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Home > Indoles and Oxindole > 94452-31-0
94452-31-0 | rac-(4aR,9bS)-2,8-dimethyl-1H,2H,3H,4H,4aH,5H,9bH-pyrido[4,3-b]indole dihydrochloride, cis
CAS No: 94452-31-0 Catalog No: AG01DWWA MDL No:
Product Description
Catalog Number:
AG01DWWA
Chemical Name:
rac-(4aR,9bS)-2,8-dimethyl-1H,2H,3H,4H,4aH,5H,9bH-pyrido[4,3-b]indole dihydrochloride, cis
CAS Number:
94452-31-0
IUPAC Name:
(4aR,9bR)-2,8-dimethyl-1,3,4,4a,5,9b-hexahydropyrido[4,3-b]indole;dihydrochloride
InChI:
InChI=1S/C13H18N2.2ClH/c1-9-3-4-12-10(7-9)11-8-15(2)6-5-13(11)14-12;;/h3-4,7,11,13-14H,5-6,8H2,1-2H3;2*1H/t11-,13+;;/m0../s1
InChI Key:
XWLFAMANDIWUKH-VZCPBZATSA-N
Properties
Complexity:
241
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
274.1g/mol
Formal Charge:
0
Heavy Atom Count:
17
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
275.217g/mol
Monoisotopic Mass:
274.1g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
15.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Free-radical degradation of high-molar-mass hyaluronan induced by ascorbate plus cupric ions: testing of stobadine and its two derivatives in function as antioxidants. | General physiology and biophysics 20120301 |
| Effects of a long-term treatment with an antioxidant pyridoindole on vascular responsiveness in diabetes-induced aging rats. | Current aging science 20110701 |
| [Changes in membrane enzymes in warm liver ischemia]. | Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 20101001 |
| Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose alpha-lipoic acid treatment. | General physiology and biophysics 20100301 |
| Effect of carboxymethylated pyridoindoles on free radical-induced haemolysis of rat erythrocytes in vitro. | Acta biochimica Polonica 20100101 |
| Reduction of oxidative stress in adjuvant arthritis. Comparison of efficacy of two pyridoindoles: stobadine dipalmitate and SMe1.2HCl. | Acta biochimica Polonica 20100101 |
| Glycoxidative and nitrosative stress in kidney of experimental diabetic rats: effects of the prydoindole antioxidant stobadine. | Neuro endocrinology letters 20100101 |
| Warm liver ischemia in experiment and lysosomal markers. | Bratislavske lekarske listy 20090101 |
| Protective effect of antioxidants against sarcoplasmic reticulum (SR) oxidation by Fenton reaction, however without prevention of Ca-pump activity. | Toxicology in vitro : an international journal published in association with BIBRA 20081001 |
| Protective effect of stobadine on NCV in streptozotocin-diabetic rats: augmentation by vitamin E. | General physiology and biophysics 20080601 |
| Stobadine-induced hastening of sensorimotor recovery after focal ischemia/reperfusion is associated with cerebrovascular protection. | Brain research 20080507 |
| Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells. | Cell biology international 20070901 |
| Effect of the pyridoindole antioxidant stobadine on ATP-utilisation by renal Na,K-ATPase in rats with streptozotocin-induced diabetes. | General physiology and biophysics 20070901 |
| Effects of stobadine and vitamin E in diabetes-induced retinal abnormalities: involvement of oxidative stress. | Archives of medical research 20070701 |
| Stobadine protects rat kidney against ischaemia/reperfusion injury. | Clinical and experimental pharmacology & physiology 20070301 |
| Inhibitory effect of stobadine on FMLP-induced chemiluminescence in human whole blood and isolated polymorphonuclear leukocytes. | Luminescence : the journal of biological and chemical luminescence 20070101 |
| Mesenteric ischemia/reperfusion-induced intestinal and vascular damage: effect of stobadine. | Methods and findings in experimental and clinical pharmacology 20070101 |
| Effects of antioxidant stobadine on protein carbonylation, advanced oxidation protein products and reductive capacity of liver in streptozotocin-diabetic rats: role of oxidative/nitrosative stress. | BioFactors (Oxford, England) 20070101 |
| Changes in the function and ultrastructure of vessels in the rat model of multiple low dose streptozotocin-induced diabetes. | General physiology and biophysics 20060901 |
| Ferritin oxidation and proteasomal degradation: protection by antioxidants. | Free radical research 20060701 |
| Effect of the pyridoindole antioxidant stobadine on the cardiac Na(+),K(+)-ATPase in rats with streptozotocin-induced diabetes. | General physiology and biophysics 20060601 |
| Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress. | Cellular and molecular neurobiology 20060101 |
| Influence of antioxidant effect of stobadine derivative in condition of kidney ischemia-reperfusion in a pre-clinical experiment (effect in therapy). | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201 |
| Influence of antioxidant effect of stobadine derivative in condition of kidney ischemia-reperfusion in a pre-clinical experiment (effect in prophylaxis). | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201 |
| Oxidative modification of rat eye lens proteins by peroxyl radicals in vitro: protection by the chain-breaking antioxidants stobadine and Trolox. | Biochimica et biophysica acta 20050630 |
| Reactive oxygen species mediate abnormal contractile response to sympathetic nerve stimulation and noradrenaline in the vas deferens of chronically diabetic rats: effects of in vivo treatment with antioxidants. | Fundamental & clinical pharmacology 20050201 |
| Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. | Molecular vision 20050119 |
| Antioxidants prevented oxidative injury of SR induced by Fe2+/H2O2/ascorbate system but failed to prevent Ca2+-ATPase activity decrease. | BioFactors (Oxford, England) 20050101 |
| Oxidative damage to Ca2+-ATPase sarcoplasmic reticulum by HOCl and protective effect of some antioxidants. | BioFactors (Oxford, England) 20050101 |
| Effect of the pyridoindole antioxidant stobadine on sodium handling of renal Na,K-ATPase in rats with streptozotocin-induced diabetes. | Acta diabetologica 20041201 |
| Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects. | Bioorganic & medicinal chemistry 20040901 |
| The effect of stobadine on the copper-induced peroxidation of egg yolk phosphatidylcholine in multilamellar liposomes. | General physiology and biophysics 20040901 |
| Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. | Central European journal of public health 20040301 |
| Effect of stobadine on leukocyte free radical generation in streptozotocin-diabetic rats: comparison with vitamin E. | Pharmacology 20040101 |
| Stobadine-modulated human neutrophil functional responsiveness: effect on particular and soluble stimulation. | Methods and findings in experimental and clinical pharmacology 20040101 |
| Determination of selective biochemical variables in pregnant and lactating mice after stobadine administration. | Methods and findings in experimental and clinical pharmacology 20031101 |
| Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effects of stobadine and vitamin E. | Neurochemical research 20030601 |
| Standardized extracts of flavonoids increase the viability of PC12 cells treated with hydrogen peroxide: effects on oxidative injury. | Archives of toxicology 20030101 |
| Pyridoindole antioxidant stobadine protected bovine serum albumin against the hydroxyl radical mediated cross-linking in vitro. | Archives of gerontology and geriatrics 20030101 |
| The pyridoindole antioxidant stobadine attenuates albuminuria, enzymuria, kidney lipid peroxidation and matrix collagen cross-linking in streptozotocin-induced diabetic rats. | Methods and findings in experimental and clinical pharmacology 20021101 |
| In vivo treatment with stobadine prevents lipid peroxidation, protein glycation and calcium overload but does not ameliorate Ca2+ -ATPase activity in heart and liver of streptozotocin-diabetic rats: comparison with vitamin E. | Biochimica et biophysica acta 20021009 |
| The pyridoindole antioxidant stobadine attenuates histochemical changes in kidney of streptozotocin-induced diabetic rats. | Acta histochemica 20020101 |
| Dietary supplementation of the pyridoindole antioxidant stobadine reduces vascular impairment in streptozotocin-diabetic rats. | Methods and findings in experimental and clinical pharmacology 20010401 |
| In vitro effect of stobadine on Fe(2+)-induced oxidative stress in rat liver mitochondria. | Bratislavske lekarske listy 20010101 |
| Processes linked to the formation of reactive oxygen species are not necessarily involved in the development of isoproterenol-induced hypertrophy of the heart. The effect of stobadine. | Biomedica biochimica acta 19910101 |
| [Effect of the atypical neuroleptics carbidine and sulpiride on dopamine biosynthesis in the synaptosomes of the nucleus accumbens septi in rats]. | Farmakologiia i toksikologiia 19870101 |
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