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CAS No: 101622-51-9 Catalog No: AG0004Z8 MDL No:MFCD00189360
Title | Journal |
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Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells. | Experimental cell research 20121001 |
Role of trefoil factor 1 in gastric cancer and relationship between trefoil factor 1 and gastrokine 1. | Oncology reports 20121001 |
Synthesis, biological evaluation, and molecular docking studies of N-((1,3-diphenyl-1H-pyrazol-4-yl)methyl)aniline derivatives as novel anticancer agents. | Bioorganic & medicinal chemistry 20120815 |
Co-ordination of cell cycle and differentiation in the developing nervous system. | The Biochemical journal 20120615 |
Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma. | Acta neuropathologica 20120401 |
Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone. | Pharmacological research 20120301 |
Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils. | Journal of cellular physiology 20120201 |
Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. | PloS one 20120101 |
Polydendrocytes display large lineage plasticity following focal cerebral ischemia. | PloS one 20120101 |
[Effect of inhibitors serine/threonine protein kinases and protein phosphatases on mitosis progression of synchronized tobacco by-2 cells]. | TSitologiia i genetika 20120101 |
Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as anti-proliferative CDK2 inhibitors. | European journal of medicinal chemistry 20111201 |
In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism. | Xenobiotica; the fate of foreign compounds in biological systems 20111101 |
Transcriptional modulation of apoptosis regulators by roscovitine and related compounds. | Apoptosis : an international journal on programmed cell death 20110701 |
Ibulocydine is a novel prodrug Cdk inhibitor that effectively induces apoptosis in hepatocellular carcinoma cells. | The Journal of biological chemistry 20110603 |
Evidence for amylase release by cyclin-dependent kinase 5 in the rat parotid. | Archives of biochemistry and biophysics 20110315 |
Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations. | Chemico-biological interactions 20110201 |
Reconstitution of human MCF-7 breast cancer cells with caspase-3 does not sensitize them to action of CDK inhibitors. | Journal of cellular biochemistry 20110101 |
Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish. | PloS one 20110101 |
Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2. | PloS one 20110101 |
Striatal signal transduction and drug addiction. | Frontiers in neuroanatomy 20110101 |
Coilin phosphomutants disrupt Cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product. | PloS one 20110101 |
Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus. | International journal of endocrinology 20110101 |
Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes. | Molecular neurodegeneration 20110101 |
Predicting the possibility of two newly isolated phenetheren ring containing compounds from Aristolochia manshuriensis as CDK2 inhibitors. | Bioinformation 20110101 |
Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: potential role of Cdk2. | Toxicology 20101205 |
Comparison of effects of protein kinase A, mitogen-activated protein kinase, and cyclin-dependent kinase blockers on rabbit ovarian granulosa cell functions. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20101201 |
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay. | European journal of medicinal chemistry 20100901 |
Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine. | Investigational new drugs 20100601 |
Previous stress exposure enhances both anxiety-like behaviour and p35 levels in the basolateral amygdala complex: modulation by midazolam. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100601 |
Cytotoxic activities of several geranyl-substituted flavanones. | Journal of natural products 20100423 |
Phosphorylation of TFIIB links transcription initiation and termination. | Current biology : CB 20100323 |
Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors. | European journal of medicinal chemistry 20100301 |
Cdk2 inhibition prolongs G1 phase progression in mouse embryonic stem cells. | Stem cells and development 20100201 |
Cytochalasin D, LY294002 and olomoucine synergize in promoting death of melanoma cells through activation of caspase-3 and apoptosis. | Melanoma research 20100201 |
Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells. | Neuroscience letters 20100118 |
The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties. | Antiviral chemistry & chemotherapy 20100105 |
Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives. | European journal of medicinal chemistry 20100101 |
The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors. | Neoplasma 20100101 |
Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. | AIDS research and therapy 20100101 |
Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis. | Advances in pharmacological sciences 20100101 |
Cell cycle inhibitor enhances the resolution of HSV-1-induced proinflammatory response in murine microglial cells. | Neurological research 20091101 |
MAP kinase dependent cyclinE/cdk2 activity promotes DNA replication in early sea urchin embryos. | Developmental biology 20091015 |
Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. | Molecular pharmacology 20091001 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
The influence of bioactive oxylipins from marine diatoms on invertebrate reproduction and development. | Marine drugs 20090901 |
The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5. | Journal of neurochemistry 20090801 |
Is olomoucine, a weak CDK2 inhibitor, able to induce apoptosis in cancer cells? | Annals of the New York Academy of Sciences 20090801 |
Interactions of olomoucine II with human liver microsomal cytochromes P450. | Drug metabolism and disposition: the biological fate of chemicals 20090601 |
Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine. | Journal of cellular biochemistry 20090601 |
Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine. | Brain research 20090406 |
Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB. | Cell proliferation 20090401 |
A cell cycle timer for asymmetric spindle positioning. | PLoS biology 20090401 |
The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease. | Aging 20090401 |
Molecular pathology of neuro-AIDS (CNS-HIV). | International journal of molecular sciences 20090301 |
ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds. | Bioorganic & medicinal chemistry 20090201 |
Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro. | Pharmaceutical research 20090201 |
Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's Disease. | Frontiers in molecular neuroscience 20090101 |
Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase. | Cell division 20090101 |
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation. | The Journal of biological chemistry 20081219 |
Hydrolytic cleavage of N6-substituted adenine derivatives by eukaryotic adenine and adenosine deaminases. | Bioscience reports 20081201 |
Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081201 |
Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells. | Biochemical pharmacology 20081201 |
BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis. | Molecular cancer therapeutics 20081201 |
Distinct functions of Cdk5(Y15) phosphorylation and Cdk5 activity in stress fiber formation and organization. | Experimental cell research 20081115 |
Involvement of septal Cdk5 in the emergence of excessive anxiety induced by stress. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080801 |
Rat focal cerebral ischemia induced astrocyte proliferation and delayed neuronal death are attenuated by cyclin-dependent kinase inhibition. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20080301 |
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. | The EMBO journal 20080109 |
Maize D4;1 and D5 cyclin proteins in germinating maize. Associated kinase activity and regulation by phytohormones. | Physiologia plantarum 20080101 |
The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo. | Molecular vision 20080101 |
Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. | AIDS research and therapy 20080101 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | Proceedings of the National Academy of Sciences of the United States of America 20071218 |
A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein. | Journal of cellular biochemistry 20071215 |
[Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20071001 |
[Effects of cyclin dependent protein kinase inhibitor olomoucine on the neuronal apoptosis after status epilepticus: experiment with rats]. | Zhonghua yi xue za zhi 20070807 |
Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model. | Brain research 20070618 |
The role of ghrelin and some intracellular mechanisms in controlling the secretory activity of chicken ovarian cells. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20070501 |
Cell cycle inhibition and retinoblastoma protein overexpression prevent Purkinje cell death in organotypic slice cultures. | Developmental neurobiology 20070501 |
Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells. | Journal of cellular biochemistry 20070415 |
Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo. | Glia 20070401 |
Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. | Brain research 20070302 |
Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. | The Journal of biological chemistry 20070302 |
Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5. | Experimental and molecular pathology 20070201 |
A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days. | British journal of cancer 20070115 |
A purine analog kinase inhibitor, calcium/calmodulin-dependent protein kinase II inhibitor 59, reveals a role for calcium/calmodulin-dependent protein kinase II in insulin-stimulated glucose transport. | Endocrinology 20070101 |
Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice. | Journal of brachial plexus and peripheral nerve injury 20070101 |
Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses. | Molecular vision 20070101 |
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. | Journal of medicinal chemistry 20061102 |
Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine. | Journal of neuroscience research 20061001 |
p27 small interfering RNA induces cell death through elevating cell cycle activity in cultured cortical neurons: a proof-of-concept study. | Cellular and molecular life sciences : CMLS 20061001 |
Hyperphosphorylation at serine 199/202 of tau factor in the gerbil hippocampus after transient forebrain ischemia. | Biochemical and biophysical research communications 20060818 |
Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53. | Cancer gene therapy 20060801 |
Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors. | Molecular neurobiology 20060801 |
Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons. | Life sciences 20060627 |
The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction. | The European journal of neuroscience 20060601 |
An efficient direct amination of cyclic amides and cyclic ureas. | Organic letters 20060525 |
[Effects of cyclin dependent protein kinase inhibitor olomoucine on the microenvironment of axonal regeneration after spinal cord injury: an experiment with rats]. | Zhonghua yi xue za zhi 20060404 |
The role of protein kinase A and cyclin-dependent (CDC2) kinase in the control of basal and IGF-II-induced proliferation and secretory activity of chicken ovarian cells. | Animal reproduction science 20060301 |
Phosphorylation of RIalpha by cyclin-dependent kinase CDK 2/cyclin E modulates the dissociation of the RIalpha-RFC40 complex. | Cell cycle (Georgetown, Tex.) 20060301 |
Selectivity and potency of cyclin-dependent kinase inhibitors. | The AAPS journal 20060301 |
Analysis on heat stress-induced hyperphosphorylation of stathmin at serine 37 in Jurkat cells by means of two-dimensional gel electrophoresis and tandem mass spectrometry. | Journal of chromatography. A 20060217 |
Zinc(II) complexes with potent cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: synthesis, characterization, X-ray structures and biological activity. | Journal of inorganic biochemistry 20060201 |
Nitric oxide modulates the expression of cell cycle regulatory genes during lateral root formation in tomato. | Journal of experimental botany 20060101 |
Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of the novel anticancer agent 17-DMAG in human plasma. | Rapid communications in mass spectrometry : RCM 20060101 |
Cyclin-dependent kinase (CDK) inhibitor olomoucine enhances gamma-irradiation-induced apoptosis and cell cycle arrest in Raji cells. | Anticancer research 20060101 |
Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes. | Toxicology 20051215 |
Molecular models of protein kinase 6 from Plasmodium falciparum. | Journal of molecular modeling 20051201 |
Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs. | European journal of pharmacology 20051107 |
Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases. | Journal of medicinal chemistry 20051103 |
Cdk2 activity is dispensable for triggering replicon initiation after transient hypoxia in T24 cells. | The FEBS journal 20051101 |
During male pronuclei formation chromatin remodeling is uncoupled from nucleus decondensation. | Journal of cellular biochemistry 20051001 |
Cdk5-dependent regulation of glucose-stimulated insulin secretion. | Nature medicine 20051001 |
Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine. | Biophysical journal 20050901 |
Role of the cell cycle in the pathobiology of central nervous system trauma. | Cell cycle (Georgetown, Tex.) 20050901 |
DNA damage induces cdk2 protein levels and histone H2B phosphorylation in SH-SY5Y neuroblastoma cells. | Journal of Alzheimer's disease : JAD 20050901 |
Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. | Cellular and molecular life sciences : CMLS 20050801 |
In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050701 |
Signaling pathways in ascidian oocyte maturation: effects of various inhibitors and activators on germinal vesicle breakdown. | Development, growth & differentiation 20050501 |
Resveratrol-induced apoptotic death in human U251 glioma cells. | Molecular cancer therapeutics 20050401 |
Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. | Cancer research 20050201 |
CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line. | The Journal of biological chemistry 20050128 |
Clinical anticancer drug development: targeting the cyclin-dependent kinases. | British journal of cancer 20050117 |
Phosphorylated amyloid-beta: the toxic intermediate in alzheimer's disease neurodegeneration. | Sub-cellular biochemistry 20050101 |
Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways. | Breast cancer research : BCR 20050101 |
N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana. | The Journal of biological chemistry 20041112 |
A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. | Journal of medicinal chemistry 20041021 |
Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase alpha regulation during the S phase of the cell cycle. | The Journal of biological chemistry 20040917 |
Mitogen-activated protein kinase regulates neurofilament axonal transport. | Journal of cell science 20040915 |
Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice. | The American journal of pathology 20040901 |
Cdk5 regulates activation and localization of Src during corneal epithelial wound closure. | Journal of cell science 20040815 |
Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040707 |
A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. | The EMBO journal 20040602 |
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. | Biochemical pharmacology 20040515 |
Cell differentiation, caspase inhibition, and macromolecular synthesis blockage, but not BCL-2 or BCL-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs. | Experimental cell research 20040415 |
Xylocydine, a novel inhibitor of cyclin-dependent kinases, prevents the tumor necrosis factor-related apoptosis-inducing ligand-induced apoptotic cell death of SK-HEP-1 cells. | The Journal of pharmacology and experimental therapeutics 20040301 |
Development of an assay to screen for inhibitors of tau phosphorylation by cdk5. | Journal of biomolecular screening 20040301 |
Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis. | Molecular cancer therapeutics 20040301 |
Activation of cyclin-dependent kinase 5 is involved in axonal regeneration. | Molecular and cellular neurosciences 20040301 |
Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases. | Journal of cell science 20040215 |
Protection of renal cells from cisplatin toxicity by cell cycle inhibitors. | American journal of physiology. Renal physiology 20040201 |
Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5. | Journal of cellular biochemistry 20040201 |
Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy. | Oncology 20040101 |
Cell cycle arrest induced in human breast cancer cells by cyclin-dependent kinase inhibitors: a comparison of the effects exerted by roscovitine and olomoucine. | Polish journal of pharmacology 20040101 |
Synergic effects of the cyclin-dependent kinase (CDK) inhibitor olomoucine and androgen-antagonist bicalutamide on prostatic cancer cell lines. | Neoplasma 20040101 |
An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis. | Journal of cell science 20031215 |
The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors. | European journal of biochemistry 20031201 |
Changes in the activities of hydroxysteroid dehydrogenases in mouse oocytes during meiotic maturation. | The Journal of reproduction and development 20031201 |
Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells. | Molecular and cellular neurosciences 20031101 |
Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors. | Bioorganic & medicinal chemistry letters 20030915 |
Prevention of dopaminergic neuronal death by cyclic AMP in mixed neuronal/glial mesencephalic cultures requires the repression of presumptive astrocytes. | Molecular pharmacology 20030901 |
Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells. | Brain research. Molecular brain research 20030819 |
Cdk2 activity is associated with depolarization of mitochondrial membrane potential during apoptosis. | Biochemical and biophysical research communications 20030613 |
Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials. | Accounts of chemical research 20030601 |
Synthesis and biological evaluations of pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 inhibitors. | European journal of medicinal chemistry 20030501 |
The specificities of protein kinase inhibitors: an update. | The Biochemical journal 20030401 |
Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH+-N7)Cl(3)].9/5H2O [Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine]. | Journal of inorganic biochemistry 20030401 |
Studies of the cell cycle of in vitro cultured skin fibroblasts in goats: work in progress. | Theriogenology 20030301 |
Growth cones contain a dynamic population of neurofilament subunits. | Cell motility and the cytoskeleton 20030301 |
Inhibition of nucleoside transport by protein kinase inhibitors. | The Journal of pharmacology and experimental therapeutics 20030201 |
In vitro glycosidation potential towards olomoucine-type cyclin-dependent kinase inhibitors in rodent and primate microsomes. | Physiological research 20030101 |
Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis. | The Journal of biological chemistry 20021213 |
Synthesis and biological activity of olomoucine II. | Bioorganic & medicinal chemistry letters 20021118 |
Inducible DNA demethylation mediated by the maize Suppressor-mutator transposon-encoded TnpA protein. | The Plant cell 20021101 |
Recent advances in cyclin-dependent kinase inhibition. Purine-based derivatives as anti-cancer agents. Roles and perspectives for the future. | Current topics in medicinal chemistry 20020901 |
PCNA protein associates to Cdk-A type protein kinases in germinating maize. | Plant molecular biology 20020901 |
Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition. | Developmental cell 20020901 |
2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent release from contact inhibition in WB-F344 cells: involvement of cyclin A. | Toxicology and applied pharmacology 20020901 |
M phase-specific expression and phosphorylation-dependent ubiquitination of the ClC-2 channel. | The Journal of biological chemistry 20020830 |
Differential effects of cyclin-dependent kinase blockers upon cell death in the developing retina. | Brain research 20020823 |
Two kinase activities are sufficient for sea urchin sperm chromatin decondensation in vitro. | Molecular reproduction and development 20020801 |
Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity. | Antimicrobial agents and chemotherapy 20020801 |
Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues. | Biochemical pharmacology 20020801 |
Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines. | Molecular pathology : MP 20020801 |
Mimosine prevents the death of glucose-deprived immunostimulated astrocytes by scavenging peroxynitrite. | Glia 20020701 |
Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture. | Journal of neurochemistry 20020701 |
Molecular mechanism of enhanced apoptotic response in U937 cells mediated by sodium butyrate. | Zhonghua zhong liu za zhi [Chinese journal of oncology] 20020701 |
Structural classification of protein kinases using 3D molecular interaction field analysis of their ligand binding sites: target family landscapes. | Journal of medicinal chemistry 20020606 |
Involvement of cyclin-dependent kinases in axotomy-induced retinal ganglion cell death. | The Journal of comparative neurology 20020520 |
A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. | Developmental biology 20020501 |
Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase. | The Journal of physiology 20020501 |
Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi. | Molecular and biochemical parasitology 20020501 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
Beta-carbolines as specific inhibitors of cyclin-dependent kinases. | Bioorganic & medicinal chemistry letters 20020408 |
The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity. | Neuroscience letters 20020405 |
Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020401 |
Kainate receptor-mediated apoptosis in primary cultures of cerebellar granule cells is attenuated by mitogen-activated protein and cyclin-dependent kinase inhibitors. | British journal of pharmacology 20020401 |
Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases. | Leukemia 20020301 |
A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication. | The Journal of biological chemistry 20020222 |
Sensitivity of the origin decision point to specific inhibitors of cellular signaling and metabolism. | Experimental cell research 20020201 |
Sequential expression patterns of apoptosis- and cell cycle-related proteins in neuronal response to severe or mild transient hypoxia. | Neuroscience 20020101 |
Comparison of the TUNEL, lamin B and annexin V methods for the detection of apoptosis by flow cytometry. | Acta histochemica 20020101 |
The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic. | EMBO reports 20011215 |
Sustained activation of p34(cdc2) is required for noscapine-induced apoptosis. | The Journal of biological chemistry 20011214 |
Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase. | Neuroreport 20011204 |
Cell cycle arrest allows centrin translation but not basal body formation during spermiogenesis in Marsilea. | Journal of cell science 20011201 |
Cell cycle-dependent control of polarised development by a cyclin-dependent kinase-like protein in the Fucus zygote. | Development (Cambridge, England) 20011101 |
Common and reversible regulation of wild-type p53 function and of ribosomal biogenesis by protein kinases in human cells. | Oncogene 20010920 |
Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum. | Biochemical pharmacology 20010801 |
Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors. | Journal of virology 20010801 |
Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010715 |
Cell death mediated by alloreactive cytotoxic T cells via the granule exocytosis or the Fas pathway is independent of p34cdc2 kinase: Fas dependent killing of cells arrested in the cell cycle. | Immunology and cell biology 20010601 |
Reversible nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase upon serum depletion. | European journal of cell biology 20010601 |
Tetrahydrobiopterin enhances apoptotic PC12 cell death following withdrawal of trophic support. | The Journal of biological chemistry 20010323 |
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. | Nature 20010315 |
Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells. | Oncogene 20010308 |
Cell cycle in the fucus zygote parallels a somatic cell cycle but displays a unique translational regulation of cyclin-dependent kinases. | The Plant cell 20010301 |
Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins. | Molecular and biochemical parasitology 20010301 |
Modulation of Sp1 activity by a cyclin A/CDK complex. | Journal of molecular biology 20010216 |
The relationship between differentiation and survival in PC12 cells treated with cyclic adenosine monophosphate in the presence of epidermal growth factor or nerve growth factor. | Neuroscience letters 20010112 |
Inhibitory effect of pentalenolactone on vascular smooth muscle cell proliferation. | European journal of pharmacology 20010105 |
Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. | Genome biology 20010101 |
5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. | Bioorganic & medicinal chemistry letters 20000306 |
2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. | Bioorganic & medicinal chemistry letters 19990104 |
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