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CAS No: 114-86-3 Catalog No: AG000AA2 MDL No:MFCD00242966
Title | Journal |
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Sulfenamide and sulfonamide derivatives of metformin can exert anticoagulant and profibrinolytic properties. | Chemico-biological interactions 20180325 |
Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat. | The Journal of toxicological sciences 20180101 |
The epigenetic regulation of HIF-1α by SIRT1 in MPP(+) treated SH-SY5Y cells. | Biochemical and biophysical research communications 20160205 |
Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria. | Toxicological sciences : an official journal of the Society of Toxicology 20130301 |
AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway. | Melanoma research 20121001 |
Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells. | The Journal of biological chemistry 20120608 |
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. | Gastroenterology 20120601 |
Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K. | The Journal of pharmacology and experimental therapeutics 20120601 |
Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line. | Toxicological sciences : an official journal of the Society of Toxicology 20120601 |
Exploration of biguanido-oxovanadium complexes as potent and selective inhibitors of protein tyrosine phosphatases. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20120601 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. | Journal of medicinal chemistry 20120524 |
Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance. | The Journal of biological chemistry 20120511 |
Adulteration of herbal antidiabetic products with undeclared pharmaceuticals: a case series in Hong Kong. | British journal of clinical pharmacology 20120501 |
Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-induced cytotoxicity during glucose deprivation. | Molecular cancer therapeutics 20120501 |
Emerging concepts: linking hypoxic signaling and cancer metabolism. | Cell death & disease 20120501 |
Milking the stroma in triple-negative breast cancer. | Cell cycle (Georgetown, Tex.) 20120415 |
Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials. | PLoS medicine 20120401 |
Phenformin as prophylaxis and therapy in breast cancer xenografts. | British journal of cancer 20120313 |
Thermodynamic origins of selective binding affinity between p-sulfonatocalix[4,5]arenes with biguanidiniums. | Organic & biomolecular chemistry 20120227 |
Metformin and phenformin block the peripheral antinociception induced by diclofenac and indomethacin on the formalin test. | Life sciences 20120102 |
Determination of metformin and other biguanides in forensic whole blood samples by hydrophilic interaction liquid chromatography-electrospray tandem mass spectrometry. | Biomedical chromatography : BMC 20120101 |
Determination of phenformin hydrochloride using molecular imprinting technology coupled with flow-injection chemiluminescence. | Luminescence : the journal of biological and chemical luminescence 20120101 |
Comprehensive evidence-based assessment and prioritization of potential antidiabetic medicinal plants: a case study from canadian eastern james bay cree traditional medicine. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
AMP-activated protein kinase plays an important evolutionary conserved role in the regulation of glucose metabolism in fish skeletal muscle cells. | PloS one 20120101 |
Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). | PloS one 20120101 |
Antidiabetic Effect of an Active Components Group from Ilex kudingcha and Its Chemical Composition. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle. | PloS one 20120101 |
The exaptation of endocrine pharmacology. | Indian journal of endocrinology and metabolism 20120101 |
Simultaneous determination of sitagliptin and metformin in pharmaceutical preparations by capillary zone electrophoresis and its application to human plasma analysis. | Analytical chemistry insights 20120101 |
Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology. | American journal of physiology. Cell physiology 20111201 |
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. | Diabetologia 20111201 |
NCI's provocative questions on cancer: some answers to ignite discussion. | Oncotarget 20111201 |
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides. | Biochemical and biophysical research communications 20111104 |
Liver uptake of biguanides in rats. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110901 |
Post-exercise protein synthesis rates are only marginally higher in type I compared with type II muscle fibres following resistance-type exercise. | European journal of applied physiology 20110801 |
Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake. | American journal of physiology. Heart and circulatory physiology 20110801 |
[Simultaneous determination of 15 anti-obesity drugs in blood by high performance liquid chromatography-tandem mass spectrometry]. | Se pu = Chinese journal of chromatography 20110801 |
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | Journal of medicinal chemistry 20110714 |
Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes. | The Journal of nutritional biochemistry 20110701 |
From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase. | Journal of neural transmission (Vienna, Austria : 1996) 20110701 |
Blockade of the antinociception induced by diclofenac, but not of indomethacin, by sulfonylureas and biguanides. | Pharmacology, biochemistry, and behavior 20110701 |
Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting. | Diabetes care 20110601 |
Use of metformin in the setting of mild-to-moderate renal insufficiency. | Diabetes care 20110601 |
Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes. | Journal of cellular biochemistry 20110501 |
Electrodeless, accurate pH determination in highly basic media using a new set of (1)H NMR pH indicators. | Journal of pharmaceutical and biomedical analysis 20110405 |
Simultaneous determination and pharmacokinetic study of metformin and rosiglitazone in human plasma by HPLC-ESI-MS. | Journal of chromatographic science 20110201 |
Addition of 2-deoxyglucose enhances growth inhibition but reverses acidification in colon cancer cells treated with phenformin. | Anticancer research 20110201 |
If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. | Aging 20110201 |
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. | Science (New York, N.Y.) 20110128 |
Does long-term metformin treatment increase cardiac lipoprotein lipase? | Metabolism: clinical and experimental 20110101 |
Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. | Cellular signalling 20110101 |
AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells. | Diabetologia 20110101 |
Complementary feeding: a Global Network cluster randomized controlled trial. | BMC pediatrics 20110101 |
Use of chemical genomics in assessment of the UPR. | Methods in enzymology 20110101 |
Sex differences in drug disposition. | Journal of biomedicine & biotechnology 20110101 |
Understanding the benefit of metformin use in cancer treatment. | BMC medicine 20110101 |
Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations. | Journal of translational medicine 20110101 |
The metabolic consequences of hepatic AMP-kinase phosphorylation in rainbow trout. | PloS one 20110101 |
Large-scale assessment of the zebrafish embryo as a possible predictive model in toxicity testing. | PloS one 20110101 |
Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. | BMJ (Clinical research ed.) 20110101 |
Metformin as an energy restriction mimetic agent for breast cancer prevention. | Journal of carcinogenesis 20110101 |
Effects of exposure to cigarette smoke prior to pregnancy in diabetic rats. | Diabetology & metabolic syndrome 20110101 |
Changes in labelling for metformin use in patients with type 2 diabetes and heart failure: documented safety outweighs theoretical risks. | Open medicine : a peer-reviewed, independent, open-access journal 20110101 |
Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice. | Aging 20101201 |
Metformin and sex: Why suppression of aging may be harmful to young male mice. | Aging 20101201 |
Metformin for aging and cancer prevention. | Aging 20101101 |
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. | Blood 20101021 |
5-aminoimidazole-4-carboxamide ribonucleoside and AMP-activated protein kinase inhibit signalling through NF-κB. | Immunology and cell biology 20101001 |
Comparison of potential risks of lactic acidosis induction by biguanides in rats. | Regulatory toxicology and pharmacology : RTP 20101001 |
Lactic acidosis induced by metformin: incidence, management and prevention. | Drug safety 20100901 |
Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond. | Future oncology (London, England) 20100801 |
Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis. | Diabetologia 20100701 |
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. | Cell metabolism 20100609 |
Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations. | Diabetes care 20100601 |
Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel. | European journal of pharmacology 20100525 |
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. | Cell metabolism 20100505 |
Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase. | Molecular membrane biology 20100401 |
AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. | Biochemical pharmacology 20100315 |
Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP. | The Biochemical journal 20100215 |
Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. | PloS one 20100101 |
Metabolic regulation of neuronal plasticity by the energy sensor AMPK. | PloS one 20100101 |
Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication. | Critical care (London, England) 20100101 |
Where does the lactate come from? A rare cause of reversible inhibition of mitochondrial respiration. | Critical care (London, England) 20100101 |
Repercussions of mild diabetes on pregnancy in Wistar rats and on the fetal development. | Diabetology & metabolic syndrome 20100101 |
A supercritical fluid chromatography/tandem mass spectrometry method for the simultaneous quantification of metformin and gliclazide in human plasma. | Indian journal of pharmaceutical sciences 20100101 |
A systems biology approach to identify effective cocktail drugs. | BMC systems biology 20100101 |
Analysis of quinapril by two solvent-saving methods: application of capillary column high-performance liquid chromatography with ultraviolet absorbance detection and LDI-TOF-MS. | Journal of AOAC International 20100101 |
Clinical evaluation of Dyslipidemia among type II diabetic patients at Public hospital Penang, Malaysia. | International archives of medicine 20100101 |
RP - HPLC method for the estimation of Tamsulosin Hydrochloride in Tablet Dosage Form. | Indian journal of pharmaceutical sciences 20100101 |
Simultaneous determination of anti-diabetes/anti-obesity drugs by LC/PDA, and targeted analysis of sibutramine analog in dietary supplements by LC/MS/MS. | Biomedical chromatography : BMC 20091201 |
A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes. | Biopharmaceutics & drug disposition 20091101 |
Glucose control and cardiovascular disease: is it important? No. | Diabetes care 20091101 |
Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes. | Diabetologia 20091001 |
The transmembrane transport of metformin by osteoblasts from rat mandible. | Archives of oral biology 20091001 |
Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. | Diabetes 20090901 |
Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20090801 |
Quasi-equilibrium analysis of the ion-pair mediated membrane transport of low-permeability drugs. | Journal of controlled release : official journal of the Controlled Release Society 20090701 |
Benzylguanidines and other galegine analogues inducing weight loss in mice. | Journal of medicinal chemistry 20090611 |
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. | Cancer research 20090515 |
Mood, side-effects and smoking outcomes among persons with and without probable lifetime depression taking varenicline. | Journal of general internal medicine 20090501 |
High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus. | Circulation 20090421 |
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. | Clinical science (London, England : 1979) 20090401 |
Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. | International journal of molecular sciences 20090401 |
Regulation of Cl(-) secretion by AMPK in vivo. | Pflugers Archiv : European journal of physiology 20090301 |
[Simultaneous determination of four highly polar anti-diabetic drugs in Chinese traditional patent medicines using high performance liquid chromatography]. | Se pu = Chinese journal of chromatography 20090301 |
Validation of anti-aging drugs by treating age-related diseases. | Aging 20090301 |
Mechanistic insight into control of CFTR by AMPK. | The Journal of biological chemistry 20090227 |
C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest. | The Journal of biological chemistry 20090102 |
Are animal models predictive for humans? | Philosophy, ethics, and humanities in medicine : PEHM 20090101 |
Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF. | PloS one 20090101 |
Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolytica. | Interdisciplinary perspectives on infectious diseases 20090101 |
A cardiologic approach to non-insulin antidiabetic pharmacotherapy in patients with heart disease. | Cardiovascular diabetology 20090101 |
Animal models for clinical and gestational diabetes: maternal and fetal outcomes. | Diabetology & metabolic syndrome 20090101 |
Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists. | PloS one 20090101 |
A patient presenting with symptomatic hypomagnesemia caused by metformin-induced diarrhoea: a case report. | Cases journal 20090101 |
Spectrophotometric method for analysis of metformin hydrochloride. | Indian journal of pharmaceutical sciences 20090101 |
Improving glycemic and cholesterol control through an integrated approach incorporating colesevelam - a clinical perspective. | Diabetes, metabolic syndrome and obesity : targets and therapy 20090101 |
Older age and phenformin therapy: a dangerous association. | Internal and emergency medicine 20081201 |
Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle. | Diabetes 20081201 |
Mechanisms of myocyte cytotoxicity induced by the multiple receptor tyrosine kinase inhibitor sunitinib. | Molecular pharmacology 20081201 |
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. | Toxicology and applied pharmacology 20081201 |
Cellular and molecular mechanisms in the long-term action of antidepressants. | Dialogues in clinical neuroscience 20081201 |
AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable channels in H441 human lung epithelial cell monolayers. | American journal of physiology. Lung cellular and molecular physiology 20081101 |
[Experimental studies on hypoglycemic effects of total flavonoid from Toona sinensis]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081101 |
Crosstalk between the AMP-activated kinase and insulin signaling pathways rescues murine blastocyst cells from insulin resistance. | Reproduction (Cambridge, England) 20080901 |
Comparison of gene expression changes induced by biguanides in db/db mice liver. | The Journal of toxicological sciences 20080801 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). | Journal of medicinal chemistry 20080612 |
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. | The Biochemical journal 20080601 |
[Cardiovascular risk and cardiometabolic risk: an epidemiological evaluation]. | Giornale italiano di cardiologia (2006) 20080401 |
Hazards posed by a banned drug--phenformin is still hanging around. | Hong Kong medical journal = Xianggang yi xue za zhi 20080201 |
Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. | The Biochemical journal 20080115 |
Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR-gamma Agonist. | PPAR research 20080101 |
Rapid and Simple RPHPLC Method for the Estimation of Metformin in Rat Plasma. | Indian journal of pharmaceutical sciences 20080101 |
Antihyperglycemic Activity of Various Fractions of Cassia auriculata Linn. in Alloxan Diabetic Rats. | Indian journal of pharmaceutical sciences 20080101 |
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. | The Biochemical journal 20071015 |
The phase shift hypothesis for the circadian component of winter depression. | Dialogues in clinical neuroscience 20070901 |
Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells. | British journal of pharmacology 20070801 |
The role of mitochondria in protection of the heart by preconditioning. | Biochimica et biophysica acta 20070801 |
Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. | American journal of physiology. Heart and circulatory physiology 20070701 |
Simultaneous determination of metformin and rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: application to a pharmacokinetic study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701 |
Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates. | Xenobiotica; the fate of foreign compounds in biological systems 20070601 |
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. | The Journal of biological chemistry 20070406 |
Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. | British journal of pharmacology 20070401 |
Simultaneous determination of metformin and glipizide in human plasma by liquid chromatography-tandem mass spectrometry. | Biomedical chromatography : BMC 20070201 |
Protein kinase CK2 acts as a signal molecule switching between the NDPK-A/AMPK alpha1 complex and NDPK-B. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070101 |
Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents. | Journal of diabetes and its complications 20070101 |
Pharmacological studies on anti-hyperglycemic effect of folium eriobotryae. | The American journal of Chinese medicine 20070101 |
Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions. | Cardiovascular diabetology 20070101 |
LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells. | Biochemical and biophysical research communications 20061222 |
Solid phase extraction--non-aqueous capillary electrophoresis for determination of metformin, phenformin and glyburide in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061020 |
[Diabetic lactic acidosis]. | Nihon rinsho. Japanese journal of clinical medicine 20060928 |
Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation. | American journal of physiology. Endocrinology and metabolism 20060901 |
Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose. | The Plant journal : for cell and molecular biology 20060701 |
AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3. | Biochemical pharmacology 20060528 |
Phenformin-induced lactic acidosis in an older diabetic patient: a recurrent drama (phenformin and lactic acidosis). | Diabetes care 20060401 |
Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. | Immunology and cell biology 20060201 |
Use of microarray biomarkers to identify longevity therapeutics. | Aging cell 20060201 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. | The Cochrane database of systematic reviews 20060125 |
[Traditional contraindications to the use of metformin -- more harmful than beneficial?]. | Deutsche medizinische Wochenschrift (1946) 20060120 |
Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells? | The Journal of biological chemistry 20051216 |
Contraindications can damage your health--is metformin a case in point? | Diabetologia 20051201 |
Identification of potential caloric restriction mimetics by microarray profiling. | Physiological genomics 20051117 |
Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177. | American journal of physiology. Renal physiology 20051101 |
Drug-induced pancreatitis: an update. | Journal of clinical gastroenterology 20050901 |
HIV/AIDS in older adults: a case report and literature review. | Geriatrics 20050901 |
Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase. | European journal of pharmacology 20050822 |
Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. | The Journal of physiology 20050801 |
Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. | The Journal of biological chemistry 20050701 |
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. | The EMBO journal 20050518 |
Metformin transport by renal basolateral organic cation transporter hOCT2. | Pharmaceutical research 20050201 |
Metabolic activation of AMP kinase in vascular smooth muscle. | Journal of applied physiology (Bethesda, Md. : 1985) 20050101 |
Effects of phentermine and phenformin on biomarkers of aging in rats. | Gerontology 20050101 |
Rapid and sensitive liquid chromatography-tandem mass spectrometric method for the quantitation of metformin in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040905 |
A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study. | British journal of clinical pharmacology 20040901 |
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. | American journal of physiology. Endocrinology and metabolism 20040801 |
[Lactic acidosis in diabetic patient treated with metformin]. | Anales de medicina interna (Madrid, Spain : 1984) 20040601 |
The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight. | European journal of pharmacology 20040319 |
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. | The EMBO journal 20040225 |
Molecularly imprinted solid-phase extraction for the screening of antihyperglycemic biguanides. | Journal of chromatography. A 20040220 |
N-bromosuccinimide-fluorescein based sensitive flow-injection chemiluminescence determination of phenformin. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20040201 |
All-cause mortality in diabetic patients treated with combinations of sulfonylureas and biguanides. | Diabetes/metabolism research and reviews 20040101 |
Effects of phenformin on the proliferation of human tumor cell lines. | Life sciences 20031219 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. | Archives of internal medicine 20031124 |
Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents. | Biochemical pharmacology 20030815 |
Severe acidosis in a patient with type 2 diabetes mellitus, hypertension, and renal failure. | Chest 20030501 |
Should we screen diabetic patients using biguanides for megaloblastic anaemia? | Australian family physician 20030501 |
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. | Molecular pharmacology 20030401 |
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. | Journal of medicinal chemistry 20030102 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. | The Cochrane database of systematic reviews 20030101 |
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. | Journal of biology 20030101 |
[A 50-year history of new drugs in Japan-the development and progress of anti-diabetic drugs and the epidemiological aspects of diabetes mellitus]. | Yakushigaku zasshi 20030101 |
At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation. | Journal of biology 20030101 |
Insulin and longevity: antidiabetic biguanides as geroprotectors. | Biogerontology 20030101 |
On the use of historical control information for trend test in carcinogenesis. | Biometrics 20021201 |
Enhanced secretion of glucagon-like peptide 1 by biguanide compounds. | Biochemical and biophysical research communications 20021115 |
A new method for determination of buformin in plasma and urine by ion-paired reversed-phase HPLC with ultraviolet detection. | Biomedical chromatography : BMC 20021001 |
[Adverse effect of biguanides]. | Nihon rinsho. Japanese journal of clinical medicine 20020901 |
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. | The Journal of pharmacology and experimental therapeutics 20020801 |
Phenformin suppresses calcium responses to glutamate and protects hippocampal neurons against excitotoxicity. | Experimental neurology 20020501 |
Response of regimens of insulin therapy in type 2 diabetes mellitus subjects with secondary failure. | The Journal of the Association of Physicians of India 20020501 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. | The Cochrane database of systematic reviews 20020101 |
Sustaining pattern of phenformin hydrochloride using various polymers and waxes. | Bollettino chimico farmaceutico 20020101 |
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Parasitic infections of the gastrointestinal tract. | Gastroenterology clinics of North America 20010901 |
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Lactic acidosis update for critical care clinicians. | Journal of the American Society of Nephrology : JASN 20010201 |
Role of sympathetic nervous system in experimental hypertension and diabetes mellitus. | Clinical and experimental hypertension (New York, N.Y. : 1993) 19990101 |
Pharmacological intervention: the antidiabetic approach. | European journal of clinical investigation 19980901 |
Lactic acidosis induced by phenformin is still a public health problem in Italy. | BMJ (Clinical research ed.) 19971129 |
Fatal phenformin-associated lactic acidosis. | Annals of internal medicine 19970715 |
Incidence of severe sideeffects during therapy with sulfonylureas and biguanides. | Hormone and metabolic research. Supplement series 19850101 |
Drug utilization and morbidity statistics for the evaluation of drug safety in Sweden. | Acta medica Scandinavica. Supplementum 19840101 |
Reduction of the severity of nephropathy in aging Fischer 344 rats treated with analogs of arylsulfonyluria. | Toxicology and applied pharmacology 19790701 |
Encephalopathy induced by oral hypoglycemic drugs. | Archives of internal medicine 19770801 |
Transitory blindness during ethanol and phenethylbiguanide induced lactic acidosis in a subject with diabetes mellitus. A case report. | Acta ophthalmologica 19770401 |
Phenformin as a cause of primary pulmonary hypertension. | British medical journal 19761211 |
Oral hypoglycaemics in diabetes mellitus. | Lancet (London, England) 19750913 |
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Phenformin and pulmonary hypertension. | British heart journal 19730801 |
The relation between phenformin therapy and lactic acidosis. | Diabetologia 19730201 |
Oral hypoglycaemic agents and cardiovascular complications of diabetes. Effect of long-term administration of tolbutamide and phenformin on the metabolism of glycosaminoglycans in normal rats. | Atherosclerosis 19730101 |
Drug-induced convulsions. Report from Boston Collaborative Drug Surveillance Program. | Lancet (London, England) 19720930 |
Phenformin-induced lactic acidosis in diabetes mellitus. | The Medical journal of Australia 19720513 |
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