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101328-85-2 | 3(2H)-Pyridazinone, 6-(4-aminophenyl)-4,5-dihydro-5-methyl-, (5R)-
CAS No: 101328-85-2 Catalog No: AG00048G MDL No:MFCD09032921
Product Description
Catalog Number:
AG00048G
Chemical Name:
3(2H)-Pyridazinone, 6-(4-aminophenyl)-4,5-dihydro-5-methyl-, (5R)-
CAS Number:
101328-85-2
Molecular Formula:
C11H13N3O
Molecular Weight:
203.2404
MDL Number:
MFCD09032921
IUPAC Name:
(4R)-3-(4-aminophenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
InChI:
InChI=1S/C11H13N3O/c1-7-6-10(15)13-14-11(7)8-2-4-9(12)5-3-8/h2-5,7H,6,12H2,1H3,(H,13,15)/t7-/m1/s1
InChI Key:
GDMRFHZLKNYRRO-SSDOTTSWSA-N
SMILES:
C[C@@H]1CC(=O)NN=C1c1ccc(cc1)N
Properties
Complexity:
280
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
203.106g/mol
Formal Charge:
0
Heavy Atom Count:
15
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
203.245g/mol
Monoisotopic Mass:
203.106g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
67.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.8
Literature
| Title | Journal |
|---|---|
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| Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity. | Human & experimental toxicology 20120901 |
| Levosimendan versus milrinone in neonates and infants after corrective open-heart surgery: a pilot study. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20120901 |
| Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. | International journal of cardiology 20120823 |
| Levosimendan versus an intra-aortic balloon pump in high-risk cardiac patients. | Journal of cardiothoracic and vascular anesthesia 20120801 |
| Effects of levosimendan on renal function in patients undergoing coronary artery surgery. | Journal of cardiothoracic and vascular anesthesia 20120801 |
| Levosimendan protection against kidney ischemia/reperfusion injuries in anesthetized pigs. | The Journal of pharmacology and experimental therapeutics 20120801 |
| Short-term levosimendan treatment protects rat testes against oxidative stress. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120801 |
| Continuous levosimendan infusion for refractory cardiogenic shock complicating severe acute dichlorvos poisoning. | The American journal of the medical sciences 20120801 |
| Levosimendan infusion in newborns after corrective surgery for congenital heart disease: randomized controlled trial. | Intensive care medicine 20120701 |
| ST-segment elevation during levosimendan infusion. | Journal of cardiovascular medicine (Hagerstown, Md.) 20120701 |
| Effects of levosimendan on TNF-alpha, BNP and MMP-1 in patients with heart failure with anemia. | Arquivos brasileiros de cardiologia 20120701 |
| Sepsis-associated takotsubo cardiomyopathy can be reversed with levosimendan. | The American journal of emergency medicine 20120601 |
| The effects of levosimendan vs dobutamine added to dopamine on liver functions assessed with noninvasive liver function monitoring in patients with septic shock. | Journal of critical care 20120601 |
| Effects of combined levosimendan and vasopressin on pulmonary function in porcine septic shock. | Inflammation 20120601 |
| A dose-response study of levosimendan in a porcine model of acute ischaemic heart failure. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20120601 |
| The predictive value of QRS duration in response to levosimendan therapy in patients with decompensated heart failure. | Acta cardiologica 20120601 |
| Dobutamine-induced changes of left atrial two-dimensional deformation predict clinical and neurohumoral improvement after levosimendan treatment in patients with acutely decompensated chronic heart failure. | International journal of cardiology 20120517 |
| Levosimendan attenuates hypoxia-induced pulmonary hypertension in a porcine model. | Journal of cardiovascular pharmacology 20120501 |
| The antiangiogenic effects of levosimendan in a CAM assay. | Microvascular research 20120501 |
| The inhibitory in-vitro effect of high-dose levosimendan on platelet function may be mediated through its action as a phosphodiesterase inhibitor. | Coronary artery disease 20120501 |
| Novel strategies for the management of right ventricular failure with pulmonary hypertension. | Thorax 20120401 |
| Prolonged antispasmodic effect in isolated radial artery graft and pronounced platelet inhibition induced by the inodilator drug, levosimendan. | Basic & clinical pharmacology & toxicology 20120301 |
| Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine. | Pediatric research 20120301 |
| Neonatal blood pressure support: the use of inotropes, lusitropes, and other vasopressor agents. | Clinics in perinatology 20120301 |
| Levosimendan does not improve cardiac output or blood pressure in a rodent model of propranolol toxicity when administered using various dosing regimens. | International journal of toxicology 20120301 |
| Beta blocker therapy, decompensated heart failure, and inotropic interactions: current perspectives. | The Israel Medical Association journal : IMAJ 20120301 |
| [Hemodynamic and efficacies of domestic levosimendan versus dobutamine in patients with acute decompensated heart failure]. | Zhonghua yi xue za zhi 20120227 |
| Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies. | Critical care medicine 20120201 |
| [The effect of levosimendan and dobutamine treatment on QT dispersion in patients with decompensated heart failure: a prospective study]. | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20120201 |
| How can you mend a broken heart? | Critical care medicine 20120201 |
| [Comparison on efficacy and safety between domestic levosimendan versus dobutamine for patients with acute decompensated heart failure]. | Zhonghua xin xue guan bing za zhi 20120201 |
| The calcium sensitizer levosimendan improves human diaphragm function. | American journal of respiratory and critical care medicine 20120101 |
| Levosimendan is superior to epinephrine in improving myocardial function after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats. | The Journal of thoracic and cardiovascular surgery 20120101 |
| Differential hemodynamic effects of levosimendan in a porcine model of neonatal hypoxia-reoxygenation. | Neonatology 20120101 |
| Levosimendan in two neonates with ischemic heart failure and pulmonary hypertension. | Neonatology 20120101 |
| Inotropic support in the NICU: ever more compounds in search of guidance? Commentary on J. Esch et al.: differential hemodynamic effects of levosimendan in a porcine model of neonatal hypoxia-reoxygenation (Neonatology 2012;101:192–200) and M.P. De Carolis et al.: levosimendan in two neonates with ischemic heart failure and pulmonary hypertension (Neonatology 2012;101:201–205). | Neonatology 20120101 |
| Preoperative treatment with levosimendan in candidates for mechanical circulatory support. | ASAIO journal (American Society for Artificial Internal Organs : 1992) 20120101 |
| A drug therapy for muscle dysfunction in respiratory disorders? | American journal of respiratory and critical care medicine 20120101 |
| Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts. | Cardiovascular diabetology 20120101 |
| Pharmacologic interventions to improve splanchnic oxygenation during ventilation with positive end-expiratory pressure. | Advances in experimental medicine and biology 20120101 |
| Levosimendan produces an additional clinical and hemodynamic benefit in patients with decompensated heart failure successfully submitted to a fluid removal treatment. | Congestive heart failure (Greenwich, Conn.) 20120101 |
| [Levosimendan reduces mortality in cardiac surgery: a systematic review and meta-analysis]. | Revista espanola de anestesiologia y reanimacion 20120101 |
| Vasoactive compounds in the neonatal period. | Current medicinal chemistry 20120101 |
| [Possibilities of using levosimendan in patients with idiopathic pulmonary hypertension]. | Terapevticheskii arkhiv 20120101 |
| Levosimendan versus an intra-aortic balloon pump in adult cardiac surgery patients with low cardiac output. | Journal of cardiothoracic and vascular anesthesia 20111201 |
| Prevention for pediatric low cardiac output syndrome: results from the European survey EuLoCOS-Paed. | Paediatric anaesthesia 20111201 |
| Effects of levosimendan on cardiac gene expression profile and post-infarct cardiac remodelling in diabetic Goto-Kakizaki rats. | Basic & clinical pharmacology & toxicology 20111101 |
| Pharmacologic therapy of heart failure in children: part of a special series on paediatric pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni. | Pharmacological research 20111101 |
| How mechanical circulatory support helps not to need it--new strategies in pediatric heart failure. | Artificial organs 20111101 |
| [Levosimendan treatment of severe acute congestive heart failure refractory to dobutamine/milrinone in children]. | Vojnosanitetski pregled 20111101 |
| [Calcium mobilizers and calcium sensitizers]. | Nihon rinsho. Japanese journal of clinical medicine 20111101 |
| Levosimendan decreases intracranial pressure after hypothermic circulatory arrest in a porcine model. | Scandinavian cardiovascular journal : SCJ 20111001 |
| Levosimendan reduces heart failure after cardiac surgery: a prospective, randomized, placebo-controlled trial. | Critical care medicine 20111001 |
| Cost-effectiveness of levosimendan in patients with acute heart failure. | Journal of cardiovascular pharmacology 20111001 |
| Age-dependent effects of milrinone and levosimendan on ventricular function and haemodynamics in newborn and mature pigs. | Cardiology in the young 20111001 |
| Treatment of acute heart failure using levosimendan for a patient with dilated cardiomyopathy, chronic renal failure, and hypertension. | Pediatric cardiology 20111001 |
| Levosimendan--an inoprotective drug or much ado about nothing? | Critical care medicine 20111001 |
| Multiple signalling pathways underlie the protective effect of levosimendan in cardiac myocytes. | European journal of pharmacology 20110930 |
| Current pharmacologic management of pediatric heart failure in congenital heart disease. | Current vascular pharmacology 20110901 |
| Management of acute cardiac failure by intracoronary administration of levosimendan. | Journal of cardiovascular pharmacology 20110901 |
| Value of IGF-I levels in the evaluation of response to treatment with levosimendan in patients with severe heart failure. | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110901 |
| Newer inotropes in pediatric heart failure. | Journal of cardiovascular pharmacology 20110801 |
| Levosimendan versus intra-aortic balloon pump in high-risk cardiac surgery patients. | Journal of cardiothoracic and vascular anesthesia 20110801 |
| Levosimendan restores the positive force-frequency relation in heart failure. | American journal of physiology. Heart and circulatory physiology 20110801 |
| No beneficial effects of levosimendan in acute porcine endotoxaemia. | Acta anaesthesiologica Scandinavica 20110801 |
| Levosimendan attenuates pulmonary vascular remodeling. | Intensive care medicine 20110801 |
| Is preoperative levosimendan indicated to treat normal left ventricular function and left ventricle outflow obstruction? | British journal of anaesthesia 20110801 |
| Effect of levosimendan and predictors of recovery in patients with peripartum cardiomyopathy, a randomized clinical trial. | Clinical research in cardiology : official journal of the German Cardiac Society 20110701 |
| Levosimendan in congenital cardiac surgery: a randomized, double-blind clinical trial. | Journal of cardiothoracic and vascular anesthesia 20110601 |
| Combined exogenous and endogenous catecholamine release associated with Tako-Tsubo like syndrome in a patient with atrio-ventricular block undergoing pace-maker implantation. | Acute cardiac care 20110601 |
| Cardiovascular effects of the combination of levosimendan and valsartan in hypertensive Dahl/Rapp rats. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20110601 |
| Beneficial association of β-blocker therapy on recovery from severe acute heart failure treatment: data from the Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support trial. | Critical care medicine 20110501 |
| Acetylation status does not affect levosimendan's hemodynamic effects in heart failure patients. | Scandinavian cardiovascular journal : SCJ 20110401 |
| Intracoronary levosimendan prevents myocardial ischemic damages and activates survival signaling through ATP-sensitive potassium channel and nitric oxide. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20110401 |
| Oral levosimendan improves filling pressure and systolic function during long-term treatment. | Scandinavian cardiovascular journal : SCJ 20110401 |
| Levosimendan: from coronary care to intensive care? | Intensive care medicine 20110401 |
| The effects of levosimendan and glibenclamide on circulatory and metabolic variables in a canine model of acute hypoxia. | Intensive care medicine 20110401 |
| Levosimendan vs. intra-aortic balloon pump in high-risk cardiac surgery. | Asian cardiovascular & thoracic annals 20110401 |
| Combined arginine vasopressin and levosimendan: a promising therapy for septic shock. | Critical care medicine 20110401 |
| Levosimendan preserves the contractile responsiveness of hypoxic human myocardium via mitochondrial K(ATP) channel and potential pERK 1/2 activation. | European journal of pharmacology 20110325 |
| Levosimendan improves pro/anti-inflammatory cytokines imbalance in male patients with advanced heart failure. A randomized, double-blind, placebo-controlled study. | International journal of cardiology 20110303 |
| Preoperative levosimendan infusion in combined aortic valve and coronary bypass surgery. | British journal of anaesthesia 20110301 |
| Mechanism of cardioprotective effect of adenocine and non-glycoside cardiotonic drugs during experimental chronic cardiac insufficiency. | Bulletin of experimental biology and medicine 20110301 |
| Weaning difficult-to-wean chronic obstructive pulmonary disease patients: a pilot study comparing initial hemodynamic effects of levosimendan and dobutamine. | Journal of critical care 20110201 |
| Levosimendan improves calcium sensitivity of diaphragm muscle fibres from a rat model of heart failure. | British journal of pharmacology 20110201 |
| Levosimendan reduces plasma cell-free DNA levels in patients with ischemic cardiomyopathy. | Journal of thrombosis and thrombolysis 20110201 |
| Levosimendan modulates programmed forms of cell death through K(ATP) channels and nitric oxide. | Journal of cardiovascular pharmacology 20110201 |
| Rotating inotrope therapy in a pediatric population with decompensated heart failure. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20110101 |
| Acute effects of levosimendan on cerebral and systemic perfusion and oxygenation in newborns: an observational study. | Neonatology 20110101 |
| The protective effects of levosimendan on ischemia/reperfusion injury and apoptosis. | Recent patents on cardiovascular drug discovery 20110101 |
| Levosimendan: from basic science to clinical trials. | Recent patents on cardiovascular drug discovery 20110101 |
| Effects of levosimendan/furosemide infusion on plasma brain natriuretic peptide, echocardiographic parameters and cardiac output in end-stage heart failure patients. | Medical science monitor : international medical journal of experimental and clinical research 20110101 |
| Levosimendan and mortality after coronary revascularisation: a meta-analysis of randomised controlled trials. | Critical care (London, England) 20110101 |
| Levosimendan inhibits release of reactive oxygen species in polymorphonuclear leukocytes in vitro and in patients with acute heart failure and septic shock: a prospective observational study. | Critical care (London, England) 20110101 |
| [Efficacy of levosimendan vs dopamine in patients with resistant cardiac failure]. | Terapevticheskii arkhiv 20110101 |
| Levosimendan for primary graft failure after heart transplantation: a 3-year follow-up. | Transplantation proceedings 20110101 |
| In vivo and in vitro evidence for pleiotropic effects of levosimendan in the intensive care setting. | Critical care (London, England) 20110101 |
| Effects of levosimendan without loading dose on systolic and diastolic function in patients with end-stage heart failure. | Cardiology journal 20110101 |
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| Exploring the ground and excited states structural diversity of levosimendan, a cardiovascular calcium sensitizer. | The journal of physical chemistry. B 20101118 |
| [Acute early postpartum cardiac failure associated with dilated cardiomyopathy: successful treatment with intra-aortic balloon counter-pulsation and levosimendan]. | Annales francaises d'anesthesie et de reanimation 20101101 |
| Do levosimendan have an adverse effect on platelet function? | International journal of cardiology 20101029 |
| Effects of combined arginine vasopressin and levosimendan on organ function in ovine septic shock. | Critical care medicine 20101001 |
| Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure. | Hypertension research : official journal of the Japanese Society of Hypertension 20101001 |
| Vasopressin, levosimendan, and cardiovascular function in septic shock. | Critical care medicine 20101001 |
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| Levosimendan as a rescue adjunct in amlodipine intoxication--a case report. | Middle East journal of anaesthesiology 20101001 |
| Levosimendan increases portal blood flow and attenuates intestinal intramucosal acidosis in experimental septic shock. | Shock (Augusta, Ga.) 20100901 |
| Direct cardiac effects of dobutamine, dopamine, epinephrine, and levosimendan in isolated septic rat hearts. | Shock (Augusta, Ga.) 20100901 |
| Absence of mitochondrial activation during levosimendan inotropic action in perfused paced guinea pig hearts as demonstrated by modular control analysis. | American journal of physiology. Regulatory, integrative and comparative physiology 20100901 |
| Acute effects of levosimendan on mitral regurgitation and diastolic function in patients with advanced chronic heart failure. | Journal of cardiovascular medicine (Hagerstown, Md.) 20100901 |
| Acute heart failure with low cardiac output: can we develop a short-term inotropic agent that does not increase adverse events? | Current heart failure reports 20100901 |
| Short-term effect of levosimendan on free light chain kappa and lambda levels in patients with decompensated chronic heart failure. | Heart and vessels 20100901 |
| Levosimendan attenuates reperfusion injury in an isolated perfused rat heart model. | Journal of cardiothoracic and vascular anesthesia 20100801 |
| Relaxant effect of Levosimendan on human uterine contractility in vitro. | American journal of obstetrics and gynecology 20100801 |
| Levosimendan in acute decompensated heart failure: systematic review and meta-analysis. | Arquivos brasileiros de cardiologia 20100801 |
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| How to treat acute decompensated heart failure in the 'beta-blocker era'? | European journal of heart failure 20100801 |
| Efficacy of levosimendan in patients with chronic heart failure: Does rhythm matter? | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20100801 |
| Levosimendan in the treatment of cardiogenic shock. | Minerva cardioangiologica 20100801 |
| Can pulmonary artery hypertension be attributed to levosimendan? A problematic based on a patient's case. | Journal of cardiovascular medicine (Hagerstown, Md.) 20100701 |
| Mechanical support for postcardiotomy cardiogenic shock: has progress been made? | Journal of cardiac surgery 20100701 |
| Levosimendan and pulmonary hypertension. | Journal of cardiovascular medicine (Hagerstown, Md.) 20100701 |
| Levosimendan - a calcium sensitising agent with potential anti-arrhythmic properties. | International journal of clinical practice 20100701 |
| Levosimendan up-regulates transforming growth factor-beta and smad signaling in the aorta in the early stage of sepsis. | Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20100701 |
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| Levosimendan and platelet function. | Journal of cardiothoracic and vascular anesthesia 20100601 |
| Comparative hemodynamic effects of levosimendan alone and in conjunction with 4-aminopyridine or calcium chloride in a rodent model of severe verapamil poisoning. | Journal of medical toxicology : official journal of the American College of Medical Toxicology 20100601 |
| [Efficacy and safety of intravenous levosimendan compared with dobutamine in decompensated heart failure]. | Zhonghua xin xue guan bing za zhi 20100601 |
| Importance of levosimendan on right ventricular function in patients with biventricular heart failure. | Critical care medicine 20100501 |
| In response to Leppikangas H, et al, Levosimendan as a rescue drug in experimental propranolol-induced myocardial depression: a randomized study. | Annals of emergency medicine 20100501 |
| Levosimendan in cardiac failure after subarachnoid hemorrhage. | The Journal of trauma 20100501 |
| Hospital costs for treatment of acute heart failure: economic analysis of the REVIVE II study. | The European journal of health economics : HEPAC : health economics in prevention and care 20100401 |
| Levosimendan reduces mortality in critically ill patients. A meta-analysis of randomized controlled studies. | Minerva anestesiologica 20100401 |
| Is levosimendan better than dobutamine in acute heart failure in patients on beta-blockade treatment? What is the evidence? | European journal of heart failure 20100401 |
| Intravenous levosimendan vs. dobutamine in acute decompensated heart failure patients on beta-blockers. | European journal of heart failure 20100401 |
| A promising new inotrope: levosimendan. | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20100401 |
| Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition. | Basic research in cardiology 20100301 |
| Levosimedan improves hemodynamics functions without sympathetic activation in severe heart failure patients: direct evidence from sympathetic neural recording. | Acute cardiac care 20100301 |
| Oxygen-wasting effect of inotropy: is there a need for a new evaluation? An experimental large-animal study using dobutamine and levosimendan. | Circulation. Heart failure 20100301 |
| Concomitant levosimendan and esmolol infusion in ischaemic cardiogenic shock. | British journal of anaesthesia 20100301 |
| Plasma B-type natriuretic peptide reduction predicts long-term response to levosimendan therapy in acutely decompensated chronic heart failure. | International journal of cardiology 20100218 |
| Levosimendan for the treatment of acute severe heart failure: a meta-analysis of randomised controlled trials. | International journal of cardiology 20100204 |
| Levosimendan and cardiac surgery. | Journal of cardiothoracic and vascular anesthesia 20100201 |
| Calcium sensitisation impairs diastolic relaxation in post-ischaemic myocardium: implications for the use of Ca(2+) sensitising inotropes after cardiac surgery. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20100201 |
| Reducing mortality in cardiac surgery with levosimendan: a meta-analysis of randomized controlled trials. | Journal of cardiothoracic and vascular anesthesia 20100201 |
| Ca2+ sensitizers: An emerging class of agents for counterbalancing weakness in skeletal muscle diseases? | Neuromuscular disorders : NMD 20100201 |
| Rationale and design of the multicentre randomized trial investigating the efficacy and safety of pulsed infusions of levosimendan in outpatients with advanced heart failure (LevoRep study). | European journal of heart failure 20100201 |
| Modulation of programmed forms of cell death by intracoronary levosimendan during regional myocardial ischemia in anesthetized pigs. | Cardiovascular drugs and therapy 20100201 |
| Levosimendan cardioprotection in acutely beta-1 adrenergic receptor blocked open chest pigs. | Acta anaesthesiologica Scandinavica 20100101 |
| Initial experience with levosimendan infusion for preoperative management of hypoplastic left heart syndrome. | Pediatric cardiology 20100101 |
| Levosimendan in acute and chronic right ventricle failure. | Acta anaesthesiologica Scandinavica 20100101 |
| Efficacy of levosimendan in Takotsubo-related cardiogenic shock. | Acta anaesthesiologica Scandinavica 20100101 |
| Superiority of levosimendan over dobutamine in right ventricle failure. | Critical care medicine 20100101 |
| The effect of levosimendan on bupivacaine-induced severe myocardial depression in anesthetized pigs. | Regional anesthesia and pain medicine 20100101 |
| Levosimendan and quality of life. | Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20100101 |
| Intravenous levosimendan-norepinephrine combination during off-pump coronary artery bypass grafting in a hemodialysis patient with severe myocardial dysfunction. | Journal of cardiothoracic surgery 20100101 |
| Effect of levosimendan in experimental verapamil-induced myocardial depression. | Scandinavian journal of trauma, resuscitation and emergency medicine 20100101 |
| Beneficial effects of levosimendan on cerebral vasospasm induced by subarachnoid haemorrhage: an experimental study. | Brain injury 20100101 |
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| [Study evaluating the impact of a combination of inotropic support and heart rate control on prognosis and stabilization rate in patients with decompensated chronic heart failure (LEGION)]. | Terapevticheskii arkhiv 20100101 |
| Levosimendan neither improves nor worsens mortality in patients with cardiogenic shock due to ST-elevation myocardial infarction. | Vascular health and risk management 20100101 |
| Neuroprotective properties of levosimendan in an in vitro model of traumatic brain injury. | BMC neurology 20100101 |
| Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study. | Critical care (London, England) 20100101 |
| [Intensive care for newborns and babies of the first year of life with acute heart failure after cardiosurgical interventions]. | Anesteziologiia i reanimatologiia 20100101 |
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| Levosimendan: from basic science to clinical practice. | Heart failure reviews 20091201 |
| Prophylactic treatment with levosimendan: a retrospective matched-control study of patients with reduced left ventricular function. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20091201 |
| Right ventricular function in myocardial infarction complicated by cardiogenic shock: Improvement with levosimendan. | Critical care medicine 20091201 |
| Levosimendan as a rescue drug in experimental propranolol-induced myocardial depression: a randomized study. | Annals of emergency medicine 20091201 |
| Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond. | Heart failure reviews 20091201 |
| Do it right? | Critical care medicine 20091201 |
| Influence of temperature on the positive inotropic effect of levosimendan, dobutamine and milrinone. | European journal of anaesthesiology 20091101 |
| Inotropic support during experimental endotoxemic shock: part I. The effects of levosimendan on splanchnic perfusion. | Anesthesia and analgesia 20091101 |
| Inotropic support during experimental endotoxemic shock: part II. A comparison of levosimendan with dobutamine. | Anesthesia and analgesia 20091101 |
| Levosimendan in early sepsis: when good ideas give poor results. | Anesthesia and analgesia 20091101 |
| Levosimendan may prevent postoperative atrial fibrillation through anti-inflammatory and antioxidant modulation. | Journal of cardiothoracic and vascular anesthesia 20091001 |
| Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats. | Journal of hypertension 20091001 |
| Levosimendan in viral myocarditis: not only an inodilator but also a cardioprotector? | European journal of clinical investigation 20091001 |
| Effects of levosimendan in experimental acute coxsackievirus myocarditis. | European journal of clinical investigation 20091001 |
| Effects of levosimendan versus dobutamine on left atrial function in decompensated heart failure. | The Canadian journal of cardiology 20091001 |
| Comparison of the effects of levosimendan and papaverine on human internal mammary artery and saphenous vein. | Cardiovascular drugs and therapy 20091001 |
| [Effect of levosimendan on B-type natriuretic peptide levels in patients with advanced heart failure: a meta-analysis]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20091001 |
| Reducing perioperative myocardial infarction with anesthetic drugs and techniques. | Current drug targets 20090901 |
| Levosimendan vs dobutamine in septic shock. | Journal of critical care 20090901 |
| Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarction. | Critical care medicine 20090901 |
| Levosimendan for calcium channel blocker poisoning in humans. | Anesthesia and analgesia 20090901 |
| Letter regarding levosimendan in a rat model of severe verapamil poisoning. | Journal of medical toxicology : official journal of the American College of Medical Toxicology 20090901 |
| Reducing the risk of major elective non-cardiac surgery: is there a role for levosimendan in the preoperative optimization of cardiac function? | Current drug targets 20090901 |
| The use of Levosimendan for myocardiopathy due to acute Chagas' disease. | International journal of cardiology 20090814 |
| Levosimendan reduces cardiac troponin release after cardiac surgery: a meta-analysis of randomized controlled studies. | Journal of cardiothoracic and vascular anesthesia 20090801 |
| Effects of intravenous and inhaled levosimendan in severe rodent sepsis. | Intensive care medicine 20090801 |
| Anti-ischemic effects of inotropic agents in experimental right ventricular infarction. | Acta anaesthesiologica Scandinavica 20090801 |
| Levosimendan in perioperative and critical care patients. | Current opinion in anaesthesiology 20090801 |
| Myocarditis. | The New England journal of medicine 20090723 |
| Levosimendan. | Indian pediatrics 20090701 |
| The influence of beta-blockade on the hemodynamic effects of levosimendan in elderly (>or= 70 years) patients with acutely decompensated systolic heart failure. | International journal of clinical pharmacology and therapeutics 20090701 |
| Combination pharmacotherapy in the treatment of experimental cardiac arrest. | The American journal of emergency medicine 20090701 |
| [Inotrope therapy in acute heart failure: a critical review of clinical and scientific evidence for levosimendan in the context of traditional treatment]. | Giornale italiano di cardiologia (2006) 20090701 |
| Lowered B-type natriuretic peptide in response to levosimendan or dobutamine treatment is associated with improved survival in patients with severe acutely decompensated heart failure. | Journal of the American College of Cardiology 20090623 |
| First experiences with intraoperative Levosimendan in pediatric cardiac surgery. | European journal of pediatrics 20090601 |
| Levosimendan is not effective in reducing pulmonary pressures in patients with idiopathic pulmonary arterial hypertension: report of two cases. | Journal of cardiovascular medicine (Hagerstown, Md.) 20090601 |
| Clinical outcome benefits of pretreatment with levosimendan. | British journal of anaesthesia 20090601 |
| Timing of levosimendan in cardiac surgery. | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20090601 |
| Use of levosimendan for treatment of cardiogenic shock associated with electrical storm. | Annals of internal medicine 20090519 |
| Levosimendan: a new therapeutic option in the treatment of primary graft dysfunction after heart transplantation. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090501 |
| The management of severe primary graft failure after cardiac transplantation. | Journal of cardiothoracic and vascular anesthesia 20090401 |
| Effects of levosimendan on the energy balance: preclinical and clinical evidence. | Journal of cardiovascular pharmacology 20090401 |
| Comparison of ischemic side effects of levosimendan and dobutamine with integrated backscatter analysis. | Clinical cardiology 20090401 |
| [Levosimendan, a new inotropic drug: experience in children with acute heart failure]. | Archivos argentinos de pediatria 20090401 |
| Levosimendan vs. dobutamine: outcomes for acute heart failure patients on beta-blockers in SURVIVE. | European journal of heart failure 20090301 |
| Levosimendan does not improve survival time in a rat model of verapamil toxicity. | Journal of medical toxicology : official journal of the American College of Medical Toxicology 20090301 |
| Treatment of serious calcium channel blocker overdose with levosimendan, a calcium sensitizer. | Anesthesia and analgesia 20090301 |
| Evaluation of 30-day mortality of levosimendan versus enoximone. | Critical care medicine 20090301 |
| Levosimendan or enoximone in refractory cardiogenic shock? | Critical care medicine 20090301 |
| Weaning failure from mechanical ventilation due to dilated cardiomyopathy: successful use of levosimendan. | Acta anaesthesiologica Scandinavica 20090301 |
| Levosimendan pre-treatment improves outcomes in patients undergoing coronary artery bypass graft surgery. | British journal of anaesthesia 20090201 |
| Levosimendan facilitates weaning from cardiopulmonary bypass in patients undergoing coronary artery bypass grafting with impaired left ventricular function. | The Annals of thoracic surgery 20090201 |
| Intermittent inotropic infusions combined with prophylactic oral amiodarone for patients with decompensated end-stage heart failure. | Journal of cardiovascular pharmacology 20090201 |
| Levosimendan in heart failure after surgical repair of cardiac rupture. | Minerva cardioangiologica 20090201 |
| Relationship between the pharmacokinetics of levosimendan and its effects on cardiovascular system. | Current drug metabolism 20090201 |
| Effectiveness and safety of levosimendan in clinical practice. | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20090201 |
| Repetitive dosing of intravenous levosimendan improves pulmonary hemodynamics in patients with pulmonary hypertension: results of a pilot study. | Journal of clinical pharmacology 20090101 |
| Levosimendan enhances force generation of diaphragm muscle from patients with chronic obstructive pulmonary disease. | American journal of respiratory and critical care medicine 20090101 |
| Effects of levosimendan and dobutamine on experimental acute lung injury in rats. | Acta histochemica 20090101 |
| Rescuing a failing heart: putting on the squeeze. | Nature medicine 20090101 |
| Levosimendan for heart-operated patients: what is the state of the art? | Recent patents on cardiovascular drug discovery 20090101 |
| Levosimendan induces NO production through p38 MAPK, ERK and Akt in porcine coronary endothelial cells: role for mitochondrial K(ATP) channel. | British journal of pharmacology 20090101 |
| Comparative effects of levosimendan and dobutamine on right ventricular function in patients with biventricular heart failure. | Heart and vessels 20090101 |
| Hemodynamic effects of levosimendan in acute myocardial infarction complicated by cardiogenic shock and high systemic vascular resistance. | Acute cardiac care 20090101 |
| Use of levosimendan in patients with ischemic heart disease following mechanical reperfusion. | Surgery today 20090101 |
| Role of potassium channels in the relaxant effect of levosimendan in guinea pig tracheal preparations. | Pharmacological reports : PR 20090101 |
| Prophylactic preoperative levosimendan administration in heart failure patients undergoing elective non-cardiac surgery: a preliminary report. | Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20090101 |
| Assessment of quality of life using three activity questionnaires in heart failure patients after monthly, intermittent administration of levosimendan during a six-month period. | Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20090101 |
| [Use of levosimendan in acute heart failure and its effect on renal function]. | Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20090101 |
| [Impact of preoperative levosimendan therapy on the volemic status and vascular tone of patients with chronic heart failure during anesthesia]. | Anesteziologiia i reanimatologiia 20090101 |
| Oral levosimendan in patients with severe chronic heart failure --the PERSIST study. | European journal of heart failure 20081201 |
| Cardiac Ca2+ signaling and Ca2+ sensitizers. | Circulation journal : official journal of the Japanese Circulation Society 20081201 |
| [Is everything which is feasible also sensible?: coronary artery bypass grafting in conscious patients -- a procedure with a perspective?]. | Der Anaesthesist 20081201 |
| Effects of levosimendan on left atrial functions in patients with ischemic heart failure. | Clinical cardiology 20081201 |
| Levosimendan and calcium sensitization of the contractile proteins in cardiac muscle: impact on heart failure. | Journal of cardiovascular pharmacology and therapeutics 20081201 |
| Levosimendan for bridging in a pediatric patient with Alström syndrome awaiting heart-lung transplantation. | Clinical research in cardiology : official journal of the German Cardiac Society 20081101 |
| Management of heart failure: a brief review and selected update. | Cardiology clinics 20081101 |
| Usefulness of dobutamine-induced changes of the two-dimensional longitudinal deformation predict clinical and neurohumoral improvement in men after levosimendan treatment in acutely decompensated chronic heart failure. | The American journal of cardiology 20081101 |
| [Superiority of levosimendan to dobutamine in postoperative low cardiac output syndrome: is it due to previous beta-blocker treatment?]. | Revista espanola de cardiologia 20081101 |
| Effects of levo- and dextrosimendan on NF-kappaB-mediated transcription, iNOS expression and NO production in response to inflammatory stimuli. | British journal of pharmacology 20081101 |
| Tricuspid valve replacement and levosimendan. | General thoracic and cardiovascular surgery 20081101 |
| Levosimendan and severe pulmonary hypertension during open heart surgery. | General thoracic and cardiovascular surgery 20081101 |
| Inotropic, vasodilating and preconditioning actions of levosimendan in the heart. | The Thoracic and cardiovascular surgeon 20081001 |
| Levosimendan in aortic valve surgery: cardiac performance and recovery. | Journal of cardiothoracic and vascular anesthesia 20081001 |
| A randomized trial evaluating different modalities of levosimendan administration in cardiac surgery patients with myocardial dysfunction. | Journal of cardiothoracic and vascular anesthesia 20081001 |
| [Determination of levosimendan and its main metabolites in human plasma with HPLC-MS/MS method]. | Yao xue xue bao = Acta pharmaceutica Sinica 20081001 |
| Use of levosimendan for cardiogenic shock in a patient with the apical ballooning syndrome. | Annals of internal medicine 20080902 |
| Strain rate analysis and levosimendan improve detection of myocardial viability by dobutamine echocardiography in patients with post-infarction left ventricular dysfunction: a pilot study. | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20080901 |
| The case for levosimendan. | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20080901 |
| Prospective observational study of levosimendan and weaning of difficult-to-wean ventilator dependent intensive care patients. | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20080901 |
| Effects of levosimendan versus dobutamine on left ventricular diastolic function in patients with cardiogenic shock after primary angioplasty. | International journal of cardiology 20080818 |
| Rescue peri-operative management of the patient with giant electrical storm and severe left ventricular dysfunction: support by levosimendan and intraaortic balloon counterpulsation. | Interactive cardiovascular and thoracic surgery 20080801 |
| Levosimendan infusion improves haemodynamics in elderly heart failure patients undergoing urgent hip fracture repair. | European journal of anaesthesiology 20080801 |
| Natriuretic peptide-guided levosimendan therapy for heart failure: a promising new approach. | International journal of cardiology 20080801 |
| The prolonged lowering effect of levosimendan on brain natriuretic peptide levels in patients with decompansated heart failure: clinical implications. | International journal of cardiology 20080801 |
| Ca2+ sensitizer superior to catecholamine during myocardial stunning? | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20080801 |
| Novel biologic mechanisms of levosimendan and its effect on the failing heart. | Expert opinion on investigational drugs 20080801 |
| Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarction. | Critical care medicine 20080801 |
| Levosimendan in cardiogenic shock: better than enoximone! | Critical care medicine 20080801 |
| BELIEF: believe it or not. | Arquivos brasileiros de cardiologia 20080801 |
| Levosimendan in patients with decompensated heart failure. | Arquivos brasileiros de cardiologia 20080801 |
| The hemodynamic and pharmacokinetic interactions between chronic use of oral levosimendan and digoxin in patients with NYHA Classes II-III heart failure. | International journal of clinical pharmacology and therapeutics 20080801 |
| Both levosimendan and dobutamine treatments result in significant reduction of NT-proBNP levels, but levosimendan has better and prolonged neurohormonal effects than dobutamine. | International journal of cardiology 20080721 |
| Defining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complex. | Biochemistry 20080715 |
| Effects of levosimendan versus dobutamine on long-term survival of patients with cardiogenic shock after primary coronary angioplasty. | International journal of cardiology 20080704 |
| Effects of levosimendan on indocyanine green plasma disappearance rate and the gastric mucosal-arterial pCO2 gradient in abdominal aortic aneurysm surgery. | Acta anaesthesiologica Scandinavica 20080701 |
| Safety and effectiveness of levosimendan in patients with predominant right heart failure. | Herz 20080701 |
| Protective effects of levosimendan and iloprost on lung injury induced by limb ischemia-reperfusion: a rabbit model. | The Journal of surgical research 20080601 |
| Repeated infusions of levosimendan: well tolerated and improves functional capacity in decompensated heart failure - a single-centre experience. | Heart, lung & circulation 20080601 |
| Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock. | Critical care medicine 20080601 |
| Inhaled levosimendan reduces mortality and release of proinflammatory mediators in a rat model of experimental ventilator-induced lung injury. | Critical care medicine 20080601 |
| Inotropic agents improve the peripheral microcirculation of patients with end-stage chronic heart failure. | Journal of cardiac failure 20080601 |
| Levo is in the air: take a deep breath! | Critical care medicine 20080601 |
| Calcium sensitizing in sepsis: is levosimendan on the right path? | Critical care medicine 20080601 |
| Perioperative cardiac evaluation: the importance of cardiac failure management. | Southern medical journal 20080601 |
| A role for the RISK pathway and K(ATP) channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart. | British journal of pharmacology 20080501 |
| [Paediatric use of levosimendan in septic shock]. | Anales de pediatria (Barcelona, Spain : 2003) 20080501 |
| [Levosimendan and low cardiac output syndrome. Does mortality really decrease? ]. | Revista espanola de cardiologia 20080501 |
| [The calcium sensitizer levosimendan gives superior results to dobutamine in postoperative low cardiac output syndrome]. | Revista espanola de cardiologia 20080501 |
| [Levosimendan for postoperative ventricular dysfunction following heart transplantation]. | Revista espanola de cardiologia 20080501 |
| [Is there a role for levosimendan in hospital emergency departments?]. | Revista espanola de cardiologia 20080501 |
| Primary graft failure and Ca2+ sensitizers after heart transplantation. | Transplantation proceedings 20080501 |
| The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study. | Interactive cardiovascular and thoracic surgery 20080401 |
| Evoked changes in cardiovascular function in rats by infusion of levosimendan, OR-1896 [(R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], dobutamine, and milrinone: comparative effects on peripheral resistance, cardiac output, dP/dt, pulse rate, and blood pressure. | The Journal of pharmacology and experimental therapeutics 20080401 |
| Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs. | The Journal of pharmacology and experimental therapeutics 20080401 |
| Pharmacokinetics of intravenous levosimendan and its metabolites in subjects with hepatic impairment. | Journal of clinical pharmacology 20080401 |
| Preoperative levosimendan in heart failure patients undergoing noncardiac surgery. | The Netherlands journal of medicine 20080401 |
| Role of levosimendan in sepsis and septic shock. | Current opinion in anaesthesiology 20080401 |
| Improvement in Doppler alternans in patients with severe heart failure: Levosimendan versus dobutamin. | International journal of cardiology 20080328 |
| Effects of levosimendan on flow-mediated vasodilation and soluble adhesion molecules in patients with advanced chronic heart failure. | Atherosclerosis 20080301 |
| Levosimendan in patients with acute myocardial ischaemia undergoing emergency surgical revascularization. | European journal of anaesthesiology 20080301 |
| Levosimendan and ventriculo-arterial coupling. | Acta anaesthesiologica Scandinavica 20080301 |
| Inoprotection review. | Anaesthesia and intensive care 20080301 |
| Can we believe in levosimendan? | Arquivos brasileiros de cardiologia 20080301 |
| Levosimendan in decompensated heart failure patients: efficacy in a Brazilian cohort. Results of the BELIEF study. | Arquivos brasileiros de cardiologia 20080301 |
| Levosimendan use in several scenarios of acute heart failure. | Arquivos brasileiros de cardiologia 20080301 |
| Effects of levosimendan on left ventricular relaxation and early filling at maintained preload and afterload conditions after aortic valve replacement for aortic stenosis. | Circulation 20080226 |
| Effect of levosimendan on right ventricular systolic and diastolic functions in patients with ischaemic heart failure. | International journal of clinical practice 20080201 |
| Levosimendan: current status and future prospects. | Current opinion in anaesthesiology 20080201 |
| Metabolism of OR-1896, a metabolite of levosimendan, in rats and humans. | Xenobiotica; the fate of foreign compounds in biological systems 20080201 |
| Management of pulmonary hypertension in the intensive care unit. | Critical care medicine 20080201 |
| Overview of emerging pharmacologic agents for acute heart failure syndromes. | European journal of heart failure 20080201 |
| Peripartum cardiomyopathy: a new successful setting for levosimendan. | International journal of cardiology 20080124 |
| Effect of levosimendan on E/E' ratio in patients with ischemic heart failure. | International journal of cardiology 20080111 |
| Levosimendan has an inhibitory effect on platelet function. | American journal of hematology 20080101 |
| Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration. | Resuscitation 20080101 |
| Effects of levosimendan on myocardial ischaemia-reperfusion injury. | European journal of anaesthesiology 20080101 |
| Early and sustained haemodynamic improvement with levosimendan compared to intraaortic balloon counterpulsation (IABP) in cardiogenic shock complicating acute myocardial infarction. | Acute cardiac care 20080101 |
| Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity. | Clinical toxicology (Philadelphia, Pa.) 20080101 |
| Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs. | American journal of physiology. Heart and circulatory physiology 20080101 |
| Inotropes in the management of acute heart failure. | Critical care medicine 20080101 |
| New pharmacologic therapies for acute heart failure. | Critical care medicine 20080101 |
| Levosimendan effect on spinal cord ischemia-reperfusion injury following aortic clamping. | Journal of cardiac surgery 20080101 |
| Protection of the spinal cord from ischemia: comparative effects of levosimendan and iloprost. | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20080101 |
| Levosimendan for ischemic preconditioning in thoracic aortic aneurysm repair. | Journal of cardiac surgery 20080101 |
| The use of more than one inotrope in acute heart failure is associated with increased mortality: a multi-centre observational study. | Acute cardiac care 20080101 |
| Levosimendan versus dobutamine in heart failure patients treated chronically with carvedilol. | Cardiovascular therapeutics 20080101 |
| Levosimendan as rescue therapy in severe cardiogenic shock after ST-elevation myocardial infarction. | Acute cardiac care 20080101 |
| Design, synthesis and structure-activity relationship studies of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives as cardiotonic agents. | Arzneimittel-Forschung 20080101 |
| The costs of treating acute heart failure: an economic analysis of the SURVIVE trial. | Journal of medical economics 20080101 |
| Effects of Levosimendan on circulating markers of oxidative and nitrosative stress in patients with advanced heart failure. | Atherosclerosis 20071201 |
| Pharmacokinetics and excretion balance of OR-1896, a pharmacologically active metabolite of levosimendan, in healthy men. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071201 |
| Hemodynamic improvement following levosimendan treatment in patients with acute myocardial infarction and cardiogenic shock. | Critical care medicine 20071201 |
| Levosimendan improves renal function in patients with acute decompensated heart failure: comparison with dobutamine. | Cardiovascular drugs and therapy 20071201 |
| Levosimendan improves renal function in acute decompensated heart failure: cause and clinical application. Editorial to: 'Levosimendan improves renal function in patients with acute decompensated heart failure: comparison with dobutamine by Yilmaz et al.'. | Cardiovascular drugs and therapy 20071201 |
| [New pharmacological treatment approaches to cardiogenic shock]. | Der Internist 20071201 |
| Levosimendan in cardiogenic shock: the magic drug for every patient? | Critical care medicine 20071201 |
| Is there a place for levosimendan in the intensive care unit? | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20071201 |
| Effects of levosimendan on coronary artery flow and cardiac performance in patients with advanced heart failure. | European journal of heart failure 20071201 |
| Inoprotection: the perioperative role of levosimendan. | Anaesthesia and intensive care 20071201 |
| Pharmacologic therapy for acute heart failure. | Cardiology clinics 20071101 |
| Antieosinophilic activity of simendans. | The Journal of pharmacology and experimental therapeutics 20071001 |
| A struggle to SURVIVE: to abandon or not to abandon levosimendan? | Cardiovascular drugs and therapy 20071001 |
| Efficacy and safety of perioperative infusion of levosimendan in patients with compromised cardiac function undergoing open-heart surgery: importance of early use. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20071001 |
| The gender differences in the relaxation to levosimendan of human internal mammary artery. | Cardiovascular drugs and therapy 20071001 |
| Pharmacological preconditioning by levosimendan is mediated by inducible nitric oxide synthase and mitochondrial KATP channel activation in the in vivo anesthetized rabbit heart model. | Vascular pharmacology 20071001 |
| Effect of levosimendan on ventriculo-arterial coupling in patients with ischemic cardiomyopathy. | Acta anaesthesiologica Scandinavica 20071001 |
| New pharmacologic options in the treatment of acute coronary syndromes and myocardial ischemia-reperfusion injury: potential role of levosimendan. | Minerva cardioangiologica 20071001 |
| Levosimendan in acute pulmonary embolism. | Anaesthesia and intensive care 20071001 |
| Preconditioning with levosimendan prevents contractile dysfunction due to H2O2-induced oxidative stress in human myocardium. | Journal of cardiovascular pharmacology 20071001 |
| Letter by Guarracino et al regarding article, 'Direct myocardial effects of levosimendan in humans with left ventricular dysfunction: alteration of force-frequency and relaxation-frequency relationships'. | Circulation 20070911 |
| Levosimendan allows detection of contractile reserve in patients with chronic ischaemic left ventricular dysfunction and non-diagnostic dobutamine echocardiography. | European journal of heart failure 20070901 |
| Levosimendan improves the initial outcome of cardiopulmonary resuscitation in a swine model of cardiac arrest. | Acta anaesthesiologica Scandinavica 20070901 |
| Levosimendan in septic shock: a case series. | British journal of anaesthesia 20070901 |
| The effects of levosimendan on myocardial function in ropivacaine toxicity in isolated guinea pig heart preparations. | Anesthesia and analgesia 20070901 |
| Is there a place for levosimendan in the intensive care unit? | Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20070901 |
| A 6-month follow-up of intermittent levosimendan administration effect on systolic function, specific activity questionnaire, and arrhythmia in advanced heart failure. | Journal of cardiac failure 20070901 |
| The cardioprotective effects of levosimendan: preclinical and clinical evidence. | Journal of cardiovascular pharmacology 20070901 |
| Patients with advanced heart failure and the effects of levosimendan. | The American journal of cardiology 20070815 |
| Effects of levosimendan on acute pulmonary embolism-induced right ventricular failure. | Critical care medicine 20070801 |
| Effects of levosimendan on quality of life and emotional stress in advanced heart failure patients. | Cardiovascular drugs and therapy 20070801 |
| The heart rules the head. | Emergency medicine Australasia : EMA 20070801 |
| Levosimendan: right for the right ventricle? | Critical care medicine 20070801 |
| Levosimendan improves renal function in patients with advanced chronic heart failure awaiting cardiac transplantation. | Journal of cardiac failure 20070801 |
| [Clinical experience with levosimendan in the emergency department of a tertiary care hospital]. | Revista espanola de cardiologia 20070801 |
| Therapies for heart failure: a report from the Heart Failure Congress 2007. | Timely topics in medicine. Cardiovascular diseases 20070713 |
| Cardiovascular effects of levosimendan in the early stages of endotoxemia. | Shock (Augusta, Ga.) 20070701 |
| Levosimendan in acute decompensation of anthracycline-induced cardiotoxicity. | International journal of cardiology 20070612 |
| Classical inotropes and new cardiac enhancers. | Heart failure reviews 20070601 |
| Experiences of levosimendan as an inotropic agent in conjunction with passive containment surgery. | Scandinavian cardiovascular journal : SCJ 20070601 |
| Myocardial depression associated with pneumococcal septic shock reversed by levosimendan. | Anaesthesia and intensive care 20070601 |
| Do calcium sensitizers affect right ventricular functions in patients with chronic heart failure? | International journal of cardiology 20070531 |
| [Calcium sensitizer: characteristics, mechanisms of action, pharmacokinetics, indication, contraindication, clinical data, and side effects]. | Nihon rinsho. Japanese journal of clinical medicine 20070528 |
| [Calcium sensitizer agents in heart failure therapy]. | Nihon rinsho. Japanese journal of clinical medicine 20070528 |
| [Combination therapy with PDE III inhibitor for heart failure]. | Nihon rinsho. Japanese journal of clinical medicine 20070528 |
| [Levosimendan for treatment of heart failure]. | Nihon rinsho. Japanese journal of clinical medicine 20070528 |
| Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized Trial. | JAMA 20070502 |
| Levosimendan: beyond its simple inotropic effect in heart failure. | Pharmacology & therapeutics 20070501 |
| Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone. | Critical care medicine 20070501 |
| Vasodilating mechanisms of levosimendan: involvement of K+ channels. | Journal of pharmacological sciences 20070501 |
| Could Ca2+ sensitizers rescue patients from chronic congestive heart failure? | British journal of pharmacology 20070401 |
| Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats. | British journal of pharmacology 20070401 |
| The use of levosimendan in comparison and in combination with dobutamine in the treatment of decompensated heart failure. | Expert opinion on pharmacotherapy 20070401 |
| Levosimendan in cardiac surgery: a unique drug for the treatment of perioperative left ventricular dysfunction or just another inodilator searching for a clinical application? | Anesthesia and analgesia 20070401 |
| The effects of levosimendan in cardiac surgery patients with poor left ventricular function. | Anesthesia and analgesia 20070401 |
| Levosimendan: a new option in acute septic cardiac failure? | Emergency medicine Australasia : EMA 20070401 |
| Direct myocardial effects of levosimendan in humans with left ventricular dysfunction: alteration of force-frequency and relaxation-frequency relationships. | Circulation 20070313 |
| Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction. | Critical care medicine 20070301 |
| Levosimendan in septic shock: another piece in the puzzle, but many pieces are still lacking. | Intensive care medicine 20070301 |
| Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study. | Intensive care medicine 20070301 |
| Dear levosimendan, the right ventricle will thank you! | Critical care medicine 20070301 |
| Levosimendan and prostaglandin E1 for uptitration of beta-blockade in patients with refractory, advanced chronic heart failure. | European journal of heart failure 20070201 |
| Levosimendan: perpetuum mobile? | European heart journal 20070201 |
| Duration of the haemodynamic action of a 24-h infusion of levosimendan in patients with congestive heart failure. | European journal of heart failure 20070101 |
| Levosimendan cardioprotection reduces the metabolic response during temporary regional coronary occlusion in an open chest pig model. | Acta anaesthesiologica Scandinavica 20070101 |
| [Role of Levosimendan in intensive care treatment of myocardial insufficiency]. | Der Anaesthesist 20070101 |
| Severe stunned myocardium after lightning strike. | Critical care medicine 20070101 |
| Mechanisms of a reduced cardiac output and the effects of milrinone and levosimendan in a model of infant cardiopulmonary bypass. | Critical care medicine 20070101 |
| Use of levosimendan, a new inodilator, for postoperative myocardial stunning in a premature neonate. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20070101 |
| Levosimendan for the treatment of acute heart failure syndromes: time to identify subpopulations of responding patients. | The American journal of cardiology 20070101 |
| Effect of severe renal failure and haemodialysis on the pharmacokinetics of levosimendan and its metabolites. | Clinical pharmacokinetics 20070101 |
| Successful use of levosimendan in a patient during cardiopulmonary bypass. | Journal of cardiac surgery 20070101 |
| The utility of levosimendan in the treatment of heart failure. | Annals of medicine 20070101 |
| Haemodynamic effects of levosimendan for low cardiac output after cardiac surgery: a case series. | Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20070101 |
| Clinical pharmacology of levosimendan. | Clinical pharmacokinetics 20070101 |
| Levosimendan: the inotrope of choice in cardiogenic shock secondary to takotsubo cardiomyopathy? | Heart, lung & circulation 20070101 |
| A strategy for high-throughput analysis of levosimendan and its metabolites in human plasma samples using sequential negative and positive ionization liquid chromatography/tandem mass spectrometric detection. | Rapid communications in mass spectrometry : RCM 20070101 |
| Medical support and surgery of the failing heart: levosimendan. | Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society 20070101 |
| Evaluation of the clinical, hemodynamic and neurohormonal response to levosimendan administration in decompensated heart failure patients. One-month follow-up. | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20070101 |
| Synthesis and bioactivity of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives. | Arzneimittel-Forschung 20070101 |
| Levosimendana. | Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular 20070101 |
| Effect of levosimendan on ventricular arrhythmias and prognostic autonomic indexes in patients with decompensated advanced heart failure secondary to ischemic or dilated cardiomyopathy. | The American journal of cardiology 20061215 |
| Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure. | European journal of heart failure 20061201 |
| Effects of serial levosimendan infusions on left ventricular performance and plasma biomarkers of myocardial injury and neurohormonal and immune activation in patients with advanced heart failure. | Heart (British Cardiac Society) 20061201 |
| Effects of levosimendan on right ventricular function in patients with advanced heart failure. | The American journal of cardiology 20061201 |
| A review of levosimendan in the treatment of heart failure. | Vascular health and risk management 20061201 |
| Cardiogenic shock after primary percutaneous coronary intervention: Effects of levosimendan compared with dobutamine on haemodynamics. | European journal of heart failure 20061101 |
| Effects of levosimendan versus dobutamine on pressure load-induced right ventricular failure. | Critical care medicine 20061101 |
| The vasodilatory effects of levosimendan on the human internal mammary artery. | Anesthesia and analgesia 20061101 |
| Intracoronary infusion of levosimendan to treat postpericardiotomy heart failure. | The Annals of thoracic surgery 20061101 |
| Levosimendan treatment after primary organ failure in heart transplantation: a direct way to recovery? | Transplantation 20061027 |
| Clinical significance of acute neurohormonal response after levosimendan treatment. | The American journal of cardiology 20061015 |
| Levosimendan for weaning from cardiopulmonary bypass after coronary artery bypass grafting. | Heart, lung & circulation 20061001 |
| Levosimendan reversing low output syndrome after heart transplantation. | The Annals of thoracic surgery 20061001 |
| Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model. | Journal of cardiovascular pharmacology 20061001 |
| Effects of levosimendan on myocardial infarct size and hemodynamics in a closed-chest porcine ischemia-reperfusion model. | Cardiovascular drugs and therapy 20061001 |
| Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: a pilot study. | Critical care medicine 20060901 |
| Early experience with Levosimendan in children with ventricular dysfunction. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060901 |
| The preconditioning effects of levosimendan. | British journal of anaesthesia 20060901 |
| A new horizon in the treatment of right ventricular failure and pulmonary hypertension associated with acute respiratory distress syndrome? | Critical care medicine 20060901 |
| Testing new drugs for heart failure in children. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060901 |
| Evidence-based use of levosimendan in different clinical settings. | European heart journal 20060801 |
| The role of potassium channels in the vasodilatory effect of levosimendan in human internal thoracic arteries. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060801 |
| Management of acute decompensated heart failure: treatment, controversy, and future directions. | Pharmacotherapy 20060801 |
| Vasorelaxing effect of levosimendan against 5-hydroxytryptamine-induced contractions in isolated human conduit bypass grafts. | The Journal of pharmacy and pharmacology 20060801 |
| The calcium sensitizer levosimendan improves carbon monoxide poisoning related stunned myocardium: a cardiac magnetic resonance study. | Acta anaesthesiologica Scandinavica 20060801 |
| [Effect of levosimendan treatment of myocardial stunning and low-output syndrome after cardiac surgery]. | Revista espanola de cardiologia 20060801 |
| The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arterioles. | British journal of pharmacology 20060701 |
| Level A in vitro-in vivo correlation (IVIVC) model with Bayesian approach to formulation series. | Journal of pharmaceutical sciences 20060701 |
| Effects of levosimendan versus dobutamine on inflammatory and apoptotic pathways in acutely decompensated chronic heart failure. | The American journal of cardiology 20060701 |
| The effect of levosimendan during long-term amiodarone treatment in dogs. | Basic & clinical pharmacology & toxicology 20060701 |
| Beneficial outcome after prostaglandin-induced post-partum cardiac arrest using levosimendan and extracorporeal membrane oxygenation. | Acta anaesthesiologica Scandinavica 20060701 |
| Levosimendan protects against experimental endotoxemic acute renal failure. | American journal of physiology. Renal physiology 20060601 |
| Preconditioning effects of levosimendan in coronary artery bypass grafting--a pilot study. | British journal of anaesthesia 20060601 |
| Levosimendan or milrinone in the type 2 diabetic patient with low ejection fraction undergoing elective coronary artery surgery. | Journal of cardiothoracic and vascular anesthesia 20060601 |
| Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs. | Journal of cardiovascular pharmacology and therapeutics 20060601 |
| Levosimendan: a novel agent in heart failure. | Recent patents on cardiovascular drug discovery 20060601 |
| Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study. | Resuscitation 20060501 |
| Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. | Intensive care medicine 20060501 |
| Potassium channel-related relaxation by levosimendan in the human internal mammary artery. | The Annals of thoracic surgery 20060501 |
| Potassium channels in the vasodilating action of levosimendan on the human umbilical artery. | Journal of the Society for Gynecologic Investigation 20060501 |
| The role of potassium channels in relaxant effect of levosimendan in rat small mesenteric arteries. | Cardiovascular drugs and therapy 20060401 |
| Levosimendan in cardiac surgery: current best available evidence. | The Annals of thoracic surgery 20060401 |
| [Levosimendan in acute heart failure: past, present and future]. | Revista espanola de cardiologia 20060401 |
| [Hemodynamic effects of levosimendan compared with dobutamine in patients with low cardiac output after cardiac surgery]. | Revista espanola de cardiologia 20060401 |
| [Therapy of acute decompensated heart failure with levosimendan]. | Medizinische Klinik (Munich, Germany : 1983) 20060322 |
| [Medical and ventilatory treatment of acute heart failure]. | Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20060309 |
| Levosimendan improves cardiopulmonary resuscitation and survival by K(ATP) channel activation. | Journal of the American College of Cardiology 20060307 |
| Ischemia-reperfusion injury changes the dynamics of Ca2+-contraction coupling due to inotropic drugs in isolated hearts. | Journal of applied physiology (Bethesda, Md. : 1985) 20060301 |
| Levosimendan therapy in decompensated chronic heart failure: favourable haemodynamic and neurohormonal effects but for how long? | European journal of heart failure 20060301 |
| Levosimendan and plasma BNP levels: do inflammatory cytokines regulate BNP in chronic decompensated heart failure? | European journal of heart failure 20060301 |
| Optimizing outcomes in the patient with acute decompensated heart failure. | American heart journal 20060301 |
| Levosimendan, a new inotropic and vasodilator agent. | Anesthesiology 20060301 |
| Effects of levosimendan on left ventricular diastolic function after primary angioplasty for acute anterior myocardial infarction: a Doppler echocardiographic study. | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20060201 |
| Levosimendan in severe right ventricular failure following mitral valve replacement. | Journal of cardiothoracic and vascular anesthesia 20060201 |
| Pre-operative use of levosimendan in two patients with severe aortic stenosis and left ventricular dysfunction. | Heart, lung & circulation 20060201 |
| Successful administration of levosimendan in a patient with low-gradient low-output aortic stenosis. | Wiener klinische Wochenschrift 20060201 |
| Newer approaches to the pharmacological management of heart failure. | Current opinion in anaesthesiology 20060201 |
| [On levosimendan in comparison with dobutamine]. | Revista espanola de anestesiologia y reanimacion 20060201 |
| [Levosimendan--an alternative to conventional inotropic treatment of patients with acute heart failure?]. | Ugeskrift for laeger 20060116 |
| Resuscitation from adrenaline resistant electro-mechanical dissociation facilitated by levosimendan in a young man with idiopathic dilated cardiomyopathy. | Resuscitation 20060101 |
| Levosimendan: a promising treatment for myocardial stunning? | Anaesthesia 20060101 |
| Levosimendan may improve survival in patients requiring mechanical assist devices for post-cardiotomy heart failure. | Critical care (London, England) 20060101 |
| Positive inotropic effect of levosimendan is correlated to its stereoselective Ca2+-sensitizing effect but not to stereoselective phosphodiesterase inhibition. | Basic & clinical pharmacology & toxicology 20060101 |
| The 2005 Scientific Sessions of the American Heart Association (AHA). | Heart failure monitor 20060101 |
| Pharmacologic treatment of heart failure due to ventricular dysfunction by myocardial stunning: potential role of levosimendan. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101 |
| The effects of Levosimendan on global haemodynamics in patients with cardiogenic shock. | Neuro endocrinology letters 20060101 |
| Levosimendan for low cardiac output: a pediatric experience. | Journal of intensive care medicine 20060101 |
| Levosimendan: a new option in acute cardiac failure. | Emergency medicine Australasia : EMA 20060101 |
| Short-term effects of levosimendan and prostaglandin E1 on hemodynamic parameters and B-type natriuretic peptide levels in patients with decompensated chronic heart failure. | European journal of heart failure 20051201 |
| Duration of the beneficial effects of levosimendan in decompensated heart failure as measured by echocardiographic indices and B-type natriuretic peptide. | Journal of cardiovascular pharmacology 20051201 |
| Levosimendan for the treatment of acute heart failure syndromes. | Expert opinion on pharmacotherapy 20051201 |
| Levosimendan: dual mechanisms for acute heart failure...and beyond? | Minerva cardioangiologica 20051201 |
| Levosimendan as a new strategy during off-pump coronary artery bypass grafting: double-blind randomized placebo-controlled trial. | Croatian medical journal 20051201 |
| Levosimendan use reduces matrix metalloproteinase-2 in patients with decompensated heart failure. | Cardiovascular drugs and therapy 20051201 |
| Ca2+-sensitisers--a promising option to treat heart failure? | Cardiovascular drugs and therapy 20051201 |
| Treatment of cardiogenic shock with levosimendan in combination with beta-adrenergic antagonists. | British journal of anaesthesia 20051101 |
| Levosimendan: a novel inotropic agent for treatment of acute, decompensated heart failure. | The Annals of pharmacotherapy 20051101 |
| Levosimendan improves postresuscitation outcomes in a rat model of CPR. | The Journal of laboratory and clinical medicine 20051101 |
| [Levosimendan]. | Deutsche medizinische Wochenschrift (1946) 20051028 |
| Levosimendan reduces plasma amino terminal proBNP in patients with decompensated heart failure. | International journal of cardiology 20051010 |
| Effects of levosimendan on restrictive left ventricular filling in severe heart failure: a combined hemodynamic and Doppler echocardiographic study. | Chest 20051001 |
| [Successful use of levosimendan in a patient with cardiogenic shock complicating acute myocardial infarction]. | La Tunisie medicale 20051001 |
| Cardioprotection: a new paradigm in the management of acute heart failure syndromes. | The American journal of cardiology 20050919 |
| Pharmacology of new agents for acute heart failure syndromes. | The American journal of cardiology 20050919 |
| Randomized clinical trials with levosimendan. | The American journal of cardiology 20050919 |
| European experience on the practical use of levosimendan in patients with acute heart failure syndromes. | The American journal of cardiology 20050919 |
| Calcium sensitizer agents: a new class of inotropic agents in the treatment of decompensated heart failure. | International journal of cardiology 20050901 |
| Hemodynamic effect of intracoronary administration of levosimendan in the anesthetized pig. | Journal of cardiovascular pharmacology 20050901 |
| Two inotropes with different mechanisms of action: contractile, PDE-inhibitory and direct myofibrillar effects of levosimendan and enoximone. | Journal of cardiovascular pharmacology 20050901 |
| Cardiac and renal effects of levosimendan, arginine vasopressin, and norepinephrine in lipopolysaccharide-treated rabbits. | Anesthesiology 20050901 |
| Levosimendan improves postresuscitation myocardial dysfunction after beta-adrenergic blockade. | The Journal of laboratory and clinical medicine 20050901 |
| Levosimendan improves hemodynamics and coronary flow reserve after percutaneous coronary intervention in patients with acute myocardial infarction and left ventricular dysfunction. | American heart journal 20050901 |
| The Ca2+-sensitizer levosimendan improves oxidative damage, BNP and pro-inflammatory cytokine levels in patients with advanced decompensated heart failure in comparison to dobutamine. | European journal of heart failure 20050801 |
| Dual regulation of myofilament Ca2+ sensitivity by levosimendan in normal and acidotic conditions in aequorin-loaded canine ventricular myocardium. | British journal of pharmacology 20050801 |
| Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure. | The American journal of cardiology 20050801 |
| What is the in vivo mechanism of action of levosimendan? | Journal of cardiac failure 20050801 |
| Anti-inflammatory and anti-apoptotic effects of levosimendan in decompensated heart failure: a novel mechanism of drug-induced improvement in contractile performance of the failing heart. | Current medicinal chemistry. Cardiovascular and hematological agents 20050701 |
| [Cost analysis of the treatment of acute decompensated heart failure. Levosimendan versus dobutamine]. | Arquivos brasileiros de cardiologia 20050701 |
| Utility of levosimendan, a new calcium sensitizing agent, in the treatment of cardiogenic shock due to myocardial stunning in patients with ST-elevation myocardial infarction: a series of cases. | Journal of clinical pharmacology 20050601 |
| An emerging role for calcium sensitisation in the treatment of heart failure. | Expert opinion on investigational drugs 20050601 |
| Levosimendan in cardiac surgery. | Journal of cardiothoracic and vascular anesthesia 20050601 |
| [Levosimendan, a revolution in the world of inotropic agents?]. | Revue medicale suisse 20050525 |
| [Cardiogenic shock-- new therapeutic strategies]. | Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20050519 |
| Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. | Intensive care medicine 20050501 |
| The myofilament force-calcium relationship as a target for positive inotropic therapy in congestive heart failure. | Cardiovascular drugs and therapy 20050501 |
| [If the myofilaments become sensitive: Ca2+-sensitizer for the therapy of heart insufficiency]. | Deutsche medizinische Wochenschrift (1946) 20050415 |
| Anti-inflammatory effects of levosimendan in decompensated heart failure: impact on weight loss and anemia. | The American journal of cardiology 20050401 |
| Levosimendan reduces plasma B-type natriuretic peptide and interleukin 6, and improves central hemodynamics in severe heart failure patients. | International journal of cardiology 20050330 |
| Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake. | Circulation 20050329 |
| Efficacy and safety of intermittent, long-term, concomitant dobutamine and levosimendan infusions in severe heart failure refractory to dobutamine alone. | The American journal of cardiology 20050315 |
| Comparison between dobutamine and levosimendan for management of postresuscitation myocardial dysfunction. | Critical care medicine 20050301 |
| Inotropic options for postresuscitation myocardial dysfunction. | Critical care medicine 20050301 |
| Levosimendan improves LV systolic and diastolic performance at rest and during exercise after heart failure. | American journal of physiology. Heart and circulatory physiology 20050201 |
| Contractile action of levosimendan and epinephrine during acidosis. | European journal of pharmacology 20050110 |
| Levosimendan in septic cardiac failure. | Intensive care medicine 20050101 |
| Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs. | Critical care medicine 20050101 |
| Levosimendan and gut mucosal blood flow--not all inotropes are created equal. | Critical care medicine 20050101 |
| Successful reversal of resistent hypodynamic septic shock with levosimendan. | Acta anaesthesiologica Scandinavica 20050101 |
| Levosimendan: a new inodilatory drug for the treatment of decompensated heart failure. | Current pharmaceutical design 20050101 |
| Pharmacological mechanisms contributing to the clinical efficacy of levosimendan. | Cardiovascular drug reviews 20050101 |
| [Use of levosimendan after cardiac arrest by ventricular fibrillation: a case report]. | La Clinica terapeutica 20050101 |
| [The novelty in the treatment of heart failure]. | Medicina (Kaunas, Lithuania) 20050101 |
| Effects of levosimendan on left ventricular functional remodelling and exercise intolerance: a tissue Doppler study. | The Journal of international medical research 20050101 |
| [Hemodynamic effects of levosimendan following cardiac surgery]. | Revista espanola de anestesiologia y reanimacion 20050101 |
| [Levosimendan in patients with acute cardiac failure]. | Archivos de cardiologia de Mexico 20050101 |
| [Levosimendan: a new strategy in the treatment of heart failure]. | Archivos de cardiologia de Mexico 20050101 |
| [Treatment of cardiogenic shock with the Ca2+ sensitizer levosimendan]. | Medizinische Klinik (Munich, Germany : 1983) 20041215 |
| Enatiomeric analysis of simendan by CE with beta-CD as chiral selector compared with CMPA-HPLC. | Biomedical chromatography : BMC 20041201 |
| Levosimendan in off-pump coronary artery bypass: a four-times masked controlled study. | Journal of cardiovascular pharmacology 20041201 |
| Successful treatment of dilative cardiomyopathy in a 12-year-old girl using the calcium sensitizer levosimendan after weaning from mechanical biventricular assist support. | Journal of cardiothoracic and vascular anesthesia 20041201 |
| Hemodynamic effects of levosimendan added to dobutamine in patients with decompensated advanced heart failure refractory to dobutamine alone. | The American journal of cardiology 20041115 |
| Pharmacokinetics of levosimendan and its active metabolite OR-1896 in rapid and slow acetylators. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041101 |
| Comparision of the inotropic effects of levosimendan, rolipram, and dobutamine on human atrial trabeculae. | Journal of cardiovascular pharmacology 20041101 |
| The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c. | Molecular and cellular biochemistry 20041101 |
| Levosimendan in daily intensive care practice--the experience of 15 centers. Background, methods and organization of the PORTLAND study. | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20041101 |
| End-stage heart failure with pulmonary hypertension: levosimendan to evaluate for heart transplantation alone versus combined heart-lung transplantation. | Transplantation 20041027 |
| Impact of levosimendan treatment on chronic heart failure. | The American journal of cardiology 20041015 |
| Pharmacodynamics and pharmacokinetics of oral levosimendan and its metabolites in patients with severe congestive heart failure: a dosing interval study. | Journal of clinical pharmacology 20041001 |
| Force-frequency relationship in intact mammalian ventricular myocardium: physiological and pathophysiological relevance. | European journal of pharmacology 20041001 |
| Levosimendan, a new calcium-sensitizing inotrope for heart failure. | Pharmacotherapy 20041001 |
| Potassium-specific effects of levosimendan on heart mitochondria. | Biochemical pharmacology 20040901 |
| Pharmacokinetics of levosimendan in pediatric patients evaluated for cardiac surgery. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20040901 |
| Resumption of atrioventricular conduction by levosimendan after radiofrequency ablation of the AV node: | Pacing and clinical electrophysiology : PACE 20040901 |
| Effect of levosimendan on balance between ATP production and consumption in isolated perfused guinea-pig heart before ischemia or after reperfusion. | Journal of cardiovascular pharmacology 20040901 |
| Levosimendan: a calcium-sensitizing agent for the treatment of patients with decompensated heart failure. | Current heart failure reports 20040901 |
| Levosimendan in patients with cardiogenic shock undergoing surgical revascularization: a case series. | Medical science monitor : international medical journal of experimental and clinical research 20040801 |
| The use of the novel calcium sensitizer levosimendan in critically ill patients. | Anaesthesia and intensive care 20040801 |
| Treatment of acute heart failure in an infant after cardiac surgery using levosimendan. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20040701 |
| On the mechanism of levosimendan-induced dopamine release in the striatum of freely moving rats. | Journal of pharmacological sciences 20040701 |
| Medical therapy in heart failure--is polypharmacy necessary? | Annals of the Academy of Medicine, Singapore 20040701 |
| The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. | Journal of the American College of Cardiology 20040616 |
| New positive inotropic agents in the treatment of left ventricular dysfunction. | Italian heart journal : official journal of the Italian Federation of Cardiology 20040601 |
| Levosimendan interacts with potassium channel blockers in human saphenous veins. | Basic & clinical pharmacology & toxicology 20040601 |
| Effects of levosimendan on circulating pro-inflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure. | The American journal of cardiology 20040515 |
| The calcium sensitizer levosimendan and cardiac arrhythmias: an analysis of the safety database of heart failure treatment studies. | Scandinavian cardiovascular journal : SCJ 20040501 |
| Pharmacokinetics of levosimendan and its circulating metabolites in patients with heart failure after an extended continuous infusion of levosimendan. | British journal of clinical pharmacology 20040401 |
| Effects of levosimendan and milrinone on oxygen consumption in isolated guinea-pig heart. | Journal of cardiovascular pharmacology 20040401 |
| Hemodynamic effects of levosimendan in patients with low-output heart failure after cardiac surgery. | International journal of clinical pharmacology and therapeutics 20040401 |
| Successful use of levosimendan in a patient with peripartum cardiomyopathy. | Anesthesia and analgesia 20040301 |
| [Levosimendan-long-term inodilation in an infant with myocardial infarction]. | Zeitschrift fur Kardiologie 20040301 |
| New therapies for heart failure. | RN 20040301 |
| Stereoselective binding of levosimendan to cardiac troponin C causes Ca2+-sensitization. | European journal of pharmacology 20040213 |
| The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig. | European journal of pharmacology 20040213 |
| [Levosimendan. Clinical indications of a new vasoactive substance]. | Der Anaesthesist 20040201 |
| Pharmacological therapy of acute cardiogenic pulmonary oedema in the emergency department. | Emergency medicine Australasia : EMA 20040201 |
| [Levosimendan in cardiology and intensive care medicine]. | Wiener klinische Wochenschrift 20040131 |
| Levosimendan: first in a new class of inodilator for acute and chronic severe heart failure. | Expert review of cardiovascular therapy 20040101 |
| [Levosimendan in heart failure]. | Recenti progressi in medicina 20040101 |
| [Usefulness of Levosimendan in patients with ventricular dysfunction before surgery]. | Archivos de cardiologia de Mexico 20040101 |
| Levosimendan. | Intensive & critical care nursing 20031201 |
| Hemodynamic effects of a continuous infusion of levosimendan in critically ill patients with cardiogenic shock requiring catecholamines. | Acta anaesthesiologica Scandinavica 20031101 |
| New and emerging drug therapies for the management of acute heart failure. | Internal medicine journal 20031101 |
| The calcium sensitizer levosimendan attenuates endotoxin-evoked myocardial dysfunction in isolated guinea pig hearts. | Intensive care medicine 20031001 |
| The role of Ca++-sensitizers for the treatment of heart failure. | Current opinion in critical care 20031001 |
| Levosimendan: implications for clinicians. | Journal of clinical pharmacology 20031001 |
| Cardiotonic drugs differentially alter cytosolic [Ca2+] to left ventricular relationships before and after ischemia in isolated guinea pig hearts. | Cardiovascular research 20031001 |
| [Levosimendan as inotropic support during coronary surgery with extracorporeal circulation in a patient with severely depressed ventricular function]. | Revista espanola de anestesiologia y reanimacion 20031001 |
| Molecular mechanism of levosimendan action: an update. | Journal of molecular and cellular cardiology 20030901 |
| Interaction of levosimendan with cardiac troponin C in the presence of cardiac troponin I peptides. | Journal of molecular and cellular cardiology 20030901 |
| [Is levosimendan an inoprotective drug in patients with acute coronary syndrome undergoing surgical revascularization?]. | Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20030901 |
| Effects of levosimendan on right ventricular function and ventriculovascular coupling in open chest pigs. | Critical care medicine 20030901 |
| Advances in positive inotropic therapy: levosimendan. | Critical care medicine 20030901 |
| The cardiotonic effects of levosimendan in guinea pig hearts are modulated by beta-adrenergic stimulation. | General physiology and biophysics 20030901 |
| Pharmacokinetic-pharmacodynamic interrelationships of intravenous and oral levosimendan in patients with severe congestive heart failure. | International journal of clinical pharmacology and therapeutics 20030801 |
| Population pharmacokinetics of levosimendan in patients with congestive heart failure. | British journal of clinical pharmacology 20030601 |
| Levosimendan: a new dual-action drug in the treatment of acute heart failure. | International journal of clinical practice 20030601 |
| Is calcium sensitization the best strategy to improve myocardial contractility in acute heart failure? | Italian heart journal : official journal of the Italian Federation of Cardiology 20030501 |
| Levosimendan in patients with low-output heart failure: lessons from the LIDO trial. | Italian heart journal : official journal of the Italian Federation of Cardiology 20030501 |
| Considerations on the efficacy and safety of levosimendan in ischemic heart failure. | Italian heart journal : official journal of the Italian Federation of Cardiology 20030501 |
| Preliminary clinical experience with the repetitive administration of levosimendan in patients with end-stage heart failure. | Italian heart journal : official journal of the Italian Federation of Cardiology 20030501 |
| The clinical experience with levosimendan in anesthesiology and in the intensive care unit. | Italian heart journal : official journal of the Italian Federation of Cardiology 20030501 |
| Levosimendan compared with dobutamine in low output patients. | Minerva anestesiologica 20030401 |
| Effect of long-term oral pretreatment with levosimendan on cardiac arrhythmias during coronary artery occlusion in conscious rats. | European journal of pharmacology 20030319 |
| Functional role of potassium channels in the vasodilating mechanism of levosimendan in porcine isolated coronary artery. | Cardiovascular drugs and therapy 20030301 |
| Vasodilating mechanisms of levosimendan. | Cardiovascular drugs and therapy 20030301 |
| Complete structure analysis of OR-1746, a complex product of cyclocondensation of arylhydrazomalononitriles containing clusters of protonated and unprotonated nitrogens, by pulsed-field-gradient heteronuclear NMR. | Journal of pharmaceutical and biomedical analysis 20030205 |
| Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization. | American heart journal 20030201 |
| Dyspnea as an end point in clinical trials of therapies for acute decompensated heart failure. | American heart journal 20030201 |
| Sustained hemodynamic effects of intravenous levosimendan. | Circulation 20030107 |
| Pharmacotherapeutic approaches for decompensated heart failure: a role for the calcium sensitiser, levosimendan? | European journal of heart failure 20030101 |
| Intravenous levosimendan treatment is cost-effective compared with dobutamine in severe low-output heart failure: an analysis based on the international LIDO trial. | European journal of heart failure 20030101 |
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| 15th Annual Congress of the European Society of Intensive Care Medicine, 29 September-2 October 2002, Barcelona, Spain: clinical research to improve outcome. | Critical care (London, England) 20030101 |
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| [Inotropic agents in advanced and refractory heart failure]. | Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20030101 |
| Levosimendan: a new approach for the treatment of patients with severe heart failure. A brief summary based on a clinical case. | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20030101 |
| Levosimendan: a review of its use in the management of acute decompensated heart failure. | Drugs 20030101 |
| Pharmacodynamic interactions of levosimendan and felodipine in patients with coronary heart disease. | Cardiovascular drugs and therapy 20030101 |
| Effects of OR-1896, a metabolite of levosimendan, on force of contraction and Ca2+ transients under acidotic condition in aequorin-loaded canine ventricular myocardium. | Naunyn-Schmiedeberg's archives of pharmacology 20021101 |
| The contractility enhancing effect of the calcium sensitiser levosimendan is not attenuated by carvedilol in healthy subjects. | European journal of clinical pharmacology 20021001 |
| Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure. | International journal of clinical pharmacology and therapeutics 20021001 |
| Positive inotropy for acute heart failure complicating myocardial infarction. | European heart journal 20020901 |
| Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebo-controlled, double-blind study (RUSSLAN). | European heart journal 20020901 |
| Effect of the calcium sensitizer levosimendan on the performance of ischaemic myocardium in anaesthetised pigs. | Cardiovascular drugs and therapy 20020901 |
| Levosimendan in regional myocardial ischemia. | Cardiovascular drugs and therapy 20020901 |
| Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. | Lancet (London, England) 20020720 |
| Development of level A, B and C in vitro-in vivo correlations for modified-release levosimendan capsules. | International journal of pharmaceutics 20020708 |
| An analysis of responses to levosimendan in the pulmonary vascular bed of the cat. | Anesthesia and analgesia 20020601 |
| Levosimendan: a new era for inodilator therapy for heart failure? | Current opinion in cardiology 20020501 |
| Levosimendan increases L-type Ca(2+) current via phosphodiesterase-3 inhibition in human cardiac myocytes. | European journal of pharmacology 20020118 |
| Beneficial effects of the Ca(2+) sensitizer levosimendan in human myocardium. | American journal of physiology. Heart and circulatory physiology 20020101 |
| Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure. | Journal of clinical pharmacology 20020101 |
| Levosimendan: a unique approach to the treatment of heart failure. | Heart disease (Hagerstown, Md.) 20020101 |
| Comparison of enoximone, amrinone, or levosimendan enriched St. Thomas' hospital cardioplegic solutions used for myocardial preservation in isolated guinea pig hearts. | Acta medica (Hradec Kralove) 20020101 |
| The development of new medical treatments for acute decompensated heart failure. | Heart failure monitor 20020101 |
| Effects of levosimendan, a novel inotropic calcium-sensitizing drug, in experimental septic shock. | Critical care medicine 20011101 |
| Levosimendan is a mitochondrial K(ATP) channel opener. | European journal of pharmacology 20011012 |
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