Axenic amastigote screening.
Compounds exhibited significant anti-promastigote activity (EC50 < 20 µM), were further screened against axenic amastigote (human life cycle parasite form) forms. Among these derivatives, Analogues 7d, 7h, 7n and 7g showed potent inhibition (EC50 0.9, 2.2 3.5 and 3.8 µM respectively) of axenic amastigotes. Especially, compound 7d exhibited two to three times more potent anti-amastigote activity than pentamidine and miltefosine (EC50 1.6 and 2.8 µM). Compounds 7c, 7b, 7f, 7j, 7k and 7a exhibited significant inhibition (EC50 5.3, 5.8, 6.4, 7.5, 9.3 and 10.0 µM respectively) of L. donovani axenic amastigotes. Compounds 7p, 7o and 7i displayed moderate anti-amastigote activity (EC50 12.3, 13.9 and 19.4 µM respectively). Axenic amastigote assay results revealed that these β-carboline derivatives exhibited potent inhibition of axenic amastigotes of L. donovani.
Intracellular amastigote screening.
Although, axenic amastigotes assay most commonly used to screen new leishmanial agents are different from intracellular amastigotes in terms of protein expression and drug susceptibility. Hence in our present study, compounds displayed potent inhibition of promastigote and axenic amastigotes were further evaluated against intracellular amastigotes to ensure their activity against clinical relevant forms of parasite.
Intracellular amastigote assay results suggested that, most of these analogues displayed potent inhibition of L. donovanimacrophagic amastigotesand the potency was comparable with miltefosine and many folds higher than pentamidine (Table 2). Especially, compound 7d ((4-(4-methoxyphenyl)piperazin-1-yl)(9-methyl-1-phenyl-9H-pyrido [3,4-b]indol-3-yl)methan-one) exhibited five times potent inhibition (EC50 1.3 µM) of intracellular amastigotes compared to miltefosine (EC50 6.4 µM). Compounds 7n and 7g were displayed potent antiamastigote activity (EC50 5.6 and 6.3 µM) than standard drugs
miltefosine and pentamidine with better selectivity index. Antiamastigote potency of 7b, 7c, 7h, 7o and 7p (EC50 7.2, 7.8, 7.9, 7.9 and 9.4 µM) is comparable with miltefosine and better than pentamidine. Compounds 7k, 7f, 7a, 7j and 7i exhibited good antiamastigote activity (EC50 10.1, 11.8, 13.5, 15.4 and 22.0 µM) with better selectivity.
Structure Activity Relationship (SAR).
Structure activity relationship study suggests that, substitution or replacement of phenyl ring has significant effect on anti-leishmanial activity as well as cytotoxicity of these analogues. Among these analogues, un-substituted phenyl derivative displayed significant inhibition of promastigotes, axenic amastigote and intracellular amastigotes of L. donovani. Ortho-para directing methyl group substitution on ortho and para position enhanced the potency against axenic amastigotes and intracellular amastigotes of L. donovani significantly, while on para substitution anti-promastigote activity altered marginally. Methoxy, chloro group substitution had strong impact on anti-leishmanial activity of these analogues, position of substitution is vital in their inhibition activity. Ortho substitution of
methoxy group showed excellent increase in inhibition potency against promastigotes and both amastigote forms of L. donovani. While methoxy substitution on ortho position slightly increased the anti-leishmanial activity, meta substitution resulted in drastic decline in activity. Chloro substitution on para and meta position has significantly increased the inhibition potency against tested forms, while on ortho substitution has marginally affected the activity. Meta directing nitro and fluoro substitution on para position haven’t showed any considerable effect on inhibition potency of these analogues.
However, fluoro substitution on ortho position and chloro di-substitution (ortho and meta) significantly decreased the anti-leishmanial potency. Replacement of phenyl ring with benzyl ring has significantly enhanced the activity. Even though pyridyl replacement resulted in increased anti-leishmanial activity, it also enhanced the cytotoxicity of these analogues. SAR studies suggested that, ortho-para directing methoxy group on para position, chloro group on para and meta position and benzyl replacement was recommended for anti-leishmanial activity of these analogues against L.
donovani.
Through the present study, we have identified new lead molecules with potent anti-leishmaninal activity against L. infantumand L. donovani. Structure activity relationship studies would be utilised to optimize the lead molecules to generate clinically effective against both drug sensitive and resistance strains of L. infantumand L. donovani.
2-Propenamide, N,N-bis(2-hydroxyethyl)-
Catalog No.:AG00063J MDL No.:
MF:C7H13NO3 MW:159.1830
|
1-Butanol, 2-amino-2-methyl-
Catalog No.:AG00063I MDL No.:MFCD09759242
MF:C5H13NO MW:103.1628
|
Oxetane, 3,3-diethyl-
Catalog No.:AG00063H MDL No.:
MF:C7H14O MW:114.1855
|
Oxetane, 3-methyl-3-[(2-propen-1-yloxy)methyl]-
Catalog No.:AG00063G MDL No.:
MF:C8H14O2 MW:142.1956
|
Silane, tris[(1,1-dimethylethyl)dioxy]methyl-
Catalog No.:AG00063F MDL No.:
MF:C13H30O6Si MW:310.4592
|
1-Oxa-4-aza-2-silacyclohexane, 2,2,4-trimethyl-
Catalog No.:AG00063E MDL No.:MFCD09263699
MF:C6H15NOSi MW:145.2749
|
Tetradecanoic acid, barium salt (2:1)
Catalog No.:AG00063D MDL No.:
MF:C28H54BaO4 MW:592.0530
|
Benzoic acid, 4-(1,1-dimethylethyl)-, barium salt (2:1)
Catalog No.:AG00063C MDL No.:
MF:C22H26BaO4 MW:491.7664
|
Octadecanoic acid, strontium salt (2:1)
Catalog No.:AG00063B MDL No.:
MF:C36H70O4Sr MW:654.5586
|
Benzonitrile, 4-(cyclopropylamino)-
Catalog No.:AG00063T MDL No.:MFCD11135501
MF:C10H10N2 MW:158.1998
|
3-Pyridinamine, N-(2-phenylethyl)-
Catalog No.:AG00063S MDL No.:
MF:C13H14N2 MW:198.2637
|
Benzenemethanamine, N-(cyclopropylmethyl)-4-methoxy-
Catalog No.:AG00063R MDL No.:MFCD11140261
MF:C12H17NO MW:191.2695
|
Benzenemethanamine, 5-bromo-N-butyl-2-fluoro-
Catalog No.:AG00063Q MDL No.:MFCD11151689
MF:C11H15BrFN MW:260.1459
|
Benzonitrile, 4-(cyclopropylmethoxy)-
Catalog No.:AG00063P MDL No.:MFCD11136694
MF:C11H11NO MW:173.2111
|
Pyridine, 3-(1E)-1-decen-1-yl-
Catalog No.:AG000646 MDL No.:
MF:C15H23N MW:217.3498
|
Benzenemethanamine, N-(3,4-difluorophenyl)-4-fluoro-
Catalog No.:AG00063O MDL No.:
MF:C13H10F3N MW:237.2204
|
Benzenemethanamine, N-(3,4-difluorophenyl)-3-fluoro-
Catalog No.:AG00063N MDL No.:
MF:C13H10F3N MW:237.2204
|
Oxazole, 2-iodo-5-phenyl-
Catalog No.:AG00063M MDL No.:
MF:C9H6INO MW:271.0545
|
2-Propenoic acid, 2-[(3-chlorobenzoyl)amino]-3-(1H-indol-3-yl)-
Catalog No.:AG000645 MDL No.:
MF:C18H13ClN2O3 MW:340.7604
|
Silane, (1E)-1-hexen-1-yltrimethoxy-
Catalog No.:AG000644 MDL No.:
MF:C9H20O3Si MW:204.3388
|
2-Propenoic acid, 2-(triethylsilyl)-, methyl ester
Catalog No.:AG000643 MDL No.:
MF:C10H20O2Si MW:200.3501
|
2-Propenoic acid, 3-(triethylsilyl)-, methyl ester, (2E)-
Catalog No.:AG000642 MDL No.:
MF:C10H20O2Si MW:200.3501
|
2-Thiazolamine, 4-(2,5-dimethylphenyl)-
Catalog No.:AG000641 MDL No.:MFCD00985673
MF:C11H12N2S MW:204.2914
|
1,3-Butadiene-1,2,3-tricarboxylic acid, 4-ethoxy-, 1,2,3-triethyl ester
Catalog No.:AG000640 MDL No.:
MF:C15H22O7 MW:314.3310
|
2H-Pyran-4,5-dicarboxylic acid, 2-oxo-, 4,5-diethyl ester
Catalog No.:AG00063Z MDL No.:
MF:C11H12O6 MW:240.2094
|
2-Pentenoic acid, 2-ethyl-4-methyl-, methyl ester
Catalog No.:AG00063Y MDL No.:
MF:C9H16O2 MW:156.2221
|
3-Pentenoic acid, 2,4-dimethyl-, ethyl ester, (2R)-
Catalog No.:AG00063X MDL No.:
MF:C9H16O2 MW:156.2221
|
3-Pentenoic acid, 2,4-dimethyl-, methyl ester, (2R)-
Catalog No.:AG00063W MDL No.:
MF:C8H14O2 MW:142.1956
|
L-Valine, N-[[(1,1-dimethylethyl)amino]carbonyl]-3-methyl-
Catalog No.:AG00063V MDL No.:MFCD12796012
MF:C11H22N2O3 MW:230.3040
|
Cyclopropanecarboxamide, 1-methyl-N-(phenylmethyl)-
Catalog No.:AG00063L MDL No.:
MF:C12H15NO MW:189.2536
|
Methanone, (2-fluorophenyl)(4-hydroxyphenyl)-
Catalog No.:AG00063U MDL No.:
MF:C13H9FO2 MW:216.2078
|
Ethanedithioamide, N1-(1-methylethyl)-N2-phenyl-
Catalog No.:AG000649 MDL No.:
MF:C11H14N2S2 MW:238.3723
|
Ethanedithioamide, N1-phenyl-N2-(phenylmethyl)-
Catalog No.:AG00064Y MDL No.:
MF:C15H14N2S2 MW:286.4151
|
Ethanedithioamide, N1-ethyl-
Catalog No.:AG00064X MDL No.:MFCD19204644
MF:C4H8N2S2 MW:148.2497
|
1H-Imidazole-4-carboxylic acid, 5-(3,3-dimethyl-1-triazen-1-yl)-, methyl ester
Catalog No.:AG00064W MDL No.:
MF:C7H11N5O2 MW:197.1945
|
Ethanone, 1-[4-(2-chloro-4-nitrophenyl)-1-piperazinyl]-
Catalog No.:AG00064V MDL No.:MFCD01895952
MF:C12H14ClN3O3 MW:283.7109
|
Ethanone, 1-[4-(4-amino-2-chlorophenyl)-1-piperazinyl]-
Catalog No.:AG00064U MDL No.:
MF:C12H16ClN3O MW:253.7279
|
1,3-Benzodioxole, 5-[1-(2-methoxyethoxy)ethyl]-
Catalog No.:AG00064T MDL No.:
MF:C12H16O4 MW:224.2530
|
Carbonic acid, methyl trichloromethyl ester
Catalog No.:AG00064S MDL No.:
MF:C3H3Cl3O3 MW:193.4131
|
2H-Pyran, 3-chlorotetrahydro-2-(1-methylethyl)-, (2R,3S)-rel-
Catalog No.:AG00064R MDL No.:
MF:C8H15ClO MW:162.6571
|
Furan, 3-chlorotetrahydro-2-(1-methylethyl)-, cis- (9CI)
Catalog No.:AG00064Q MDL No.:
MF:C7H13ClO MW:148.6305
|
1-Octanol, 8-nitro-
Catalog No.:AG00064P MDL No.:
MF:C8H17NO3 MW:175.2255
|
Butanedioic acid, 2-hexyl-, 1,4-dimethyl ester
Catalog No.:AG00064O MDL No.:
MF:C12H22O4 MW:230.3007
|
1,4-Dioxin, 2,3-dihydro-2,3,5,6-tetraphenyl-, cis- (9CI)
Catalog No.:AG00064N MDL No.:
MF:C28H22O2 MW:390.4731
|
5,8,10,14,17-Eicosapentaenoic acid, 12-hydroperoxy-, (5Z,8Z,10E,14Z,17Z)-
Catalog No.:AG00064M MDL No.:
MF:C20H30O4 MW:334.4498
|
Silanol, 1-methoxy-1-phenyl-1-[tris(trimethylsilyl)methyl]-
Catalog No.:AG00064L MDL No.:
MF:C17H36O2Si4 MW:384.8085
|
2-Propyn-1-ol, 3-cyclopropyl-
Catalog No.:AG00064K MDL No.:MFCD06654125
MF:C6H8O MW:96.1271
|
2-Propynal, 3-cyclopropyl-
Catalog No.:AG00064J MDL No.:
MF:C6H6O MW:94.1112
|
Ethanone, 1-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-
Catalog No.:AG00064H MDL No.:MFCD04972966
MF:C10H8F4O2 MW:236.1629
|
Ethanone, 1-[3-(difluoromethoxy)phenyl]-
Catalog No.:AG00064G MDL No.:MFCD00236220
MF:C9H8F2O2 MW:186.1554
|
1-Piperazinebutanoic acid, 4-[2-(diphenylmethoxy)ethyl]-, hydrochloride (1:2)
Catalog No.:AG00064F MDL No.:
MF:C23H32Cl2N2O3 MW:455.4178
|
1-Piperazinecarboxylic acid, 4-[(1-naphthalenylamino)carbonyl]-, ethyl ester
Catalog No.:AG00064E MDL No.:
MF:C18H21N3O3 MW:327.3776
|
Benzoic acid, 2-formyl-, anhydride with 2-formylbenzoic acid
Catalog No.:AG00064D MDL No.:
MF:C16H10O5 MW:282.2476
|
2-Pyridinecarboxylic acid, 2-cyclohexylhydrazide
Catalog No.:AG00064C MDL No.:
MF:C12H17N3O MW:219.2829
|
10H-Phenothiazine, 2-chloro-10-(2-chloropropyl)-
Catalog No.:AG00064B MDL No.:
MF:C15H13Cl2NS MW:310.2414
|
10H-Phenothiazine-10-ethanamine, N-(2-chloroethyl)-N,α-dimethyl-, hydrochloride (1:1)
Catalog No.:AG00064A MDL No.:
MF:C18H22Cl2N2S MW:369.3517
|
10H-Phenothiazine, 2-chloro-10-(1-methyl-3-piperidinyl)-
Catalog No.:AG00065K MDL No.:
MF:C18H19ClN2S MW:330.8749
|
10H-Phenothiazine, 3-chloro-10-(1-methyl-3-piperidinyl)-
Catalog No.:AG00065J MDL No.:
MF:C18H19ClN2S MW:330.8749
|
10H-Phenothiazine, 2-chloro-10-(1-methyl-4-piperidinyl)-
Catalog No.:AG00065I MDL No.:
MF:C18H19ClN2S MW:330.8749
|
10H-Phenothiazine, 2-chloro-10-[(1-methyl-4-piperidinyl)methyl]-
Catalog No.:AG00065H MDL No.:
MF:C19H21ClN2S MW:344.9014
|
10H-Phenothiazine, 10-(2-chloropropyl)-
Catalog No.:AG00065G MDL No.:
MF:C15H14ClNS MW:275.7964
|
10H-Phenothiazine-10-methanamine, α-ethyl-N,N-dimethyl-
Catalog No.:AG00065F MDL No.:
MF:C17H20N2S MW:284.4191
|
10H-Phenothiazine-10-ethanol, 2-methyl-, 10-methanesulfonate
Catalog No.:AG00065E MDL No.:
MF:C16H17NO3S2 MW:335.4411
|
10H-Phenothiazine, 2-methoxy-10-(1-methyl-3-piperidinyl)-
Catalog No.:AG00065D MDL No.:
MF:C19H22N2OS MW:326.4558
|
10H-Phenothiazine, 3-methoxy-10-(1-methyl-4-piperidinyl)-
Catalog No.:AG00065C MDL No.:
MF:C19H22N2OS MW:326.4558
|
10H-Phenothiazine, 2-methoxy-10-[(1-methyl-4-piperidinyl)methyl]-
Catalog No.:AG00065B MDL No.:
MF:C20H24N2OS MW:340.4824
|
10H-Phenothiazine, 3-methoxy-10-[(1-methyl-3-piperidinyl)methyl]-
Catalog No.:AG00065A MDL No.:
MF:C20H24N2OS MW:340.4824
|
10H-Phenothiazine, 3-methoxy-10-[(1-methyl-4-piperidinyl)methyl]-
Catalog No.:AG000659 MDL No.:
MF:C20H24N2OS MW:340.4824
|
10H-Phenothiazine, 10-(1-methyl-3-piperidinyl)-
Catalog No.:AG000658 MDL No.:
MF:C18H20N2S MW:296.4298
|
2-Pentenoic acid, 5-[2-[bis(4-chlorophenyl)methoxy]cyclohexyl]-, methyl ester, [1α(E),2β]- (9CI)
Catalog No.:AG000657 MDL No.:
MF:C25H28Cl2O3 MW:447.3940
|
2-Pentenoic acid, 5-[2-[(4-bromophenyl)methoxy]cyclohexyl]-, methyl ester, [1α(E),2β]- (9CI)
Catalog No.:AG000656 MDL No.:
MF: MW:
|
Pyridine, 3-bromo-4-(phenylmethoxy)-
Catalog No.:AG000652 MDL No.:MFCD11226996
MF:C12H10BrNO MW:264.1179
|
3-Pyridinecarboxylic acid, carboxyphenylmethyl ester
Catalog No.:AG000655 MDL No.:MFCD06804522
MF:C14H11NO4 MW:257.2414
|
2-Benzoxazolecarboxylic acid, sodium salt (1:1)
Catalog No.:AG000651 MDL No.:MFCD17676126
MF:C8H4NNaO3 MW:185.1120
|
2H-Indol-2-one, 1,3-dihydro-3-(6-hydroxy-1,3-benzodioxol-5-yl)-
Catalog No.:AG000650 MDL No.:MFCD16659827
MF:C15H11NO4 MW:269.2521
|
Acetamide, 2-[(3,4-difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-, hydrochloride (1:2)
Catalog No.:AG00064Z MDL No.:MFCD22689439
MF:C20H26Cl2F2N4O MW:447.3494
|
2-Propenoic acid, 2-[(1-oxodecyl)amino]-, methyl ester
Catalog No.:AG000654 MDL No.:
MF:C14H25NO3 MW:255.3532
|
Ethanone, 1-[(4S)-4-(1-methylethyl)-2-thioxo-3-thiazolidinyl]-
Catalog No.:AG000653 MDL No.:MFCD10570251
MF:C8H13NOS2 MW:203.3249
|
Benzofuran, 2,3,4,5,6,7-hexahydro-
Catalog No.:AG00065N MDL No.:
MF:C8H12O MW:124.1803
|
Benzofuran, 2,3,4,5,6,7-hexahydro-2-methyl-
Catalog No.:AG00065M MDL No.:
MF:C9H14O MW:138.2069
|
4(3H)-Pyrimidinone, 6-hydroxy-2-(2-pyridinyl)-
Catalog No.:AG00065L MDL No.:MFCD11109859
MF:C9H7N3O2 MW:189.1708
|
Pyrimidine, 4,6-dichloro-5-methyl-2-(2-pyridinyl)-
Catalog No.:AG00066C MDL No.:MFCD18844051
MF:C10H7Cl2N3 MW:240.0887
|
Pyrimidine, 4,6-dichloro-5-phenyl-2-(2-pyridinyl)-
Catalog No.:AG00066B MDL No.:
MF:C15H9Cl2N3 MW:302.1581
|
Pyrimidine, 5-methyl-2-(2-pyridinyl)-
Catalog No.:AG00066A MDL No.:
MF:C10H9N3 MW:171.1986
|
Pyrimidine, 2-(2-pyridinyl)-
Catalog No.:AG000669 MDL No.:
MF:C9H7N3 MW:157.1720
|
1,3-Propanedione, 1,3-di-2-pyridinyl-
Catalog No.:AG000668 MDL No.:MFCD01321157
MF:C13H10N2O2 MW:226.2307
|
3,3'-Bipyridazine
Catalog No.:AG000667 MDL No.:MFCD08275257
MF:C8H6N4 MW:158.1600
|
Benzene, 2-bromo-1-(1-methylethyl)-4-nitro-
Catalog No.:AG000663 MDL No.:MFCD12024309
MF:C9H10BrNO2 MW:244.0852
|
1,4-Benzenediol, 2-chloro-, monoacetate (9CI)
Catalog No.:AG000662 MDL No.:
MF:C8H9ClO4 MW:204.6077
|
Cyclobutanepropanoic acid, 3-oxo-, methyl ester
Catalog No.:AG00065T MDL No.:MFCD19441111
MF:C8H12O3 MW:156.1791
|
Cyclobutanepentanoic acid, 3-oxo-, ethyl ester
Catalog No.:AG00065S MDL No.:MFCD23135412
MF:C11H18O3 MW:198.2588
|
Methanone, (4-methyl-1-piperazinyl)-4-piperidinyl-, hydrochloride (1:2)
Catalog No.:AG00065R MDL No.:MFCD05864745
MF:C11H23Cl2N3O MW:284.2258
|
3-Piperidinecarboxamide, hydrochloride (1:1)
Catalog No.:AG00065Q MDL No.:
MF:C6H13ClN2O MW:164.6332
|
Cyclopropanesulfonamide, N-[(4-nitrophenyl)methyl]-
Catalog No.:AG00065P MDL No.:MFCD22493432
MF:C10H12N2O4S MW:256.2783
|
Cyclopropanesulfonamide, N-[(4-aminophenyl)methyl]-
Catalog No.:AG00065O MDL No.:MFCD20352157
MF:C10H14N2O2S MW:226.2954
|
3-Oxazolidineacetonitrile, 4-phenyl-, (4R)-
Catalog No.:AG000661 MDL No.:
MF:C11H12N2O MW:188.2258
|
Acetamide, N-[4-(2-pyrazinyl)phenyl]-
Catalog No.:AG000660 MDL No.:
MF:C12H11N3O MW:213.2352
|
Acetamide, N-[4-(4-oxido-2-pyrazinyl)phenyl]-
Catalog No.:AG00065Z MDL No.:
MF:C12H11N3O2 MW:229.2346
|
2-Pyrimidinamine, N-methyl-N-phenyl-4-(4-pyridinyl)-
Catalog No.:AG00065Y MDL No.:
MF:C16H14N4 MW:262.3092
|
3-Quinolinecarboxylicacid,8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-
Catalog No.:AG00065X MDL No.:
MF:C18H19ClFN3O3 MW:379.8132
|
Benzenepropanoic acid, 3-chloro-2,4,5-trifluoro-β-oxo-, ethyl ester
Catalog No.:AG00065W MDL No.:MFCD09037898
MF:C11H8ClF3O3 MW:280.6276
|
3-Quinolinecarboxylic acid, 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-
Catalog No.:AG00065V MDL No.:MFCD08706388
MF:C13H8ClF2NO3 MW:299.6573
|
1,3,5-Triazine-2,4-diamine, N2-methyl-6-(2,2,2-trifluoroethoxy)-
Catalog No.:AG00065U MDL No.:MFCD00452913
MF:C6H8F3N5O MW:223.1558
|
2,2'-BIPYRAZINE
Catalog No.:AG000666 MDL No.:MFCD00010288
MF:C8H6N4 MW:158.1600
|
1H-Pyrazol-5-amine, 1-methyl-3-phenyl-
Catalog No.:AG000665 MDL No.:MFCD00067874
MF:C10H11N3 MW:173.2144
|
1H-Pyrazole-3-carboxylic acid, 1-methyl-5-phenyl-, ethyl ester
Catalog No.:AG000664 MDL No.:MFCD08060533
MF:C13H14N2O2 MW:230.2625
|
1H-Pyrazole-3-carboxylic acid, 1-methyl-5-phenyl-
Catalog No.:AG000671 MDL No.:MFCD08271933
MF:C11H10N2O2 MW:202.2093
|
1H-Pyrazole-3-carboxylic acid, 5-methyl-1-phenyl-
Catalog No.:AG000670 MDL No.:MFCD00124910
MF:C11H10N2O2 MW:202.2093
|
1H-Pyrazole-1-carboxylic acid, ethyl ester
Catalog No.:AG00066Z MDL No.:
MF:C6H8N2O2 MW:140.1399
|
1H-Pyrazole-1-acetic acid, ethyl ester
Catalog No.:AG00066Y MDL No.:MFCD00159620
MF:C7H10N2O2 MW:154.1665
|
Ethanone, 1-(3,5-dimethyl-1H-pyrazol-1-yl)-
Catalog No.:AG00066X MDL No.:
MF:C7H10N2O MW:138.1671
|
Ethanone, 1-(1H-pyrazol-1-yl)-
Catalog No.:AG00066W MDL No.:
MF:C5H6N2O MW:110.1139
|
Methanone, phenyl-1H-pyrazol-1-yl-
Catalog No.:AG00066V MDL No.:
MF:C10H8N2O MW:172.1833
|
1H-Pyrazole, 1-(phenylmethyl)-
Catalog No.:AG00066U MDL No.:MFCD00462231
MF:C10H10N2 MW:158.1998
|
1H-Pyrazole, 4-phenyl-
Catalog No.:AG00066T MDL No.:MFCD00462204
MF:C9H8N2 MW:144.1732
|
1H-Pyrazole, 1-methyl-4-phenyl-
Catalog No.:AG00066S MDL No.:MFCD12964229
MF:C10H10N2 MW:158.1998
|
Benzene, 1,3-dichloro-2,4-dinitro-
Catalog No.:AG00066R MDL No.:MFCD00823272
MF:C6H2Cl2N2O4 MW:236.9971
|
1,3-Benzenediamine, 2,4-dinitro-
Catalog No.:AG00066Q MDL No.:
MF:C6H6N4O4 MW:198.1362
|
2,1,3-Benzoxadiazole, 4-chloro-7-nitro-
Catalog No.:AG00066P MDL No.:MFCD00005808
MF:C6H2ClN3O3 MW:199.5514
|
2,1,3-Benzoxadiazole, 4-azido-7-nitro-
Catalog No.:AG00066O MDL No.:
MF:C6H2N6O3 MW:206.1185
|
Pyridine, 2-fluoro-5-[[2-(nitromethylene)-1-imidazolidinyl]methyl]-
Catalog No.:AG00066N MDL No.:
MF:C10H11FN4O2 MW:238.2183
|
Pyridine, 2-bromo-5-(bromomethyl)-
Catalog No.:AG00066M MDL No.:MFCD11656267
MF:C6H5Br2N MW:250.9186
|
3-Pyridinecarbonyl chloride, 6-(methylthio)-
Catalog No.:AG00066L MDL No.:
MF:C7H6ClNOS MW:187.6466
|
3-Pyridinemethanol, 6-phenoxy-
Catalog No.:AG00066K MDL No.:MFCD02682069
MF:C12H11NO2 MW:201.2212
|
4-Pyridinemethanol, 2,6-dichloro-
Catalog No.:AG00066J MDL No.:MFCD00052638
MF:C6H5Cl2NO MW:178.0160
|
Pyridine, 5-(chloromethyl)-2-methoxy-
Catalog No.:AG00066I MDL No.:MFCD10697570
MF:C7H8ClNO MW:157.5975
|
Pyridine, 2,6-dichloro-4-(chloromethyl)-
Catalog No.:AG00066H MDL No.:MFCD03783562
MF:C6H4Cl3N MW:196.4617
|
Pyridine, 2-chloro-4-(chloromethyl)-
Catalog No.:AG00066G MDL No.:MFCD09991655
MF:C6H5Cl2N MW:162.0166
|
1-Propanone, 2-(2,4-dichlorophenoxy)-1-(1-piperidinyl)-
Catalog No.:AG00066F MDL No.:MFCD01339369
MF:C14H17Cl2NO2 MW:302.1963
|
Pyridine, 4-bromo-2-hydrazinyl-
Catalog No.:AG00066E MDL No.:MFCD00234091
MF:C5H6BrN3 MW:188.0252
|
1,2,4-Triazolo[4,3-a]pyridin-3-amine, 7-bromo-
Catalog No.:AG00066D MDL No.:
MF:C6H5BrN4 MW:213.0347
|
1,2,4-Triazolo[4,3-a]pyridine, 7-bromo-3-(2-fluorophenyl)-
Catalog No.:AG000679 MDL No.:
MF:C12H7BrFN3 MW:292.1065
|
1,2,4-Triazolo[4,3-a]pyridine, 7-chloro-3-(2-fluorophenyl)-
Catalog No.:AG000678 MDL No.:
MF:C12H7ClFN3 MW:247.6555
|
1,2,4-Triazolo[4,3-a]pyridine, 7-bromo-3-(2-chlorophenyl)-
Catalog No.:AG000677 MDL No.:
MF:C12H7BrClN3 MW:308.5611
|
1,2,4-Triazolo[4,3-a]pyridine, 7-chloro-3-(2-chlorophenyl)-5-methyl-
Catalog No.:AG000676 MDL No.:
MF:C13H9Cl2N3 MW:278.1367
|
1,2,4-Triazolo[4,3-a]pyridine, 7-chloro-3-(2-chlorophenyl)-
Catalog No.:AG000675 MDL No.:
MF:C12H7Cl2N3 MW:264.1101
|
Ethanedione, 1,1'-[1,6-hexanediylbis(oxy-4,1-phenylene)]bis[2-phenyl- (9CI)
Catalog No.:AG00067P MDL No.:
MF:C34H30O6 MW:534.5984
|
Ethanedione, 1,1'-[1,3-propanediylbis(oxy-4,1-phenylene)]bis[2-phenyl- (9CI)
Catalog No.:AG00067O MDL No.:
MF:C31H24O6 MW:492.5187
|
1-Butanol, 4-(methoxymethoxy)-
Catalog No.:AG00067N MDL No.:
MF:C6H14O3 MW:134.1736
|
Pyridine, 4,6-dichloro-3-methoxy-2-methyl-
Catalog No.:AG000674 MDL No.:MFCD11847534
MF:C7H7Cl2NO MW:192.0426
|
2-Oxazolamine, 4,5-dihydro-5-(methoxymethyl)-
Catalog No.:AG00067M MDL No.:
MF:C5H10N2O2 MW:130.1451
|
2-Pyridinecarboxylic acid, 4-chloro-3-methoxy-6-phenyl-
Catalog No.:AG000673 MDL No.:
MF:C13H10ClNO3 MW:263.6764
|
2H-1-Benzopyran-6-carbonitrile, 7-hydroxy-4,8-dimethyl-2-oxo-
Catalog No.:AG00067L MDL No.:
MF:C12H9NO3 MW:215.2048
|
2H-Pyran, 3-chlorotetrahydro-2-(1-methylethyl)-, cis- (9CI)
Catalog No.:AG00067K MDL No.:
MF:C8H15ClO MW:162.6571
|
Ethanone, 2-[[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amino]-1-(1-piperidinyl)-
Catalog No.:AG00067J MDL No.:
MF:C16H22N2O3 MW:290.3575
|
2-Propanone, 1-(1-methyl-2-imidazolidinylidene)-, (1E)-
Catalog No.:AG00067I MDL No.:
MF:C7H12N2O MW:140.1830
|
2(3H)-Furanone, dihydro-3-(phenylmethoxy)-
Catalog No.:AG00067H MDL No.:
MF:C11H12O3 MW:192.2112
|
2H-1-Benzopyran-2-one, 7-ethyl-4-methyl-
Catalog No.:AG00067G MDL No.:
MF:C12H12O2 MW:188.2225
|
2H-1-Benzopyran-4-acetamide, 7-hydroxy-2-oxo-
Catalog No.:AG00067F MDL No.:MFCD06001840
MF:C11H9NO4 MW:219.1935
|
2H-Naphtho[1,2-b]pyran-4-acetic acid, 2-oxo-
Catalog No.:AG00067E MDL No.:MFCD00434035
MF:C15H10O4 MW:254.2375
|
1-Decen-3-one, 10-iodo-
Catalog No.:AG00067D MDL No.:
MF:C10H17IO MW:280.1459
|
1,6-Tetradecadien-3-one, 14-iodo-, (6E)-
Catalog No.:AG00067C MDL No.:
MF:C14H23IO MW:334.2363
|
4-Cyclotetradecen-1-one, (4E)-
Catalog No.:AG00067B MDL No.:
MF:C14H24O MW:208.3398
|
Bicyclo[7.2.2]tridec-9(13)-ene
Catalog No.:AG00067A MDL No.:
MF:C13H22 MW:178.3138
|
3-Pyridinecarboxylic acid, 4-[(4-ethoxy-1,4-dioxobutyl)amino]-, ethyl ester
Catalog No.:AG000672 MDL No.:
MF:C14H18N2O5 MW:294.3031
|
1H-Pyrido[4,3-b]azepine-4-carboxylic acid, 2,3-dihydro-5-hydroxy-2-oxo-, ethyl ester
Catalog No.:AG00067R MDL No.:
MF:C12H12N2O4 MW:248.2347
|
1,1'-Biphenyl, 4-nitro-4'-(trifluoromethoxy)-
Catalog No.:AG00067Q MDL No.:MFCD21609608
MF:C13H8F3NO3 MW:283.2027
|
Carbonic acid, diphenyl ester
Catalog No.:AG000685 MDL No.:MFCD00003037
MF:C13H10O3 MW:214.2167
|
Phosphorous acid, diphenyl ester
Catalog No.:AG000684 MDL No.:
MF:C12H10O3P- MW:233.1798
|
1,2-Ethanediamine, N1,N2-dimethyl-N1-(phenylmethyl)-
Catalog No.:AG000683 MDL No.:MFCD00014856
MF:C11H18N2 MW:178.2740
|
Benzeneacetic acid, 2-methylpropyl ester
Catalog No.:AG000682 MDL No.:MFCD00026482
MF:C12H16O2 MW:192.2542
|
Butanoic acid, 4-oxo-4-(phenylamino)-
Catalog No.:AG000681 MDL No.:MFCD00029825
MF:C10H11NO3 MW:193.1992
|
Benzeneacetic acid, phenylmethyl ester
Catalog No.:AG000680 MDL No.:MFCD00022045
MF:C15H14O2 MW:226.2705
|
Benzeneacetic acid, (4-methoxyphenyl)methyl ester
Catalog No.:AG00067Z MDL No.:
MF:C16H16O3 MW:256.2964
|
Benzeneacetic acid, 3-methylbutyl ester
Catalog No.:AG00067Y MDL No.:MFCD00026517
MF:C13H18O2 MW:206.2808
|
Benzeneacetic acid, 2-phenylethyl ester
Catalog No.:AG00067X MDL No.:MFCD00022049
MF:C16H16O2 MW:240.2970
|
Benzeneacetic acid, (2E)-3,7-dimethyl-2,6-octadien-1-yl ester
Catalog No.:AG00067W MDL No.:MFCD00072225
MF:C18H24O2 MW:272.3820
|
Benzenesulfonic acid, 3-[2-(4-aminophenyl)diazenyl]-
Catalog No.:AG00067V MDL No.:
MF:C12H11N3O3S MW:277.2990
|
Boroxin, 2,4,6-trimethoxy-
Catalog No.:AG00067U MDL No.:MFCD00005946
MF:C3H9B3O6 MW:173.5330
|
Benzene, 1,3,5-triethyl-
Catalog No.:AG00067T MDL No.:MFCD00009261
MF:C12H18 MW:162.2713
|
1,3,5-Triazine, 2,4,6-triethylhexahydro-
Catalog No.:AG00067S MDL No.:
MF:C9H21N3 MW:171.2831
|
Octanoic acid, compd. with 2,2'-iminobis[ethanol] (1:1)
Catalog No.:AG000648 MDL No.:
MF:C12H27NO4 MW:249.3471
|