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113617-63-3 | 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5,6,8-trifluoro-1,4-dihydro-4-oxo-, rel-
CAS No: 113617-63-3 Catalog No: AG00096D MDL No:MFCD00864858
Product Description
Catalog Number:
AG00096D
Chemical Name:
3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5,6,8-trifluoro-1,4-dihydro-4-oxo-, rel-
CAS Number:
113617-63-3
Molecular Formula:
C19H20F3N3O3
Molecular Weight:
395.3756
MDL Number:
MFCD00864858
IUPAC Name:
1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-5,6,8-trifluoro-4-oxoquinoline-3-carboxylic acid
InChI:
InChI=1S/C19H20F3N3O3/c1-8-5-24(6-9(2)23-8)17-14(21)13(20)12-16(15(17)22)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6H2,1-2H3,(H,27,28)/t8-,9+
InChI Key:
QIPQASLPWJVQMH-DTORHVGOSA-N
SMILES:
C[C@@H]1N[C@H](C)CN(C1)c1c(F)c(F)c2c(c1F)n(cc(c2=O)C(=O)O)C1CC1
UNII:
660932TPY6
NSC Number:
758614
Properties
Complexity:
691
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
395.146g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
9
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
395.382g/mol
Monoisotopic Mass:
395.146g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
72.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.9
Literature
| Title | Journal |
|---|---|
| Comparative mutant prevention concentration and mechanism of resistance to veterinary fluoroquinolones in Staphylococcus pseudintermedius. | Veterinary dermatology 20120801 |
| Simultaneous determination of fluoroquinolones in foods of animal origin by a high performance liquid chromatography and a liquid chromatography tandem mass spectrometry with accelerated solvent extraction. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120215 |
| Characterization of Pseudomonas aeruginosa isolates from dogs and cats in Japan: current status of antimicrobial resistance and prevailing resistance mechanisms. | Microbiology and immunology 20120201 |
| Mutant prevention concentration and phenotypic and molecular basis of fluoroquinolone resistance in clinical isolates and in vitro-selected mutants of Escherichia coli from dogs. | Veterinary microbiology 20120127 |
| Multiclass analysis of 23 veterinary drugs in milk by ultraperformance liquid chromatography-electrospray tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120115 |
| Post-antibiotic effect of orbifloxacin against Escherichia coli and Pseudomonas aeruginosa isolates from dogs. | Acta veterinaria Scandinavica 20120101 |
| Complications from residual adnexal structures following enucleation in three dogs. | Journal of the American Veterinary Medical Association 20111215 |
| Comparative pharmacokinetics of orbifloxacin in healthy and Pasteurella multocida infected ducks. | British poultry science 20111001 |
| Rapid screening method for quinolone residues in livestock and fishery products using immobilised metal chelate affinity chromatographic clean-up and liquid chromatography-fluorescence detection. | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110901 |
| Multidrug-resistant Acinetobacter baumannii in veterinary clinics, Germany. | Emerging infectious diseases 20110901 |
| Pharmacokinetic-pharmacodynamic integration of orbifloxacin in Japanese quail (Coturnix japonica) following oral and intravenous administration. | Journal of veterinary pharmacology and therapeutics 20110801 |
| Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents. | Bioorganic & medicinal chemistry letters 20110715 |
| Allometric scaling of orbifloxacin disposition in nine mammal species: a retrospective analysis. | The Journal of veterinary medical science 20110601 |
| 2010 ACVIM small animal consensus statement on leptospirosis: diagnosis, epidemiology, treatment, and prevention. | Journal of veterinary internal medicine 20110101 |
| Short-term synaptic plasticity in the dentate gyrus of monkeys. | PloS one 20110101 |
| Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases. | Veterinary medicine international 20110101 |
| Determination of residual fluoroquinolones in honey by liquid chromatography using metal chelate affinity chromatography. | Journal of AOAC International 20110101 |
| Solvent-free microwave-assisted extraction of fluoroquinolones from soil and liquid chromatography-fluorescence determination. | Journal of chromatography. A 20101119 |
| Short communication: Fluoroquinolone susceptibility of Staphylococcus aureus strains isolated from caprine clinical mastitis in southeast Spain. | Journal of dairy science 20101101 |
| Single-step extraction followed by LC for determination of (fluoro)quinolone drug residues in muscle, eggs, and milk. | Journal of separation science 20100401 |
| Rapid determination of fluoroquinolone residues in honey by a microbiological screening method and liquid chromatography. | Journal of AOAC International 20100101 |
| Quantitation of fluoroquinolones in honey using tandem mass spectrometry (LC-MS/MS): nested validation with two mass spectrometers. | Journal of AOAC International 20100101 |
| Pharmacokinetics and milk distribution characteristics of orbifloxacin following intravenous and intramuscular injection in lactating ewes. | Journal of veterinary pharmacology and therapeutics 20090801 |
| Human-to-dog transmission of methicillin-resistant Staphylococcus aureus. | Emerging infectious diseases 20090801 |
| Free-radical-induced oxidative and reductive degradation of fluoroquinolone pharmaceuticals: kinetic studies and degradation mechanism. | The journal of physical chemistry. A 20090709 |
| Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of orbifloxacin in Korean Hanwoo cattle. | Journal of veterinary pharmacology and therapeutics 20090601 |
| Rapid determination of 19 quinolone residues in spiked fish and pig muscle by high-performance liquid chromatography (HPLC) tandem mass spectrometry. | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090301 |
| Approaches for application of sub and supercritical fluid extraction for quantification of orbifloxacin from plasma and milk: application to disposition kinetics. | Analytica chimica acta 20090105 |
| [Simultaneous determination of 19 quinolone residues in honey using high performance liquid chromatography-tandem mass spectrometry]. | Se pu = Chinese journal of chromatography 20090101 |
| Implementation of terbium-sensitized luminescence in sequential-injection analysis for automatic analysis of orbifloxacin. | Analytical and bioanalytical chemistry 20081201 |
| Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections. | Veterinary microbiology 20080918 |
| Quality by design, part I: application of NIR spectroscopy to monitor tablet manufacturing process. | Journal of pharmaceutical sciences 20080901 |
| Quality by design, part II: application of NIR spectroscopy to monitor the coating process for a pharmaceutical sustained release product. | Journal of pharmaceutical sciences 20080901 |
| Quality by design, part III: study of curing process of sustained release coated products using NIR spectroscopy. | Journal of pharmaceutical sciences 20080901 |
| Drug resistance mechanism of the fish-pathogenic bacterium Lactococcus garvieae. | Journal of fish diseases 20080601 |
| Pharmacokinetics and milk penetration of orbifloxacin after intravenous and intramuscular injections to dromedary lactating camels (Camelus dromedaries). | Journal of veterinary pharmacology and therapeutics 20080601 |
| Multiresidue determination of quinolones in animal and fishery products by HPLC. | Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20080601 |
| Pharmacokinetic-pharmacodynamic integration of orbifloxacin in rabbits after intravenous, subcutaneous and intramuscular administration. | Journal of veterinary pharmacology and therapeutics 20080201 |
| Pharmacokinetics and milk penetration of orbifloxacin after intravenous, subcutaneous, and intramuscular administration to lactating goats. | Journal of dairy science 20070901 |
| [Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry]. | Se pu = Chinese journal of chromatography 20070701 |
| Lack of inhibitory effects of several fluoroquinolones on cytochrome P-450 3A activities at clinical dosage in dogs. | Journal of veterinary pharmacology and therapeutics 20070201 |
| Antimicrobial testing of selected fluoroquinolones against Pseudomonas aeruginosa isolated from canine otitis. | Journal of the American Animal Hospital Association 20070101 |
| Efficacy of orbifloxacin tablets for the treatment of superficial and deep pyoderma due to Staphylococcus intermedius infection in dogs. | The Canadian veterinary journal = La revue veterinaire canadienne 20061001 |
| The pharmacokinetics of orbifloxacin in the horse following oral and intravenous administration. | Journal of veterinary pharmacology and therapeutics 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Comparison of pharmacodynamic and pharmacokinetic indices of efficacy for 5 fluoroquinolones toward pathogens of dogs and cats. | Journal of veterinary internal medicine 20060101 |
| Inhibitory effect of several fluoroquinolones on hepatic microsomal cytochrome P-450 1A activities in dogs. | Journal of veterinary pharmacology and therapeutics 20051201 |
| Hepatocellular toxicosis associated with the alternate administration of carprofen and meloxicam in a siberian husky. | The Journal of veterinary medical science 20051001 |
| Multiresidue determination of fluoroquinolones in shrimp by liquid chromatography-fluorescence-mass spectrometry. | Journal of AOAC International 20050101 |
| Modulation of cellular immune response by orbifloxacin in noninfected and E. coli-infected mice. | Immunopharmacology and immunotoxicology 20050101 |
| In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections. | Research in veterinary science 20040801 |
| Determination of quinolones and fluoroquinolones in fish tissue and seafood by high-performance liquid chromatography with electrospray ionisation tandem mass spectrometric detection. | Journal of chromatography. A 20021220 |
| Multiresidue analysis of fluoroquinolone antibiotics in chicken tissue using liquid chromatography-fluorescence-multiple mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021115 |
| Comparative serum pharmacokinetics of the fluoroquinolones enrofloxacin, difloxacin, marbofloxacin, and orbifloxacin in dogs after single oral administration. | Journal of veterinary pharmacology and therapeutics 20020201 |
| Determination of plasma and skin concentrations of orbifloxacin in dogs with clinically normal skin and dogs with pyoderma. | Veterinary therapeutics : research in applied veterinary medicine 20020101 |
| Pharmacokinetics of orbifloxacin and its concentration in body fluids and in endometrial tissues of mares. | Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20010701 |
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