200,000+ products from a single source!
sales@angenechem.com
101626-70-4 | 4H-Thiazolo[4,5-d]azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propen-1-yl)-
CAS No: 101626-70-4 Catalog No: AG00050T MDL No:
Product Description
Catalog Number:
AG00050T
Chemical Name:
4H-Thiazolo[4,5-d]azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propen-1-yl)-
CAS Number:
101626-70-4
Molecular Formula:
C10H15N3S
Molecular Weight:
209.3112
IUPAC Name:
6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine
InChI:
InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12)
InChI Key:
DHSSDEDRBUKTQY-UHFFFAOYSA-N
SMILES:
C=CCN1CCc2c(CC1)nc(s2)N
UNII:
7AM2J46Z1Y
Properties
Complexity:
210
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
209.099g/mol
Formal Charge:
0
Heavy Atom Count:
14
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
209.311g/mol
Monoisotopic Mass:
209.099g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
70.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5
Literature
| Title | Journal |
|---|---|
| Update on the role of antipsychotics in the treatment of Tourette syndrome. | Neuropsychiatric disease and treatment 20120101 |
| Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP Models of Parkinson's Disease In Vitro and In Vivo. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Functional potencies of dopamine agonists and antagonists at human dopamine D₂ and D₃ receptors. | European journal of pharmacology 20110901 |
| European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment. | European child & adolescent psychiatry 20110401 |
| nardosinane-type sesquiterpenoids from the formosan soft coral Paralemnalia thyrsoides. | Marine drugs 20110101 |
| The neuroprotective effect of talipexole from paraquat-induced cell death in dopaminergic neuronal cells. | Neurotoxicology 20101201 |
| [Dopaminergic neuroprotection and reconstruction of neural network tiara]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20101001 |
| Effect of bromocriptine on the severity of ovarian hyperstimulation syndrome and outcome in high responders undergoing assisted reproduction. | Journal of human reproductive sciences 20100101 |
| Oxidative neurodegeneration is prevented by UCP0045037, an allosteric modulator for the reduced form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7. | International journal of molecular sciences 20091101 |
| Pharmacokinetic profile of talipexole in healthy volunteers is not altered when it is co-administered with Madopar (co-beneldopa). | Journal of clinical pharmacy and therapeutics 20090601 |
| Effective control of catatonia in Parkinson's disease by electroconvulsive therapy: a case report. | European journal of neurology 20090201 |
| Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury. | Oxidative medicine and cellular longevity 20090101 |
| Bromocriptine, a dopamine D(2) receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells. | European journal of pharmacology 20081119 |
| The frequency of cardiac valvular regurgitation in Parkinson's disease. | Movement disorders : official journal of the Movement Disorder Society 20080515 |
| Clinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients. | Movement disorders : official journal of the Movement Disorder Society 20080430 |
| Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria? | Genes, brain, and behavior 20080301 |
| Dopamine receptor agonists reverse behavioral abnormalities of alpha-synuclein transgenic mouse, a new model of Parkinson's disease. | Journal of neuroscience research 20080215 |
| Mechanism of decongestant activity of alpha 2-adrenoceptor agonists. | Pulmonary pharmacology & therapeutics 20080101 |
| Pharmacological modulation of dopaminergic brain activity and its reflection in spectral frequencies of the rat electropharmacogram. | Neuropsychobiology 20080101 |
| MPP(+)-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine. | Purinergic signalling 20070901 |
| alpha2-adrenoceptor agonists as nasal decongestants. | Pulmonary pharmacology & therapeutics 20070101 |
| Pre-junctional alpha2-adrenoceptors modulation of the nitrergic transmission in the pig urinary bladder neck. | Neurourology and urodynamics 20070101 |
| Antagonistic activity of ascorbic acid (vitamin C) on dopaminergic modulation: apomorphine-induced stereotypic behavior in mice. | Pharmacology 20060101 |
| Immunohistochemical and functional evidence for a noradrenergic regulation in the horse penile deep dorsal vein. | International journal of impotence research 20041201 |
| Drug treatment of Parkinson's disease. | Dialogues in clinical neuroscience 20040901 |
| Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. | Sleep 20040501 |
| An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. | Sleep 20040501 |
| Blood pressure and alpha-vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca. | European journal of pharmacology 20040405 |
| Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor. | BMC biology 20040101 |
| Effects of an alpha2-adrenoceptor agonist in nasal mucosa. | Archives of physiology and biochemistry 20031001 |
| Repeated administration of methamphetamine causes hypersensitivity of D2 receptor in rat ventral tegmental area. | Neuroscience letters 20030821 |
| Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. | Neuroscience research 20030801 |
| Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors. | The Journal of pharmacology and experimental therapeutics 20030401 |
| Inhibitory effects of D2 agonists by striatal injection on excessive release of dopamine and hyperactivity induced by Bay K 8644 in rats. | Neuroscience 20030101 |
| Prolonged drug-induced hypothermia in experimental stroke. | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20030101 |
| Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. | The Journal of pharmacology and experimental therapeutics 20021101 |
| Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor. | The Journal of pharmacology and experimental therapeutics 20021101 |
| Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries. | Fundamental & clinical pharmacology 20020801 |
| Impaired endothelial alpha-2 adrenergic receptor-mediated vascular relaxation in the fructose-fed rat. | Hypertension research : official journal of the Japanese Society of Hypertension 20020301 |
| Influence of sildenafil on central dopamine-mediated behaviour in male rats. | Life sciences 20020215 |
| Neuroleptic-like profile of the cannabinoid agonist, HU 210, on rodent behavioural models. | Progress in neuro-psychopharmacology & biological psychiatry 20020101 |
| alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator. | British journal of pharmacology 20011001 |
| Identification of the dopamine autoreceptor in the guinea-pig retina as D(2) receptor using novel subtype-selective antagonists. | British journal of pharmacology 20010801 |
| Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins. | Biochemical pharmacology 20010501 |
| Analysis of ligand activation of alpha 2-adrenoceptor subtypes under conditions of equal G alpha protein stoichiometry. | Naunyn-Schmiedeberg's archives of pharmacology 20010501 |
| [A-56-year-old woman with parkinsonism, whose mother had Parkinson's disease]. | No to shinkei = Brain and nerve 20010501 |
| Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole. | European journal of pharmacology 20010406 |
| Postjunctional alpha(2C)-adrenoceptor contractility in human saphenous vein. | European journal of pharmacology 20010216 |
| Receptor reserve analysis of the human alpha(2C)-adrenoceptor using. | European journal of pharmacology 20010112 |
| Nonlinear analysis of partial dopamine agonist effects on cAMP in C6 glioma cells. | Journal of pharmacological and toxicological methods 20010101 |
| Intranasal application of the alpha2-adrenoceptor agonist BHT-920 produces decongestion in the cat. | American journal of rhinology 20010101 |
| Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors. | British journal of pharmacology 20000401 |
| Talipexole protects dopaminergic neurons from methamphetamine toxicity in C57BL/6N mouse. | Neuroscience letters 19980515 |
| Dopaminergic modulation of lithium/pilocarpine-induced status epilepticus in rats. | Methods and findings in experimental and clinical pharmacology 19970901 |
| Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland. | The Journal of pharmacology and experimental therapeutics 19960401 |
| Behavioral and biochemical changes after bilateral electrolytic lesions of the red nucleus of rat. | Pharmacology, biochemistry, and behavior 19950501 |
| Effects of staurosporine on the pressor responses to alpha-adrenoceptor agonists in pithed rats: a comparison with nifedipine. | Pharmacology 19910101 |
| Alpha 2-adrenoceptor-blocking properties of midaglizole (DG-5128) in rats. | Archives internationales de pharmacodynamie et de therapie 19900101 |
| Comparison of the effects of haloperidol, remoxipride and raclopride on 'pre'- and postsynaptic dopamine receptors in the rat brain. | Naunyn-Schmiedeberg's archives of pharmacology 19880401 |
| Pharmacological characterization of spinal alpha adrenoceptors related to blood pressure control in rats. | The Journal of pharmacology and experimental therapeutics 19870101 |
| Imidazole has similar behavioural effects to yohimbine. | Psychopharmacology 19860101 |
| Behavioural pharmacology of imidazole, a potential antidepressant agent. | Archives internationales de pharmacodynamie et de therapie 19851001 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.