200,000+ products from a single source!
sales@angenechem.com
Home > Other Building Blocks > 1015-89-0
1015-89-0 | Phenanthridin-6(5H)-one
CAS No: 1015-89-0 Catalog No: AG0004MR MDL No:MFCD00004988
Product Description
Catalog Number:
AG0004MR
Chemical Name:
Phenanthridin-6(5H)-one
CAS Number:
1015-89-0
Molecular Formula:
C13H9NO
Molecular Weight:
195.2167
MDL Number:
MFCD00004988
IUPAC Name:
5H-phenanthridin-6-one
InChI:
InChI=1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
InChI Key:
RZFVLEJOHSLEFR-UHFFFAOYSA-N
SMILES:
O=c1[nH]c2ccccc2c2c1cccc2
EC Number:
213-804-3
UNII:
AVQ13AUB5J
Properties
Complexity:
263
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
195.068g/mol
Formal Charge:
0
Heavy Atom Count:
15
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
195.221g/mol
Monoisotopic Mass:
195.068g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
29.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.5
Literature
| Title | Journal |
|---|---|
| Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton. | Organic & biomolecular chemistry 20120521 |
| Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors. | Nature biotechnology 20120219 |
| Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride. | Journal of enzyme inhibition and medicinal chemistry 20111201 |
| PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity. | Multiple sclerosis (Houndmills, Basingstoke, England) 20110701 |
| Synthesis and evaluation of C-ring aromatized analogues of phenanthridone alkaloids. | Archives of pharmacal research 20110701 |
| Effects of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose)polymerase-1 activity (PARP-1), on locomotor networks of the rat isolated spinal cord. | Cellular and molecular neurobiology 20110501 |
| One-pot formation of C-C and C-N bonds through palladium-catalyzed dual C-H activation: synthesis of phenanthridinones. | Angewandte Chemie (International ed. in English) 20110207 |
| A highly sensitive RP-HPLC-fluorescence method to study aldehyde oxidase activity. | Journal of AOAC International 20110101 |
| Molecular Mechanisms Underlying Cell Death in Spinal Networks in Relation to Locomotor Activity After Acute Injury in vitro. | Frontiers in cellular neuroscience 20110101 |
| Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model. | International journal of critical illness and injury science 20110101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors. | Bioorganic & medicinal chemistry letters 20090501 |
| Attenuation of bromobenzene-induced hepatotoxicity by poly(ADP-ribose) polymerase inhibitors. | Research communications in molecular pathology and pharmacology 20090101 |
| Chronic exposure of the oligochaete Lumbriculus variegatus to polycyclic aromatic compounds (PACs): bioavailability and effects on reproduction. | Environmental science & technology 20080501 |
| A novel spectrophotometric method for determination of kinetic constants of aldehyde oxidase using multivariate calibration method. | Journal of biochemical and biophysical methods 20080424 |
| Total synthesis of 7-deoxypancratistatin-1-carboxaldehyde and carboxylic acid via solvent-free intramolecular aziridine opening: phenanthrene to phenanthridone cyclization strategy. | Organic letters 20080207 |
| Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. | Bioorganic & medicinal chemistry letters 20071115 |
| A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation. | Journal of immunology (Baltimore, Md. : 1950) 20070701 |
| Synthesis of some members of the hydroxylated phenanthridone subclass of the Amaryllidaceae alkaloid family. | The Journal of organic chemistry 20070330 |
| Effects of proximity on the relaxation dynamics of flindersine and 6(5H)-phenanthridinone. | The journal of physical chemistry. A 20070118 |
| 6,(5H)-phenanthridinone protects against carbon tetrachloride-induced cytotoxicity in human HepG2 cells. | Research communications in molecular pathology and pharmacology 20070101 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. | Journal of medicinal chemistry 20050811 |
| Fungal biotransformation of benzo[f]quinoline, benzo[h]quinoline, and phenanthridine. | Applied microbiology and biotechnology 20050501 |
| The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways. | Toxicology and applied pharmacology 20050101 |
| Dual regulation of AP-2alpha transcriptional activation by poly(ADP-ribose) polymerase-1. | The Biochemical journal 20040815 |
| An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors. | Analytical biochemistry 20040301 |
| Hepatoprotective effects of 6(5H)-phenanthridinone from chemical-induced centrilobular necrosis. | Research communications in molecular pathology and pharmacology 20040101 |
| Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries. | Bioorganic & medicinal chemistry 20030815 |
| Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries. | Journal of medicinal chemistry 20030703 |
| Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia. | The Journal of pharmacology and experimental therapeutics 20030601 |
| Nicotinamide is a potent inhibitor of proinflammatory cytokines. | Clinical and experimental immunology 20030101 |
| Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. | British journal of pharmacology 20021101 |
| Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents. | Critical care medicine 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| A new strategy towards the total synthesis of phenanthridone alkaloids: synthesis of (+)-2,7-dideoxypancratistatin as a model study. | Chemical communications (Cambridge, England) 20020321 |
| Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia. | Cell death and differentiation 20010901 |
| Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors. | Bioorganic & medicinal chemistry letters 20010709 |
| Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast. | Cancer research 20010515 |
| Comparative metabolism of phenanthridine by carp (Cyprinus carpio) and midge larvae (Chironomus riparius). | Environmental pollution (Barking, Essex : 1987) 20010101 |
| Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase. | Proceedings of the National Academy of Sciences of the United States of America 19960514 |
| N-acetylcysteine protects lymphocytes from nitrogen mustard-induced apoptosis. | Biochemical pharmacology 19960503 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.