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102767-28-2

102767-28-2 | 1-Pyrrolidineacetamide, α-ethyl-2-oxo-, (αS)-

CAS No: 102767-28-2 Catalog No: AG0008BR MDL No:MFCD03265610

Product Description

Catalog Number:
AG0008BR
Chemical Name:
1-Pyrrolidineacetamide, α-ethyl-2-oxo-, (αS)-
CAS Number:
102767-28-2
Molecular Formula:
C8H14N2O2
Molecular Weight:
170.2090
MDL Number:
MFCD03265610
IUPAC Name:
(2S)-2-(2-oxopyrrolidin-1-yl)butanamide
InChI:
InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1
InChI Key:
HPHUVLMMVZITSG-LURJTMIESA-N
SMILES:
CC[C@H](N1CCCC1=O)C(=O)N
EC Number:
600-348-9
UNII:
44YRR34555
NSC Number:
760119

Properties

Complexity:
203  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
170.106g/mol
Formal Charge:
0
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
170.212g/mol
Monoisotopic Mass:
170.106g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
63.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.3  

Literature

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Abnormal facilitatory mechanisms in motor cortex of migraine with aura. European journal of pain (London, England) 20111001
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A prospective study of levetiracetam efficacy in epileptic syndromes with continuous spikes-waves during slow sleep. Seizure 20111001
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Levetiracetam monotherapy--outcomes from an epilepsy clinic. Seizure 20110901
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[Paroxysmal tonic upward gaze deviation triggered by valproic acid within the context of focal epilepsy]. Revista de neurologia 20110901
Perioral myoclonia with absences and myoclonic status aggravated by oxcarbazepine. Epileptic disorders : international epilepsy journal with videotape 20110901
Pharmacokinetics of levetiracetam after oral and intravenous administration of a single dose to clinically normal cats. American journal of veterinary research 20110901
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Levetiracetam exhibits protective properties on rat Schwann cells in vitro. Journal of the peripheral nervous system : JPNS 20110901
Neuroprotective effect of levetiracetam on hippocampal sclerosis-like change in spontaneously epileptic rats. Brain research bulletin 20110810
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Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma. Neurology 20110809
Levetiracetam is associated with improved cognitive outcome for patients with intracranial hemorrhage. Neurocritical care 20110801
Epilepsy and trimethylaminuria: A new case report and literature review. Brain & development 20110801
Levetiracetam monotherapy in patients with brain tumor-related epilepsy: seizure control, safety, and quality of life. Journal of neuro-oncology 20110801
Motor symptoms of schizophrenia: is tardive dyskinesia a symptom or side effect? A modern treatment. Current psychiatry reports 20110801
No effect of oral contraceptives on the metabolism of levetiracetam. Epilepsy research 20110801
Postpartum cerebral venous thrombosis. Obstetrics and gynecology 20110801
Pregnancy complicated by recurrent brain abscess after extraction of an infected tooth. Obstetrics and gynecology 20110801
Curing of oscillating larynx by levetiracetam. Archives of neurology 20110801
Cost-utility analysis of levetiracetam and phenytoin for posttraumatic seizure prophylaxis. The Journal of trauma 20110801
[The effectiveness of levetiracetam in the treatment of neuropathic pain]. Revista de neurologia 20110716
The anticonvulsant levetiracetam for the treatment of pain in polyneuropathy: a randomized, placebo-controlled, cross-over trial. European journal of pain (London, England) 20110701
Second-line status epilepticus treatment: comparison of phenytoin, valproate, and levetiracetam. Epilepsia 20110701
Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes. Naunyn-Schmiedeberg's archives of pharmacology 20110701
A randomized, double-blind, placebo-controlled trial of levetiracetam for dyskinesia in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 20110701
Pregabalin or placebo used adjunctively with levetiracetam in refractory partial-onset epilepsy: a post hoc efficacy and safety analysis in combined clinical trials. Current medical research and opinion 20110701
Pharmacokinetics of levetiracetam in neonates with seizures. The Journal of pediatrics 20110701
Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model. Epilepsia 20110701
Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: a systematic review and meta-analysis. Epilepsia 20110701
Evaluation of the subjective and reinforcing effects of diphenhydramine, levetiracetam, and valproic acid. Journal of psychopharmacology (Oxford, England) 20110601
11-Deoxycortisol impedes GABAergic neurotransmission and induces drug-resistant status epilepticus in mice. Neuropharmacology 20110601
Restless Leg Syndrome in ADHD children: levetiracetam as a reasonable therapeutic option. Brain & development 20110601
Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo-controlled trial. The Journal of clinical psychiatry 20110601
Clinical diagnosis and successful treatment of inflammatory cerebral amyloid angiopathy. Neurocritical care 20110601
The use of lacosamide in refractory status epilepticus. Neurocritical care 20110601
Levetiracetam efficacy in patients with Lennox-Gastaut syndrome. Presentation of a case. Neurologia (Barcelona, Spain) 20110601
The effects of valproic acid and levetiracetam on chicken embryos. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20110601
A combination of levetiracetam and tiapride for outpatient alcohol detoxification: a case series. Journal of addiction medicine 20110601
Levetiracetam in children and adolescents with epilepsy and hemiplegic cerebral palsy. Journal of paediatrics and child health 20110501
A prospective open-labeled trial with levetiracetam in pediatric epilepsy syndromes: continuous spikes and waves during sleep is definitely a target. Seizure 20110501
The safety and efficacy of add-on levetiracetam in elderly patients with focal epilepsy: a one-year observational study. Seizure 20110501
Early treatment after stroke for the prevention of late epileptic seizures: a report on the problems performing a randomised placebo-controlled double-blind trial aimed at anti-epileptogenesis. Seizure 20110501
The effect of levetiracetam monotherapy on subjective sleep quality and objective sleep parameters in patients with epilepsy: compared with the effect of carbamazepine-CR monotherapy. Seizure 20110501
Effect of valproate, lamotrigine and levetiracetam on excitability and firing properties of CA1 neurons in rat brain slices. Cellular and molecular neurobiology 20110501
Conclusions of the available meta-analyses exploring the efficacy of levetiracetam. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20110501
Meta-analysis of randomized trials on first line and adjunctive levetiracetam. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20110501
Generic substitution of levetiracetam resulting in increased incidence of breakthrough seizures. The Annals of pharmacotherapy 20110501
[Effects of levetiracetam on the expression of NCAM and GAP-43 mRNA in the hippocampus of rats with epilepsy]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110501
Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes. Bulletin of experimental biology and medicine 20110501
Role of Ca(V)2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory. Behavioural brain research 20110415
Tonic seizures: a diagnostic clue of anti-LGI1 encephalitis? Neurology 20110412
Levetiracetam in brain ischemia: clinical implications in neuroprotection and prevention of post-stroke epilepsy. Brain & development 20110401
Levetiracetam in chronic daily headache: a double-blind, randomised placebo-controlled study. (The Australian KEPPRA Headache Trial [AUS-KHT]). Cephalalgia : an international journal of headache 20110401
Nocturnal frontal lobe epilepsy presenting with restless leg syndrome-like symptoms. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20110401
Successful treatment of refractory simple motor status epilepticus with lacosamide and levetiracetam. Seizure 20110401
Levetiracetam for treatment of neonatal seizures. Journal of child neurology 20110401
Simultaneous quantification of levetiracetam and gabapentin in plasma by ultra-pressure liquid chromatography coupled with tandem mass spectrometry detection. Therapeutic drug monitoring 20110401
A multicenter, randomized, placebo-controlled trial of levetiracetam in children and adolescents with newly diagnosed absence epilepsy. Epilepsia 20110401
Safety of non-therapeutic levetiracetam ingestions--a poison center based study. Pharmacoepidemiology and drug safety 20110401
Use of intravenous levetiracetam for management of acute seizures in neonates. Pediatric neurology 20110401
Clinical experience with generic levetiracetam in people with epilepsy. Epilepsia 20110401
[Efficacy of new antiepileptic drugs and the next generation drugs]. Brain and nerve = Shinkei kenkyu no shinpo 20110401
Childhood febrile convulsions and déjà vu in adulthood. British journal of hospital medicine (London, England : 2005) 20110401
[Rational combinations of antiepileptic drugs for refractory epilepsy]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20110401
Voluntary alcohol consumption and plasma beta-endorphin levels in alcohol preferring rats chronically treated with levetiracetam: a preliminary study. Physiology & behavior 20110328
Levetiracetam: a review of its use in epilepsy. Drugs 20110305
Elderly patient with acquired long QT syndrome secondary to Levetiracetam. Neurologia (Barcelona, Spain) 20110301
Early valproic acid exposure alters functional organization in the primary visual cortex. Experimental neurology 20110301
Elderly patients with migraine: an open-label study on prophylaxis therapy with levetiracetam. Central nervous system agents in medicinal chemistry 20110301
Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy. Epilepsy research 20110301
[Transient splenial lesion in influenza A H1N1 2009 infection]. Der Radiologe 20110301
Protein kinase inhibitor as a potential candidate for epilepsy treatment. Epilepsia 20110301
[Are clinical features derived from evidences and experiences outside of Japan applicable to clinical practices in Japan? Comparisons of results among studies conducted in US, Europe, Asian Countries and Japan]. Brain and nerve = Shinkei kenkyu no shinpo 20110301
The efficacy of bromides, stiripentol and levetiracetam in two patients with malignant migrating partial seizures in infancy. Epileptic disorders : international epilepsy journal with videotape 20110301
Efficacy and tolerability of levetiracetam in children with epilepsy. Brain & development 20110201
Neurocognitive effects of brivaracetam, levetiracetam, and lorazepam. Epilepsia 20110201
Status epilepticus. Indian journal of pediatrics 20110201
Performance characteristics of a new levetiracetam immunoassay and method comparison with a high-performance liquid chromatography method. Therapeutic drug monitoring 20110201
Higher evening antiepileptic drug dose for nocturnal and early-morning seizures. Epilepsy & behavior : E&B 20110201
The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital. Journal of veterinary pharmacology and therapeutics 20110201
Suspected phenobarbital-induced pseudolymphoma in a cat. Journal of the American Veterinary Medical Association 20110201
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Prophylactic anticonvulsants after subarachnoid hemorrhage. World neurosurgery 20110201
Comparison of short-duration levetiracetam with extended-course phenytoin for seizure prophylaxis after subarachnoid hemorrhage. World neurosurgery 20110201
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Improvement of early diagnosed post-anoxic myoclonus with levetiracetam. Intensive care medicine 20110101
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Non-convulsive status epilepticus in the postanesthesia care unit following meningioma excision. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110101
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A case of levetiracetam-induced thrombocytopenia. Epileptic disorders : international epilepsy journal with videotape 20101201
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Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam. Epilepsia 20090301
Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in Chinese patients with refractory partial-onset seizures. Epilepsia 20090301
Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy. Epilepsia 20090301
Retention of new AEDs in institutionalized intellectually disabled patients with epilepsy. Seizure 20090301
Effects of levetiracetam on generalized discharges monitored with ambulatory EEG in epileptic patients. Seizure 20090301
Effects of lamotrigine compared with levetiracetam on anger, hostility, and total mood in patients with partial epilepsy. Epilepsia 20090301
Safety and pharmacokinetics of intravenous levetiracetam infusion as add-on in status epilepticus. Epilepsia 20090301
Symptomatic complex partial status epilepticus manifesting as utilization behavior of a mobile phone. Epilepsy & behavior : E&B 20090301
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. European journal of pharmacology 20090301
The effect of levetiracetam on tremor severity and functionality in patients with multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England) 20090301
Post-hypoxic myoclonic status: the prognosis is not always hopeless. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20090301
Once-daily extended-release levetiracetam as adjunctive treatment of partial-onset seizures in patients with epilepsy: a double-blind, randomized, placebo-controlled trial. Epilepsia 20090301
Effects of levetiracetam on chronic pain in multiple sclerosis: results of a pilot, randomized, placebo-controlled study. European journal of neurology 20090301
Charles Bonnet syndrome disappearing with carbamazepine and valproic acid but not with levetiracetam. Acta neurologica Belgica 20090301
Levetiracetam for seizures in children with brain tumors and other cancers. Pediatric blood & cancer 20090201
Electrochemical determination of levetiracetam by screen-printed based biosensors. Bioelectrochemistry (Amsterdam, Netherlands) 20090201
Intravenous levetiracetam terminates refractory focal status epilepticus. Neurocritical care 20090101
Retention rates of new antiepileptic drugs in localization-related epilepsy: a single-center study. Acta neurologica Scandinavica 20090101
Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism. Seizure 20090101
Rapid effect of levetiracetam in a case of juvenile myoclonic epilepsy. Epilepsy & behavior : E&B 20090101
Levetiracetam in children with refractory status epilepticus. Epilepsy & behavior : E&B 20090101
Intravenous levetiracetam for epileptic seizure emergencies in older people. Gerontology 20090101
No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy. Epilepsy research 20090101
Efficacy and safety of levetiracetam (3,000 mg/Day) as an adjunctive therapy in Chinese patients with refractory partial seizures. European neurology 20090101
Safety and efficacy of levetiracetam for critically ill patients with seizures. Neurocritical care 20090101
Pharmacologic treatment for the core deficits and associated symptoms of autism in children. Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners 20090101
[Role of monotherapy with new antiepileptic drugs in the treatment of childhood epilepsy]. Medicina 20090101
[When a seizure occurs...]. Revue medicale de Liege 20090101
Linezolid-induced complex partial seizures in a patient with epilepsy. Scandinavian journal of infectious diseases 20090101
Levetiracetam improves intention tremor in fragile x-associated tremor/ataxia syndrome. Clinical neuropharmacology 20090101
Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta neurologica Scandinavica. Supplementum 20090101
Dramatic effect of levetiracetam on posthypoxic myoclonus: difficult weaning from mechanical ventilation. Clinical neuropharmacology 20090101
Pancytopenia associated with levetiracetam treatment. Clinical drug investigation 20090101
[Juvenile myoclonic epilepsy with recurrent myoclonic status: efficacy of valproate]. Therapie 20090101
Face-related ictal hallucinations and illusions and reflex-type phenomena. The Journal of neuropsychiatry and clinical neurosciences 20090101
[Levetiracetam (keppra) in the treatment of different epileptic syndromes in adults]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101
Brivaracetam and seletracetam, two new SV2A ligands, improve paroxysmal dystonia in the dt sz mutant hamster. European journal of pharmacology 20081228
Initial management of epilepsy. The New England journal of medicine 20081204
Levetiracetam in newly diagnosed late-onset post-stroke seizures: a prospective observational study. Epilepsy research 20081201
Effect of levetiracetam on cognitive functions and quality of life: a one-year follow-up study. Epileptic disorders : international epilepsy journal with videotape 20081201
Optimal prevention of seizures induced by high-dose busulfan. Pharmacotherapy 20081201
An unusual cause of collapse and neck pain. Emergency medicine journal : EMJ 20081201
The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus. Epilepsia 20081201
[Follow-up study on levetiracetam monotherapy in children with epilepsy]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20081201
Preemptive levetiracetam decreases postoperative pain in rats. Neuro endocrinology letters 20081201
Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats. Brain research bulletin 20081125
Quantification of levetiracetam in human plasma by liquid chromatography-tandem mass spectrometry: application to therapeutic drug monitoring. Journal of pharmaceutical and biomedical analysis 20081104
The effects of levetiracetam on cognition: a non-interventional surveillance study. Epilepsy & behavior : E&B 20081101
Levetiracetam in stiff-person syndrome. Journal of neurology 20081101
Levetiracetam in absence epilepsy. Developmental medicine and child neurology 20081101
Partial seizures and atypical absence seizures as a single ictal event in a patient with Lennox-Gastaut syndrome. Journal of child neurology 20081101
[Non-convulsive epileptic status reverted with intravenous levetiracetam]. Revista de neurologia 20081101
Bioequivalence of two formulations of levetiracetam. International journal of clinical pharmacology and therapeutics 20081101
Visualization of SV2A conformations in situ by the use of Protein Tomography. Biochemical and biophysical research communications 20081031
Successful treatment of Holmes tremor by levetiracetam. Movement disorders : official journal of the Movement Disorder Society 20081030
Antiemetic properties of the antiepileptic drug levetiracetam. The New England journal of medicine 20081023
New antiepileptic drugs in pediatric epilepsy. Brain & development 20081001
Cognitive fMRI and soluble telencephalin assessment in patients with localization-related epilepsy. Acta neurologica Scandinavica 20081001
The efficacy and tolerability of Levetiracetam as an add-on therapy in patients with startle epilepsy. Seizure 20081001
Levetiracetam prevents kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes. Epilepsia 20081001
Levetiracetam monotherapy for late poststroke seizures in the elderly. Epilepsy & behavior : E&B 20081001
Tolerability and dosing experience of intravenous levetiracetam in children and infants. Epilepsy research 20081001
Positive and negative psychotropic effects of levetiracetam. Epilepsy & behavior : E&B 20081001
Impending status epilepticus and anxiety in a pregnant woman treated with levetiracetam. Epilepsy & behavior : E&B 20081001
Pyridoxine supplementation for the treatment of levetiracetam-induced behavior side effects in children: preliminary results. Epilepsy & behavior : E&B 20081001
Levetiracetam versus phenytoin for seizure prophylaxis in severe traumatic brain injury. Neurosurgical focus 20081001
Comparative cognitive effects of levetiracetam and topiramate in intractable epilepsy. Psychiatry and clinical neurosciences 20081001
Treatment of seizures in a patient with Batten's disease. The Nurse practitioner 20081001
Simple and validated HPLC-UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080915
Effects of topiramate and levetiracetam vs placebo on habituation of contingent negative variation in migraine patients. Neuroscience letters 20080912
Reporting and analysis of open-label extension studies of anti-epileptic drugs. Epilepsy research 20080901
Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery. Neurology 20080826
Levetiracetam as a possible cause of fulminant liver failure. Neurology 20080826
Antinociceptive efficacy of levetiracetam in a mice model for painful diabetic neuropathy. Acta anaesthesiologica Scandinavica 20080801
Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A. British journal of pharmacology 20080801
Early detection of behavioral side effects of antiepileptic treatment using handheld computers. Epilepsy & behavior : E&B 20080801
Brivaracetam: a rational drug discovery success story. British journal of pharmacology 20080801
Effect of levetiracetam on the postmastectomy pain syndrome. European journal of neurology 20080801
Off-label use of antiepileptic drugs for the treatment of neonatal seizures. Pediatric neurology 20080801
Levetiracetam in continuous spike waves during slow-wave sleep syndrome. Pediatric neurology 20080801
Perspectives on interactions between antiepileptic drugs (AEDs) and antimicrobial agents. Epilepsia 20080801
PKA-mediated phosphorylation is a novel mechanism for levetiracetam, an antiepileptic drug, activating ROMK1 channels. Biochemical pharmacology 20080715
Add-on levetiracetam in children and adolescents with refractory epilepsy: results of an open-label multi-centre study. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20080701
Development of tolerance to levetiracetam in rats with chronic epilepsy. Epilepsia 20080701
Effects of uridine on kindling. Epilepsy & behavior : E&B 20080701
Anticonvulsive and antiepileptogenic effects of levetiracetam in the audiogenic kindling model. Epilepsia 20080701
Prolonged neurophysiologic effects of levetiracetam after oral administration in humans. Epilepsia 20080701
Thrombocytopenia during levetiracetam therapy. Epilepsy research 20080701
The risk of paradoxical levetiracetam effect is increased in mentally retarded patients. Epilepsia 20080701
Levetiracetam for treatment of premenstrual dysphoric disorder: a pilot, open-label study. Archives of women's mental health 20080701
Emesis responsive to levetiracetam. Journal of neurology, neurosurgery, and psychiatry 20080701
Termination of absence status epilepticus by low-dose intravenous levetiracetam. Epilepsia 20080701
Reversible panhypogammaglobulinemia associated with the antiepileptic agent levetiracetam. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080701
The efficacy and tolerability of levetiracetam in pharmacoresistant epileptic dogs. Veterinary journal (London, England : 1997) 20080601
Implications of antiinflammatory properties of the anticonvulsant drug levetiracetam in astrocytes. Journal of neuroscience research 20080601
Levetiracetam as monotherapy or add-on to valproate in the treatment of acute mania-a randomized open-label study. Psychopharmacology 20080601
An in vivo [18F]MK-9470 microPET study of type 1 cannabinoid receptor binding in Wistar rats after chronic administration of valproate and levetiracetam. Neuropharmacology 20080601
Intramuscular, intravenous and oral levetiracetam in dogs: safety and pharmacokinetics. Journal of veterinary pharmacology and therapeutics 20080601
Activity, tolerability and efficacy of levetiracetam on cerebellar symptoms in multiple sclerosis patients: a pilot kinematic study. European journal of neurology 20080601
Levetiracetam-associated hyponatremia. Seizure 20080601
Tolerability and efficacy of oral loading of levetiracetam. Neurology 20080527
Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture. Neuroscience letters 20080516
Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. Journal of neurology, neurosurgery, and psychiatry 20080501
Treatment of tardive dyskinesia with levetiracetam in a transplant patient. Acta neurologica Scandinavica 20080501
Encephalopathy induced by levetiracetam added to valproate. Acta neurologica Scandinavica 20080501
Clinical predictors in patients with refractory epilepsy exposed to levetiracetam: a single-center study. Acta neurologica Scandinavica 20080501
Levetiracetam versus carbamazepine monotherapy for partial epilepsy in children less than 16 years of age. Journal of child neurology 20080501
Effect of levetiracetam on cortical excitability: a transcranial magnetic stimulation study. European journal of neurology 20080501
Should we accept the status quo? Time for new trials in status epilepticus. Journal of neurology, neurosurgery, and psychiatry 20080501
Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenetics and genomics 20080501
Efficacy of levetiracetam in children with epilepsy younger than 2 years of age. Journal of child neurology 20080501
Use of propofol anesthesia and adjunctive treatment with levetiracetam and gabapentin in managing status epilepticus in a patient of acute intermittent porphyria. Epilepsia 20080501
Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs. Current neurovascular research 20080501
Seizure-freedom with combination therapy in localization-related epilepsy. Seizure 20080401
High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam. Progress in neuro-psychopharmacology & biological psychiatry 20080401
Effects of levetiracetam on EEG abnormalities in juvenile myoclonic epilepsy. Epilepsia 20080401
Intravenous levetiracetam: treatment experience with the first 50 critically ill patients. Epilepsy & behavior : E&B 20080401
Effects of levetiracetam on tardive dyskinesia: a randomized, double-blind, placebo-controlled study. The Journal of clinical psychiatry 20080401
Clinical picture of EPM1-Unverricht-Lundborg disease. Epilepsia 20080401
Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain. Bioorganic & medicinal chemistry 20080315
Levetiracetam as an adjunct to phenobarbital treatment in cats with suspected idiopathic epilepsy. Journal of the American Veterinary Medical Association 20080315
HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam. Brain research 20080314
Translocation-positive acute myeloid leukemia associated with valproic acid therapy. Pediatric blood & cancer 20080301
Long-term levetiracetam treatment affects reproductive endocrine function in female Wistar rats. Seizure 20080301
Serum concentration/dose ratio of levetiracetam before, during and after pregnancy. Seizure 20080301
The use of levetiracetam in a child with nonconvulsive status epilepticus. Journal of child neurology 20080301
A pilot trial of levetiracetam in eyelid myoclonia with absences (Jeavons syndrome). Epilepsia 20080301
Intravenous levetiracetam in children with epilepsy. Pediatric neurology 20080301
Rapid dosage titration of levetiracetam in children. Pharmacotherapy 20080301
Pharmaco-EEG-based assessment of interaction between ethanol and levetiracetam. Alcohol (Fayetteville, N.Y.) 20080301
Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures. Neurology 20080219
Effect of levetiracetam on depression and anxiety in adult epileptic patients. Progress in neuro-psychopharmacology & biological psychiatry 20080215
Response of infantile spasms to levetiracetam. Neurology 20080212
Dramatic weight loss with levetiracetam. Epilepsia 20080201
Effects of levetiracetam as an add-on therapy on cognitive function and quality of life in patients with refractory partial seizures. Epilepsy & behavior : E&B 20080201
Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats. Epilepsy research 20080201
Levetiracetam in patients with impulsive aggression: a double-blind, placebo-controlled trial. The Journal of clinical psychiatry 20080201
Levetiracetam has no acute effects on brain gamma-aminobutyric acid levels. Epilepsy & behavior : E&B 20080201
Effect of levetiracetam on cardiac repolarization in healthy subjects: a single-dose, randomized, placebo- and active-controlled, four-way crossover study. Clinical therapeutics 20080201
Levetiracetam for the treatment of hot flashes: a phase II study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20080101
Long-term effects of levetiracetam and topiramate in clinical practice: A head-to-head comparison. Seizure 20080101
Levetiracetam monotherapy in juvenile myoclonic epilepsy. Seizure 20080101
Levetiracetam in the treatment of antipsychotics-resistant Tourette syndrome. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20080101
The effect of anticonvulsant drugs on the fibrinolytic activity of tissue plasminogen activator. Cerebrovascular diseases (Basel, Switzerland) 20080101
Levetiracetam in juvenile myoclonic epilepsy: long-term efficacy in newly diagnosed adolescents. Developmental medicine and child neurology 20080101
Exacerbations of seizures by levetiracetam. Epilepsia 20080101
Sporadic multiple cerebral cavernomatosis: report of a case and review of literature. The neurologist 20080101
Retrospective population pharmacokinetic analysis of levetiracetam in children and adolescents with epilepsy: dosing recommendations. Clinical pharmacokinetics 20080101
Hemodiafiltration and high-flux hemodialysis significantly reduce serum valproate levels inducing epileptic seizures: case report. Blood purification 20080101
Efficacy of levetiracetam in hemifacial spasm: a case report. Clinical neuropharmacology 20080101
The effects of levetiracetam on alcohol consumption in alcohol-dependent subjects: an open label study. The American journal of drug and alcohol abuse 20080101
[Levetiracetam and restless leg syndrome]. Neurologia (Barcelona, Spain) 20080101
Levetiracetam in patients with epilepsy and chronic liver disease: observations in a case series. Clinical neuropharmacology 20080101
Treatment of juvenile myoclonic epilepsy. CNS neuroscience & therapeutics 20080101
Levetiracetam for stiff-person syndrome: report of 2 patients. Clinical neuropharmacology 20080101
Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis. Clinical pharmacokinetics 20080101
Levetiracetam for the treatment of co-occurring alcohol dependence and anxiety: case series and review. The American journal of drug and alcohol abuse 20080101
[The investigation of cataleptic muscle tonus changes in rats after audiogenic seizures]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20080101
[Use of keppra during the radiotherapy in patients with brain tumors and epileptic seizures after surgical treatment]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101
Correlation of increase in phosphene threshold with reduction of migraine frequency: observation of levetiracetam-treated subjects. Headache 20080101
Antiepileptic drugs in aneurysmal subarachnoid hemorrhage. Reviews in neurological diseases 20080101
[Endocrine effects of antiepileptic drugs]. Przeglad lekarski 20080101
[The possibilities of using keppra (levetiracetam) in different neurological diseases]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101
Are psychiatric adverse events of antiepileptic drugs a unique entity? A study on topiramate and levetiracetam. Epilepsia 20071201
A pilot study transitioning children onto levetiracetam monotherapy to improve language dysfunction associated with benign rolandic epilepsy. Epilepsy & behavior : E&B 20071201
The new antiepileptic drugs. Archives of disease in childhood. Education and practice edition 20071201
[Use of levetiracetam in the management of post-anoxic myoclonias. A report of two cases]. Neurologia (Barcelona, Spain) 20071201
Switching from branded to generic antiepileptic drugs as a confounding factor and unpredictable diagnostic pitfall in epilepsy management. Epileptic disorders : international epilepsy journal with videotape 20071201
Levetiracetam and bleeding disorders. Acta neurologica Belgica 20071201
Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetam. Neurology 20071127
Long-term use of Levetiracetam in patients with severe childhood-onset epilepsy. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20071101
Lack of pharmacokinetic interaction of levetiracetam on carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy. Epilepsia 20071101
Adjunctive therapy of uncontrolled partial seizures with levetiracetam in Australian patients. Epilepsy & behavior : E&B 20071101
Levetiracetam monotherapy in newly diagnosed cryptogenic West syndrome. Pediatric neurology 20071101
[DRESS syndrome after carbamazepine]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20071101
[The use of levetiracetam in monotherapy in post-stroke seizures in the elderly population]. Revista de neurologia 20071101
Levetiracetam. Drugs of today (Barcelona, Spain : 1998) 20071101
Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy. Neurology 20071030
Orofacial dystonia related to Sjogren's syndrome. Clinical rheumatology 20071001
Prolonged exposure to levetiracetam reveals a presynaptic effect on neurotransmission. Epilepsia 20071001
The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation. Epilepsia 20071001
Levetiracetam, phenytoin, and valproate act differently on rat bone mass, structure, and metabolism. Epilepsia 20071001
Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy. The Journal of pharmacology and experimental therapeutics 20071001
Effects of levetiracetam vs topiramate and placebo on visually evoked phase synchronization changes of alpha rhythm in migraine. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20071001
Impact of levetiracetam on mood and cognition during prednisone therapy. European psychiatry : the journal of the Association of European Psychiatrists 20071001
Levetiracetam monotherapy in Alzheimer patients with late-onset seizures: a prospective observational study. European journal of neurology 20071001
Therapeutic drug monitoring of levetiracetam by high-performance liquid chromatography with photodiode array ultraviolet detection: preliminary observations on correlation between plasma concentration and clinical response in patients with refractory epilepsy. Therapeutic drug monitoring 20071001
[Analysis of the cost-effectiveness of treatment for refractory partial epilepsy: a simulation model for pregabalin and levetiracetam]. Revista de neurologia 20071001
Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetam. Journal of chromatographic science 20071001
A double blind randomized placebo control trial of levetiracetam in Tourette syndrome. Movement disorders : official journal of the Movement Disorder Society 20070915
Retrospective analysis of the efficacy and tolerability of levetiracetam in patients with metastatic brain tumors. Journal of neuro-oncology 20070901
Current treatment of myoclonic astatic epilepsy: clinical experience at the Children's Hospital of Philadelphia. Epilepsia 20070901
Accidental overdosage of levetiracetam in two children caused no side effects. Epilepsy & behavior : E&B 20070901
Modeling and simulation of intravenous levetiracetam pharmacokinetic profiles in children to evaluate dose adaptation rules. Epilepsy research 20070901
[Levetiracetam in the treatment of epilepsy in adults. Experience with monotherapy]. Revista de neurologia 20070901
[Effect of levetiracetam on the sodium currents of rat hippocampal neurons exposed to coriaria lactone]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070901
Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 20070828
An open trial of levetiracetam for segmental and generalized dystonia. Movement disorders : official journal of the Movement Disorder Society 20070815
Tuberous sclerosis successfully treated with levetiracetam monotherapy: 18 months of follow-up. Pharmacy world & science : PWS 20070801
Suicidal ideation in epilepsy and levetiracetam therapy. Epilepsy & behavior : E&B 20070801
Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats. Neuropharmacology 20070801
Levetiracetam for manic behavior in hospitalized geriatric patients with dementia of the Alzheimer's type. Journal of clinical psychopharmacology 20070801
[Effectiveness and safety of levetiracetam in patients with essential tremor: data from an open 11-week follow-up trial]. Revista de neurologia 20070801
The SKATE study: an open-label community-based study of levetiracetam as add-on therapy for adults with uncontrolled partial epilepsy. Epilepsy research 20070801
An open-label trial of levetiracetam in severe myoclonic epilepsy of infancy. Neurology 20070717
[Probable levetiracetam-induced psychosis]. Medicina clinica 20070714
Efficacy and safety of levetiracetam as adjunctive treatment of refractory partial seizures in a multicentre open-label single-arm trial in Korean patients. Seizure 20070701
Levetiracetam for the treatment of epilepsy among adults with intellectual disabilities. Journal of intellectual disability research : JIDR 20070701
Influence of levetiracetam on the anticonvulsant efficacy of conventional antiepileptic drugs against audiogenic seizures in DBA/2 mice. Epilepsy research 20070701
Effect of age and comedication on levetiracetam pharmacokinetics and tolerability. Epilepsia 20070701
Levetiracetam attenuates spontaneous spike-and-wave discharges in DBA/2J mice. Epilepsy research 20070701
Levetiracetam as adjunctive therapy for refractory anxiety disorders. The Journal of clinical psychiatry 20070701
Coexistence of epileptic nocturnal wanderings and an arachnoid cyst. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20070615
Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection. Brain research 20070602
Levetiracetam or oxcarbazepine as monotherapy in newly diagnosed benign epilepsy of childhood with centrotemporal spikes (BECTS): an open-label, parallel group trial. Brain & development 20070601
Levetiracetam in three cases of progressive myoclonus epilepsy. Pharmacy world & science : PWS 20070601
Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy. Seizure 20070601
Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation. Epilepsia 20070601
The effect of levetiracetam in startle disease. Journal of neurology 20070601
Efficacy and tolerability of levetiracetam in children younger than 4 years: a retrospective review. Epilepsia 20070601
Pharmacokinetics of levetiracetam in infants and young children with epilepsy. Epilepsia 20070601
Juvenile myoclonic epilepsy: a benign disorder? Personality traits and psychiatric symptoms. Epilepsy & behavior : E&B 20070601
Status gelasticus associated with levetiracetam as add-on treatment. Epileptic disorders : international epilepsy journal with videotape 20070601
Saliva and serum levetiracetam concentrations in patients with epilepsy. Therapeutic drug monitoring 20070601
Effects of levetiracetam in lipid peroxidation level, nitrite-nitrate formation and antioxidant enzymatic activity in mice brain after pilocarpine-induced seizures. Cellular and molecular neurobiology 20070501
Single-dose pharmacokinetics of levetiracetam in healthy Chinese male subjects. British journal of clinical pharmacology 20070501
The influence of antiepileptic drugs on cognition: a comparison of levetiracetam with topiramate. Epilepsy & behavior : E&B 20070501
The safety of levetiracetam. Expert opinion on drug safety 20070501
Levetiracetam-induced diffuse interstitial lung disease. Journal of child neurology 20070501
Levetiracetam in nonconvulsive status epilepticus in childhood: a case report. Journal of child neurology 20070501
Levetiracetam monotherapy for children and adolescents with benign rolandic seizures. Seizure 20070401
Prospective assessment of levetiracetam pharmacokinetics during dose escalation in 4- to 12-year-old children with partial-onset seizures on concomitant carbamazepine or valproate. Epilepsy research 20070401
Modulation of AMPA receptors in cultured cortical neurons induced by the antiepileptic drug levetiracetam. Epilepsia 20070401
Levetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: an isobolographic analysis in the mouse maximal electroshock model. Epilepsia 20070401
Dramatic response to levetiracetam in post-ischaemic Holmes' tremor. Journal of neurology, neurosurgery, and psychiatry 20070401
Adjuvant levetiracetam in adolescent mania. Journal of clinical psychopharmacology 20070401
Levetiracetam monotherapy in children with epilepsy. Pediatric neurology 20070401
[Efficacy and safety of levetiracetam (keppra) add-on treatment in adult patients with refractory epilepsy in two tertiary centers]. Harefuah 20070401
Role of intravenous levetiracetam in status migrainosus. The journal of headache and pain 20070401
No kinetic interaction between levetiracetam and cyclosporine: a case report. Journal of child neurology 20070401
MERRF syndrome without ragged-red fibers: the need for molecular diagnosis. Biochemical and biophysical research communications 20070323
Levetiracetam as a treatment option in non-convulsive status epilepticus. Epilepsy research 20070301
Dose-response population analysis of levetiracetam add-on treatment in refractory epileptic patients with partial onset seizures. Epilepsy research 20070301
Retention rate of levetiracetam in children with intractable epilepsy at 1 year. Seizure 20070301
Anticonvulsants in sports: ethical considerations. Epilepsy & behavior : E&B 20070301
Levetiracetam in clinical practice: long-term experience in patients with refractory epilepsy referred to a tertiary epilepsy center. Epilepsy & behavior : E&B 20070301
Levetiracetam intravenous infusion as an alternative to oral dosing in patients with partial-onset seizures. Epilepsia 20070301
Psychic disturbances associated with sodium valproate plus levetiracetam. The Annals of pharmacotherapy 20070301
Levetiracetam prophylaxis in pediatric migraine--an open-label study. Headache 20070301
Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 20070206
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology 20070201
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