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96946-42-8

96946-42-8 | Isoquinolinium,2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-,(1R,1'R,2R,2'R)-, dibenzenesulfonate

CAS No: 96946-42-8 Catalog No: AG00IJVM MDL No:MFCD00871018

Product Description

Catalog Number:
AG00IJVM
Chemical Name:
Isoquinolinium,2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-,(1R,1'R,2R,2'R)-, dibenzenesulfonate
CAS Number:
96946-42-8
Molecular Formula:
C65H82N2O18S2
Molecular Weight:
1243.4792
MDL Number:
MFCD00871018
IUPAC Name:
benzenesulfonate;5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
InChI:
InChI=1S/C53H72N2O12.2C6H6O3S/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6;2*7-10(8,9)6-4-2-1-3-5-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3;2*1-5H,(H,7,8,9)/q+2;;/p-2/t42-,43-,54-,55-;;/m1../s1
InChI Key:
XXZSQOVSEBAPGS-DONVQRBFSA-L
SMILES:
[O-]S(=O)(=O)c1ccccc1.[O-]S(=O)(=O)c1ccccc1.COc1cc2c(cc1OC)CC[N@+]([C@@H]2Cc1ccc(c(c1)OC)OC)(C)CCC(=O)OCCCCCOC(=O)CC[N@@+]1(C)CCc2c([C@H]1Cc1ccc(c(c1)OC)OC)cc(c(c2)OC)OC
UNII:
80YS8O1MBS

Properties

Complexity:
1560  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
1242.5g/mol
Formal Charge:
0
Heavy Atom Count:
87  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
1243.487g/mol
Monoisotopic Mass:
1242.5g/mol
Rotatable Bond Count:
26  
Topological Polar Surface Area:
258A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1. Anesthesiology 20160101
Hemodynamic and hormonal stress responses to endotracheal tube and ProSeal Laryngeal Mask Airway™ for laparoscopic gastric banding. Anesthesiology 20120801
Light levels of anaesthesia after relaxation for tracheal intubation - comparison of succinylcholine and cis-atracurium. Acta anaesthesiologica Scandinavica 20120701
Comparison of the variability of the onset and recovery from neuromuscular blockade with cisatracurium versus rocuronium in elderly patients under total intravenous anesthesia. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120701
The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis. British journal of clinical pharmacology 20120501
Comparative study on the pharmacodynamics of cisatracurium: continuous infusion or intermittent bolus injection. Contemporary clinical trials 20120501
Neuromuscular blocking agents for electroconvulsive therapy: a systematic review. Acta anaesthesiologica Scandinavica 20120101
Anesthesia for patients with alpha-mannosidosis--a case series of 10 patients. Paediatric anaesthesia 20111201
Influence of anesthesia on the results of intraoperative diagnostic electromyostimulation in patients with anorectal malformation. Journal of pediatric surgery 20111101
Increases in heart rate and systolic blood pressure in anesthetized dogs affected with X-linked muscular dystrophy after cisatracurium administration: a retrospective study. Paediatric anaesthesia 20110801
Suicide with cisatracurium and thiopental: forensic and analytical aspects. Journal of analytical toxicology 20110701
[Impact of gender on the dose-effect relationship of cisatracurium]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110601
[Heart failure and anaphylactic shock. A report of two cases]. Annales de cardiologie et d'angeiologie 20110401
[Anesthetic considerations in Miller Fisher syndrome]. Revista espanola de anestesiologia y reanimacion 20110401
No regional difference in cisatracurium dose-response and time-course-of-action between patients in China and Bosnia. British journal of anaesthesia 20110301
Cisatracurium pharmacokinetics and pharmacodynamics during hypothermic cardiopulmonary bypass in infants and children. Paediatric anaesthesia 20110301
[Comparison of atracurium, cisatracurium and vecuronium during anaesthesia for laparoscopic surgery]. Anestezjologia intensywna terapia 20110101
Neuromuscular blockers and ARDS. The New England journal of medicine 20101223
Neuromuscular blockers and ARDS. The New England journal of medicine 20101223
Neuromuscular blockers and ARDS. The New England journal of medicine 20101223
Effect of an intravenous infusion of lidocaine on cisatracurium-induced neuromuscular block duration: a randomized-controlled trial. Acta anaesthesiologica Scandinavica 20101101
Neuromuscular blockers in early acute respiratory distress syndrome. The New England journal of medicine 20100916
Neuromuscular blocking agents in ARDS. The New England journal of medicine 20100916
Postoperative residual curarization from intermediate-acting neuromuscular blocking agents delays recovery room discharge. British journal of anaesthesia 20100901
The effects of low-dose ephedrine on intubating conditions following low-dose priming with cisatracurium. Journal of clinical anesthesia 20100901
Cisatracurium-induced neuromuscular block during total intravenous anaesthesia in a patient with Charcot-Marie-Tooth disease. European journal of anaesthesiology 20100701
Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011. Anesthesiology 20100701
Determining the potency of neuromuscular blockers: are traditional methods flawed? British journal of anaesthesia 20100601
Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs. Anesthesiology 20100401
The effect of local anesthetics on the inhibition of adult muscle-type nicotinic acetylcholine receptors by nondepolarizing muscle relaxants. European journal of pharmacology 20100325
Determination of atracurium, cisatracurium and mivacurium with their impurities in pharmaceutical preparations by liquid chromatography with charged aerosol detection. Journal of chromatography. A 20100219
The use of emergency medical cooling system pads in the treatment of malignant hyperthermia. European journal of anaesthesiology 20100101
[Effect of sevoflurane versus propofol-remifentanil anesthesia on neuromuscular blockade by continuous cisatracurium infusion]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100101
Hemodynamic effects of atracurium and cisatracurium and the use of diphenhydramine and cimetidine. Revista brasileira de anestesiologia 20100101
Studies on the pharmacokinetics of cisatracurium in anesthetized dogs: in vitro-in vivo correlations. Journal of veterinary pharmacology and therapeutics 20091201
Clinical predictors of duration of action of cisatracurium and rocuronium administered long-term. American journal of critical care : an official publication, American Association of Critical-Care Nurses 20090901
Partial neuromuscular blockade in humans enhances muscle blood flow during exercise independently of muscle oxygen uptake and acetylcholine receptor blockade. American journal of physiology. Regulatory, integrative and comparative physiology 20090401
Comparative study of neuromuscular blocking and hemodynamic effects of rocuronium and cisatracurium under sevoflurane or total intravenous anesthesia. Middle East journal of anaesthesiology 20090201
Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor. Molecular pharmacology 20090101
Priming with rocuronium to accelerate the onset time of cisatracurium during intubation. Journal of the Chinese Medical Association : JCMA 20090101
Presynaptic M1, M2, and A1 receptors play roles in tetanic fade induced by pancuronium or cisatracurium. Journal of anesthesia 20090101
Neuromuscular blockade of slow twitch muscle fibres elevates muscle oxygen uptake and energy turnover during submaximal exercise in humans. The Journal of physiology 20081215
Dose-dependency of pharmacokinetic/pharmacodynamic parameters after intravenous bolus doses of cisatracurium. British journal of anaesthesia 20081201
Acute coronary syndrome in cisatracurium-induced anaphylactic shock: Kounis syndrome. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20081201
Laryngeal injuries and intubating conditions with or without muscular relaxation: an equivalence study. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20081001
Clinical pharmacology of cisatracurium during nitrous oxide-propofol anesthesia in children. Journal of clinical anesthesia 20080901
Antifibrillatory actions of cisatracurium: an atrial specific M2 receptor antagonist. Journal of cardiovascular electrophysiology 20080801
Influence of gender on the course of neuromuscular block following a single bolus dose of cisatracurium or rocuronium. European journal of anaesthesiology 20080701
Tachyphylaxis to cisatracurium--case reports and literature review. Middle East journal of anaesthesiology 20080601
Thinking activates EMG in scalp electrical recordings. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20080501
Reversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine. British journal of anaesthesia 20080501
[Anesthetic management in a patient with bullous emphysema]. Revista espanola de anestesiologia y reanimacion 20080401
The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature. The Journal of physiology 20080215
[Remifentanil bolus for cesarean section in high-risk patients: study of 12 cases]. Revista espanola de anestesiologia y reanimacion 20080201
Neuromuscular effects of cisatracurium in morbidly obese patients. Middle East journal of anaesthesiology 20080201
[Use of nondepolarizing myorelaxants in neonates]. Anesteziologiia i reanimatologiia 20080101
[Type IV anaphylactic reaction and ST-elevation acute coronary syndrome due to coronary vasospasm secondary to administration of cisatracurium]. Medicina intensiva 20080101
[Indications and uses of neuromuscular blocking agents in the ICU]. Annales francaises d'anesthesie et de reanimation 20080101
Neuromuscular blockade in cardiac surgery: an update for clinicians. Annals of cardiac anaesthesia 20080101
Comparison of cardiac output measurements between NICO and the pulmonary artery catheter during repeat surgery for total hip replacement. European journal of anaesthesiology 20071201
Anaphylaxis to vecuronium: the use of basophil CD63 expression as a possible screening tool to identify a safe alternative. Journal of clinical anesthesia 20071101
[Neurilemoma of the brachial plexus: clinical characteristics and anesthetic management during resection]. Revista espanola de anestesiologia y reanimacion 20071101
The effect of neuromuscular blockers in patients with intra-abdominal hypertension. Intensive care medicine 20071001
[Priming technique with cisatracurium Onset time at the laryngeal muscles]. Der Anaesthesist 20071001
Cisatracurium in cardiac surgery--continuous infusion vs. bolus administration. Middle East journal of anaesthesiology 20071001
Skin reactions to intradermal neuromuscular blocking agent injections: a randomized multicenter trial in healthy volunteers. Anesthesiology 20070801
Xylazine premedication does not modify the onset and duration of cisatracurium blockade in anaesthetized dogs. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20070601
Effects of prone position on alveolar dead space and gas exchange during general anaesthesia in surgery of long duration. European journal of anaesthesiology 20070501
Pharmacological dissection of the human gastro-oesophageal segment into three sphincteric components. The Journal of physiology 20070501
Infusions of rocuronium and cisatracurium exert different effects on rat diaphragm function. Intensive care medicine 20070501
Influence of acute normovolaemic haemodilution on the dose-response relationship and time course of action of cisatracurium besylate. British journal of anaesthesia 20070301
Muscle relaxation does not influence venous oxygen saturation during cardiopulmonary bypass. Journal of clinical anesthesia 20070301
[Bispectral index monitoring during intrahospital transport]. Revista espanola de anestesiologia y reanimacion 20070301
Tracheal intubating conditions and pharmacodynamics following cisatracurium in infants and children undergoing halothane and thiopental-fentanyl anesthesia. Paediatric anaesthesia 20070201
Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium. Anaesthesia 20070101
Influence of cisatracurium on entropy values during propofol-remifentanil anesthesia. Anesthesia and analgesia 20070101
Cisatracurium in 'weakening doses' assists in weaning from sedation and withdrawal following extended use of inhaled isoflurane. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20070101
[Effect of propofol in combination with ephedrine upon the onset time of cisatracurium]. Revista da Associacao Medica Brasileira (1992) 20070101
[Influence of neostigmine on the course of neuromuscular blockade with rocuronium or cisatracurium: a randomized, double-blind trial]. Revista espanola de anestesiologia y reanimacion 20070101
[Anesthetic implications of Swyer-James syndrome]. Revista espanola de anestesiologia y reanimacion 20061201
Cisatracurium vs. Rocuronium: A prospective, comparative, randomized study in adult patients under total intravenous anaesthesia. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20061101
Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade. Anesthesiology 20060901
Modeling of twitch fade based on slow interaction of nondepolarizing muscle relaxants with the presynaptic receptors. Journal of pharmacokinetics and pharmacodynamics 20060801
Cisatracurium: myographical and electrophysiological studies in the isolated rat muscle. Fundamental & clinical pharmacology 20060601
Cisatracurium or rocuronium versus rocuronium-cisatracurium combination. Middle East journal of anaesthesiology 20060601
Cisatracurium versus vecuronium: a comparative, double blind, randomized, multicenter study in adult patients under propofol/fentanyl/N2O anesthesia. Minerva anestesiologica 20060501
Addition of cisatracurium to lidocaine for intravenous regional anesthesia. Journal of clinical anesthesia 20060501
Pharmacokinetics and pharmacodynamics of a 0.1 mg/kg dose of cisatracurium besylate in children during N2O/O2/propofol anesthesia. Anesthesia and analgesia 20060301
[Aspiration pneumonia and pulmonary edema due to laryngeal spasm: differential diagnosis]. Revista espanola de anestesiologia y reanimacion 20060301
[Comments on the article 'Emergency tracheostomy to resolve an unforeseen difficult airway]. Revista espanola de anestesiologia y reanimacion 20060101
Resistance to cisatracurium in a patient with MELAS syndrome. Paediatric anaesthesia 20051201
Anaphylaxis to cisatracurium following negative skin testing. Anaesthesia and intensive care 20051201
Anesthesia for an adult with mucopolysaccharidosis I. Journal of clinical anesthesia 20051201
Anesthetic implications of traumatic pulmonary hernia repair. Journal of clinical anesthesia 20051201
[Patient with right ventricular arrhythmogenic dysplasia, ascites and ulcerative colitis: anesthetic management during major abdominal surgery]. Revista espanola de anestesiologia y reanimacion 20051201
Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials. Anesthesiology 20051001
Does pancuronium or cisatracurium delay the rate of arousal following remifentanil-based anesthesia? Middle East journal of anaesthesiology 20051001
Perinatal neuroprotection by muscle relaxants against hypoxic-ischemic lesions: is it a possible hypothesis? The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20050801
Central command and the cutaneous vascular response to isometric exercise in heated humans. The Journal of physiology 20050601
Comparative cost-analysis of a propofol-cisatracurium-based anesthesia with remifentanil or fentanyl for laparoscopic surgery. Surgical laparoscopy, endoscopy & percutaneous techniques 20050601
Infusion and bolus administration of cisatracurium--effects on histamine release. Middle East journal of anaesthesiology 20050601
Randomised controlled trial comparing cisatracurium and vecuronium infusions in a paediatric intensive care unit. Intensive care medicine 20050501
[Value of skin tests for the choice of a neuromuscular blocking agent after an anaphylactic reaction]. Annales francaises d'anesthesie et de reanimation 20050501
Changes in bispectral index values during lumbar arthrodesis. European journal of anaesthesiology 20050501
[Monitoring of consciousness with BIS during induction of anesthesia. Which muscle relaxant?]. Il Giornale di chirurgia 20050401
Variability of duration of action of neuromuscular-blocking drugs in elderly patients. Acta anaesthesiologica Scandinavica 20050301
Complete recovery from prolonged cardiac arrest following self-administration of cisatracurium. European journal of anaesthesiology 20050101
[Comparative assessment of rocuronium bromide and cysatracurium besylate used during endosurgical operations in children]. Anesteziologiia i reanimatologiia 20050101
[Comparison of gastric aspirate volume after intubation in patients with and without symptoms of gastroesophageal reflux disease]. Revista espanola de anestesiologia y reanimacion 20050101
[Infant boy with propionic acidemia: anesthetic implications]. Revista espanola de anestesiologia y reanimacion 20050101
[Intracranial pressure response during secretion aspiration after administration of a muscle relaxant]. Enfermeria intensiva 20050101
Anesthesia for a child with Wolf-Hirshhorn syndrome. Paediatric anaesthesia 20041101
Comparison of cisatracurium and vecuronium by infusion in neonates and small infants after congenital heart surgery. Anesthesiology 20041101
Assessment of neuromuscular and haemodynamic effects of cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia in elderly patients. European journal of anaesthesiology 20041101
General anaesthesia in a patient with motor neuron disease. European journal of anaesthesiology 20041101
The effects of cisatracurium on morbidly obese women. Anesthesia and analgesia 20041001
Train-of-four to monitor neuromuscular blockade? Chest 20041001
A prospective randomized comparison of train-of-four monitoring and clinical assessment during continuous ICU cisatracurium paralysis. Chest 20041001
Desflurane and remifentanil use during resection of a cardiac pheochromocytoma. Journal of cardiothoracic and vascular anesthesia 20041001
Combined general and epidural anesthesia for a child with alagille syndrome: a case report. Paediatric anaesthesia 20040901
An investigation of non-depolarizing muscle relaxants on embryonic development in cultured rat embryos. European journal of anaesthesiology 20040901
Recovery from neuromuscular block following infusion of cisatracurium using either sevoflurane or propofol for anaesthesia. European journal of anaesthesiology 20040901
Inadvertent epidural administration of cisatracurium. European journal of anaesthesiology 20040801
Cisatracurium, but not mivacurium, inhibits survival and axonal growth of neonatal and adult rat peripheral neurons in vitro. Neuroscience letters 20040722
Characterization of embryonic cardiac pacemaker and atrioventricular conduction physiology in Xenopus laevis using noninvasive imaging. American journal of physiology. Heart and circulatory physiology 20040601
Colonic anastomotic disruption in the immediate postoperative period. International journal of colorectal disease 20040501
Update on muscle relaxants. Paediatric anaesthesia 20040501
Comparison of the neuromuscular blocking effect of cisatracurium and atracurium on the larynx and the adductor pollicis. Acta anaesthesiologica Scandinavica 20040501
Narcolepsy and cardiac surgery: can anesthesia with propofol and remifentanil be safe? Journal of cardiothoracic and vascular anesthesia 20040401
Intraoperative jet ventilation during aortic coarctation repair in an infant. Journal of cardiothoracic and vascular anesthesia 20040401
Anaesthetic implications of LEOPARD syndrome. Paediatric anaesthesia 20040401
Potential neuroprotective properties of atracurium and cisatracurium in neurosurgical anaesthesia. European journal of anaesthesiology 20040401
The effect of cisatracurium and rocuronium on cisatracurium precurarization and the priming principle. Journal of clinical anesthesia 20040301
Acute motor axonal polyneuropathy after a cisatracurium infusion and concomitant corticosteroid therapy. British journal of anaesthesia 20040201
Antagonism of cisatracurium and rocuronium block at a tactile train-of-four count of 2: should quantitative assessment of neuromuscular function be mandatory? Anesthesia and analgesia 20040101
Pharmacodynamic interactions between cisatracurium and rocuronium. Anesthesia and analgesia 20040101
A comparison of the efficacy of cisatracurium and atracurium in kidney transplantation operation. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20040101
Neuromuscular blockade does not change the incidence or severity of pharyngolaryngeal discomfort after LMA anesthesia. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20040101
[Safety and quality of myoplegia in different types of abdominal surgeries]. Anesteziologiia i reanimatologiia 20040101
Modification of mediators of immune reaction after general anaesthesia. Allergologia et immunopathologia 20040101
Central command is capable of modulating sweating from non-glabrous human skin. The Journal of physiology 20031215
Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031101
Gastric emptying in mechanically ventilated critically ill patients: effect of neuromuscular blocking agent. Intensive care medicine 20031001
Anesthetic management of a patient having a carcinoid syndrome. Middle East journal of anaesthesiology 20031001
Recurarization in the recovery room following the use of magnesium sulphate. British journal of anaesthesia 20030901
Possible underestimation of the relative incidence of anaphylactic reactions to benzylisoquinoline neuromuscular blocking agents. European journal of anaesthesiology 20030701
Low-dose rocuronium and tracheal intubation. Middle East journal of anaesthesiology 20030601
A role for muscle relaxation in patients with abdominal compartment syndrome? Intensive care medicine 20030201
A comparison of tubocurarine, rocuronium, and cisatracurium in the prevention and reduction of succinylcholine-induced muscle fasciculations. AANA journal 20030201
Cortical activity assessed by Narcotrend in relation to haemodynamic responses to tracheal intubation at different stages of cortical suppression and reflex control. European journal of anaesthesiology 20030101
General anaesthesia with remifentanil and cisatracurium for a superobese patient. European journal of anaesthesiology 20030101
Small trials and drug safety: when will we learn? Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20030101
Comparative fading responses induced by mivacurium, cisatracurium, and d-tubocurarine in the evoked muscular compound action potentials of the cat. Journal of anesthesia 20030101
[Nimbex in patients with blood diseases]. Anesteziologiia i reanimatologiia 20030101
[Anesthesia with propofol, remifentanil and cisatracurium in renal transplantation]. Revista espanola de anestesiologia y reanimacion 20030101
Atracurium, cisatracurium, vecuronium and rocuronium in patients with renal failure. Minerva anestesiologica 20030101
A comparison of two depths of prolonged neuromuscular blockade induced by cisatracurium in mechanically ventilated critically ill patients. Intensive care medicine 20021201
Effect of different doses of cisatracurium on intraocular pressure in sedated patients. European journal of anaesthesiology 20021101
Different intradermal skin testing response to atracurium and cisatracurium after an anaphylactoid reaction during general anaesthesia. Anaesthesia and intensive care 20021001
[Precurarization of succinylcholine with cisatracurium: the influence of the precurarization interval]. Der Anaesthesist 20020901
Anaphylactic reaction after cisatracurium administration. European journal of anaesthesiology 20020901
Laudanosine, an atracurium and cisatracurium metabolite. European journal of anaesthesiology 20020701
Tachyphylaxis associated with continuous cisatracurium versus pancuronium therapy. Pharmacotherapy 20020701
Multiple estimates of EC(50). Anesthesiology 20020701
[Neuromuscular blockade with cisatracurium in infants andchildren. Its course under sevoflurane anesthesia]. Der Anaesthesist 20020501
Double-blind comparison of the variability in spontaneous recovery of cisatracurium- and vecuronium-induced neuromuscular block in adult and elderly patients. Acta anaesthesiologica Scandinavica 20020401
Does ester hydrolysis change the in vitro degradation rate of cisatracurium and atracurium? British journal of anaesthesia 20020401
Dose requirements and recovery profile of an infusion of cisatracurium during liver transplantation. Journal of clinical anesthesia 20020301
Postoperative residual curarization with cisatracurium and rocuronium infusions. European journal of anaesthesiology 20020201
Efficacy of tactile-guided reversal from cisatracurium-induced neuromuscular block. Anesthesiology 20020101
A longer pretreatment interval does not improve cisatracurium precurarization. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20020101
[Modern nondepolarizing myorelaxants in cardiac surgery]. Anesteziologiia i reanimatologiia 20020101
[Carboxyperitoneum and clinical efficacy of nondepolarizing relaxants with different types of metabolism]. Anesteziologiia i reanimatologiia 20020101
Anaphylactoid reactions after cisatracurium administration in six patients. Anesthesia and analgesia 20011101
The kinetics of competitive antagonism by cisatracurium of embryonic and adult nicotinic acetylcholine receptors. Molecular pharmacology 20011001
The influence of atracurium, cisatracurium, and mivacurium on the proliferation of two human cell lines in vitro. Anesthesia and analgesia 20010901
Different patterns of mast cell activation by muscle relaxants in human skin. Anesthesiology 20010901
The pharmacokinetics of cisatracurium in patients with acute respiratory distress syndrome. Anesthesia and analgesia 20010801
Edrophonium antagonism of cisatracurium-induced neuromuscular block: dose requirements in children and adults. Anaesthesia and intensive care 20010801
The interpretation of train-of-four monitoring in intensive care: what about the muscle site and the current intensity? Intensive care medicine 20010601
Does discontinuation of desflurane at the time of neostigmine administration speed recovery from cisatracurium block compared to that with a propofol-based technique? Acta anaesthesiologica Scandinavica 20010501
Dose-response relationship and infusion requirement of cisatracurium besylate in infants and children during nitrous oxide-narcotic anesthesia. Anesthesiology 20010501
[Recovery of neuromuscular block after continuous infusion of cisatracurium in patients with renal dysfunction]. Annales francaises d'anesthesie et de reanimation 20010501
The lumbar paravertebral region provides a novel site to assess neuromuscular block at the diaphragm. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010401
Severe anaphylactic reaction to cisatracurium in a child. Anesthesia and analgesia 20010301
Comparison of cisatracurium-induced neuromuscular blockade between immediate postpartum and nonpregnant patients. Journal of clinical anesthesia 20010301
[The effect of anesthetic technique on recovery from neuromuscular blockade with cisatracurium]. Revista espanola de anestesiologia y reanimacion 20010301
Drug compatibility differences with propofol injectable emulsion products. Critical care medicine 20010201
[Cisatracurium in coronary bypass operations--a comparison with pancuronium. Hemodynamic and neuromuscular effects in patients under chronic beta blocker treatment]. Der Anaesthesist 20010201
Newer neuromuscular blocking agents: how do they compare with established agents? Drugs 20010101
Use of cisatracurium during fast-track cardiac surgery. British journal of anaesthesia 20010101
Recent advances in myorelaxant therapy. Paediatric anaesthesia 20010101
Recovery of neuromuscular block in morbidly obese patients following an infusion of rocuronium. Acta anaesthesiologica Belgica 20010101
Muscle relaxants in paediatric day case surgery. European journal of anaesthesiology. Supplement 20010101
[Use of the new non-depolarizing myorelaxant, Nimbex, for anesthesiologic maintenance in high-risk thoracic operations]. Vestnik khirurgii imeni I. I. Grekova 20010101
Effects of pretreatment with cisatracurium, rocuronium, and d-tubocurarine on succinylcholine-induced fasciculations and myalgia: a comparison with placebo. Journal of clinical anesthesia 19991201
Severe anaphylactic reaction to cisatracurium. Anesthesia and analgesia 19990201
Prolonged weakness after cisatracurium infusion: a case report. Critical care medicine 19980701
The lack of histamine release with cisatracurium: a double-blind comparison with vecuronium. Anesthesia and analgesia 19970301

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