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10191-42-1 | Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-
CAS No: 10191-42-1 Catalog No: AG0005XD MDL No:
Product Description
Catalog Number:
AG0005XD
Chemical Name:
Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-
CAS Number:
10191-42-1
Molecular Formula:
C19H22N2
Molecular Weight:
278.3914
IUPAC Name:
2-[1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
InChI:
InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3
InChI Key:
CBEQULMOCCWAQT-UHFFFAOYSA-N
SMILES:
Cc1ccc(cc1)C(=CCN1CCCC1)c1ccccn1
Properties
Complexity:
336
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
278.178g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
278.399g/mol
Monoisotopic Mass:
278.178g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
16.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
1
XLogP3:
3.9
Literature
| Title | Journal |
|---|---|
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| Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats. | European journal of pharmacology 20071208 |
| First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005. | Aviation, space, and environmental medicine 20070501 |
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| Quantification of antihistamine acrivastine in plasma by solid-phase extraction and high-performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20070104 |
| H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells. | Carcinogenesis 20060901 |
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| Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20060213 |
| Histaminergic neurons protect the developing hippocampus from kainic acid-induced neuronal damage in an organotypic coculture system. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125 |
| Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry. | Rapid communications in mass spectrometry : RCM 20060101 |
| Spectrophotometric determination of some antihistaminic drugs using 7,7,8,8-tetracyanoquinodimethane (TCNQ). | Journal of AOAC International 20060101 |
| The butterbur extract petasin has no effect on skin test reactivity induced by different stimuli: a randomized, double-blind crossover study using histamine, codeine, methacholine, and aeroallergen solutions. | Journal of investigational allergology & clinical immunology 20060101 |
| Excitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H2 receptors in vitro. | Neuroscience research 20051101 |
| Transport of hydroxyzine and triprolidine across bovine olfactory mucosa: role of passive diffusion in the direct nose-to-brain uptake of small molecules. | International journal of pharmaceutics 20050930 |
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| Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20050401 |
| Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. | Journal of pharmaceutical sciences 20050301 |
| Antihistamine effects of triprolidine from the transdermal administration of the TPX matrix in rats. | Archives of pharmacal research 20050101 |
| Adsorptive stripping voltammetric determination of triprolidine hydrochloride in pharmaceutical tablets. | Farmaco (Societa chimica italiana : 1989) 20050101 |
| Homology modelling and binding site mapping of the human histamine H1 receptor. | European journal of medicinal chemistry 20041101 |
| Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein. | The Journal of biological chemistry 20040813 |
| New plastic membrane and carbon paste ion selective electrodes for the determination of triprolidine. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20040701 |
| Activation of histamine H1-receptor enhances neurotrophic factor secretion from cultured astrocytes. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040601 |
| Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040301 |
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| Histamine inhibits atrial myocytic ANP release via H2 receptor-cAMP-protein kinase signaling. | American journal of physiology. Regulatory, integrative and comparative physiology 20030801 |
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| P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. | Drug metabolism and disposition: the biological fate of chemicals 20030301 |
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| Electrochemical behaviour and determination of acrivastine in pharmaceuticals and human urine. | Journal of pharmaceutical and biomedical analysis 20021107 |
| Enhanced transdermal delivery of triprolidine from the ethylene-vinyl acetate matrix. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20021101 |
| Mechanisms of relaxant action of a pyranocoumarin from Peucedanum japonicum in isolated rat thoracic aorta. | Planta medica 20021001 |
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| Controlled release of triprolidine using ethylene-vinyl acetate membrane and matrix systems. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020901 |
| Histamine H(2) -like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [(3) H]tiotidine binding. | Journal of neurochemistry 20020601 |
| Endogenous histamine in the medial septum-diagonal band complex increases the release of acetylcholine from the hippocampus: a dual-probe microdialysis study in the freely moving rat. | The European journal of neuroscience 20020501 |
| Transdermal delivery of triprolidine using TPX polymer membrane. | International journal of pharmaceutics 20020320 |
| Enhanced bioavailability of triprolidine from the transdermal TPX matrix system in rabbits. | International journal of pharmaceutics 20020302 |
| Cardiotoxicity of new antihistamines and cisapride. | Toxicology letters 20020227 |
| Application of TPX polymer membranes for the controlled release of triprolidine. | International journal of pharmaceutics 20020131 |
| Kinetic spectrophotometric methods for the quantitation of triprolidine in bulk and in drug formulations. | Journal of pharmaceutical and biomedical analysis 20010901 |
| Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010801 |
| Lipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems. | Pharmaceutical research 20010501 |
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| Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures. | The Analyst 20010401 |
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| Role of mast cells in zymosan-induced peritoneal inflammation in Balb/c and mast cell-deficient WBB6F1 mice. | Journal of leukocyte biology 20010101 |
| The effects of single and repeated administration of ebastine on cognition and psychomotor performance in comparison to triprolidine and placebo in healthy volunteers. | Current medical research and opinion 20010101 |
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