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93-35-6 | 7-Hydroxycoumarine
CAS No: 93-35-6 Catalog No: AG003V9R MDL No:MFCD00006878
Product Description
Catalog Number:
AG003V9R
Chemical Name:
7-Hydroxycoumarine
CAS Number:
93-35-6
Molecular Formula:
C9H6O3
Molecular Weight:
162.1421
MDL Number:
MFCD00006878
IUPAC Name:
7-hydroxychromen-2-one
InChI:
InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H
InChI Key:
ORHBXUUXSCNDEV-UHFFFAOYSA-N
SMILES:
Oc1ccc2c(c1)oc(=O)cc2
EC Number:
202-240-3
UNII:
60Z60NTL4G
NSC Number:
19790
Properties
Complexity:
222
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
162.032g/mol
Formal Charge:
0
Heavy Atom Count:
12
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
162.144g/mol
Monoisotopic Mass:
162.032g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
46.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.6
Literature
| Title | Journal |
|---|---|
| Hepatoprotective effect of 7-Hydroxycoumarin against Methyl glyoxal toxicity via activation of Nrf2. | Chemico-biological interactions 20171001 |
| Protective Effects of 7-Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol-Induced Myocardial Infarction in Rats. | Journal of biochemical and molecular toxicology 20160301 |
| Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice. | Chemico-biological interactions 20140605 |
| Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris. | Fitoterapia 20140601 |
| 7-Hydroxycoumarin modulates the oxidative metabolism, degranulation and microbial killing of human neutrophils. | Chemico-biological interactions 20131025 |
| Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions. | Journal of applied toxicology : JAT 20130201 |
| Synthesis and biological evaluation of coumarin derivatives as inhibitors of Mycobacterium bovis (BCG). | Chemical biology & drug design 20121201 |
| Effect of colloidal silica on the spectral behaviour of 7-hydroxycoumarin in aqueous medium. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101 |
| Mechanism of anti-inflammatory activity of umbelliferone 6-carboxylic acid isolated from Angelica decursiva. | Journal of ethnopharmacology 20121031 |
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| Uricosuric and nephroprotective properties of Ramulus Mori ethanol extract in hyperuricemic mice. | Journal of ethnopharmacology 20121011 |
| Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases. | Neurotoxicology 20121001 |
| Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. | Molecules (Basel, Switzerland) 20120919 |
| Synthesis and antibacterial activities of novel 4-hydroxy-7-hydroxy- and 3-carboxycoumarin derivatives. | Molecules (Basel, Switzerland) 20120910 |
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| Quencher-free molecular beacon tethering 7-hydroxycoumarin detects targets through protonation/deprotonation. | Bioorganic & medicinal chemistry 20120715 |
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| Implementing best practices and validation of cryopreservation techniques for microorganisms. | TheScientificWorldJournal 20120101 |
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| Inhibitory effects of 6-alkoxycoumarin and 7-alkoxycoumarin derivatives on lipopolysaccharide/interferon γ-stimulated nitric oxide production in RAW264 cells. | Biological & pharmaceutical bulletin 20120101 |
| Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors. | Journal of medicinal chemistry 20111222 |
| Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of β-hematin formation. | Journal of pharmaceutical and biomedical analysis 20111215 |
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| Oxygen therapy improves energy metabolism in focal cerebral ischemia. | Brain research 20110930 |
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| 1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase. | Drug metabolism and disposition: the biological fate of chemicals 20110901 |
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| Umbelliferone and esculetin: inhibitors or substrates for polyphenol oxidases? | Biological & pharmaceutical bulletin 20081201 |
| Synthesis and free radical scavenging activity of some new spiropyranocoumarins. | Bioorganic & medicinal chemistry letters 20081101 |
| 7-hydroxycoumarin-hemicyanine hybrids: a new class of far-red emitting fluorogenic dyes. | Organic letters 20081002 |
| [Studies on chemical constituents from Elaeocarpus sylvestris]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081001 |
| Protective effects of dietary chamomile tea on diabetic complications. | Journal of agricultural and food chemistry 20080910 |
| Synthesis and properties of umbelliferone-nitroxide radical hybrid compounds as fluorescence and spin-label probes. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080901 |
| Studies of coumarins from the Chinese drug Qianhu, XXVII: structure of a new simple coumarin glycoside from Bai-Hua Qianhu, Peucedanum praeruptorum. | Chemical & pharmaceutical bulletin 20080901 |
| [Study on fluorescent properties of coumarin derivatives and determination of trace iron]. | Guang pu xue yu guang pu fen xi = Guang pu 20080901 |
| Latent fluorophores based on a self-immolative linker strategy and suitable for protease sensing. | Bioconjugate chemistry 20080801 |
| Evaluation of natural substances from Evolvulus alsinoides L. with the purpose of determining their antioxidant potency. | Journal of enzyme inhibition and medicinal chemistry 20080801 |
| [Studies on chemical constituents of Peucedanum delavayi]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801 |
| Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle. | Journal of experimental botany 20080701 |
| Analysis of ciprofloxacin by a simple high-performance liquid chromatography method. | Journal of chromatographic science 20080701 |
| A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening. | Assay and drug development technologies 20080601 |
| [Studies on chemical constituents of Saussurea laniceps]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501 |
| [Study on steroids of Cacalia tangutica]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501 |
| [Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080401 |
| Optimizing glycosyltransferase specificity via 'hot spot' saturation mutagenesis presents a catalyst for novobiocin glycorandomization. | Chemistry & biology 20080401 |
| [Studies on chemical constituents of the roots of Angelica pubescens]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080401 |
| Separation and identification of botanical insecticide 7-hydroxycoumarin and its biological activity against Aphis craccivora and Culex pipiens pallens. | Natural product research 20080310 |
| Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae. | Bioorganic & medicinal chemistry 20080301 |
| Artemisinin and CYP2A6 activity in healthy subjects. | European journal of clinical pharmacology 20080301 |
| Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships. | Journal of medicinal chemistry 20080227 |
| Rapid probing of photocatalytic activity on titania-based self-cleaning materials using 7-hydroxycoumarin fluorescent probe. | Analytica chimica acta 20080204 |
| Development of micromarkers with various photoluminescence colors as tracers for shadowing pursuits. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080201 |
| Substrate arrays for fluorescence-based enzyme fingerprinting and high-throughput screening. | Annals of the New York Academy of Sciences 20080101 |
| Comparison of the effect of 4-hydroxycoumarin and umbelliferone on the phase transition of dipalmitoylphosphatidylcholine (DPPC) bilayers. | Pharmacological reports : PR 20080101 |
| TAC-scaffolded tripeptides as artificial hydrolytic receptors: a combinatorial approach toward esterase mimics. | Journal of combinatorial chemistry 20080101 |
| A review of coumarin derivatives in pharmacotherapy of breast cancer. | Current medicinal chemistry 20080101 |
| Biosynthetic origin of the 1-oxygen of umbelliferone in the root tissue of sweet potato. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101 |
| In vitro evaluation of hepatic and extra-hepatic metabolism of coumarins using rat subcellular fractions: correlation of in vitro clearance with in vivo data. | Drug metabolism and drug interactions 20080101 |
| A novel fluorogenic coumarin substrate for monitoring acid phosphatase activity at low pH environment. | Current chemical genomics 20080101 |
| [Chemical constituents from roots of Ferula sinkiangensis]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071101 |
| Synthesis and anti-inflammatory activity of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its ester derivatives. | Bioorganic & medicinal chemistry letters 20071015 |
| Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida. | Journal of ethnopharmacology 20070815 |
| Rapid densitometric method for simultaneous analysis of umbelliferone, psoralen, and eugenol in herbal raw materials using HPTLC. | Journal of separation science 20070801 |
| Effect of umbelliferone on tail tendon collagen and haemostatic function in streptozotocin-diabetic rats. | Basic & clinical pharmacology & toxicology 20070801 |
| Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae). | Journal of ethnopharmacology 20070725 |
| Protective effect of Umbelliferone on membranous fatty acid composition in streptozotocin-induced diabetic rats. | European journal of pharmacology 20070702 |
| Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity constants of various hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition. | European journal of medicinal chemistry 20070701 |
| Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture. | Planta medica 20070701 |
| Capillary electrochromatography of selected phenolic compounds of Chamomilla recutita. | Journal of chromatography. A 20070622 |
| The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy. | Blood 20070601 |
| Induction of phase I and II drug metabolism in rat small intestine and colon in vitro. | Drug metabolism and disposition: the biological fate of chemicals 20070601 |
| Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. | Fundamental & clinical pharmacology 20070601 |
| Evaluation of the content and stability of the constituents of mother tinctures and tinctures: the case of Crataegus oxyacantha L. and Hieracium pilosella L. | Journal of pharmaceutical and biomedical analysis 20070509 |
| A review of the hepatotoxic plant Lantana camara. | Critical reviews in toxicology 20070501 |
| Determination of six bioactive components of Saussurea katochaete by capillary electrophoresis. | Biomedical chromatography : BMC 20070401 |
| Fluorogenic substrates for lipases, esterases, and acylases using a TIM-mechanism for signal release. | Biotechnology journal 20070201 |
| CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients? | Pharmacogenomics 20070201 |
| Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis. | The Journal of biological chemistry 20070105 |
| In silico prediction of pregnane X receptor activators by machine learning approaches. | Molecular pharmacology 20070101 |
| Enhanced resistance to Salmonella enterica serovar Typhimurium infection in mice after coumarin treatment. | Microbes and infection 20070101 |
| [Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070101 |
| Antitumor and immunomodulatory effect of coumarin and 7-hydroxycoumarin against Sarcoma 180 in mice. | Journal of experimental therapeutics & oncology 20070101 |
| [Studies on the chemical constituents of the aerial parts of Seseli mairei]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070101 |
| Influence of umbelliferone on membrane-bound ATPases in streptozotocin-induced diabetic rats. | Pharmacological reports : PR 20070101 |
| Phytochemical and antinociceptive properties of Matayba elaeagnoides Radlk. barks. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101 |
| New Samarium(III), Gadolinium(III), and Dysprosium(III) Complexes of Coumarin-3-Carboxylic Acid as Antiproliferative Agents. | Metal-based drugs 20070101 |
| Influence of umbelliferone on glycoprotein components in diabetic rats. | Toxicology mechanisms and methods 20070101 |
| Tetrapleura tetraptera: molluscicidal activity and chemical constituents. | African journal of traditional, complementary, and alternative medicines : AJTCAM 20070101 |
| Inhibition of MMP-2 secretion from brain tumor cells suggests chemopreventive properties of a furanocoumarin glycoside and of chalcones isolated from the twigs of Dorstenia turbinata. | Phytochemistry 20061201 |
| In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais. | Drug metabolism and pharmacokinetics 20061201 |
| Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus. | Archives of pharmacal research 20061201 |
| [Studies on chemical constituents from fruits of Paliurus ramosissimus]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201 |
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | Journal of molecular graphics & modelling 20061101 |
| OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. | PLoS medicine 20061101 |
| Simultaneous determination of urinary metabolites of methoxypsoralens in human and Umbelliferae medicines by high-performance liquid chromatography. | Journal of chromatographic science 20060901 |
| [Tissue-like cultures of rat hepatocytes in study of phase I and phase II drug metabolism]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060901 |
| Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. | Archives of pharmacal research 20060801 |
| Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers. | Drug metabolism and disposition: the biological fate of chemicals 20060701 |
| Interface of AOT/Brij mixed reverse micellar systems: conductometric and spectrophotometric investigations. | Journal of colloid and interface science 20060615 |
| Antioxidant role of Umbelliferone in STZ-diabetic rats. | Life sciences 20060613 |
| Molluscicidal activity of Ferula asafoetida, Syzygium aromaticum and Carum carvi and their active components against the snail Lymnaea acuminata. | Chemosphere 20060601 |
| Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisations. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction. | Drug metabolism and disposition: the biological fate of chemicals 20060401 |
| Relationships between chemical composition, physical properties and transfection efficiency of polysaccharide-spermine conjugates. | Biomaterials 20060301 |
| Accumulation of coumarins in Arabidopsis thaliana. | Phytochemistry 20060201 |
| Use of the land snail Helix aspersa as sentinel organism for monitoring ecotoxicologic effects of urban pollution: an integrated approach. | Environmental health perspectives 20060101 |
| [A new dicoumarin from stem bark of Wikstroemia indica]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060101 |
| Inter-species comparison of 7-hydroxycoumarin glucuronidation and sulfation in liver S9 fractions. | In vitro cellular & developmental biology. Animal 20060101 |
| Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation. | Methods in molecular biology (Clifton, N.J.) 20060101 |
| Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. | Methods in molecular biology (Clifton, N.J.) 20060101 |
| Electrochemical profiles of Herba Saussureae Involucratae by capillary electrophoresis with electrochemical detection. | Phytochemical analysis : PCA 20060101 |
| Gitksan medicinal plants--cultural choice and efficacy. | Journal of ethnobiology and ethnomedicine 20060101 |
| Rapid analysis of coumarins using surface plasmon resonance. | Journal of AOAC International 20060101 |
| Chemical constituents of Selinum cryptotaenium. | Journal of Asian natural products research 20060101 |
| Ethnopharmacological evaluation of radal (leaves of Lomatia hirsuta) and isolation of 2-methoxyjuglone. | BMC complementary and alternative medicine 20060101 |
| Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats. | Journal of medicinal food 20060101 |
| Synthesis, characterization, and cytotoxic activity of new lanthanum(III) complexes of bis-coumarins. | Bioinorganic chemistry and applications 20060101 |
| Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors. | Bioinorganic chemistry and applications 20060101 |
| A direct fluorometric assay for tissue transglutaminase. | Analytical biochemistry 20051215 |
| Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6. | Biochemical and biophysical research communications 20051209 |
| Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies. | Drug metabolism and disposition: the biological fate of chemicals 20051101 |
| Synthesis and antiinflammatory activity of coumarin derivatives. | Journal of medicinal chemistry 20051006 |
| New diorganotin(IV) derivatives of 7-hydroxycoumarin (umbelliferone) and their adducts with 1,10-phenanthroline. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051001 |
| Activation of mitogen activated protein kinase pathways and melanogenesis by novel nitro-derivatives of 7-hydroxycomarin in human malignant melanoma cells. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050901 |
| An odorant-binding protein facilitates odorant transfer from air to hydrophilic surroundings in the blowfly. | Chemical senses 20050901 |
| Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin. | Cancer chemotherapy and pharmacology 20050801 |
| Effects of coumarin and 7OH-coumarin on bcl-2 and Bax expression in two human lung cancer cell lines in vitro. | Cell biology international 20050801 |
| Accumulation of biologically active furanocoumarins in agitated cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams. | Die Pharmazie 20050801 |
| [Interaction between bovine serum albumin and umbelliferone with/without metal ions of Cu2+ or Zn2+]. | Guang pu xue yu guang pu fen xi = Guang pu 20050801 |
| Antihyperlipidemic and antidiabetic effects of umbelliferone in streptozotocin diabetic rats. | The Yale journal of biology and medicine 20050701 |
| Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases. | Analytical biochemistry 20050601 |
| Sulfation in dog. | Current drug metabolism 20050601 |
| Post-stress metabolism involves umbelliferone production in anthocyanin-producing and nonproducing cells of Glehnia littoralis suspension cultures. | Journal of plant physiology 20050601 |
| Plant-derived anti-inflammatory compounds affect MIF tautomerase activity. | International immunopharmacology 20050501 |
| In vitro free radical and ONOO- scavengers from Sophora flavescens. | Archives of pharmacal research 20050501 |
| Effects of iron on Vitamin C/copper-induced hydroxyl radical generation in bicarbonate-rich water. | Free radical research 20050501 |
| Impact of umbelliferone on erythrocyte redox status in STZ-diabetic rats. | The Yale journal of biology and medicine 20050501 |
| Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6. | The Journal of biological chemistry 20050401 |
| Design and development of a fluorescent probe for monitoring hydrogen peroxide using photoinduced electron transfer. | Bioorganic & medicinal chemistry 20050215 |
| Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice. | Cancer chemotherapy and pharmacology 20050201 |
| The influence of brain death on liver function. | Liver international : official journal of the International Association for the Study of the Liver 20050201 |
| Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8. | Drug metabolism and disposition: the biological fate of chemicals 20050101 |
| A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies. | Journal of pharmacological and toxicological methods 20050101 |
| [Determination of scopoletin and umbelliferone contents in Saussurea medusa Maxim by high-performance liquid chromatography]. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050101 |
| Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20050101 |
| Accumulation of biologically active furanocoumarins in Ruta graveolens ssp. divaricata (Tenore) Gams in vitro culture. | Die Pharmazie 20050101 |
| Glucuronidation and sulfation of 7-hydroxycoumarin in liver matrices from human, dog, monkey, rat, and mouse. | In vitro cellular & developmental biology. Animal 20050101 |
| Functional characterization of single nucleotide polymorphisms with amino acid substitution in CYP1A2, CYP2A6, and CYP2B6 found in the Japanese population. | Drug metabolism and pharmacokinetics 20041201 |
| Determination of CC-5013, an analogue of thalidomide, in human plasma by liquid chromatography-mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041125 |
| Evidence for concurrent effects of exposure to environmental cadmium and lead on hepatic CYP2A6 phenotype and renal function biomarkers in nonsmokers. | Environmental health perspectives 20041101 |
| A study of the role of cell cycle events mediating the action of coumarin derivatives in human malignant melanoma cells. | Cancer letters 20041008 |
| Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats. | British journal of cancer 20041004 |
| Novel squalene-hopene cyclase inhibitors derived from hydroxycoumarins and hydroxyacetophenones. | Chemical & pharmaceutical bulletin 20041001 |
| Glucosylation of phenolic compounds by Pharbitis nil hairy roots: I. Glucosylation of coumarin and flavone derivatives. | Bioscience, biotechnology, and biochemistry 20041001 |
| Umbelliferone released from hairy root cultures of Pharbitis nil treated with copper sulfate and its subsequent glucosylation. | Bioscience, biotechnology, and biochemistry 20040901 |
| Metabolic and structural viability of precision-cut rat lung slices in culture. | Xenobiotica; the fate of foreign compounds in biological systems 20040801 |
| Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation. | Archives of biochemistry and biophysics 20040715 |
| Effect of bisphenol A on drug metabolising enzymes in rat hepatic microsomes and precision-cut rat liver slices. | Archives of toxicology 20040701 |
| Validated assays for human cytochrome P450 activities. | Drug metabolism and disposition: the biological fate of chemicals 20040601 |
| Aldehyde detection by chromogenic/fluorogenic oxime bond fragmentation. | Organic & biomolecular chemistry 20040521 |
| Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase. | Bioorganic & medicinal chemistry letters 20040503 |
| Functional co-expression of xenobiotic metabolizing enzymes, rat cytochrome P450 1A1 and UDP-glucuronosyltransferase 1A6, in yeast microsomes. | Biochimica et biophysica acta 20040503 |
| An active and water-soluble truncation mutant of the human UDP-glucuronosyltransferase 1A9. | Molecular pharmacology 20040401 |
| Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects. | Toxicology letters 20040321 |
| Investigation of intracellular signalling events mediating the mechanism of action of 7-hydroxycoumarin and 6-nitro-7-hdroxycoumarin in human renal cells. | Cancer letters 20040308 |
| Anthrone and oxanthrone C-glycosides from Picramnia latifolia collected in Peru. | Journal of natural products 20040301 |
| Apoptosis and cell cycle disturbances induced by coumarin and 7-hydroxycoumarin on human lung carcinoma cell lines. | Lung cancer (Amsterdam, Netherlands) 20040301 |
| [Isolation and structure identification of the chemical constituents from pine needles of Pinus massoniana Lamb]. | Yao xue xue bao = Acta pharmaceutica Sinica 20040301 |
| Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon. | Xenobiotica; the fate of foreign compounds in biological systems 20040301 |
| Phase I and II enzyme characterization of two sources of HepG2 cell lines. | Xenobiotica; the fate of foreign compounds in biological systems 20040301 |
| Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation. | Toxicology in vitro : an international journal published in association with BIBRA 20040201 |
| Absolute stereochemistry of dihydrofuroangelicins bearing C-8 substituted double bonds: a combined chemical/exciton chirality protocol. | Organic & biomolecular chemistry 20040107 |
| [Isolation and structural identification of chemical constituents from Selaginella tamariscina (Beauv.) Spring]. | Yao xue xue bao = Acta pharmaceutica Sinica 20040101 |
| Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer. | Current pharmaceutical design 20040101 |
| Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations. | Xenobiotica; the fate of foreign compounds in biological systems 20040101 |
| Quantitative changes of secondary metabolites of Matricaria chamomilla by abiotic stress. | Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101 |
| Genetics of tobacco use. | Tobacco induced diseases 20040101 |
| Study of inhibition of CYP2A6 by some drugs derived from quinoline. | The Journal of pharmacy and pharmacology 20031201 |
| 'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies. | Xenobiotica; the fate of foreign compounds in biological systems 20031201 |
| Modulation of mitogen-activated protein kinases by 6-nitro-7-hydroxycoumarin mediates apoptosis in renal carcinoma cells. | European journal of pharmacology 20031128 |
| The first fluorogenic assay for detecting a Baeyer-Villigerase activity in microbial cells. | Organic & biomolecular chemistry 20031021 |
| Coumarins from Peucedanum wulongense. | Journal of Asian natural products research 20030901 |
| Application of capillary electrophoresis with pH-mediated sample stacking to analysis of coumarin metabolites in microsomal incubations. | Journal of pharmaceutical and biomedical analysis 20030808 |
| A low background high-throughput screening (HTS) fluorescence assay for lipases and esterases using acyloxymethylethers of umbelliferone. | Bioorganic & medicinal chemistry letters 20030707 |
| Interactions of a series of novel spiropyranocoumarin derivatives with reactive oxygen species. | The Journal of pharmacy and pharmacology 20030701 |
| Spectrofluorimetric analysis of 7-hydroxycoumarin binding to bovine phenol sulfotransferase. | Biochimica et biophysica acta 20030530 |
| Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives. | Journal of natural products 20030501 |
| Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin. | International journal of clinical pharmacology and therapeutics 20030401 |
| Fluorogenic stereochemical probes for transaldolases. | Chemistry (Weinheim an der Bergstrasse, Germany) 20030217 |
| Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. | Journal of agricultural and food chemistry 20030212 |
| Comparative metabolism and kinetics of coumarin in mice and rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030201 |
| Protection of coumarins against linoleic acid hydroperoxide-induced cytotoxicity. | Chemico-biological interactions 20030106 |
| Is neuroprotective efficacy of nNOS inhibitor 7-NI dependent on ischemic intracellular pH? | American journal of physiology. Heart and circulatory physiology 20030101 |
| CYP2A13-catalysed coumarin metabolism: comparison with CYP2A5 and CYP2A6. | Xenobiotica; the fate of foreign compounds in biological systems 20030101 |
| Chemical constituents from the Hydrangea chinensis. | Archives of pharmacal research 20030101 |
| Potential functional foods in the traditional Maori diet. | Mutation research 20030101 |
| Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel. | In vitro cellular & developmental biology. Animal 20030101 |
| Structural requirements of hydroxylated coumarins for in vitro anti-Helicobacter pylori activity. | In vivo (Athens, Greece) 20030101 |
| Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125 |
| Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. | Journal of natural products 20021101 |
| Characterization of testosterone metabolism and 7-hydroxycoumarin conjugation by rat and human liver slices after storage in liquid nitrogen for 1 h up to 6 months. | Xenobiotica; the fate of foreign compounds in biological systems 20021101 |
| [Prediction of eluotropic sequence of solutes in countercurrent chromatography]. | Se pu = Chinese journal of chromatography 20021101 |
| Inhibition of bovine phenol sulfotransferase (bSULT1A1) by CoA thioesters. Evidence for positive cooperativity and inhibition by interaction with both the nucleotide and phenol binding sites. | The Journal of biological chemistry 20021018 |
| A high-performance liquid chromatography method using ultraviolet detection for the quantitation of flavopiridol from human plasma. | Biomedical chromatography : BMC 20020901 |
| Phenotypic polymorphism of CYP2A6 activity in a Chinese population. | European journal of clinical pharmacology 20020801 |
| [Studies on the chemical constituents from the roots and rhizomes of Gerbera piloselloides]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020801 |
| Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices. | Xenobiotica; the fate of foreign compounds in biological systems 20020501 |
| Superoxide organic chemistry within the liposomal bilayer, part II: a correlation between location and chemistry. | Free radical biology & medicine 20020401 |
| Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females. | Pharmacogenetics 20020401 |
| Some coumarins and triphenylethene derivatives as inhibitors of human testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD type 3): further studies with tamoxifen on the rat testes microsomal enzyme. | Journal of enzyme inhibition and medicinal chemistry 20020401 |
| A novel ISFET-type biosensor based on P450 monooxygenases. | Biosensors & bioelectronics 20020301 |
| Characterization by liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry of two coupled oxidative-conjugative metabolic pathways for 7-ethoxycoumarin in human liver microsomes treated with alamethicin. | Drug metabolism and disposition: the biological fate of chemicals 20020301 |
| A rapid fluorescence-based assay for detecting soluble methane monooxygenase. | Applied microbiology and biotechnology 20020201 |
| Inhibitory effects of phenylpropanoid metabolites on copper-induced protein oxidative modification of mice brain homogenate, in vitro. | Biological trace element research 20020201 |
| An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles. | Biochemical and biophysical research communications 20020111 |
| Induction of 4-hydroxycinnamate decarboxylase in Klebsiella oxytoca cells exposed to substrates and non-substrate 4-hydroxycinnamate analogs. | Bioscience, biotechnology, and biochemistry 20011201 |
| [Constituents of Liguliria vellerea (Franch.) Hand-Mazz]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20011201 |
| Crystal structure of gamma-chymotrypsin in complex with 7-hydroxycoumarin. | Journal of molecular biology 20011130 |
| Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products. | Archives of biochemistry and biophysics 20011101 |
| Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin. | Lung cancer (Amsterdam, Netherlands) 20011101 |
| [Nonpolar components of the leaves of Philadelphus coronarius L]. | Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20011101 |
| Characterization of peroxidase-mediated chlorophyll bleaching in strawberry fruit. | Phytochemistry 20011001 |
| Tissue slices revisited: evaluation and development of a short-term incubation for integrated drug metabolism. | Drug metabolism and disposition: the biological fate of chemicals 20011001 |
| The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins. | Archives of biochemistry and biophysics 20011001 |
| Study of the in vitro cytotoxic potential of natural and synthetic coumarin derivatives using human normal and neoplastic skin cell lines. | Melanoma research 20011001 |
| A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives. | Bioorganic & medicinal chemistry letters 20010903 |
| [Studies on chemical constituents of Stellera chamejasma L]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010701 |
| Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion. | Drug metabolism and disposition: the biological fate of chemicals 20010601 |
| Consumption of watercress fails to alter coumarin metabolism in humans. | Drug metabolism and disposition: the biological fate of chemicals 20010601 |
| Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships. | Journal of natural products 20010501 |
| Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur. | Japanese journal of cancer research : Gann 20010501 |
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