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Home > Fluorides > 1138220-19-5
1138220-19-5 | 2,4-Thiazolidinedione, 5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]Methylene]-
CAS No: 1138220-19-5 Catalog No: AG0009SM MDL No:
Product Description
Catalog Number:
AG0009SM
Chemical Name:
2,4-Thiazolidinedione, 5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]Methylene]-
CAS Number:
1138220-19-5
Molecular Formula:
C14H8FNO4S
Molecular Weight:
305.2810
IUPAC Name:
(5E)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
InChI:
InChI=1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6+
InChI Key:
OYYVWNDMOQPMGE-WUXMJOGZSA-N
SMILES:
O=C1SC(=Cc2ccc(o2)c2ccc(cc2O)F)C(=O)N1
Properties
Complexity:
484
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1
Exact Mass:
305.016g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
305.279g/mol
Monoisotopic Mass:
305.016g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
105A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7
Literature
| Title | Journal |
|---|---|
| Pharmacological profile of phosphatidylinositol 3-kinases and related phosphatidylinositols mediating endothelin(A) receptor-operated native TRPC channels in rabbit coronary artery myocytes. | British journal of pharmacology 20120801 |
| Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors. | Cancer research 20120201 |
| Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca(2+)](i), I(Ca), and Ca(2+) transients in HL-1 cardiomyocytes. | Journal of biomedical science 20120101 |
| A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. | Molecular cancer research : MCR 20110701 |
| Key role of phosphoinositide 3-kinase class IB in pancreatic cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20101015 |
| Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. | Journal of medicinal chemistry 20060629 |
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