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955272-06-7 | 2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
CAS No: 955272-06-7 Catalog No: AG003ABG MDL No:MFCD09961532
Product Description
Catalog Number:
AG003ABG
Chemical Name:
2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
CAS Number:
955272-06-7
Molecular Formula:
C19H15ClN4O2
Molecular Weight:
366.8010
MDL Number:
MFCD09961532
IUPAC Name:
2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione
InChI:
InChI=1S/C19H15ClN4O2/c1-12-18-15(10-17(25)23(12)11-13-6-4-5-9-21-13)22-24(19(18)26)16-8-3-2-7-14(16)20/h2-10,22H,11H2,1H3
InChI Key:
DNKYHHFCPXKFIY-UHFFFAOYSA-N
SMILES:
Clc1ccccc1n1[nH]c2c(c1=O)c(C)n(c(=O)c2)Cc1ccccn1
Properties
Complexity:
675
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
366.088g/mol
Formal Charge:
0
Heavy Atom Count:
26
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
366.805g/mol
Monoisotopic Mass:
366.088g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
65.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.3
Literature
| Title | Journal |
|---|---|
| NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling. | Arteriosclerosis, thrombosis, and vascular biology 20140801 |
| Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. | Clinical science (London, England : 1979) 20130201 |
| Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism. | PloS one 20110101 |
| Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. | American journal of physiology. Renal physiology 20101201 |
| First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. | Journal of medicinal chemistry 20101111 |
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