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10024-89-2 | Morpholine, hydrochloride (1:1)
CAS No: 10024-89-2 Catalog No: AG0001D7 MDL No:MFCD00035287
Product Description
Catalog Number:
AG0001D7
Chemical Name:
Morpholine, hydrochloride (1:1)
CAS Number:
10024-89-2
Molecular Formula:
C4H10ClNO
Molecular Weight:
123.5813
MDL Number:
MFCD00035287
IUPAC Name:
morpholine;hydrochloride
InChI:
InChI=1S/C4H9NO.ClH/c1-3-6-4-2-5-1;/h5H,1-4H2;1H
InChI Key:
JXYZHMPRERWTPM-UHFFFAOYSA-N
SMILES:
C1CNCCO1.Cl
EC Number:
233-029-4
UNII:
28G373717I
Properties
Complexity:
34.5
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
123.045g/mol
Formal Charge:
0
Heavy Atom Count:
7
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
123.58g/mol
Monoisotopic Mass:
123.045g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
21.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Copper(I) (pseudo)halide complexes with neocuproine and aminomethylphosphines derived from morpholine and thiomorpholine - in vitro cytotoxic and antimicrobial activity and the interactions with DNA and serum albumins. | Chemical biology & drug design 20131101 |
| A mechanistic and kinetic study on the decomposition of morpholine. | The journal of physical chemistry. A 20120726 |
| Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer. | Bioorganic & medicinal chemistry letters 20120715 |
| Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b. | Journal of neurophysiology 20120701 |
| A convenient route to optically pure α-alkyl-β-(sec-amino)alanines. | Amino acids 20120601 |
| 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition. | Bioorganic & medicinal chemistry 20120401 |
| Ultra-trace level analysis of morpholine, cyclohexylamine, and diethylaminoethanol in steam condensate by gas chromatography with multi-mode inlet, and flame ionization detection. | Journal of chromatography. A 20120316 |
| Metabolism and pharmacokinetics of morinidazole in humans: identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP glucuronosyltransferase 1A9. | Drug metabolism and disposition: the biological fate of chemicals 20120301 |
| Shedding light by cancer redox-human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye. | Chemical communications (Cambridge, England) 20111028 |
| Ceric ammonium nitrate-catalyzed azidation of 1,2-anhydro sugars: application in the synthesis of structurally diverse sugar-derived morpholine 1,2,3-triazoles and 1,4-oxazin-2-ones. | The Journal of organic chemistry 20110805 |
| Morpholine catalyzed direct C3 alkenylation of indoles with α,β-unsaturated aldehydes. | Chemical communications (Cambridge, England) 20110728 |
| Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines. | Bioorganic & medicinal chemistry 20110701 |
| Nickel-catalyzed amination of aryl sulfamates. | Angewandte Chemie (International ed. in English) 20110225 |
| Unexpected side products in the conjugation of an amine-derivatized morpholino oligomer with p-isothiocyanate benzyl DTPA and their removal. | Nuclear medicine and biology 20110201 |
| Analyses of gene function in amphioxus embryos by microinjection of mRNAs and morpholino oligonucleotides. | Methods in molecular biology (Clifton, N.J.) 20110101 |
| [Synthesis of 2'-aminometylmorpholino nucleoside analogues containing 4'-carboxymethyl lynker group]. | Bioorganicheskaia khimiia 20110101 |
| Chemical genetics approach to identify new small molecule modulators of cell growth by phenotypic screening of Saccharomyces cerevisiae strains with a library of morpholine-derived compounds. | Organic & biomolecular chemistry 20101221 |
| A nanochannel array-based electrochemical device for quantitative label-free DNA analysis. | ACS nano 20101123 |
| Synthesis of enantiopure 3-substituted morpholines. | The Journal of organic chemistry 20101105 |
| Design of more potent squalene synthase inhibitors with multiple activities. | Bioorganic & medicinal chemistry 20101101 |
| Chalcogenides of the aminomethylphosphines derived from 1-methylpiperazine, 1-ethylpiperazine and morpholine: NMR, DFT and structural studies for determination of electronic and steric properties of the phosphines. | Dalton transactions (Cambridge, England : 2003) 20100828 |
| Synthesis, electrochemical studies and anticancer activity of ferrocenyl oxindoles. | Dalton transactions (Cambridge, England : 2003) 20100821 |
| Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. | The Journal of biological chemistry 20100723 |
| Acortatarins A and B, two novel antioxidative spiroalkaloids with a naturally unusual morpholine motif from Acorus tatarinowii. | Organic letters 20100416 |
| Total regioselective transformation of aromatic aziridine 2-carboxamides into 2-aminoamides promoted by active manganese. | The Journal of organic chemistry 20100402 |
| Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. | Rapid communications in mass spectrometry : RCM 20100315 |
| Evaluation of stereochemically dense morpholine-based scaffolds as proline surrogates in beta-turn peptides. | Organic & biomolecular chemistry 20100221 |
| One-pot synthesis of 1,3-disubstituted allenes from 1-alkynes, aldehydes, and morpholine. | Journal of the American Chemical Society 20100217 |
| Synthesis, structural characterization and antiproliferative and toxic bio-activities of copper(II) and nickel(II) citronellal N4-ethylmorpholine thiosemicarbazonates. | Journal of inorganic biochemistry 20100201 |
| Spectroscopic characterization of charge-transfer complexes of morpholine with chloranilic and picric acids in organic media: crystal structure of bis(morpholinium 2,4,6-trinitrocyclohexanolate). | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100201 |
| Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin. | Journal of medicinal chemistry 20100128 |
| Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). | Bioorganic & medicinal chemistry letters 20100115 |
| Catalytic SNAr reaction of non-activated fluoroarenes with amines via Ru eta6-arene complexes. | Chemical communications (Cambridge, England) 20100114 |
| Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. | Bioorganic & medicinal chemistry letters 20100101 |
| Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability. | Bioorganic & medicinal chemistry letters 20091101 |
| Novel 4-(morpholin-4-yl)-N'-(arylidene)benzohydrazides: synthesis, antimycobacterial activity and QSAR investigations. | European journal of medicinal chemistry 20091001 |
| Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells. | Oncogene 20090820 |
| Muscarinic receptor 1 agonist activity of novel N-aryl carboxamide substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models. | Bioorganic & medicinal chemistry 20090801 |
| Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities. | European journal of medicinal chemistry 20090701 |
| Exploring the PI3K alpha and gamma binding sites with 2,6-disubstituted isonicotinic derivatives. | Bioorganic & medicinal chemistry letters 20090415 |
| Morpholine containing CB2 selective agonists. | Bioorganic & medicinal chemistry letters 20090315 |
| Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity. | Bioorganic & medicinal chemistry 20090215 |
| The effect of bacterial glutathione S-transferase on morpholine degradation. | Biotechnology journal 20090201 |
| Practical synthesis of a p38 MAP kinase inhibitor. | The Journal of organic chemistry 20090116 |
| Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents. | Bioorganic & medicinal chemistry letters 20090115 |
| Bromoethylsulfonium salt--a more effective annulation agent for the synthesis of 6- and 7-membered 1,4-heterocyclic compounds. | Organic letters 20090115 |
| Intercalating, cytotoxic, antitumour activity of 8-chloro and 4-morpholinopyrimido [4',5':4,5]thieno(2,3-b)quinolines. | Journal of photochemistry and photobiology. B, Biology 20090109 |
| Quantum chemical studies for oxidation of morpholine by Cytochrome P450. | Journal of inorganic biochemistry 20090101 |
| Zebrafish dorsal root ganglia neural precursor cells adopt a glial fate in the absence of neurogenin1. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20081119 |
| Chromatographic behavior of zwitterionic enalapril-exploring the conditions for lipophilicity assessment. | Journal of pharmaceutical and biomedical analysis 20081104 |
| Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitors. | Bioorganic & medicinal chemistry letters 20081015 |
| Stereoselective cyclopropanation of serine- and threonine-derived oxazines to access new morpholine-based scaffolds. | Organic & biomolecular chemistry 20080921 |
| Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst. | Organic & biomolecular chemistry 20080807 |
| Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition. | Bioorganic & medicinal chemistry letters 20080415 |
| Morpholine-based immonium and halogenoamidinium salts as coupling reagents in Peptide synthesis1. | The Journal of organic chemistry 20080404 |
| New stimuli-responsive polymers derived from morpholine and pyrrolidine. | Journal of materials science. Materials in medicine 20080401 |
| Sampling and analytical methodology development for the determination of primary and secondary low molecular weight amines in ambient air. | Journal of environmental monitoring : JEM 20080301 |
| CNS-derived glia ensheath peripheral nerves and mediate motor root development. | Nature neuroscience 20080201 |
| Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart. | Nuclear medicine and biology 20080201 |
| Arachidonic acid as a retrograde signal controlling growth and dynamics of retinotectal arbors. | Developmental neurobiology 20080101 |
| Isostructural materials achieved by using structurally equivalent donors and acceptors in halogen-bonded cocrystals. | Chemistry (Weinheim an der Bergstrasse, Germany) 20080101 |
| Spirocyclic oxetanes: synthesis and properties. | Angewandte Chemie (International ed. in English) 20080101 |
| New oligonucleotide analogues based on morpholine subunits joined by oxalyl diamide tether. | Bioorganic chemistry 20070601 |
| Convenient route to enantiopure fmoc-protected morpholine-3-carboxylic acid. | The Journal of organic chemistry 20070525 |
| Spectroscopic and kinetic evidence for an accumulating intermediate in an SNV reaction with amine nucleophiles. Reaction of methyl beta-methylthio-alpha-nitrocinnamate with piperidine and morpholine. | The Journal of organic chemistry 20070427 |
| Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: a late-stage diversification approach to potent 5HT1B antagonists. | Bioorganic & medicinal chemistry 20070115 |
| Physiological, biochemical, and genetic characterization of an alicyclic amine-degrading Mycobacterium sp. strain THO100 isolated from a morpholine-containing culture of activated sewage sludge. | Archives of microbiology 20061101 |
| Rhodococcus sp. strain TM1 plays a synergistic role in the degradation of piperidine by Mycobacterium sp. strain THO100. | Archives of microbiology 20060901 |
| Asymmetric synthesis of 1-(2- and 3-haloalkyl)azetidin-2-ones as precursors for novel piperazine, morpholine, and 1,4-diazepane annulated beta-lactams. | The Journal of organic chemistry 20060901 |
| Nyctalopin is essential for synaptic transmission in the cone dominated zebrafish retina. | The European journal of neuroscience 20060901 |
| Asymmetric synthesis of enantioenriched (+)-elaeokanine A. | The Journal of organic chemistry 20060721 |
| Photoaddition of N-substituted piperazines to C60: an efficient approach to the synthesis of water-soluble fullerene derivatives. | Chemistry (Weinheim an der Bergstrasse, Germany) 20060717 |
| Palladium-catalyzed intermolecular alpha-arylation of zinc amide enolates under mild conditions. | Journal of the American Chemical Society 20060419 |
| PET modulated fluorescent sensing from the BF2 chelated azadipyrromethene platform. | Organic & biomolecular chemistry 20060307 |
| Comments on the ring-opening polymerization of morpholine-2,5-dione derivatives by various metal catalysts and characterization of the products formed in the reactions involving R2SnX2, where X = OPr(i) and NMe2 and R = Bu(n), Ph and p-Me2NC6H4. | Dalton transactions (Cambridge, England : 2003) 20060214 |
| Synthesis of new nitrogen analogues of salacinol and deoxynojirimycin and their evaluation as glycosidase inhibitors. | The Journal of organic chemistry 20060203 |
| Aminolysis of 2,4-dinitrophenyl X-substituted benzoates and Y-substituted phenyl benzoates in MeCN: effect of the reaction medium on rate and mechanism. | Chemistry (Weinheim an der Bergstrasse, Germany) 20060123 |
| Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo. | Hippocampus 20060101 |
| Polarization and orientation of retinal ganglion cells in vivo. | Neural development 20060101 |
| Kinetic and binding studies with purified recombinant proteins ferredoxin reductase, ferredoxin and cytochrome P450 comprising the morpholine mono-oxygenase from Mycobacterium sp. strain HE5. | The FEBS journal 20050301 |
| Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX. | Bioorganic & medicinal chemistry letters 20050117 |
| Arginine-rich peptide conjugation to morpholino oligomers: effects on antisense activity and specificity. | Bioconjugate chemistry 20050101 |
| From hydrocolloids to high specific surface area porous supports for catalysis. | Biomacromolecules 20050101 |
| Synthesis, enantiomeric resolution, and selective C-11 methylation of a highly selective radioligand for imaging the norepinephrine transporter with positron emission tomography. | Chirality 20040801 |
| Ruthenium-catalyzed anti-Markovnikov hydroamination of vinylarenes. | Journal of the American Chemical Society 20040310 |
| Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. | Toxicological sciences : an official journal of the Society of Toxicology 20040101 |
| Molecular cloning, nucleotide sequencing and expression of genes encoding a cytochrome P450 system involved in secondary amine utilization in Mycobacterium sp. strain RP1. | Research in microbiology 20040101 |
| [Polyfunctional molecules and their components in the processes of aromatic nucleophilic substitution. II. Nucleophilic modification of 3',5'-bis-O-(alpha,beta,alpha',beta'-tetrafluoropyridyl-gamma)thymidine]. | Bioorganicheskaia khimiia 20040101 |
| Interactions of novel morpholine and hexamethylene derivatives of anthracycline antibiotics with DNA. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101 |
| Insights into the origin of high activity and stability of catalysts derived from bulky, electron-rich monophosphinobiaryl ligands in the Pd-catalyzed C-N bond formation. | Journal of the American Chemical Society 20031119 |
| [Antithrombotic effects of morpholine and piperazine ring derivatives and their molecular mechanism]. | Yao xue xue bao = Acta pharmaceutica Sinica 20030901 |
| Detection of in vivo genotoxicity of endogenously formed N-nitroso compounds and suppression by ascorbic acid, teas and fruit juices. | Mutation research 20030805 |
| Rhodium-catalyzed anti-Markovnikov hydroamination of vinylarenes. | Journal of the American Chemical Society 20030514 |
| Determination of the DS and substituent distribution of cationic alkyl polyglycosides and cationic starch ethers by GLC after dealkylation with morpholine. | Carbohydrate research 20030404 |
| Trichloroacetylation of some cyclic enamines. | Chemical & pharmaceutical bulletin 20030401 |
| [Research concerning rutin semisynthetic derivatives, synthesis and pharmaco-toxicological properties of some new morpholine and piperidine derivatives]. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20030101 |
| Enantiopure beta-hydroxy morpholine amides from terminal epoxides by carbonylation at 1 atm. | Angewandte Chemie (International ed. in English) 20021216 |
| The formation of paracetamol (acetaminophen) adducts with hydrogen-bond acceptors. | Acta crystallographica. Section B, Structural science 20021201 |
| Natural abundance nitrogen-15 nuclear magnetic resonance spectral studies on selected donors. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20021001 |
| An amino alcohol ligand for highly enantioselective addition of organozinc reagents to aldehydes: serendipity rules. | Organic letters 20020627 |
| Helicobacter pylori does not mediate the formation of carcinogenic N-nitrosamines. | Helicobacter 20020601 |
| Tumor pretargeting in mice using (99m)Tc-labeled morpholino, a DNA analog. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020301 |
| [Influence of thyroid hormones on memory imprinting of chemical signals in early development of sturgeon Acipenser gueldenstaedti]. | Zhurnal evoliutsionnoi biokhimii i fiziologii 20020101 |
| A cytochrome P450 and a ferredoxin isolated from Mycobacterium sp. strain HE5 after growth on morpholine. | Applied microbiology and biotechnology 20010801 |
| Comparison of morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis. | Genesis (New York, N.Y. : 2000) 20010701 |
| Determination of morpholine in air by derivatisation with 1-naphthylisothiocyanate and HPLC analysis. | The Analyst 20010201 |
| Final report on the safety assessment of Cetethyl Morpholinium Ethosulfate. | International journal of toxicology 20010101 |
| Thiomorpholine and morpholine oxidation by a cytochrome P450 in Mycobacterium aurum MO1. Evidence of the intermediates by in situ 1H NMR. | Biodegradation 19980101 |
| [Pharmacological studies on yohimbic acid ethyl ester (A 38) and 4-=2-(p-butoxyphenyl)-1,3-dioxolan-2-ylmethyl=-morpholine methobromide (Q 160) as well as the influence of these substances on reserpine action]. | Arzneimittel-Forschung 19550801 |
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