial fibrillation: a meta-analysis of randomized placebo-controlled clinical trials. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120101
Intravenous ibandronate acutely reduces bone hyperresorption in chronic critical illness. Journal of intensive care medicine 20120101
Effect of monthly ibandronate on hip structural geometry in men with low bone density. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120101
Efficacy and safety of a novel delayed-release risedronate 35 mg once-a-week tablet. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120101
Effects of teriparatide in postmenopausal women with osteoporosis pre-treated with bisphosphonates: 36-month results from the European Forsteo Observational Study. European journal of endocrinology 20120101
Impact of oral ibandronate 150 mg once monthly on bone structure and density in post-menopausal osteoporosis or osteopenia derived from in vivo μCT. Bone 20120101
Factors associated with treatment of women with osteoporosis or osteopenia from a national survey. BMC women's health 20120101
[The research on the expression and localization of multiple myeloma associated antigen MMSA-1]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120101
Exposure to bisphosphonates and risk of cancer: a protocol for nested case-control studies using the QResearch primary care database. BMJ open 20120101
Risedronate's Role in Reducing Hip Fracture in Postmenopausal Women with Established Osteoporosis. Clinical medicine insights. Arthritis and musculoskeletal disorders 20120101
A literature review to explore the link between treatment satisfaction and adherence, compliance, and persistence. Patient preference and adherence 20120101
Bilateral atypical insufficiency fractures of the proximal tibia and a unilateral distal femoral fracture associated with long-term intravenous bisphosphonate therapy: a case report. Journal of medical case reports 20120101
Epidemiological aspects of rheumatoid arthritis patients affected by oral bisphosphonate-related osteonecrosis of the jaws. Head & face medicine 20120101
Time associated with intravenous zoledronic acid administration in patients with breast or prostate cancer and bone metastasis. Cancer management and research 20120101
Effect of local zoledronate on implant osseointegration in a rat model. BMC musculoskeletal disorders 20120101
MiR-133a in human circulating monocytes: a potential biomarker associated with postmenopausal osteoporosis. PloS one 20120101
Possible role of oral ibandronate administration in Osteonecrosis of the Jaw: a case report. International journal of immunopathology and pharmacology 20120101
Active Referral Intervention following Fragility Fractures Leads to Enhanced Osteoporosis Follow-Up Care. Journal of osteoporosis 20120101
Severe hypercalcemia due to teriparatide. Indian journal of pharmacology 20120101
Clinical utility of risedronate in postmenopausal osteoporosis: patient considerations with delayed-release formulation. International journal of women's health 20120101
Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects. PloS one 20120101
Idiopathic calcinosis cutis of nasal dorsum. Journal of cutaneous and aesthetic surgery 20120101
Osteoporosis in men. Journal of osteoporosis 20120101
Dietary pseudopurpurin improves bone geometry architecture and metabolism in red-bone Guishan goats. PloS one 20120101
Teriparatide - Indications beyond osteoporosis. Indian journal of endocrinology and metabolism 20120101
Osteonecrosis of jaw associated with bisphosphonate use. Indian journal of endocrinology and metabolism 20120101
Pathogenesis and bisphosphonate treatment of skeletal events and bone pain in metastatic cancer: focus on ibandronate. Onkologie 20120101
Ibandronate and cementless total hip arthroplasty: densitometric measurement of periprosthetic bone mass and new therapeutic approach to the prevention of aseptic loosening. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 20120101
[Polymers as excipients used in the technology of coated tablets containing ibandronic acid derivatives (bisphosphonates)]. Polimery w medycynie 20120101
Active home-based cancer treatment. Journal of multidisciplinary healthcare 20120101
Phase II study of loading-dose ibandronate treatment in patients with breast cancer and bone metastases suffering from moderate to severe pain. Onkologie 20120101
Impact of long-term cinacalcet, ibandronate or teriparatide therapy on bone mineral density of hemodialysis patients: a pilot study. American journal of nephrology 20120101
Bisphosphonates for osteoporosis in primary biliary cirrhosis. The Cochrane database of systematic reviews 20111207
Cost-effectiveness of zoledronic acid in the prevention of skeletal-related events in patients with bone metastases secondary to advanced renal cell carcinoma: application to France, Germany, and the United Kingdom. The European journal of health economics : HEPAC : health economics in prevention and care 20111201
Daily or monthly ibandronate prevents or restores deteriorations of bone mass, architecture, biomechanical properties and markers of bone turnover in androgen-deficient aged rats. The aging male : the official journal of the International Society for the Study of the Aging Male 20111201
Zoledronate, ibandronate and clodronate enhance osteoblast differentiation in a dose dependent manner--a quantitative in vitro gene expression analysis of Dlx5, Runx2, OCN, MSX1 and MSX2. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20111201
Renal safety of ibandronate 6 mg infused over 15 min versus 60 min in breast cancer patients with bone metastases: a randomized open-label equivalence trial. Breast (Edinburgh, Scotland) 20111201
Effects of intravenous ibandronate injection on renal function in women with postmenopausal osteoporosis at high risk for renal disease--the DIVINE study. Bone 20111201
Monthly or weekly bisphosphonate? Evaluation of satisfaction in patients with postmenopausal osteoporosis using OPSAT-Q questionnaire during the BOOSTER study in Croatia. Clinical rheumatology 20111201
Impact of medication adherence on health care utilization and productivity: self-reported data from a cohort of postmenopausal women on osteoporosis therapy. Clinical therapeutics 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Optimising the use of bone-targeted agents in patients with metastatic cancers: a practical guide for medical oncologists. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20111101
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Integrated model for denosumab and ibandronate pharmacodynamics in postmenopausal women. Biopharmaceutics & drug disposition 20111101
Ask the doctor. I'm looking for information on Prolia and Reclast as alternatives to Boniva. Harvard women's health watch 20111101
The GISS trial: a phase II prevention trial of screening plus goserelin, ibandronate, versus screening alone in premenopausal women at increased risk of breast cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20111001
Analysis of the comparative effectiveness of 3 oral bisphosphonates in a large managed care organization: adherence, fracture rates, and all-cause cost. Journal of managed care pharmacy : JMCP 20111001
Effect of ibandronate on disseminated tumor cells in the bone marrow of patients with primary breast cancer: a pilot study. Anticancer research 20111001
Changes in renal function after different tandem hematopoietic stem-cell transplantation approaches in patients with multiple myeloma. Journal of Korean medical science 20111001
Benefit of infusions with ibandronate treatment in children with osteogenesis imperfecta. Chinese medical journal 20111001
Parenteral bisphosphonates for osteoporosis in patients with primary biliary cirrhosis. American journal of therapeutics 20110901
A comparative study of intravenous ibandronate and pamindronate in patients with bone metastases from breast or lung cancer: effect on metastatic bone pain. American journal of therapeutics 20110901
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High-resolution computed tomography for clinical imaging of bone microarchitecture. Clinical orthopaedics and related research 20110801
Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis. Calcified tissue international 20110801
Administration of sodium ibandronate in the treatment of complicated giant cell tumor of the spine. Spine 20110801
Non-surgical management of stage 3 biphosphonate-related oroantral fistula. The British journal of oral & maxillofacial surgery 20110701
Effect of bisphosphonates on anodized and heat-treated titanium surfaces: an animal experimental study. Journal of periodontology 20110701
The kidney and bisphosphonates. Bone 20110701
The relationship between the chemistry and biological activity of the bisphosphonates. Bone 20110701
[Assessment of volumetric bone mineral density and geometry for hip with clinical CT device]. Clinical calcium 20110701
Effects of intravenous zoledronic acid and oral ibandronate on early changes in markers of bone turnover in patients with bone metastases from non-small cell lung cancer. International journal of clinical oncology 20110601
Advances in glucocorticoid-induced osteoporosis. Current rheumatology reports 20110601
New imaging modalities in bone. Current rheumatology reports 20110601
Intravenous bisphosphonates for post-menopausal osteoporosis: adherence to a network guideline. Journal of clinical pharmacy and therapeutics 20110601
Bisphosphonate-associated atypical fracture of the femur: Spontaneous healing with drug holiday and re-appearance after resumed drug therapy with bilateral simultaneous displaced fractures--a case report. Acta orthopaedica 20110601
Effects of D-003 (10 mg/day) on bone mineral density of the lumbar spine and femoral neck in postmenopausal women: a randomized, double-blinded study. The Korean journal of internal medicine 20110601
Intravenous ibandronate or sodium-fluoride--a 3.5 years study on bone density and fractures in Crohn's disease patients with osteoporosis. Journal of gastrointestinal and liver diseases : JGLD 20110601
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Commentary on an article by Jacob S. Vandermeer et al.: 'Local administration of ibandronate and bone morphogenetic protein-2 after ischemic osteonecrosis of the immature femoral head. A combined therapy that stimulates bone formation and decreases femoral head deformity'. The Journal of bone and joint surgery. American volume 20110518
Local administration of ibandronate and bone morphogenetic protein-2 after ischemic osteonecrosis of the immature femoral head: a combined therapy that stimulates bone formation and decreases femoral head deformity. The Journal of bone and joint surgery. American volume 20110518
Adherence and profile of non-persistence in patients treated for osteoporosis--a large-scale, long-term retrospective study in The Netherlands. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110501
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Low-magnitude high-frequency vibration (LMHFV) enhances bone remodeling in osteoporotic rat femoral fracture healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110501
Oral bisphosphonates and risk of subtrochanteric or diaphyseal femur fractures in a population-based cohort. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110501
Association of menopausal vasomotor symptoms with increased bone turnover during the menopausal transition. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110401
Bisphosphonates for post-menopausal osteoporosis: are they all the same? QJM : monthly journal of the Association of Physicians 20110401
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Evidence of sustained vertebral and nonvertebral antifracture efficacy with ibandronate therapy: a systematic review. Therapeutic advances in musculoskeletal disease 20110401
Efficacy, side effects and route of administration are more important than frequency of dosing of anti-osteoporosis treatments in determining patient adherence: a critical review of published articles from 1970 to 2009. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110301
Bisphosphonates affect migration ability and cell viability of HUVEC, fibroblasts and osteoblasts in vitro. Oral diseases 20110301
Bisphosphonates in phenytoin-induced bone disorder. Bone 20110301
Bone mineral disease in children after renal transplantation in steroid-free and steroid-treated patients--a prospective study. Pediatric transplantation 20110301
Azathioprine-induced fever in sarcoidosis. The Annals of pharmacotherapy 20110301
Treatment of lumbar pars interarticularis stress injuries in athletes with intravenous bisphosphonates: five case studies. Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 20110301
The treatment of symptomatic osteoporotic spinal compression fractures. The Journal of the American Academy of Orthopaedic Surgeons 20110301
Prevalence, pathophysiology, screening and management of osteoporosis in gastric cancer patients. Journal of gastric cancer 20110301
Stability indicating ion chromatography method for the simultaneous determination of ibandronate sodium drug substance and its impurities. Journal of pharmaceutical and biomedical analysis 20110220
Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. The Journal of biological chemistry 20110204
[Bisphosphonate treatment of osteoporosis and other skeletal diseases]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20110204
Osteonecrosis of the jaw and the role of macrophages. Journal of the National Cancer Institute 20110202
Bisphosphonates: restrictions for vasculogenesis and angiogenesis: inhibition of cell function of endothelial progenitor cells and mature endothelial cells in vitro. Clinical oral investigations 20110201
[Osteoporosis treatment with biphosphonates: Approaches to care reality]. Atencion primaria 20110201
The efficacy of bisphosphonates in the prevention of vertebral, hip, and nonvertebral-nonhip fractures in osteoporosis: a network meta-analysis. Seminars in arthritis and rheumatism 20110201
Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110201
Bisphosphonates inhibit phosphorylation of signal transducer and activator of transcription 3 and expression of suppressor of cytokine signaling 3: implications for their effects on innate immune function and osteoclastogenesis. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110201
Effects of ibandronate-hydroxyapatite on resorptive activity of osteoclasts. Archives of medical science : AMS 20110201
Bones and Crohn's: no benefit of adding sodium fluoride or ibandronate to calcium and vitamin D. World journal of gastroenterology 20110121
Ibandronate promotes osteogenic differentiation of periodontal ligament stem cells by regulating the expression of microRNAs. Biochemical and biophysical research communications 20110107
Failure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW). Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110101
Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. Acta oncologica (Stockholm, Sweden) 20110101
Ibandronate affects bone growth and mineralization in rats with normal and reduced renal function. Pediatric nephrology (Berlin, Germany) 20110101
Computational insights into binding of bisphosphates to farnesyl pyrophosphate synthase. Current medicinal chemistry 20110101
Antifracture efficacy of currently available therapies for postmenopausal osteoporosis. Drugs 20110101
[Ibandronate]. Clinical calcium 20110101
The association of adherence to osteoporosis therapies with fracture, all-cause medical costs, and all-cause hospitalizations: a retrospective claims analysis of female health plan enrollees with osteoporosis. Journal of managed care pharmacy : JMCP 20110101
When do bisphosphonates make the most sense? The Journal of family practice 20110101
The cost effectiveness of zoledronic acid 5 mg for the management of postmenopausal osteoporosis in women with prior fractures: evidence from Finland, Norway and the Netherlands. Journal of medical economics 20110101
Management of osteoporosis and associated quality of life in post menopausal women. BMC musculoskeletal disorders 20110101
[Effects of rat serum containing Chinese herbal medicine Sangen Decoction on osteoclastogenesis and bone resorption of osteoclasts induced by polymethylmethacrylate particles]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110101
(Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis. Arthritis research & therapy 20110101
The influence of bisphosphonates on human osteoblast migration and integrin aVb3/tenascin C gene expression in vitro. Head & face medicine 20110101
The role of i.v. ibandronate administration in osteoporosis therapy. Endokrynologia Polska 20110101
Updated recommendations for the diagnosis and management of osteoporosis: a local perspective. Annals of Saudi medicine 20110101
The facial skeleton in patients with osteoporosis: a field for disease signs and treatment complications. Journal of osteoporosis 20110101
Aromatase inhibitor-associated bone and musculoskeletal effects: new evidence defining etiology and strategies for management. Breast cancer research : BCR 20110101
Atrial fibrillation and the use of oral bisphosphonates. Therapeutics and clinical risk management 20110101
Fracture prevention in postmenopausal women. BMJ clinical evidence 20110101
Bisphosphonates can reduce bone hunger after parathyroidectomy in patients with primary hyperparathyroidism and osteitis fibrosa cystica. Revista brasileira de reumatologia 20110101
Role of zoledronic acid in the prevention and treatment of osteoporosis. Clinical interventions in aging 20110101
Bone health in patients with multiple sclerosis. Journal of osteoporosis 20110101
Zoledronic acid preserves bone structure and increases survival but does not limit tumour incidence in a prostate cancer bone metastasis model. PloS one 20110101
Emerging strategies and therapies for treatment of Paget's disease of bone. Drug design, development and therapy 20110101
Reporting characteristics of cancer pain: a systematic review and quantitative analysis of research publications in palliative care journals. Indian journal of palliative care 20110101
Association of Serum Phosphate and Related Factors in ESRD-Related Vascular Calcification. International journal of nephrology 20110101
If you don't take it - it can't work: the consequences of not being treated or nonadherence to osteoporosis therapy. Therapeutics and clinical risk management 20110101
Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model. Arthritis research & therapy 20110101
Adverse cutaneous drug reactions to ibandronate. European journal of dermatology : EJD 20110101
Cost of non-persistence with oral bisphosphonates in post-menopausal osteoporosis treatment in France. BMC health services research 20110101
[Regression of an osteolytic lesion in a patient with multiple myeloma treated with clodronate after a successful therapy with bortezomib-based regimen]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 20110101
Metastatic breast carcinoma in the mandible presenting as a periodontal abscess: a case report. Journal of medical case reports 20110101
Clinical utility of denosumab for treatment of bone loss in men and women. Clinical interventions in aging 20110101
Bone turnover is adequately suppressed in osteoporotic patients treated with bisphosphonates in daily practice. BMC musculoskeletal disorders 20110101
The evidence for efficacy of osteoporosis treatment in men with primary osteoporosis: a systematic review and meta-analysis of antiresorptive and anabolic treatment in men. Journal of osteoporosis 20110101
Orbital inflammatory disease in a patient treated with zoledronate. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101
Increased human defensine levels hint at an inflammatory etiology of bisphosphonate-associated osteonecrosis of the jaw: an immunohistological study. Journal of translational medicine 20110101
Increased fracture rate in women with breast cancer: a review of the hidden risk. BMC cancer 20110101
Indian commentary on the 2009 KDIGO clinical practice guideline for the diagnosis, evaluation, and treatment of chronic kidney disease-mineral and bone disorders. Indian journal of nephrology 20110101
The relative efficacy of nine osteoporosis medications for reducing the rate of fractures in post-menopausal women. BMC musculoskeletal disorders 20110101
Effect of Cistanches Herba aqueous extract on bone loss in ovariectomized rat. International journal of molecular sciences 20110101
Tumour macrophages as potential targets of bisphosphonates. Journal of translational medicine 20110101
The role of galenic innovation in improving treatment compliance and persistence: three case studies. ClinicoEconomics and outcomes research : CEOR 20110101
Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates. Drug design, development and therapy 20110101
[The role of i.v. ibandronate administration in osteoporosis therapy]. Endokrynologia Polska 20110101
Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: population based retrospective cohort study. BMJ (Clinical research ed.) 20110101
Tumor cells and tumor-associated macrophages: secreted proteins as potential targets for therapy. Clinical & developmental immunology 20110101
Osteonecrosis of the jaws associated with the use of bisphosphonates. Discussion over 52 cases. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 20110101
Biochemical bone turnover markers and osteoporosis in older men: where are we? Journal of osteoporosis 20110101
[Osteonecrosis of the jaw associated with oral treatment with ibandronate]. Anales del sistema sanitario de Navarra 20110101
Osteopenia and osteoporosis in people living with HIV: multiprofessional approach. HIV/AIDS (Auckland, N.Z.) 20110101
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