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101363-10-4 | 7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-
CAS No: 101363-10-4 Catalog No: AG0004AN MDL No:MFCD00865073
Product Description
Catalog Number:
AG0004AN
Chemical Name:
7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-
CAS Number:
101363-10-4
Molecular Formula:
C17H18FN3O3S
Molecular Weight:
363.4065
MDL Number:
MFCD00865073
IUPAC Name:
7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
InChI:
InChI=1S/C17H18FN3O3S/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24/h8-9H,2-7H2,1H3,(H,23,24)
InChI Key:
NJCJBUHJQLFDSW-UHFFFAOYSA-N
SMILES:
CN1CCN(CC1)c1c(F)cc2c3c1SCCn3cc(c2=O)C(=O)O
UNII:
Y521XM2900
NSC Number:
759835
Properties
Complexity:
608
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
363.105g/mol
Formal Charge:
0
Heavy Atom Count:
25
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
363.407g/mol
Monoisotopic Mass:
363.105g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
89.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.3
Literature
| Title | Journal |
|---|---|
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| Effects of bio-compatible metal ions on rufloxacin photochemistry, photophysics and photosensitization: copper(II). | Journal of photochemistry and photobiology. B, Biology 20101202 |
| Photosensitization induced by the antibacterial fluoroquinolone Rufloxacin leads to mutagenesis in yeast. | Mutation research 20101013 |
| Quinolones for uncomplicated acute cystitis in women. | The Cochrane database of systematic reviews 20060719 |
| Rufloxacin induced photosensitization in bio-models of increasing complexity. | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20050301 |
| Photochemical properties of ofloxacin involved in oxidative DNA damage: a comparison with rufloxacin. | Chemical research in toxicology 20030401 |
| Type II guanine oxidation photoinduced by the antibacterial fluoroquinolone Rufloxacin in isolated DNA and in 2'-deoxyguanosine. | Chemical research in toxicology 20020901 |
| Photoinduced N-demethylation of rufloxacin and its methyl ester under aerobic conditions. | Photochemistry and photobiology 20020901 |
| Optimization and validation of a CZE method for rufloxacin hydrochloride determination in coated tablets. | Journal of pharmaceutical and biomedical analysis 20020615 |
| Daily norfloxacin is more effective than weekly rufloxacin in prevention of spontaneous bacterial peritonitis recurrence. | Digestive diseases and sciences 20020601 |
| 6-Aminoquinolones as new potential anti-HIV agents. | Journal of medicinal chemistry 20001005 |
| Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening. | Antimicrobial agents and chemotherapy 20001001 |
| Anti-toxoplasma activities of 24 quinolones and fluoroquinolones in vitro: prediction of activity by molecular topology and virtual computational techniques. | Antimicrobial agents and chemotherapy 20001001 |
| Effects of some quinolones on imipenem-induced seizures in DBA/2 mice. | General pharmacology 19940301 |
| The in-vitro activity of two new quinolones: rufloxacin and MF 961. | The Journal of antimicrobial chemotherapy 19920601 |
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