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Home > Imidazoles > 102676-86-8
102676-86-8 | Benzonitrile, 4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]-
CAS No: 102676-86-8 Catalog No: AG00082L MDL No:
Product Description
Catalog Number:
AG00082L
Chemical Name:
Benzonitrile, 4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]-
CAS Number:
102676-86-8
Molecular Formula:
C14H13N3
Molecular Weight:
223.2731
IUPAC Name:
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
InChI:
InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2
InChI Key:
CLPFFLWZZBQMAO-UHFFFAOYSA-N
SMILES:
N#Cc1ccc(cc1)[C@@H]1CCCc2n1cnc2
Properties
Complexity:
311
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
223.111g/mol
Formal Charge:
0
Heavy Atom Count:
17
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
223.279g/mol
Monoisotopic Mass:
223.111g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
41.6A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
2.1
Literature
| Title | Journal |
|---|---|
| Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System During Early Development in Zebrafish. | Endocrinology 20160201 |
| Temporal changes in biological responses and uncertainty in assessing risks of endocrine-disrupting chemicals: insights from intensive time-course studies with fish. | Toxicological sciences : an official journal of the Society of Toxicology 20150401 |
| Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. | Proceedings of the National Academy of Sciences of the United States of America 20150203 |
| Effects of bisphenol A and fadrozole exposures on cyp19a1 expression in the Murray rainbowfish, Melanotaenia fluviatilis. | Archives of environmental contamination and toxicology 20140801 |
| Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. | Journal of medicinal chemistry 20140626 |
| The 2,2',4,4'-tetrabromodiphenyl ether hydroxylated metabolites 5-OH-BDE-47 and 6-OH-BDE-47 stimulate estradiol secretion in the ovary by activating aromatase expression. | Toxicology 20130308 |
| Blocking estradiol synthesis affects memory for songs in auditory forebrain of male zebra finches. | Neuroreport 20121114 |
| Involvement of FGF9/16/20 subfamily in female germ cell development of the Nile tilapia, Oreochromis niloticus. | Fish physiology and biochemistry 20121001 |
| Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer. | Journal of medicinal chemistry 20120823 |
| Screening for modulatory effects on steroidogenesis using the human H295R adrenocortical cell line: a metabolomics approach. | Chemical research in toxicology 20120820 |
| Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome. | Journal of medicinal chemistry 20120726 |
| Label-free Raman spectroscopy for accessing intracellular anticancer drug release on gold nanoparticles. | The Analyst 20120621 |
| Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. | Bioorganic & medicinal chemistry 20120401 |
| Neovascularization is attenuated with aldosterone synthase inhibition in rats with retinopathy. | Hypertension (Dallas, Tex. : 1979) 20120301 |
| Rapid and widespread effects of 17β-estradiol on intracellular signaling in the male songbird brain: a seasonal comparison. | Endocrinology 20120301 |
| Corncob bedding alters the effects of estrogens on aggressive behavior and reduces estrogen receptor-α expression in the brain. | Endocrinology 20120201 |
| Environmentally realistic exposure to the herbicide atrazine alters some sexually selected traits in male guppies. | PloS one 20120101 |
| McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia. | Orphanet journal of rare diseases 20120101 |
| Sex-biased miRNA expression in Atlantic halibut (Hippoglossus hippoglossus) brain and gonads. | Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20120101 |
| [Role of medical treatment for symptomatic leiomyoma management in premenopausal women]. | Journal de gynecologie, obstetrique et biologie de la reproduction 20111201 |
| Genistein induces breast cancer-associated aromatase and stimulates estrogen-dependent tumor cell growth in in vitro breast cancer model. | Toxicology 20111118 |
| Effects of lifetime chemical inhibition of aromatase on the sexual differentiation, sperm characteristics and fertility of medaka (Oryzias latipes) and zebrafish (Danio rerio). | Aquatic toxicology (Amsterdam, Netherlands) 20111001 |
| Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. | Hypertension (Dallas, Tex. : 1979) 20110901 |
| Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates. | ChemMedChem 20110801 |
| 4-(Morpholin-4-yl)-3-(trifluoro-meth-yl)-benzonitrile. | Acta crystallographica. Section E, Structure reports online 20110701 |
| Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives. | Journal of medicinal chemistry 20110414 |
| Synthesis of some novel androstanes as potential aromatase inhibitors. | Steroids 20110401 |
| Neuroendocrine contributions to sexual partner preference in birds. | Frontiers in neuroendocrinology 20110401 |
| Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase. | Journal of medicinal chemistry 20110324 |
| The potency and clinical efficacy of aromatase inhibitors across the breast cancer continuum. | Annals of oncology : official journal of the European Society for Medical Oncology 20110301 |
| Effects of environmental endocrine disruptors on pubertal development. | Journal of clinical research in pediatric endocrinology 20110301 |
| Eight-year follow-up of a girl with McCune-Albright syndrome. | Journal of clinical research in pediatric endocrinology 20110301 |
| Intracerebral estrogen provision increases cytogenesis and neurogenesis in the injured zebra finch brain. | Developmental neurobiology 20110201 |
| Distribution and sexually dimorphic expression of steroid receptor coactivator-1 (SRC-1) in the zebra finch brain. | General and comparative endocrinology 20110115 |
| Species extrapolation for the 21st century. | Environmental toxicology and chemistry 20110101 |
| N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2). | Bioorganic & medicinal chemistry letters 20110101 |
| Expression profiles of reproduction- and thyroid hormone-related transcripts in the brains of chemically-induced intersex frogs. | Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20110101 |
| Oxygenated-blood colour change thresholds for perceived facial redness, health, and attractiveness. | PloS one 20110101 |
| Methylation status of cMHM and expression of sex-specific genes in adult sex-reversed female chickens. | Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20110101 |
| Neuroendocrine disruption: more than hormones are upset. | Journal of toxicology and environmental health. Part B, Critical reviews 20110101 |
| Combined liquid and solid-phase extraction improves quantification of brain estrogen content. | Frontiers in neuroanatomy 20110101 |
| The evolution of the multicoloured face of mandrills: insights from the perceptual space of colour vision. | PloS one 20110101 |
| Sex differences in brain aromatase activity: genomic and non-genomic controls. | Frontiers in endocrinology 20110101 |
| Neurosteroid biosynthesis and function in the brain of domestic birds. | Frontiers in endocrinology 20110101 |
| Neuroprotective actions of neurosteroids. | Frontiers in endocrinology 20110101 |
| Estradiol synthesis and action at the synapse: evidence for 'synaptocrine' signaling. | Frontiers in endocrinology 20110101 |
| N-[(4-Amino-5-sulfanyl-idene-4,5-dihydro-1H-1,2,4-triazol-3-yl)meth-yl]-4-methyl-benzamide. | Acta crystallographica. Section E, Structure reports online 20101001 |
| Steroidal and gonadal effects on neural cell proliferation in vitro in an adult songbird. | Brain research 20100910 |
| Regulation of thyroid hormone-, oestrogen- and androgen-related genes by triiodothyronine in the brain of Silurana tropicalis. | Journal of neuroendocrinology 20100901 |
| FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice. | Journal of hypertension 20100901 |
| Temporal expression and steroidal regulation of piRNA pathway genes (mael, piwi, vasa) during Silurana (Xenopus) tropicalis embryogenesis and early larval development. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20100801 |
| Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-'ouabain' pathway. | American journal of physiology. Heart and circulatory physiology 20100801 |
| Sexual incentive motivation in male rats requires both androgens and estrogens. | Hormones and behavior 20100701 |
| Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone. | The Journal of pharmacology and experimental therapeutics 20100701 |
| A transcriptomics-based biological framework for studying mechanisms of endocrine disruption in small fish species. | Aquatic toxicology (Amsterdam, Netherlands) 20100701 |
| Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis. | PLoS genetics 20100701 |
| Studies on feminization, sex determination, and differentiation of the Southern catfish, Silurus meridionalis--a review. | Fish physiology and biochemistry 20100601 |
| Transcriptomics in ecotoxicology. | Analytical and bioanalytical chemistry 20100601 |
| 17beta-Estradiol levels in male zebra finch brain: combining Palkovits punch and an ultrasensitive radioimmunoassay. | General and comparative endocrinology 20100515 |
| Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). | Bioorganic & medicinal chemistry letters 20100515 |
| Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development. | General and comparative endocrinology 20100401 |
| Low levels of the herbicide atrazine alter sex ratios and reduce metamorphic success in Rana pipiens tadpoles raised in outdoor mesocosms. | Environmental health perspectives 20100401 |
| Testosterone metabolites differentially maintain adult morphology in a sexually dimorphic neuromuscular system. | Developmental neurobiology 20100301 |
| Sensitivity of New Zealand mudsnail Potamopyrgus antipodarum (Gray) to a specific aromatase inhibitor. | Chemosphere 20100301 |
| Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). | Journal of medicinal chemistry 20100225 |
| Elevated plasma endoglin (CD105) predicts decreased response and survival in a metastatic breast cancer trial of hormone therapy. | Breast cancer research and treatment 20100201 |
| Molecular cloning of two isoforms of 11beta-hydroxylase and their expressions in the Nile tilapia, Oreochromis niloticus. | General and comparative endocrinology 20100101 |
| Neural expression and post-transcriptional dosage compensation of the steroid metabolic enzyme 17beta-HSD type 4. | BMC neuroscience 20100101 |
| The zebra finch neuropeptidome: prediction, detection and expression. | BMC biology 20100101 |
| Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk. | BMC systems biology 20100101 |
| Facilitation of male sexual behavior in Syrian hamsters by the combined action of dihydrotestosterone and testosterone. | PloS one 20100101 |
| Determinants of menarche. | Reproductive biology and endocrinology : RB&E 20100101 |
| Expression of estrogen receptor beta and phosphorylation of estrogen receptor alpha serine 167 correlate with progression-free survival in patients with metastatic breast cancer treated with aromatase inhibitors. | Oncology 20100101 |
| FACE: the barefaced facts of AI potency. | Cancer management and research 20100101 |
| Expression and localization of forkhead transcriptional factor 2 (Foxl2) in the gonads of protogynous wrasse, Halichoeres trimaculatus. | Biology of sex differences 20100101 |
| Aromatase immunoreactivity in fetal ovine neuronal cell cultures exposed to oxidative injury. | European journal of histochemistry : EJH 20091229 |
| Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors. | Analytical biochemistry 20091101 |
| Rapid steroid influences on visually guided sexual behavior in male goldfish. | Hormones and behavior 20091101 |
| Structure, function, regulation and polymorphism of human cytochrome P450 2A6. | Current drug metabolism 20090901 |
| Profiling neuroendocrine gene expression changes following fadrozole-induced estrogen decline in the female goldfish. | Physiological genomics 20090807 |
| Altered gene expression in the brain and ovaries of zebrafish (Danio rerio) exposed to the aromatase inhibitor fadrozole: microarray analysis and hypothesis generation. | Environmental toxicology and chemistry 20090801 |
| In situ hybridization to detect spatial gene expression in medaka. | Ecotoxicology and environmental safety 20090501 |
| Short term treatment with aromatase inhibitor induces sex change in the protogynous wrasse, Halichoeres trimaculatus. | General and comparative endocrinology 20090501 |
| Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor. | Environmental health perspectives 20090401 |
| Recovery of motor and cognitive function after cerebellar lesions in a songbird: role of estrogens. | The European journal of neuroscience 20090301 |
| Sex reversal of the amphibian, Xenopus tropicalis, following larval exposure to an aromatase inhibitor. | Aquatic toxicology (Amsterdam, Netherlands) 20090131 |
| Estradiol induces sexual behavior in female túngara frogs. | Hormones and behavior 20090101 |
| Masculinization of the European sea bass (Dicentrarchus labrax) by treatment with an androgen or aromatase inhibitor involves different gene expression and has distinct lasting effects on maturation. | General and comparative endocrinology 20090101 |
| Skin blood perfusion and oxygenation colour affect perceived human health. | PloS one 20090101 |
| OVEX1, a novel chicken endogenous retrovirus with sex-specific and left-right asymmetrical expression in gonads. | Retrovirology 20090101 |
| The aromatase inhibitor fadrozole and the 5-reductase inhibitor finasteride affect gonadal differentiation and gene expression in the frog Silurana tropicalis. | Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20090101 |
| Role of neo-adjuvant hormonal therapy in the treatment of breast cancer: a review of clinical trials. | International journal of general medicine 20090101 |
| In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. | Journal of medicinal chemistry 20081225 |
| Neuroethology of reward and decision making. | Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20081212 |
| Economic evaluation of fulvestrant as an extra step in the treatment sequence for ER-positive advanced breast cancer. | British journal of cancer 20081209 |
| Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (Oryzias latipes) exposed to fadrozole and 17beta-trenbolone. | Environmental toxicology and chemistry 20081201 |
| Forebrain steroid levels fluctuate rapidly during social interactions. | Nature neuroscience 20081101 |
| Fluorescence in situ hybridization techniques (FISH) to detect changes in CYP19a gene expression of Japanese medaka (Oryzias latipes). | Toxicology and applied pharmacology 20081015 |
| Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. | Journal of medicinal chemistry 20081009 |
| Androstenedione up-regulation of endometrial aromatase expression via local conversion to estrogen: potential relevance to the pathogenesis of endometriosis. | The Journal of clinical endocrinology and metabolism 20080901 |
| Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone. | European heart journal 20080901 |
| Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity. | Journal of medicinal chemistry 20080828 |
| Role of estrogen receptors and aromatase on brain protein synthesis rates in ovariectomized female rats fed genistein. | Nutritional neuroscience 20080801 |
| Benzo(a)pyrene decreases brain and ovarian aromatase mRNA expression in Fundulus heteroclitus. | Aquatic toxicology (Amsterdam, Netherlands) 20080730 |
| Glial aromatization increases the expression of bone morphogenetic protein-2 in the injured zebra finch brain. | Journal of neurochemistry 20080701 |
| CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma. | Drug metabolism and disposition: the biological fate of chemicals 20080501 |
| Ovarian P450 aromatase activity in the catfish Heteropneustes fossilis: seasonal changes and effects of catecholestrogens. | General and comparative endocrinology 20080501 |
| The specific estrogen receptor antagonist ICI 182,780 masculinizes development of the zebra finch syrinx. | General and comparative endocrinology 20080401 |
| DNA microarray application in ecotoxicology: experimental design, microarray scanning, and factors affecting transcriptional profiles in a small fish species. | Environmental toxicology and chemistry 20080301 |
| DNA microarray-based ecotoxicological biomarker discovery in a small fish model species. | Environmental toxicology and chemistry 20080301 |
| Long-term safety of aromatase inhibitors in the treatment of breast cancer. | Therapeutics and clinical risk management 20080201 |
| The adaptive significance of temperature-dependent sex determination in a reptile. | Nature 20080131 |
| Sex determination: some like it hot (and some don't). | Nature 20080131 |
| Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone. | Endocrinology 20080101 |
| Inhibition of injury-induced glial aromatase reveals a wave of secondary degeneration in the songbird brain. | Glia 20080101 |
| Aromatase inhibitors: past, present and future in breast cancer therapy. | Medical oncology (Northwood, London, England) 20080101 |
| Combined effects of DHEA and fadrozole on aggression and neural VIP immunoreactivity in the non-breeding male song sparrow. | Hormones and behavior 20080101 |
| Transmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity. | American journal of veterinary research 20080101 |
| Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development. | BMC developmental biology 20080101 |
| Degree of sex differentiation of genetic female chicken treated with different doses of an aromatase inhibitor. | Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20080101 |
| Dimorphic expression of dmrt1 and cyp19a1 (ovarian aromatase) during early gonadal development in pejerrey, Odontesthes bonariensis. | Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20080101 |
| Gonadal expression of Sf1 and aromatase during sex determination in the red-eared slider turtle (Trachemys scripta), a reptile with temperature-dependent sex determination. | Differentiation; research in biological diversity 20071201 |
| Aromatase expression and cell proliferation following injury of the adult zebra finch hippocampus. | Developmental neurobiology 20071201 |
| Letrozole in advanced breast cancer: the PO25 trial. | Breast cancer research and treatment 20071001 |
| The early days of letrozole. | Breast cancer research and treatment 20071001 |
| The discovery and mechanism of action of letrozole. | Breast cancer research and treatment 20071001 |
| Comparison of fathead minnow ovary explant and H295R cell-based steroidogenesis assays for identifying endocrine-active chemicals. | Ecotoxicology and environmental safety 20070901 |
| Tamoxifen induces masculinization of genetic females and regulates P450 aromatase and Müllerian inhibiting substance mRNA expression in Japanese flounder (Paralichthys olivaceus). | Molecular reproduction and development 20070901 |
| Imidazolylmethylbenzophenones as highly potent aromatase inhibitors. | Journal of medicinal chemistry 20070726 |
| Estrogen mediation of injury-induced cell birth in neuroproliferative regions of the adult zebra finch brain. | Developmental neurobiology 20070701 |
| Molecular cloning of doublesex and mab-3-related transcription factor 1, forkhead transcription factor gene 2, and two types of cytochrome P450 aromatase in Southern catfish and their possible roles in sex differentiation. | The Journal of endocrinology 20070701 |
| Windows of embryonic sexual lability in two lizard species with environmental sex determination. | Ecology 20070701 |
| Mechanistic computational model of ovarian steroidogenesis to predict biochemical responses to endocrine active compounds. | Annals of biomedical engineering 20070601 |
| Elevated plasma tissue inhibitor of metalloproteinase-1 level predicts decreased response and survival in metastatic breast cancer. | Cancer 20070515 |
| Establishment of the need for oestrogen during implantation in non-human primates. | Reproductive biomedicine online 20070501 |
| Endocrine control of sexual behavior in sneaker males of the peacock blenny Salaria pavo: effects of castration, aromatase inhibition, testosterone and estradiol. | Hormones and behavior 20070401 |
| Fertilizing ability of chicken sperm bearing the W chromosome. | Poultry science 20070401 |
| Linkage of biochemical responses to population-level effects: a case study with vitellogenin in the fathead minnow (Pimephales promelas). | Environmental toxicology and chemistry 20070301 |
| Offspring sex is not related to maternal allocation of yolk steroids in the lizard Bassiana duperreyi (Scincidae). | Physiological and biochemical zoology : PBZ 20070101 |
| A graphical systems model to facilitate hypothesis-driven ecotoxicogenomics research on the teleost brain-pituitary-gonadal axis. | Environmental science & technology 20070101 |
| [mRNA expression of genes related to avian sex determination during female-to-male sex reversal in ZW chicken embryos]. | Yi chuan = Hereditas 20070101 |
| Fugu (Takifugu rubripes) sexual differentiation: CYP19 regulation and aromatase inhibitor induced testicular development. | Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20070101 |
| The OECD Validation Program of the H295R Steroidogenesis Assay for the Identification of In Vitro Inhibitors and Inducers of Testosterone and Estradiol Production. Phase 2: Inter-Laboratory Pre-Validation Studies (8 pp). | Environmental science and pollution research international 20070101 |
| Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production. | Toxicology and applied pharmacology 20061115 |
| Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles. | Toxicology 20061110 |
| Effects of aromatase inhibitors on in vitro steroidogenesis by Atlantic salmon (Salmo salar) gonadal and brain tissue. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20061001 |
| Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis. | Journal of the National Cancer Institute 20060920 |
| Individual differences in estrogen receptor alpha in select brain nuclei are associated with individual differences in aggression. | Hormones and behavior 20060801 |
| Masculinization of female golden rabbitfish Siganus guttatus using an aromatase inhibitor treatment during sex differentiation. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060801 |
| Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. | Journal of medicinal chemistry 20060727 |
| Use of aromatase inhibitors to increase final height. | Molecular and cellular endocrinology 20060725 |
| In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity. | Toxicology letters 20060701 |
| Inhibition of cytochrome p450 brain aromatase reduces two male specific sexual behaviours in the male Endler guppy (Poecilia reticulata). | General and comparative endocrinology 20060701 |
| Testosterone and aggression: Berthold, birds and beyond. | Journal of neuroendocrinology 20060701 |
| Second- and third-generation aromatase inhibitors as first-line endocrine therapy in postmenopausal metastatic breast cancer patients: a pooled analysis of the randomised trials. | British journal of cancer 20060619 |
| Evaluation of a commercial kit for measuring vitellogenin in the fathead minnow (Pimephales promelas). | Ecotoxicology and environmental safety 20060601 |
| Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosterone-synthase inhibition? | Journal of hypertension 20060601 |
| Investigation of aldosterone-synthase inhibition in rats. | Journal of hypertension 20060601 |
| Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. | Journal of medicinal chemistry 20060406 |
| Antiestrogens inhibit xenoestrogen-induced brain aromatase activity but do not prevent xenoestrogen-induced feminization in Japanese medaka (Oryzias latipes). | Environmental health perspectives 20060401 |
| Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates. | Environmental health perspectives 20060401 |
| Screening and testing for endocrine disruption in fish-biomarkers as 'signposts,' not 'traffic lights,' in risk assessment. | Environmental health perspectives 20060401 |
| Relationship between brain and ovary aromatase activity and isoform-specific aromatase mRNA expression in the fathead minnow (Pimephales promelas). | Aquatic toxicology (Amsterdam, Netherlands) 20060310 |
| Effects of aromatizable and nonaromatizable androgens on the sex inversion of red-spotted grouper (Epinephelus akaara). | Fish physiology and biochemistry 20060301 |
| Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of estradiol product formation. | Toxicology 20060215 |
| Effects of estrogen in the male rat medial amygdala: infusion of an aromatase inhibitor lowers mating and bovine serum albumin-conjugated estradiol implants do not promote mating. | Neuroendocrinology 20060101 |
| The effect of aromatase inhibitor, fadrozole, on sGnRHa stimulated LH secretion in goldfish (Carassius auratus) and common carp (Cyprinus carpio). | Reproductive biology 20060101 |
| Three-dimensional model of cytochrome P450 human aromatase. | Journal of enzyme inhibition and medicinal chemistry 20051201 |
| New aromatase inhibitors as second-line endocrine therapy in postmenopausal patients with metastatic breast carcinoma: a pooled analysis of the randomized trials. | Cancer 20051001 |
| Extragonadal synthesis of estradiol is protective against kainic acid excitotoxic damage to the hippocampus. | Neuroreport 20050928 |
| Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans. | Drug metabolism and disposition: the biological fate of chemicals 20050901 |
| Estrogen provision by reactive glia decreases apoptosis in the zebra finch (Taeniopygia guttata). | Journal of neurobiology 20050801 |
| The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors. | The Journal of steroid biochemistry and molecular biology 20050801 |
| Aromatase inhibition abolishes courtship behaviours in the ring dove (Streptopelia risoria) and reduces androgen and progesterone receptors in the hypothalamus and anterior pituitary gland. | Molecular and cellular biochemistry 20050801 |
| Evidence that estrogen regulates the sex change of honeycomb grouper (Epinephelus merra), a protogynous hermaphrodite fish. | Journal of experimental zoology. Part A, Comparative experimental biology 20050601 |
| Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. | Journal of medicinal chemistry 20050324 |
| Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. | Journal of medicinal chemistry 20050310 |
| Enantiomeric resolution of new aromatase inhibitors by liquid chromatography on cellulose chiral stationary phases. | Journal of separation science 20050301 |
| Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model. | Toxicological sciences : an official journal of the Society of Toxicology 20050201 |
| Antiandrogenic effects in short-term in vivo studies of the fungicide fenarimol. | Toxicology 20050201 |
| Effects of sex steroids and their inhibitors on endocrine parameters and gender growth differences in Eurasian perch (Perca fluviatilis) juveniles. | Steroids 20050201 |
| Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes. | Reproductive biology and endocrinology : RB&E 20050101 |
| Dehydroepiandrosterone regulates astroglia reaction to denervation of olfactory glomeruli. | Glia 20041115 |
| Evidence for concurrent effects of exposure to environmental cadmium and lead on hepatic CYP2A6 phenotype and renal function biomarkers in nonsmokers. | Environmental health perspectives 20041101 |
| Successful detection of (anti-)androgenic and aromatase inhibitors in pre-spawning adult fathead minnows (Pimephales promelas) using easily measured endpoints of sexual development. | Aquatic toxicology (Amsterdam, Netherlands) 20041018 |
| Effects of estrogens during embryonal development on crowing in the domestic fowl. | Physiology & behavior 20040930 |
| Combined effect of testosterone and apocynin on nitric oxide and superoxide production in PMA-differentiated THP-1 cells. | Biochimica et biophysica acta 20040917 |
| Glial aromatization decreases neural injury in the zebra finch (Taeniopygia guttata): influence on apoptosis. | Journal of neuroendocrinology 20040801 |
| Differential expression pattern and steroid hormone sensitivity of SNAP-25 and synaptoporin mRNA in the telencephalic song control nucleus HVC of the zebra finch. | The Journal of comparative neurology 20040712 |
| Effects of follicle stimulating hormone on estradiol-17 beta production and P-450 aromatase (CYP19) activity and mRNA expression in brown trout vitellogenic ovarian follicles in vitro. | General and comparative endocrinology 20040601 |
| Modulation by steroid hormones of a 'sexy' acoustic signal in an Oscine species, the Common Canary Serinus canaria. | Anais da Academia Brasileira de Ciencias 20040601 |
| Aromatase inhibition in the treatment of advanced breast cancer: is there a relationship between potency and clinical efficacy? | British journal of cancer 20040504 |
| Aromatase modulation alters gonadal differentiation in developing zebrafish (Danio rerio). | Aquatic toxicology (Amsterdam, Netherlands) 20040414 |
| Characterization of stable human aromatase expressed in E. coli. | Steroids 20040401 |
| Aromatase inhibitor induces complete sex change in the protogynous honeycomb grouper (Epinephelus merra). | Molecular reproduction and development 20040301 |
| Expression of aromatase mRNA and effects of aromatase inhibitor during ovarian development in the medaka, Oryzias latipes. | Journal of experimental zoology. Part A, Comparative experimental biology 20040301 |
| Sex inversion of sexually immature honeycomb grouper (Epinephelus merra) by aromatase inhibitor. | Zoological science 20040301 |
| Fulvestrant is an effective and well-tolerated endocrine therapy for postmenopausal women with advanced breast cancer: results from clinical trials. | British journal of cancer 20040301 |
| Presynaptic N-methyl-D-aspartate receptor expression is increased by estrogen in an aromatase-rich area of the songbird hippocampus. | The Journal of comparative neurology 20040216 |
| Expression of androgen receptor mRNA in zebra finch song system: developmental regulation by estrogen. | The Journal of comparative neurology 20040216 |
| The effects of the aromatase inhibitor fadrozole hydrochloride on fetuses and uteri in late pregnant rats. | The Journal of endocrinology 20040201 |
| A comparison of human H295R and rat R2C cell lines as in vitro screening tools for effects on aromatase. | Toxicology letters 20040115 |
| First-line endocrine treatment of breast cancer: aromatase inhibitor or antioestrogen? | British journal of cancer 20040112 |
| An aromatase inhibitor or high water temperature induce oocyte apoptosis and depletion of P450 aromatase activity in the gonads of genetic female zebrafish during sex-reversal. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20040101 |
| Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens. | Breast cancer research : BCR 20040101 |
| Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune-Albright syndrome. | The Journal of clinical endocrinology and metabolism 20031201 |
| Does alligator testis produce estradiol? A comparison of ovarian and testicular aromatase. | Biology of reproduction 20031001 |
| Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030924 |
| Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase. | Journal of neurobiology 20030915 |
| Effect of non-steroidal aromatase inhibitor on blood plasma ovarian steroid and thyroid hormones in laying hen (Gallus domesticus). | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20030901 |
| Degree of sex reversal as related to plasma steroid levels in genetic female chickens (Gallus domesticus) treated with Fadrozole. | Molecular reproduction and development 20030801 |
| Applicability of the intratumor aromatase preclinical model to predict clinical trial results with endocrine therapy. | American journal of clinical oncology 20030801 |
| Role of aromatization in anticipatory and consummatory aspects of sexual behavior in male rats. | Hormones and behavior 20030801 |
| Estradiol in the male rat amygdala facilitates mounting but not ejaculation. | Physiology & behavior 20030701 |
| Delayed implantation induced by fadrozole hydrochloride in rats. | Contraception 20030701 |
| Vitellogenin synthesis via androgens in primary cultures of tilapia hepatocytes. | General and comparative endocrinology 20030615 |
| Endogenous estrogen formation is neuroprotective in model of cerebellar ataxia. | Endocrine 20030601 |
| Estrogen regulates tyrosine hydroxylase expression in the neonate mouse midbrain. | Journal of neurobiology 20030301 |
| Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor. | Fertility and sterility 20030301 |
| Aromatase inhibition affects testosterone-induced masculinization of song and the neural song system in female canaries. | Journal of neurobiology 20030205 |
| DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos. | Biology of reproduction 20030201 |
| Characterization of a cDNA encoding P-450 aromatase (CYP19) from Japanese eel ovary and its expression in ovarian follicles during induced ovarian development. | General and comparative endocrinology 20030201 |
| Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. | Archives of biochemistry and biophysics 20030101 |
| Double-blind randomised trial comparing the non-steroidal aromatase inhibitors letrozole and fadrozole in postmenopausal women with advanced breast cancer. | Annals of oncology : official journal of the European Society for Medical Oncology 20030101 |
| Induction of XY sex reversal by estrogen involves altered gene expression in a teleost, tilapia. | Cytogenetic and genome research 20030101 |
| Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6. | Drug metabolism reviews 20021101 |
| Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis. | International journal for parasitology 20021001 |
| Effects of the aromatase inhibitor fadrozole on plasma sex steroid secretion, spermatogenesis and epididymis morphology in the lizard, Podarcis sicula. | Molecular reproduction and development 20020901 |
| Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators. | Toxicological sciences : an official journal of the Society of Toxicology 20020901 |
| Relationship of serum HER-2/neu and serum CA 15-3 in patients with metastatic breast cancer. | Clinical chemistry 20020801 |
| Aromatase inhibitors block natural sex change and induce male function in the protandrous black porgy, Acanthopagrus schlegeli Bleeker: possible mechanism of natural sex change. | Biology of reproduction 20020601 |
| Morphological sex reversal upon short-term exposure to endocrine modulators in juvenile fathead minnow (Pimephales promelas). | Toxicology letters 20020510 |
| Evaluation of the aromatase inhibitor fadrozole in a short-term reproduction assay with the fathead minnow (Pimephales promelas). | Toxicological sciences : an official journal of the Society of Toxicology 20020501 |
| Testosterone promotes paternal behaviour in a monogamous mammal via conversion to oestrogen. | Proceedings. Biological sciences 20020422 |
| Detection of aromatase inhibitors in vitro using rat ovary microsomes. | Toxicology letters 20020324 |
| Elevated serum Her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020315 |
| Post-hatching hormonal modulation of a sexually dimorphic neuromuscular system controlling song in zebra finches. | Brain research 20020308 |
| Development of sexual partner preference in the zebra finch: a socially monogamous, pair-bonding animal. | Archives of sexual behavior 20020201 |
| Sex change in the protandrous black porgy, Acanthopagrus schlegeli: a review in gonadal development, estradiol, estrogen receptor, aromatase activity and gonadotropin. | The Journal of experimental zoology 20011201 |
| Sex reversal and aromatase in chicken. | The Journal of experimental zoology 20011201 |
| [An elderly woman with breast cancer and multiple liver metastasis that responded well to combination therapy of fadrozole and tamoxifen]. | Gan to kagaku ryoho. Cancer & chemotherapy 20011201 |
| A summary of second-line randomized studies of aromatase inhibitors. | The Journal of steroid biochemistry and molecular biology 20011201 |
| A comparative approach to structure-function studies of mammalian aromatases. | The Journal of steroid biochemistry and molecular biology 20011201 |
| Are differences in the available aromatase inhibitors and inactivators significant? | Clinical cancer research : an official journal of the American Association for Cancer Research 20011201 |
| [Hepatic infusion of docetaxel using PEIT for a patient with stage IV breast cancer]. | Gan to kagaku ryoho. Cancer & chemotherapy 20011101 |
| [Two cases of effective weekly paclitaxel administration for metastatic breast cancer]. | Gan to kagaku ryoho. Cancer & chemotherapy 20011101 |
| Enantioselectivity of some 1-[(benzofuran-2-yl) phenylmethyl] imidazoles as aromatase (P450AROM) inhibitors. | Journal of enzyme inhibition 20011101 |
| Estrogen stimulates brain-derived neurotrophic factor expression in embryonic mouse midbrain neurons through a membrane-mediated and calcium-dependent mechanism. | Journal of neuroscience research 20011015 |
| Expression of AMH, SF1, and SOX9 in gonads of genetic female chickens during sex reversal induced by an aromatase inhibitor. | Developmental dynamics : an official publication of the American Association of Anatomists 20011001 |
| Effect of the aromatase inhibitor CGS-16949A on pregnancy and secretion of progesterone, estradiol-17beta, prostaglandins E and F2alpha (PGE; PGF2alpha) and pregnancy specific protein B (PSPB) in 90-day ovariectomized pregnant ewes. | Prostaglandins & other lipid mediators 20010901 |
| Advances in aromatase inhibition: clinical efficacy and tolerability in the treatment of breast cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010901 |
| Sex reversal in Nile tilapia (Oreochromis niloticus) using a nonsteroidal aromatase inhibitor. | The Journal of experimental zoology 20010701 |
| [Developments of hormonal agents for breast cancer]. | Gan to kagaku ryoho. Cancer & chemotherapy 20010701 |
| [Endocrine therapy for advanced or recurrent breast cancer]. | Gan to kagaku ryoho. Cancer & chemotherapy 20010701 |
| Brain aromatase is neuroprotective. | Journal of neurobiology 20010615 |
| Regulation of plasma gonadotropin II secretion by sex steroids, aromatase inhibitors, and antiestrogens in the protandrous black porgy, Acanthopagrus schlegeli Bleeker. | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20010601 |
| Evaluation of the male pubertal onset assay to detect testosterone and steroid biosynthesis inhibitors in CD rats. | Toxicological sciences : an official journal of the Society of Toxicology 20010401 |
| Aromatase inhibition reduces specifically one display of the ring dove courtship behavior. | General and comparative endocrinology 20010401 |
| A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. | Journal of medicinal chemistry 20010301 |
| Masculinized sexual partner preference in female zebra finches with sex-reversed gonads. | Hormones and behavior 20010201 |
| Synthesis, evaluation and QSAR studies of highly potent aromatase inhibitors of the piperidinedione type. | Anti-cancer drug design 20010201 |
| [Endometriosis and aromatase inhibitor]. | Nihon rinsho. Japanese journal of clinical medicine 20010101 |
| Intracellular aromatase and its relevance to the pharmacological efficacy of aromatase inhibitors. | The Journal of steroid biochemistry and molecular biology 20010101 |
| Synergistic effect of CGS16949A and 5-fluorouracil on a human breast cancer cell line. | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20010101 |
| [A case of effective bisphosphonate therapy of sequential pamidronate and incadronate for bone metastases from breast cancer]. | Gan to kagaku ryoho. Cancer & chemotherapy 20000801 |
| Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell. | The Journal of steroid biochemistry and molecular biology 19960501 |
| A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19920101 |
| The effect of the aromatase inhibitor, rogletimide (pyridoglutethimide), on guinea pig adrenal cell steroidogenesis and placental microsomal aromatase activity: comparison with aminoglutethimide and CGS 16949A. | The Journal of steroid biochemistry and molecular biology 19911101 |
| Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. | Journal of medicinal chemistry 19910201 |
| Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. | The Journal of steroid biochemistry and molecular biology 19901220 |
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