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101827-46-7 | 1-Naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-, hydrochloride (1:1)
CAS No: 101827-46-7 Catalog No: AG0005NO MDL No:MFCD00917064
Product Description
Catalog Number:
AG0005NO
Chemical Name:
1-Naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-, hydrochloride (1:1)
CAS Number:
101827-46-7
Molecular Formula:
C23H28ClN
Molecular Weight:
353.9281
MDL Number:
MFCD00917064
IUPAC Name:
1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride
InChI:
InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
InChI Key:
LJBSAUIFGPSHCN-UHFFFAOYSA-N
SMILES:
CN(Cc1cccc2c1cccc2)Cc1ccc(cc1)C(C)(C)C.Cl
UNII:
R8XA2029ZI
Properties
Complexity:
374
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
353.191g/mol
Formal Charge:
0
Heavy Atom Count:
25
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
353.934g/mol
Monoisotopic Mass:
353.191g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
3.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Chiral N-benzyl-N-methyl-1-(naphthalen-1-yl)ethanamines and their in vitro antifungal activity against Cryptococcus neoformans, Trichophyton mentagrophytes and Trichophyton rubrum. | European journal of medicinal chemistry 20131001 |
| Determination of butenafine hydrochloride in human plasma by liquid chromatography electrospray ionization-mass spectrometry following its topical administration in human subjects. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111115 |
| A simple and rapid method to assess butenafine hydrochloride in skin samples and a comparative cutaneous retention study of two marketed formulations. | Biomedical chromatography : BMC 20111001 |
| Stability-indicating LC assay for butenafine hydrochloride in creams using an experimental design for robustness evaluation and photodegradation kinetics study. | Journal of chromatographic science 20110801 |
| RP-HPLC method for simultaneous determination of butenafine hydrochloride and betamethasone dipropionate in a cream formulation. | Journal of AOAC International 20110101 |
| [Activity of butenafine against ocular pathogenic filamentous fungi in vitro]. | [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20100101 |
| Butenafine and superficial mycoses: current status. | Expert opinion on drug metabolism & toxicology 20080701 |
| An unprecedented rearrangement in collision-induced mass spectrometric fragmentation of protonated benzylamines. | Journal of mass spectrometry : JMS 20060901 |
| [The effect of propyl gallate on the activity of various antifungal drugs against filamentous fungi in vitro]. | [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20060401 |
| In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenafine, against clinically important fungi in comparison with fluconazole and butenafine. | Biological & pharmaceutical bulletin 20050801 |
| Comparative efficacy of topical 1% butenafine and 1% clotrimazole in tinea cruris and tinea corporis: a randomized, double-blind trial. | The Journal of dermatological treatment 20050101 |
| Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. | International journal of dermatology 20030901 |
| Butenafine: an update of its use in superficial mycoses. | Skin therapy letter 20020901 |
| Experimental and conformational analyses of interactions between butenafine and lipids. | Antimicrobial agents and chemotherapy 20011201 |
| Efficacy and safety of butenafine in superficial dermatophytoses (tinea pedis, tinea cruris, tinea corporis). | Journal of the Indian Medical Association 20010501 |
| Butenafine hydrochloride (Mentax) cream for the treatment of hyperkeratotic type tinea pedis and its transfer into the horny layer, with or without concomitant application of 20% urea ointment (Keratinamin). | Mycoses 20010101 |
| Azole antifungal agents related to naftifine and butenafine. | Archiv der Pharmazie 20000601 |
| Butenafine hydrochloride: for the treatment of interdigital tinea pedis. | Expert opinion on pharmacotherapy 20000301 |
| Butenafine, a fungicidal benzylamine derivative, used once daily for the treatment of interdigital tinea pedis. | International journal of dermatology 19980601 |
| Butenafine. | Drugs 19980301 |
| Two mechanisms of butenafine action in Candida albicans. | Antimicrobial agents and chemotherapy 19930401 |
| [Synthesis and antifungal activity of butenafine hydrochloride (KP-363), a new benzylamine antifungal agent]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 19910201 |
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