Antifungal Paints and Coatings

Inventor: C. Steven McDaniel 
Current Assignee: Reactive Surfaces Ltd LLP

 

Abstract

Antifungal and antimicrobial peptides, polypeptides and proteins, as well as antifungal compositions and coating surfaces having antifungal properties, are disclosed as antifungal additives for coatings and other coatings. Coatings are also used to treat and/or inhibit the growth of mold, mold and other fungi and bacteria on objects susceptible to such infestation, such as building materials.

 

Description
Cross-reference to related applications
This application is a divisional application from the prior U.S. Patent Application Serial No. 10/080,000. U.S. Provisional Application No. 10/884,355, filed on July 2, 2004, claims priority to U.S. Provisional Application 60/485,234, filed on July 3, 2003.

 

Background of the invention

1. Field of invention

The present invention generally relates to antifungal and antibacterial compositions and methods of using such compositions to prevent or prevent the growth of fungi on stored coatings and susceptible surfaces. More specifically, the invention relates to such compositions comprising antifungal and antimicrobial peptides, polypeptides or proteins, and to methods of making and using such compositions.

2. Description of related technologies

Today, influencing indoor, work and entertainment environments is a major environmental issue for indoor and outdoor surface fungal growth. Fungi (such as mold, mold) are not only unsightly on bare surfaces, but also destroy wood, fibers and other materials that, if left untreated, can seriously damage buildings and other structures and equipment. In the past few years, it has become increasingly apparent that exposure to certain fungi or their spores can seriously affect the health of humans, pets and other animals. Although fungi are certainly not the only factors that adversely affect indoor air quality, in many cases they have been identified as a major contributor to indoor air quality problems. In fact, the term “sick building syndrome” was recently coined to describe buildings in which various physical, chemical and biological factors (including growing fungi and/or their spores) severely impaired air quality and led to occupants. Uncomfortable or sick. Problems such as allergies, asthma, infections, and long-term effects of mycotoxins are just a few of the many real health effects associated with mold contamination in indoor and outdoor environments.

 

Fungi (including true fungi, molds and molds) are eukaryotes with cell walls that resemble plants but do not contain chlorophyll. The species of fungi, molds and molds is between 100,000 and 200,000 depending on the classification method used. Pathogenic fungi are particularly noteworthy and cause significant damage to individuals who come into contact with them. There are currently about 300 human pathogens known, but it is believed that there are many other fungal pathogens that have not yet been discovered. The field of medical mycology has emerged due to the increase in the number of diseases and deaths associated with fungi.

 

Fungi grow in the form of saprophytic plants, that is, in a suitable moist environment, the fungus is able to break down organic matter to obtain the nutrients needed for growth. Architectural and decorative materials such as wood and paper wall panels, wallpaper, fabrics, carpets and leather provide the necessary organic matter. Nowadays, a particularly problematic fungal genus, Stachybotrys chartarum, is sometimes found in buildings with excessive humidity in the room. It is usually grown in nature on cellulose-rich plant material. Building materials that are often damaged in water (such as ceilings, wallpaper, Sheetrock®, and cellulosic resin wallboard (fiberboard). Stachybotrys may produce mycotoxins, depending on the temperature, pH and humidity conditions in which the mold grows, ie Toxic compounds.

 

Other common fungi that can be grown in residential and commercial buildings are Aspergillus sp., Penicillium sp., Fusarium sp., Alternaria dianthicola, Gypsophila Aureobasidium pullulans (also known as Pullularia pullulans), Phago granivivora and Cladosporium sp. In some cases, due to structural defects in the building, mechanical system design errors and/or operational problems, water damage, excessive humidity, water leakage, condensation, water infiltration or flooding can result in a humid indoor environment, thereby promoting these fungi Growth. . Despite the use of technologically advanced building materials and more energy efficient construction and operations than in the past, even modern and commercial buildings are not immune to fungal infestation. Ventilation in modern homes tends to be poor, although the use of air conditioners reduces humidity and makes mold more difficult to grow, today's central air conditioning systems can also promote the spread of mold spores throughout the home. Today, the use of paper products in home and commercial buildings further promotes mold growth. Indoor or outdoor surfaces that are heavily contaminated with dirt and/or oil can also provide a source of food for the fungus. Fragile structures and materials that are difficult to clean or neglect to clean are particularly susceptible to fungal attack. Fungi are also known to contaminate stored paint, fuel and many other industrial products.

 

Fungal colonies are usually filamentous and have filamentous cells called hyphae. Under appropriate environmental conditions, the hyphae grow into a network of intertwined cells called mycelium. The mycelium can be seen by the naked eye, and the appearance is ugly, blurred green, blue-gray or black.

 

Most antifungal chemicals are not specific to infected organisms and may be harmful to the environment, including toxicity to plants and animals. Identifying fungal-specific reagents is much more difficult than finding bacterial-specific reagents because fungal cells have many similarities to cells of higher organisms, while bacterial cells are significantly different. Therefore, fungicides are often more toxic to humans and animals than fungicides. U.S. Patent No. 5,882,731 (Owens) describes a number of common and proprietary chemical mold-containing products which have been investigated as additives for water-based latex mixtures. Some known antifungal agents used in the coatings industry are: 8-quinoline copper (II) (CAS No. 10380-28-6); zinc oxide (CAS No. 1314-13-2); dimethyl two Zinc thiocarbamate (CAS No. 137-30-4); 2-Mercaptobenzothiazole zinc salt (CAS No. 155-04-4); Barium metaborate (CAS No. 13701-59-2); Tributyl benzoate Tin ester (CAS No. 4342-36-3); ditributyltin salicylate (CAS No. 22330-14-9), tributyltin oxide (CAS No. 56-35-9); p-hydroxybenzoate: Ethyl p-hydroxybenzoate (CAS No. 120-47-8), propyl p-hydroxybenzoate (CAS No. 94-13-3) methyl p-hydroxybenzoate (CAS No. 99-76-3) and p-hydroxybenzene Butyl formate (CAS No. 94-26-8); methylene bis(thiocyanate) (CAS No. 6317-18-6); 1,2-benzothiazolin-3-one (CAS No. 2654- 33-5); 2-mercaptobenzothiazole (CAS No. 149-30-4); 5-chloro-2-methyl-3(2H)-isothiazolone (CAS No. 57373-19-0); 2- Methyl-3(2H)-isothiazolone (CAS No. 57373-20-3); 2-pyridine thiol-N-zinc oxide (CAS No. 13463-41-7); tetrahydro-3,5-di Methyl-2H-1,3,5-thiadiazine-2-thione (CAS No. 533-74-4); N-trichloromethane - thio-4-cyclohexene-1,2-dicarboximide (CAS No. 133-06-2); 2-n-octyl-4-isothiazolin-3-one (CAS No. 26530-20 -1); 2,4,5,6-tetrachloroisophthalonitrile (CAS No. 1897-45-6); 3-iodo-2-propynyl butyl carbamate (CAS No. 55406-53- 6); diiodomethyl-p-tolylsulfone (CAS No. 20018-09-1); N-(trichloromethyl-thio)phthalimide (CAS No. 133-07-3); N -Hydroxy-methyl-N-methyl-dithiocarbamate (CAS No. 51026-28-9); 2-pyridinethiol-1-oxide sodium (CAS No. 15922-78-8); 2- (Thiocyanatomethylthio)benzothiazole (CAS No. 21564-17-0); 2-4 (thiazolyl) benzimidazole (CAS No. 148-79-8). See V. M. King, "Biocides, fungicides and algicides", Chapter 2. 29, pp. 261-267; and D. L. Campbell, "Biodegradation of Coatings," Chapter 1. 54, pp. 654-661; 14th edition of the Coatings and Coatings Test Manual. Gardner-Sward Handbook, JV Koleske, ed. (1995), American Society for Testing and Materials, Ann Arbor, Michigan. Currently, the North American Pesticide Action Network (PAN) is listed on its Internet Chemistry Database at www.panna.org. The above chemical substances and more than 700 other chemical substances designated as pesticides having antifungal properties in soil and wood.

The mode of action of some metal-based antifungals is believed to be the chelation of metals necessary for biological growth. It is believed that certain nitrogen and/or sulfur containing antifungal agents act by decoupling oxidative phosphorylation in fungal cells or inhibiting oxidation of glucose. Paraben compounds (also known as hydroxybenzoates) are believed to affect the activity and integrity of the membrane.

 

 

Angenechem offers numbers of Antifungal Agents as ark pharm:

901780-28-7	65286-77-3	65286-55-7
65286-38-6	65284-92-6	65284-56-2
65284-04-0	650626-15-6	650626-13-4
650625-31-3	650625-23-3	650624-71-8
650622-12-1	650622-19-8	650622-06-3
650622-00-7	650616-60-7	650616-17-4
650616-16-3	650616-15-2	650616-12-9
650612-97-8	650612-93-4	650612-89-8
650612-87-6	650610-30-3	650608-21-2
650607-95-7	650607-91-3	940881-63-0
650607-78-6	650607-73-1	650607-55-9
650606-96-5	650606-93-2	650606-33-0
650606-92-1	650606-85-2	650606-31-8
650606-28-3	650606-27-2	650606-13-6
650606-12-5	650606-11-4	650605-96-2