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95-25-0 | 5-Chloro-2(3H)-benzoxazolone
CAS No: 95-25-0 Catalog No: AG003494 MDL No:MFCD00005717
Product Description
Catalog Number:
AG003494
Chemical Name:
5-Chloro-2(3H)-benzoxazolone
CAS Number:
95-25-0
Molecular Formula:
C7H4ClNO2
Molecular Weight:
169.5652
MDL Number:
MFCD00005717
IUPAC Name:
5-chloro-3H-1,3-benzoxazol-2-one
InChI:
InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
InChI Key:
TZFWDZFKRBELIQ-UHFFFAOYSA-N
SMILES:
Clc1ccc2c(c1)[nH]c(=O)o2
EC Number:
202-403-9
UNII:
H0DE420U8G
Properties
Complexity:
185
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
168.993g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
169.564g/mol
Monoisotopic Mass:
168.993g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
38.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.8
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| In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A. | Drug metabolism and pharmacokinetics 20051001 |
| Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. | Bioorganic & medicinal chemistry letters 20050915 |
| Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa. | Drug metabolism and disposition: the biological fate of chemicals 20050801 |
| Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats. | Xenobiotica; the fate of foreign compounds in biological systems 20050801 |
| Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20050701 |
| Enzyme-selective effects of nitric oxide on affinity and maximum velocity of various rat cytochromes P450. | Drug metabolism and disposition: the biological fate of chemicals 20050601 |
| Minipig cytochrome P450 2E1: comparison with human enzyme. | Drug metabolism and disposition: the biological fate of chemicals 20050601 |
| Effect of age and postoperative time on cytochrome p450 enzyme activity following liver transplantation. | Journal of clinical pharmacology 20050601 |
| Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050501 |
| Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics. | Hepatology (Baltimore, Md.) 20050501 |
| In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. | Clinical pharmacology and therapeutics 20050501 |
| [Ratio spectrophotometry and its application to assay of compound pharmacy preparations]. | Guang pu xue yu guang pu fen xi = Guang pu 20050401 |
| The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. | Drug metabolism and disposition: the biological fate of chemicals 20050301 |
| The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation. | Mutagenesis 20050301 |
| Cytochrome P-450 activity is differentially altered in severely injured patients. | Critical care medicine 20050301 |
| Comparison of cytochrome P4502E1 (CYP2E1) activity and hepatic and lymphocyte mRNA expression in patients with chronic hepatitis C. | Toxicology letters 20050115 |
| Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050101 |
| Validation of a simple bioanalytical method for the determination of DRF-6196, a novel oxazolidinone, in mouse plasma: application to a single-dose pharmacokinetic study. | Arzneimittel-Forschung 20050101 |
| Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba. | Drugs & aging 20050101 |
| High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20050101 |
| Effects of etodolac on P450 isoform-specific activities in human hepatic microsomes. | Arzneimittel-Forschung 20050101 |
| The effect of isoniazid containing regimen on CYP2E1 during antituberculosis therapy. | Research communications in molecular pathology and pharmacology 20050101 |
| Bioequivalence revisited: influence of age and sex on CYP enzymes. | Clinical pharmacology and therapeutics 20041201 |
| Comparative studies of the effects of two novel sugar drug candidates on the CYP 1A2 and CYP 2E1 enzymes in different sexed rats using a 'cocktail' approach. | Molecules (Basel, Switzerland) 20041130 |
| Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities. | Journal of pharmacological sciences 20041101 |
| In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. | Clinical pharmacology and therapeutics 20041101 |
| Bioactivation of 1,1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung. | The Journal of pharmacology and experimental therapeutics 20040901 |
| A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study. | British journal of clinical pharmacology 20040901 |
| Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils. | Xenobiotica; the fate of foreign compounds in biological systems 20040901 |
| Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. | Xenobiotica; the fate of foreign compounds in biological systems 20040901 |
| Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity. | British journal of clinical pharmacology 20040801 |
| Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. | Journal of pain and symptom management 20040801 |
| Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation. | Chemical research in toxicology 20040801 |
| Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression. | American journal of physiology. Cell physiology 20040701 |
| The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney. | Drug metabolism and disposition: the biological fate of chemicals 20040701 |
| Validated assays for human cytochrome P450 activities. | Drug metabolism and disposition: the biological fate of chemicals 20040601 |
| Assessment of drug-drug interaction potential of enfuvirtide in human immunodeficiency virus type 1-infected patients. | Clinical pharmacology and therapeutics 20040601 |
| Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats. | The Journal of pharmacy and pharmacology 20040601 |
| Presence of cytochrome P450 enzymes in human CD34+ haematopoietic progenitor cells. | General physiology and biophysics 20040601 |
| Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. | Xenobiotica; the fate of foreign compounds in biological systems 20040501 |
| Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040401 |
| ATP release triggered by activation of the Ca2+-activated K+ channel in human airway Calu-3 cells. | American journal of respiratory cell and molecular biology 20040301 |
| Age-related changes in the protein and mRNA levels of CYP2E1 and CYP3A isoforms as well as in their hepatic activities in Wistar rats. What role for oxidative stress? | Archives of toxicology 20040301 |
| Phase I and II enzyme characterization of two sources of HepG2 cell lines. | Xenobiotica; the fate of foreign compounds in biological systems 20040301 |
| Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1. | British journal of clinical pharmacology 20040201 |
| Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride. | International journal of pharmaceutics 20040128 |
| Characteristics and a functional implication of Ca(2+)-activated K(+) current in mouse aortic endothelial cells. | Pflugers Archiv : European journal of physiology 20040101 |
| The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture. | Drug metabolism and disposition: the biological fate of chemicals 20040101 |
| Annular leucocytoclastic vasculitis induced by chlorzoxazone. | The British journal of dermatology 20040101 |
| Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study. | Breast cancer research : BCR 20040101 |
| Identification of sequences responsible for intracellular targeting and membrane binding of rat CYP2E1 in yeast. | Biochemistry 20031216 |
| Comparison of chlorzoxazone one-sample methods to estimate CYP2E1 activity in humans. | European journal of clinical pharmacology 20031201 |
| Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies. | Clinical pharmacology and therapeutics 20031201 |
| 'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies. | Xenobiotica; the fate of foreign compounds in biological systems 20031201 |
| GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer. | Drug metabolism and disposition: the biological fate of chemicals 20031101 |
| Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. | Drug metabolism and disposition: the biological fate of chemicals 20031101 |
| Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism. | Clinical pharmacology and therapeutics 20031101 |
| CYP2E1 regulation by benzene and other small organic chemicals in rat liver and peripheral lymphocytes. | Toxicology letters 20030915 |
| Simultaneous determination of aspirin and isosorbide 5-mononitrate in formulation by reversed phase high pressure liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20030821 |
| Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF. | American journal of physiology. Cell physiology 20030801 |
| Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes. | Toxicology in vitro : an international journal published in association with BIBRA 20030801 |
| CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. | Hepatology (Baltimore, Md.) 20030801 |
| Effects of glucose on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate. | Journal of pharmaceutical sciences 20030801 |
| Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C- and tyrosine kinase-dependent mechanism. | Journal of neurochemistry 20030801 |
| Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. | Life sciences 20030718 |
| Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate. | Life sciences 20030606 |
| Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats. | Drug metabolism and disposition: the biological fate of chemicals 20030601 |
| How useful is the 'cocktail approach' for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo? | Journal of clinical pharmacy and therapeutics 20030601 |
| Functional characterization of three human cytochrome p450 2E1 variants with amino acid substitutions. | Xenobiotica; the fate of foreign compounds in biological systems 20030601 |
| Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2. | Xenobiotica; the fate of foreign compounds in biological systems 20030601 |
| Cytochrome P450 expression and testosterone metabolism in the liver of deer. | Toxicology 20030501 |
| Construction and assessment of models of CYP2E1: predictions of metabolism from docking, molecular dynamics, and density functional theoretical calculations. | Journal of medicinal chemistry 20030424 |
| Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice. | Drug metabolism and disposition: the biological fate of chemicals 20030401 |
| Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. | Hepatology (Baltimore, Md.) 20030401 |
| The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine. | International archives of occupational and environmental health 20030401 |
| Kinetic study of alkaline induced hydrolysis of the skeletal muscle relaxant chlorzoxazone using ratio spectra first derivative spectrophotometry. | Farmaco (Societa chimica italiana : 1989) 20030401 |
| Metabolism of chloroform in the human liver and identification of the competent P450s. | Drug metabolism and disposition: the biological fate of chemicals 20030301 |
| Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. | Hepatology (Baltimore, Md.) 20030301 |
| Pharmacokinetics of intravenous chlorzoxazone in rats with dehydration and rehydration: effects of food intakes. | Biopharmaceutics & drug disposition 20030301 |
| Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. | Clinical pharmacology and therapeutics 20030301 |
| Study of the fragmentation mechanism of protonated 6-hydroxychlorzoxazone: application in simultaneous analysis of CYP2E1 activity with major human cytochrome P450s. | Analytical chemistry 20030201 |
| Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferation. | The Journal of biological chemistry 20030131 |
| Determination of 6-hydroxychlorzoxazone and chlorzoxazone in porcine microsome samples. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030125 |
| Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells. | Brain research 20030103 |
| Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. | Archives of biochemistry and biophysics 20030101 |
| Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans. | British journal of clinical pharmacology 20030101 |
| Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel. | In vitro cellular & developmental biology. Animal 20030101 |
| In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole. | Drug metabolism and pharmacokinetics 20030101 |
| Heterologous expression of mouse cytochrome P450 2e1 in V79 cells: construction and characterisation of the cell line and comparison with V79 cell lines stably expressing rat P450 2E1 and human P450 2E1. | Alternatives to laboratory animals : ATLA 20030101 |
| Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. | Drug metabolism and disposition: the biological fate of chemicals 20021201 |
| Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs. | Archives of toxicology 20021201 |
| Validated HPLC method for determination of chlorzoxazone in human serum and its application in a clinical pharmacokinetic study. | Die Pharmazie 20021201 |
| Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency. | Biochemistry 20021126 |
| Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125 |
| Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population. | Xenobiotica; the fate of foreign compounds in biological systems 20021101 |
| [Simultaneous determination of three probe drugs by reversed-phase high performance liquid chromatography]. | Se pu = Chinese journal of chromatography 20021101 |
| Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. | Biochemical pharmacology 20021001 |
| Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption. | Human reproduction (Oxford, England) 20021001 |
| Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure. | Journal of cardiac failure 20021001 |
| Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress. | Antioxidants & redox signaling 20021001 |
| Cytochrome P4502E1 phenotyping by the measurement of the chlorzoxazone metabolic ratio: assessment of its usefulness in workers exposed to styrene. | International archives of occupational and environmental health 20020901 |
| Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. | Clinical pharmacology and therapeutics 20020901 |
| Cytochrome P450 2E1 and 3A activities do not differ between Mexicans and European Americans. | Clinical pharmacology and therapeutics 20020901 |
| Watercress has no Importance for the elimination of ethanol by CYP2E1 inhibition. | Pharmacology & toxicology 20020901 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Effect of methacrylonitrile on cytochrome P-450 2E1 (CYP2E1) expression in male F344 rats. | Journal of toxicology and environmental health. Part A 20020412 |
| Effects of cysteine on the pharmacokinetics of intravenous chlorzoxazone in rats with protein-calorie malnutrition. | Biopharmaceutics & drug disposition 20020401 |
| Inhibition of cytochromes P450 by antifungal imidazole derivatives. | Drug metabolism and disposition: the biological fate of chemicals 20020301 |
| The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20020301 |
| Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. | Biochemical pharmacology 20020301 |
| Effects of flavonoids isolated from Scutellariae radix on cytochrome P-450 activities in human liver microsomes. | Journal of toxicology and environmental health. Part A 20020301 |
| Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. | Pharmacology & toxicology 20020301 |
| Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects. | British journal of clinical pharmacology 20020201 |
| Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase. | Journal of hepatology 20020101 |
| Fondaparinux sodium is not metabolised in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs. | Clinical pharmacokinetics 20020101 |
| Mechanism of aerobic transformation of carbon tetrachloride by poplar cells. | Biodegradation 20020101 |
| Stability of cytochrome P450 enzymes in human liver samples stored in different tissue preservation buffers. | Research communications in molecular pathology and pharmacology 20020101 |
| Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. | Toxicology letters 20011215 |
| Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells. | American journal of physiology. Lung cellular and molecular physiology 20011101 |
| Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver. | The Journal of pharmacology and experimental therapeutics 20011101 |
| Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices. | Journal of pineal research 20011101 |
| Assessment of cytochrome P450 activity by a five-drug cocktail approach. | Clinical pharmacology and therapeutics 20011101 |
| In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9). | British journal of clinical pharmacology 20011101 |
| An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A). | British journal of clinical pharmacology 20011101 |
| Toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic cytochrome P450 in F344 rats. | Archives of toxicology 20011101 |
| Cytochrome CYP2E1 phenotyping and genotyping in the evaluation of health risks from exposure to polluted environments. | Toxicology letters 20011015 |
| The effect of endotoxin on hepatocyte nuclear factor 1 nuclear protein binding: potential implications on CYP2E1 expression in the rat. | The Journal of pharmacy and pharmacology 20011001 |
| Metabolism of vanoxerine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes. | Drug metabolism and disposition: the biological fate of chemicals 20010901 |
| Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama). | Chemico-biological interactions 20010831 |
| Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats. | Drug metabolism and disposition: the biological fate of chemicals 20010801 |
| Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate. | Drug metabolism and disposition: the biological fate of chemicals 20010801 |
| Expression of cytochrome P450 2E1 in normal human bronchial epithelial cells and activation by ethanol in culture. | Archives of toxicology 20010801 |
| Chlorzoxazone: a probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachloride-intoxicated rat. | Human & experimental toxicology 20010801 |
| Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia. | American journal of physiology. Lung cellular and molecular physiology 20010701 |
| The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone. | Human & experimental toxicology 20010701 |
| Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine. | Drug metabolism and disposition: the biological fate of chemicals 20010601 |
| Spectrofluorometric determination of ibuprofen in pharmaceutical formulations. | Journal of pharmaceutical and biomedical analysis 20010601 |
| Genetic and dietary factors affecting human metabolism of 1,3-butadiene. | Chemico-biological interactions 20010601 |
| Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics. | Alcoholism, clinical and experimental research 20010601 |
| A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4'-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6beta-hydroxylation. | Chemico-biological interactions 20010516 |
| Metabolic capacity and interindividual variation in toxicokinetics of styrene in volunteers. | Human & experimental toxicology 20010501 |
| Mitochondrial dysfunction by gamma-irradiation accompanies the induction of cytochrome P450 2E1 (CYP2E1) in rat liver. | Toxicology 20010321 |
| In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene. | Drug metabolism and disposition: the biological fate of chemicals 20010301 |
| Tissue-specific alterations in the 6-hydroxylation of chlorzoxazone following traumatic brain injury in the rat. | Drug metabolism and disposition: the biological fate of chemicals 20010301 |
| Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds. | The Journal of pharmacology and experimental therapeutics 20010301 |
| Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney. | Toxicological sciences : an official journal of the Society of Toxicology 20010301 |
| Cytochrome P450 expression and related metabolism in human buccal mucosa. | Carcinogenesis 20010301 |
| Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. | Xenobiotica; the fate of foreign compounds in biological systems 20010301 |
| Assessment of CFTR chloride channel openers in intact normal and cystic fibrosis murine epithelia. | British journal of pharmacology 20010201 |
| Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes. | Drug metabolism and disposition: the biological fate of chemicals 20010201 |
| One hundred percent online identity check of pharmaceutical products by near-infrared spectroscopy on the packaging line. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20010101 |
| Characterization of xenobiotic-metabolizing cytochrome P450 (CYP) forms in ringed and grey seals from the Baltic Sea and reference sites. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010101 |
| High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1. | Rapid communications in mass spectrometry : RCM 20010101 |
| EBIO, an agent causing maintained epithelial chloride secretion by co-ordinate actions at both apical and basolateral membranes. | Pflugers Archiv : European journal of physiology 20010101 |
| In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. | British journal of clinical pharmacology 20000401 |
| Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels. | American journal of physiology. Cell physiology 20000301 |
| [Rhabdomyolysis and cholestatic hepatitis under treatment with simvastatin and chlorzoxazone]. | Schweizerische medizinische Wochenschrift 19990403 |
| Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression. | Archives of toxicology 19990201 |
| CYP2E1-dependent benzene toxicity: the role of extrahepatic benzene metabolism. | Archives of toxicology 19990101 |
| [Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage]. | Praxis 19981007 |
| Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype. | Pharmacogenetics 19981001 |
| Cytochrome P450 catalyzed oxidation of monochlorobenzene, 1,2- and 1,4-dichlorobenzene in rat, mouse, and human liver microsomes. | Chemico-biological interactions 19980814 |
| Identification of CYP2E1 in marmoset monkey. | Biochimica et biophysica acta 19980217 |
| Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. | The Journal of pharmacology and experimental therapeutics 19980201 |
| Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone. | Cancer research 19970715 |
| In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians. | The Journal of pharmacology and experimental therapeutics 19961001 |
| Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene. | The Journal of pharmacology and experimental therapeutics 19960101 |
| Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes. | Toxicology and applied pharmacology 19950501 |
| Renal tumorigenicity of 1,1-dichloroethene in mice: the role of male-specific expression of cytochrome P450 2E1 in the renal bioactivation of 1,1-dichloroethene. | Toxicology and applied pharmacology 19950101 |
| Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1. | Molecular pharmacology 19920201 |
| Chlorzoxazone-induced spasmotic torticollis. | JAMA 19811204 |
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