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918311-87-2 | UCL 2077
CAS No: 918311-87-2 Catalog No: AG006GG1 MDL No:
Product Description
Catalog Number:
AG006GG1
Chemical Name:
UCL 2077
CAS Number:
918311-87-2
Molecular Formula:
C25H22N2
Molecular Weight:
350.4556
IUPAC Name:
1,1,1-triphenyl-N-(pyridin-3-ylmethyl)methanamine
InChI:
InChI=1S/C25H22N2/c1-4-12-22(13-5-1)25(23-14-6-2-7-15-23,24-16-8-3-9-17-24)27-20-21-11-10-18-26-19-21/h1-19,27H,20H2
InChI Key:
PQFNWDHABGBCHB-UHFFFAOYSA-N
SMILES:
c1ccc(cc1)C(c1ccccc1)(c1ccccc1)NCc1cccnc1
Properties
Complexity:
371
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
350.178g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
350.465g/mol
Monoisotopic Mass:
350.178g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
24.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5.1
Literature
| Title | Journal |
|---|---|
| Inhibition of the slow afterhyperpolarization restores the classical spike timing-dependent plasticity rule obeyed in layer 2/3 pyramidal cells of the prefrontal cortex. | Journal of neurophysiology 20120101 |
| A mathematical model of adult GnRH neurons in mouse brain and its bifurcation analysis. | Journal of theoretical biology 20110507 |
| The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. | Molecular pharmacology 20101201 |
| Two slow calcium-activated afterhyperpolarization currents control burst firing dynamics in gonadotropin-releasing hormone neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100505 |
| Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain. | Cellular and molecular life sciences : CMLS 20081001 |
| Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). | Molecular pharmacology 20061101 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
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