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91-21-4 | 1,2,3,4-Tetrahydroisoquinoline
CAS No: 91-21-4 Catalog No: AG003DA8 MDL No:MFCD00006896
Product Description
Catalog Number:
AG003DA8
Chemical Name:
1,2,3,4-Tetrahydroisoquinoline
CAS Number:
91-21-4
Molecular Formula:
C9H11N
Molecular Weight:
133.1903
MDL Number:
MFCD00006896
IUPAC Name:
1,2,3,4-tetrahydroisoquinoline
InChI:
InChI=1S/C9H11N/c1-2-4-9-7-10-6-5-8(9)3-1/h1-4,10H,5-7H2
InChI Key:
UWYZHKAOTLEWKK-UHFFFAOYSA-N
SMILES:
N1CCc2c(C1)cccc2
EC Number:
202-050-0
UNII:
56W89FBX3E
NSC Number:
15312
Properties
Complexity:
111
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
133.089g/mol
Formal Charge:
0
Heavy Atom Count:
10
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
133.194g/mol
Monoisotopic Mass:
133.089g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
12A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.6
Literature
| Title | Journal |
|---|---|
| The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer. | Proceedings of the National Academy of Sciences of the United States of America 20140902 |
| Bioactive alkaloid extracts from Narcissus broussonetii: mass spectral studies. | Journal of pharmaceutical and biomedical analysis 20121101 |
| Regiochemistry of the condensation of 2-aroyl-cyclohexanones and 2-cyanoacetamide: 13C-labeling studies and semiempirical MO calculations. | The Journal of organic chemistry 20120907 |
| Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold. | European journal of medicinal chemistry 20120801 |
| (S)-4-tert-Butyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole. | Acta crystallographica. Section E, Structure reports online 20120801 |
| Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists. | Bioorganic & medicinal chemistry letters 20120601 |
| First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours. | British journal of cancer 20120410 |
| MCR synthesis of praziquantel derivatives. | Chemical biology & drug design 20120401 |
| Pictet-Spenglerase involved in tetrahydroisoquinoline antibiotic biosynthesis. | Current opinion in chemical biology 20120401 |
| Concise route to 3-arylisoquinoline skeleton by Lewis acid catalyzed C(sp3)-H bond functionalization and its application to formal synthesis of (±)-tetrahydropalmatine. | Organic letters 20120316 |
| Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy. | ACS combinatorial science 20120312 |
| (S)-Benzyl 3-phenyl-carbamoyl-1,2,3,4-tetra-hydro-isoquinoline-2-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20120301 |
| Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists. | Journal of medicinal chemistry 20120223 |
| Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis. | The Journal of biological chemistry 20120210 |
| Effect of trabectedin on the QT interval in patients with advanced solid tumor malignancies. | Cancer chemotherapy and pharmacology 20120201 |
| Monitoring on-chip Pictet-Spengler reactions by integrated analytical separation and label-free time-resolved fluorescence. | Chemistry (Weinheim an der Bergstrasse, Germany) 20120123 |
| Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy. | ACS combinatorial science 20120109 |
| (S)-4-Phenyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole. | Acta crystallographica. Section E, Structure reports online 20120101 |
| The role of circulating serotonin in the development of chronic obstructive pulmonary disease. | PloS one 20120101 |
| Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. | PloS one 20120101 |
| Genome expression profile analysis of the immature maize embryo during dedifferentiation. | PloS one 20120101 |
| Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids. | Cancer cell international 20120101 |
| A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma. | PloS one 20120101 |
| Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats. | PloS one 20120101 |
| Trabectedin as a new chemotherapy option in the treatment of relapsed platinum sensitive ovarian cancer. | Current pharmaceutical design 20120101 |
| Acceleration of anaerobic cysteine transformations to sulfane sulfur consequent to γ-glutamyl transpeptidase inhibition. | TheScientificWorldJournal 20120101 |
| Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities. | Pharmacognosy reviews 20120101 |
| A possible novel anti-inflammatory mechanism for the pharmacological prolyl hydroxylase inhibitor 3,4-dihydroxybenzoate: implications for use as a therapeutic for Parkinson's disease. | Parkinson's disease 20120101 |
| The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: a novel function for a nonribosomal peptide synthetase. | Methods in enzymology 20120101 |
| Electrochemical synthesis and chemistry of chiral 1-cyanotetrahydroisoquinolines. An approach to the asymmetric syntheses of the alkaloid (-)-crispine a and its natural (+)-antipode. | The Journal of organic chemistry 20111202 |
| Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives. | Anticancer research 20111201 |
| (1R,3S)-N-Benzhydryl-2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carbothio-amide. | Acta crystallographica. Section E, Structure reports online 20111201 |
| CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling. | Immune network 20111201 |
| Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. | ACS chemical biology 20111118 |
| Direct functionalization of (un)protected tetrahydroisoquinoline and isochroman under iron and copper catalysis: two metals, two mechanisms. | The Journal of organic chemistry 20111104 |
| A highly efficient and enantioselective access to tetrahydroisoquinoline alkaloids: asymmetric hydrogenation with an iridium catalyst. | Angewandte Chemie (International ed. in English) 20111104 |
| Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives. | Bioorganic & medicinal chemistry 20111101 |
| Expedient entry to the piperazinohydroisoquinoline ring system using a sequential Ugi/Pictet-Spengler/reductive methylation reaction protocol. | Chemical communications (Cambridge, England) 20111014 |
| Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents. | Bioorganic & medicinal chemistry letters 20111001 |
| 2-[(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]-4-phenyl-1,3-thia-zole. | Acta crystallographica. Section E, Structure reports online 20111001 |
| 2-(2-Hy-droxy-phen-yl)-3,4-dihydro-iso-quinolin-1(2H)-one. | Acta crystallographica. Section E, Structure reports online 20111001 |
| 2-(4-Bromo-phen-yl)-3,4-dihydro-isoquinolin-2-ium thio-cyanate hemihydrate. | Acta crystallographica. Section E, Structure reports online 20111001 |
| Identification of novel allosteric modulators for the G-protein coupled US28 receptor of human cytomegalovirus. | Bioorganic & medicinal chemistry letters 20110915 |
| Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds. | Organic letters 20110902 |
| XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinking-mimetic alkaloids. | Chemistry & biology 20110826 |
| Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids. | The Journal of organic chemistry 20110819 |
| Eosin Y catalyzed visible light oxidative C-C and C-P bond formation. | Organic letters 20110805 |
| Both stereoselective (R)- and (S)-1-Methyl-1,2,3,4-tetrahydroisoquinoline enantiomers protect striatal terminals against rotenone-induced suppression of dopamine release. | Neurotoxicity research 20110801 |
| Modulation of leukotriene D4 attenuates the development of seizures in mice. | Prostaglandins, leukotrienes, and essential fatty acids 20110801 |
| 2-(4-Iodo-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-1-carbonitrile. | Acta crystallographica. Section E, Structure reports online 20110801 |
| Structure-based design of novel boronic acid-based inhibitors of autotaxin. | Journal of medicinal chemistry 20110714 |
| Comparison of enveloping distribution sampling and thermodynamic integration to calculate binding free energies of phenylethanolamine N-methyltransferase inhibitors. | The Journal of chemical physics 20110714 |
| Dietary inhibitors of monoamine oxidase A. | Journal of neural transmission (Vienna, Austria : 1996) 20110701 |
| Asymmetric total synthesis of (-)-saframycin A from L-tyrosine. | The Journal of organic chemistry 20110701 |
| Ortho-rhom-bic polymorph of (6,7-dimeth-oxy-1,2,3,4-tetra-hydro-isoquinolin-1-yl)methanol. | Acta crystallographica. Section E, Structure reports online 20110701 |
| Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2). | Bioorganic & medicinal chemistry letters 20110615 |
| Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism. | Xenobiotica; the fate of foreign compounds in biological systems 20110601 |
| 6,7-Dimeth-oxy-3-meth-oxy-carbonyl-1-(2-meth-oxy-phen-yl)-3,4-dihydro-isoquinoline 2-oxide. | Acta crystallographica. Section E, Structure reports online 20110601 |
| (1S,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20110601 |
| 2-(2-Iodo-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-1-carbonitrile. | Acta crystallographica. Section E, Structure reports online 20110601 |
| (1S,3S)-Methyl 6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20110601 |
| Chiral capillary electrophoresis-mass spectrometry of tetrahydroisoquinoline-derived neurotoxins: observation of complex stereoisomerism. | Journal of chromatography. A 20110520 |
| 1,5-Substituted nipecotic amides: selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability. | Bioorganic & medicinal chemistry letters 20110515 |
| (S)-2-Benzyl-N-(2,6-diisopropyl-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide. | Acta crystallographica. Section E, Structure reports online 20110501 |
| Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities. | Journal of medicinal chemistry 20110428 |
| A synthetic route to highly substituted 1,2,3,4-tetrahydroisoquinolines via Yb(OTf)3 -catalyzed diastereoselective ring opening of bridged oxazolidines: asymmetric synthesis of 2-azapodophyllotoxin. | Chemistry (Weinheim an der Bergstrasse, Germany) 20110418 |
| Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach. | Journal of medicinal chemistry 20110414 |
| Methyl 1-cyclo-hexyl-6,7-dimeth-oxy-3,4-dihydro-isoquinoline-3-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20110401 |
| Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids. | Chemical communications (Cambridge, England) 20110321 |
| The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs. | Bioorganic & medicinal chemistry letters 20110315 |
| Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists. | Bioorganic & medicinal chemistry letters 20110301 |
| Optically active diaryl tetrahydroisoquinoline derivatives. | Acta crystallographica. Section C, Crystal structure communications 20110301 |
| [Design, synthesis, and PPARalpha/gamma agonistic activity of novel tetrahydroisoquinoline derivatives]. | Yao xue xue bao = Acta pharmaceutica Sinica 20110301 |
| Synthesis of anisotropic CdS nanostructures via a single-source route. | Journal of nanoscience and nanotechnology 20110201 |
| Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists. | Bioorganic & medicinal chemistry letters 20110101 |
| Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. | Bioorganic & medicinal chemistry letters 20110101 |
| Liposarcoma: molecular genetics and therapeutics. | Sarcoma 20110101 |
| In silico quantitative structure-activity relationship studies on P-gp modulators of tetrahydroisoquinoline-ethyl-phenylamine series. | BMC structural biology 20110101 |
| Anticancer and antimetastatic activities of Renieramycin M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells. | Anticancer research 20110101 |
| Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor. | Chemical & pharmaceutical bulletin 20110101 |
| The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | International journal of molecular sciences 20110101 |
| 1-(2-Bromobenzoyl)-6,7-(methylene-dioxy)isoquinoline. | Acta crystallographica. Section E, Structure reports online 20110101 |
| N-(9,11-Dimeth-oxy-4-oxo-2,3,4,6,7,11b-hexa-hydro-1H-pyrido[2,1-a]isoquinolin-3-yl)benzamide. | Acta crystallographica. Section E, Structure reports online 20110101 |
| (3S)-2-Benzyl-3-carb-oxy-1,2,3,4-tetra-hydro-isoquinolinium chloride monohydrate. | Acta crystallographica. Section E, Structure reports online 20110101 |
| (S)-N-Benzyl-2-methyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide. | Acta crystallographica. Section E, Structure reports online 20110101 |
| Feasibility Assessment of Micro-Electrode Chip Assay as a Method of Detecting Neurotoxicity in vitro. | Frontiers in neuroengineering 20110101 |
| Global diversity of Ascidiacea. | PloS one 20110101 |
| Synthesis and pharmacological evaluation of 1-isopropyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel antihypertensive agents. | Chemical & pharmaceutical bulletin 20110101 |
| ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration. | Frontiers in molecular neuroscience 20110101 |
| Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment. | Marine drugs 20110101 |
| Investigational approaches for mesothelioma. | Frontiers in oncology 20110101 |
| Synthesis and structure-active relationship of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline anticonvulsants. | Chemical & pharmaceutical bulletin 20101201 |
| (1R,3S)-Methyl 6,7-dimeth-oxy-1-(4-meth-oxy-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20101201 |
| 4-Chloro-N-methyl-2-(1,2,3,4-tetra-hydro-isoquinolin-1-yl)aniline. | Acta crystallographica. Section E, Structure reports online 20101201 |
| Design, synthesis, and in vitro evaluation of potential West Nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds. | Journal of combinatorial chemistry 20101108 |
| A suitable preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and their ring homologs with a reusable Preyssler heteropolyacid as catalyst. | Molecular diversity 20101101 |
| The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors. | Molecular pharmacology 20101101 |
| PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity. | British journal of pharmacology 20101101 |
| Total synthesis of (+)-korupensamine B via an atropselective intermolecular biaryl coupling. | Journal of the American Chemical Society 20101013 |
| A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. | Nature communications 20101005 |
| An unusual reactivity of BBr(3): Accessing tetrahydroisoquinoline units from N-phenethylimides. | Organic & biomolecular chemistry 20100921 |
| Specific inhibitors of the breast cancer resistance protein (BCRP). | ChemMedChem 20100903 |
| Synthesis, structure and DNA cleavage studies of coumarin analogues of tetrahydroisoquinoline and protoberberine alkaloids. | European journal of medicinal chemistry 20100901 |
| Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. | Bioorganic & medicinal chemistry letters 20100901 |
| Synthesis of novel tetrahydroisoquinoline bronchodilators. | Bioorganic & medicinal chemistry letters 20100901 |
| Neurotoxic effects of tetrahydroisoquinolines and underlying mechanisms. | Experimental neurobiology 20100901 |
| Recent synthetic approaches to 6,15-iminoisoquino[3,2-b]3-benzazocine compounds. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100823 |
| Synthesis of tetrahydroisoquinoline alkaloids via anodic cyanation as the key step. | The Journal of organic chemistry 20100820 |
| Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors. | Journal of medicinal chemistry 20100812 |
| Derivatives of tetrahydroisoquinoline: synthesis and initial evaluation of novel non-peptide antagonists of the alpha(IIb)beta(3)-integrin. | Bioorganic & medicinal chemistry letters 20100801 |
| A review of trabectedin (ET-743): a unique mechanism of action. | Molecular cancer therapeutics 20100801 |
| Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: cholesterol acyltransferase and lipid peroxidation. | Chemical & pharmaceutical bulletin 20100801 |
| Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae). | Natural product communications 20100701 |
| Catechol-O-methyltransferase: potential relationship to idiopathic hypertension. | Archives of medical science : AMS 20100630 |
| 4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione. | Acta crystallographica. Section E, Structure reports online 20100401 |
| 2'-Methyl-3,5-diphenyl-spiro-[4,6-dioxa-2-aza-bicyclo-[3.2.0]hept-2-ene-7,4'-iso-quinoline]-1',3'(2'H,4'H)-dione. | Acta crystallographica. Section E, Structure reports online 20100401 |
| 4-[(2,4-Dimethyl-thia-zol-5-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione. | Acta crystallographica. Section E, Structure reports online 20100401 |
| 4-[(2,5-Dimethyl-1,3-thia-zol-4-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione. | Acta crystallographica. Section E, Structure reports online 20100401 |
| Catalytic enantioselective 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines with alpha,beta-unsaturated aldehydes. | Journal of the American Chemical Society 20100331 |
| Preventative effects of 1,3-dimethyl- and 1,3-dimethyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline on MPTP-induced Parkinson's disease-like symptoms in mice. | Brain research 20100319 |
| Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds. | Bioorganic & medicinal chemistry letters 20100301 |
| Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonists. | Bioorganic & medicinal chemistry letters 20100301 |
| Enantiospecific stereodivergent synthesis of trans- and cis-N(2),3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolines. | Chemistry, an Asian journal 20100301 |
| {(1R,3S)-2-Benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl}diphenyl-methanol. | Acta crystallographica. Section E, Structure reports online 20100301 |
| Trabectedin: a review of its use in soft tissue sarcoma and ovarian cancer. | Drugs 20100212 |
| Pictet-Spengler reactions for the synthesis of pharmaceutically relevant heterocycles. | Current opinion in drug discovery & development 20100101 |
| Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures. | BMC plant biology 20100101 |
| Trabectedin for metastatic soft tissue sarcoma: a retrospective single center analysis. | Marine drugs 20100101 |
| Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells. | Journal of neuroinflammation 20100101 |
| New developments in treatment of ovarian carcinoma: focus on trabectedin. | Cancer management and research 20100101 |
| [Bioactivity diversity and functional mechanism of tetrahydroisoquinoline alkaloids]. | Yao xue xue bao = Acta pharmaceutica Sinica 20100101 |
| Biochemistry and occurrence of o-demethylation in plant metabolism. | Frontiers in physiology 20100101 |
| A highly enantioselective access to tetrahydroisoquinoline and beta-carboline alkaloids with simple noyori-type catalysts in aqueous media. | Chemistry (Weinheim an der Bergstrasse, Germany) 20091207 |
| Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells. | Atherosclerosis 20091201 |
| A class of novel N-(3S-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-amino acid derivatives: their synthesis, anti-thrombotic activity evaluation, and 3D QSAR analysis. | European journal of medicinal chemistry 20091201 |
| (1R,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20091201 |
| Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists. | Bioorganic & medicinal chemistry letters 20091101 |
| Graphite-supported gold nanoparticles as efficient catalyst for aerobic oxidation of benzylic amines to imines and N-substituted 1,2,3,4-tetrahydroisoquinolines to amides: synthetic applications and mechanistic study. | Chemistry, an Asian journal 20091005 |
| Selective functionalization of sp(3) C-H bonds adjacent to nitrogen using (diacetoxyiodo)benzene (DIB). | The Journal of organic chemistry 20091002 |
| Facile synthesis and in vitro properties of 1-alkyl- and 1-alkyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline derivatives on PC12 cells. | European journal of medicinal chemistry 20091001 |
| Estimation of relationship between descriptors and cytotoxicity of newly synthesized 1,2,3,4-tetrahydroisoquinoline derivatives. | Anticancer research 20091001 |
| Oxaziridine-mediated intramolecular amination of sp(3)-hybridized C-H bonds. | Journal of the American Chemical Society 20090909 |
| The use of positron emission tomography in soft tissue sarcoma patients under therapy with trabectedin. | Marine drugs 20090901 |
| Bioactivity-guided mapping and navigation of chemical space. | Nature chemical biology 20090801 |
| Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines. | Anticancer research 20090801 |
| Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. | International journal of molecular sciences 20090801 |
| Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines. | Biochemical pharmacology 20090715 |
| Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition. | Molecular cancer therapeutics 20090701 |
| (S)-Methyl 2-[(3R,4R)-2-benzyl-3-(2-fur-yl)-1-oxo-1,2,3,4-tetra-hydro-isoquinoline-4-carboxamido]-3-(1H-indol-3-yl)propanoate. | Acta crystallographica. Section E, Structure reports online 20090701 |
| A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. | Journal of enzyme inhibition and medicinal chemistry 20090601 |
| Estimation of relationship between the structure of 1,2,3,4-tetrahydroisoquinoline derivatives determined by a semiempirical molecular-orbital method and their cytotoxicity. | Anticancer research 20090601 |
| Methyl trans-(±)-1-oxo-2-phenethyl-3-(thio-phen-2-yl)-1,2,3,4-tetra-hydro-isoquinoline-4-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20090601 |
| Fast and sensitive liquid chromatography/electrospray mass spectrometry method to study ocular penetration of EDL-155, a novel antitumor agent for retinoblastoma in rats. | Journal of mass spectrometry : JMS 20090501 |
| Capillary electrophoretic study of small, highly sulfated, non-sugar molecules interacting with antithrombin. | Electrophoresis 20090501 |
| Biosynthesis of 3-hydroxy-5-methyl-o-methyltyrosine in the saframycin/ safracin biosynthetic pathway. | Journal of microbiology and biotechnology 20090501 |
| Facile synthesis of a benzindenoazepine alkaloid, bulgaramine, via samarium diiodide promoted ring expansion of an alpha-aminocarbonyl compound. | Organic letters 20090416 |
| Atropisomeric small molecule Bcl-2 ligands: determination of bioactive conformation. | Bioorganic & medicinal chemistry letters 20090315 |
| Enantioselective synthesis of schulzeines B and C via a beta-lactone-derived surrogate for bishomoserine aldehyde. | Organic letters 20090305 |
| The synthesis of N-phenoxyethyl-1-substituted-1,2,3,4-tetrahydroisoquinolines and their alpha1-adrenoceptor blocking activity. | European journal of medicinal chemistry 20090301 |
| Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem. | Natural product reports 20090301 |
| The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease. | Journal of neurochemistry 20090101 |
| Application of the statistical methods in systematic structure-activity relationship analysis of thiazole, benzothiazole and tetrahydroisoquinoline derivatives with biological activity. | Acta poloniae pharmaceutica 20090101 |
| Solution-phase parallel annulation of (thio)hydantoins to tetrahydroisoquinolines and tetrahydro-beta-carbolines containing the 2-arylethyl amine scaffold. | Journal of combinatorial chemistry 20090101 |
| ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines. | PloS one 20090101 |
| Treatment with 1,2,3,4,-tetrahydroisoquinoline affects glutamate release in the striatum but not the binding of [3H]MK-801 to NMDA receptors in the dopaminergic structures of the rat brain. | Pharmacological reports : PR 20090101 |
| Possible treatment concepts for the levodopa-related hyperhomocysteinemia. | Cardiovascular psychiatry and neurology 20090101 |
| Role of trabectedin in the treatment of soft tissue sarcoma. | OncoTargets and therapy 20090101 |
| Trabectedin: the evidence for its place in therapy in the treatment of soft tissue sarcoma. | Core evidence 20090101 |
| A concise total synthesis of (-)-quinocarcin via aryne annulation. | Journal of the American Chemical Society 20081224 |
| Synthetic studies on Et-743. Assembly of the pentacyclic core and a formal total synthesis. | The Journal of organic chemistry 20081219 |
| Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and Parkinson's disease brain. | Journal of neurochemistry 20081201 |
| Recent progress in the total synthesis of naphthyridinomycin and lemonomycin tetrahydroisoquinoline antitumor antibiotics (TAAs). | Chemical Society reviews 20081201 |
| Pharmacological modulation of leukotriene D(4) attenuates the development of opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome. | European journal of pharmacology 20081119 |
| Synthesis of chiral 3-methyl- and 3-methyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline and prevention of MPP+ -induced cytotoxicity. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20081101 |
| Synthesis and preliminary biological evaluation of new carbon-11 labeled tetrahydroisoquinoline derivatives as SERM radioligands for PET imaging of ER expression in breast cancer. | European journal of medicinal chemistry 20081001 |
| HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride. | Cellular signalling 20081001 |
| Effects, in an in-vivo model system, of 1,2,3,4-tetrahydroisoquinoline on glioma. | Anti-cancer drugs 20081001 |
| Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. | The Journal of biological chemistry 20080905 |
| Copper-catalyzed oxidative sp3 C-H bond arylation with aryl boronic acids. | Organic letters 20080904 |
| N-Methyl-isosalsoline from Hammada scoparia. | Acta crystallographica. Section E, Structure reports online 20080901 |
| Enantioselective synthesis of (R)-(+)- and (S)-(-)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation. | Bioorganic & medicinal chemistry letters 20080715 |
| Concise synthesis of the CDE ring system of tetrahydroisoquinoline alkaloids using carbophilic Lewis acid-catalyzed hydroamidation and oxidative Friedel-Crafts cyclization. | The Journal of organic chemistry 20080704 |
| Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer. | Bioorganic & medicinal chemistry letters 20080615 |
| Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. | European journal of medicinal chemistry 20080601 |
| Simultaneous analysis of 1,2,3,4-tetrahydroisoquinolines by high-performance liquid chromatography using 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsulfonyl chloride as a fluorescent labeling reagent. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080501 |
| SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure. | Bioorganic & medicinal chemistry 20080301 |
| New 1,2,3,4-tetrahydroisoquinoline derivatives as modulators of proteolytic cleavage of amyloid precursor proteins. | Bioorganic & medicinal chemistry 20080215 |
| Synthesis of carbon-11 labeled 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium derivatives as new potential PET SKCa channel imaging agents. | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20080201 |
| Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents. | Chemical & pharmaceutical bulletin 20080201 |
| Trabectedin and its potential in the treatment of soft tissue sarcoma. | Therapeutics and clinical risk management 20080201 |
| Metabolism of praziquantel in kingfish Seriola lalandi. | Diseases of aquatic organisms 20080124 |
| Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95. | Pulmonary pharmacology & therapeutics 20080101 |
| Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives. | Bioorganic & medicinal chemistry 20080101 |
| Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase. | Bioorganic & medicinal chemistry 20080101 |
| Selective androgen receptor modulators in preclinical and clinical development. | Nuclear receptor signaling 20080101 |
| A Phase II study of trabectedin single agent in patients with recurrent ovarian cancer previously treated with platinum-based regimens. | British journal of cancer 20071217 |
| Substituted tetrahydroisoquinoline compound B3 inhibited P-glycoprotein-mediated multidrug resistance in-vitro and in-vivo. | The Journal of pharmacy and pharmacology 20071201 |
| Synthesis and antifungal activities of novel 2-aminotetralin derivatives. | Journal of medicinal chemistry 20071101 |
| Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. | Journal of medicinal chemistry 20071004 |
| Synthesis of carbon-11 labeled biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues as new potential PET glioma tumor imaging agents. | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20071001 |
| Fatty acyl amides of endogenous tetrahydroisoquinolines are active at the recombinant human TRPV1 receptor. | Bioorganic & medicinal chemistry 20070915 |
| Cardioprotective effects of novel tetrahydroisoquinoline analogs of nitrobenzylmercaptopurine riboside in an isolated perfused rat heart model of acute myocardial infarction. | American journal of physiology. Heart and circulatory physiology 20070601 |
| Determination of a potent non-competitive AMPA receptor antagonist in rat brain. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501 |
| Synthesis and in vitro evaluation of tetrahydroisoquinolinyl benzamides as ligands for sigma receptors. | Bioorganic & medicinal chemistry letters 20070501 |
| Identification of a series of tetrahydroisoquinoline derivatives as potential therapeutic agents for breast cancer. | Bioorganic & medicinal chemistry letters 20070501 |
| Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore. | Bioorganic & medicinal chemistry letters 20070201 |
| Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors. | Bioorganic & medicinal chemistry 20070201 |
| The effect of modulation of gamma-glutamyl transpeptidase and nitric oxide synthase activity on GSH homeostasis in HepG2 cells. | Fundamental & clinical pharmacology 20070201 |
| Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions. | Journal of medicinal chemistry 20070125 |
| Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondrial NADH-ubiquinone oxidoreductase inhibition. | Neurotoxicology 20070101 |
| Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis and aggregation. | Thrombosis research 20070101 |
| Quantitative structure-activity relationship modeling of growth hormone secretagogues agonist activity of some tetrahydroisoquinoline 1-carboxamides. | Chemical biology & drug design 20070101 |
| Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons. | PloS one 20070101 |
| IBX-mediated oxidative Ugi-type multicomponent reactions: application to the N and C1 functionalization of tetrahydroisoquinoline. | Angewandte Chemie (International ed. in English) 20070101 |
| Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. | PloS one 20070101 |
| Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD? | Behavioral and brain functions : BBF 20070101 |
| Stereochemical diversity in asymmetric cyclization via memory of chirality. | Journal of the American Chemical Society 20061206 |
| Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels. | Journal of medicinal chemistry 20061130 |
| Syntheses of aporphine and homoaporphine alkaloids by intramolecular ortho-arylation of phenols with aryl halides via SRN1 reactions in liquid ammonia. | The Journal of organic chemistry 20061027 |
| Solid-phase synthesis of tetrahydro-beta-carbolines and tetrahydroisoquinolines by stereoselective intramolecular N-carbamyliminium Pictet-Spengler reactions. | Chemistry (Weinheim an der Bergstrasse, Germany) 20061025 |
| Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14alpha-demethylase (CYP51) of fungi. | Bioorganic & medicinal chemistry letters 20061015 |
| Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries. | Biochemical and biophysical research communications 20061013 |
| De novo biosynthesis of morphine in animal cells: an evidence-based model. | Medical science monitor : international medical journal of experimental and clinical research 20061001 |
| Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues. | Journal of medicinal chemistry 20060921 |
| Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase. | Journal of medicinal chemistry 20060907 |
| Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton. | Journal of medicinal chemistry 20060907 |
| Random chemistry as a new tool for the generation of small-compound libraries. | Archiv der Pharmazie 20060901 |
| Affinity of 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives to the ion channel binding site of the NMDA receptor complex. | European journal of medicinal chemistry 20060801 |
| [Asymmetric intramolecular conjugate addition of chiral enolates via non-equilibrium]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060801 |
| Synthetic studies on Et-743. Asymmetric, stereocontrolled construction of the tetrahydroisoquinoline core via radical cyclization on a glyoxalimine. | Organic letters 20060720 |
| Synthesis and SAR of novel histamine H3 receptor antagonists. | Bioorganic & medicinal chemistry letters 20060701 |
| 3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents. | Archiv der Pharmazie 20060701 |
| Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G. | Bioorganic & medicinal chemistry letters 20060615 |
| Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability. | Bioorganic & medicinal chemistry letters 20060515 |
| The mechanism of 1,2,3,4-tetrahydroisoquinolines neuroprotection: the importance of free radicals scavenging properties and inhibition of glutamate-induced excitotoxicity. | Journal of neurochemistry 20060501 |
| Acetylcholinesterase inhibitors from Stephania venosa tuber. | The Journal of pharmacy and pharmacology 20060501 |
| Development of the Pictet-Spengler reaction catalyzed by AuCl3/AgOTf. | The Journal of organic chemistry 20060317 |
| 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors. | Bioorganic & medicinal chemistry letters 20060315 |
| 1-Benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diols as novel affinity and photoaffinity probes for beta-adrenoceptor subtypes. | Bioorganic & medicinal chemistry 20060315 |
| The solution to a deep stereochemical conundrum: studies toward the tetrahydroisoquinoline alkaloids. | Angewandte Chemie (International ed. in English) 20060303 |
| 1-Benzyl-1,2,3,4-tetrahydroisoquinoline passes through the blood-brain barrier of rat brain: an in vivo microdialysis study. | Neuroscience letters 20060227 |
| Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives. | European journal of medicinal chemistry 20060201 |
| Capillary liquid chromatography-tandem mass spectrometry of tetrahydroisoquinoline derived neurotoxins: a study on the blood-brain barrier of rat brain. | Journal of chromatography. A 20060127 |
| Trabectedin: Ecteinascidin 743, Ecteinascidin-743, ET 743, ET-743, NSC 684766. | Drugs in R&D 20060101 |
| [Syntheses and ring-closures of difunctional tetrahydroisoquinolines]. | Acta pharmaceutica Hungarica 20060101 |
| [Synthesis of isothioureas derived from tetrahydroisoquinoline and NOS inhibitory activity]. | Yao xue xue bao = Acta pharmaceutica Sinica 20051101 |
| Synthesis of the tetrahydroisoquinoline alkaloid (+/-)-renieramycin G and A (+/-)-lemonomycinone analogue from a common intermediate. | Journal of the American Chemical Society 20050914 |
| P2X(7) receptor: Death or life? | Purinergic signalling 20050901 |
| Synthesis and neurotoxicity of tetrahydroisoquinoline derivatives for studying Parkinson's disease. | Biological & pharmaceutical bulletin 20050801 |
| Alkaloids from Alangium javanicum and Alangium grisolleoides that mediate Cu2+-dependent DNA strand scission. | Journal of natural products 20050801 |
| Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine. | Journal of medicinal chemistry 20050728 |
| 1,2,3,4-Tetrahydroisoquinoline protects terminals of dopaminergic neurons in the striatum against the malonate-induced neurotoxicity. | Brain research 20050727 |
| Treatment with 1,2,3,4-tetrahydroisoquinolone affects the levels of nitric oxide, S-nitrosothiols, glutathione and the enzymatic activity of gamma-glutamyl transpeptidase in the dopaminergic structures of rat brain. | Brain research 20050712 |
| SPE-HPLC determination of new tetrahydroisoquinoline derivatives in rat plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705 |
| Synthesis of a novel class of fatty acids-derived isoquinolines. | Chemistry and physics of lipids 20050601 |
| Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells. | Journal of natural products 20050601 |
| Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring. | Journal of medicinal chemistry 20050519 |
| Decrease in cytosolic phospholipase A2alpha mRNA levels by reactive oxygen species via MAP kinase pathways in PC12 cells: effects of dopaminergic neurotoxins. | Cellular signalling 20050501 |
| Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues. | Bioorganic & medicinal chemistry letters 20050401 |
| Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers. | Bioorganic & medicinal chemistry 20050215 |
| QSAR of estrogen receptor modulators: exploring selectivity requirements for ER(alpha) versus ER(beta) binding of tetrahydroisoquinoline derivatives using E-state and physicochemical parameters. | Bioorganic & medicinal chemistry letters 20050215 |
| Chiral CE separation of dopamine-derived neurotoxins. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050201 |
| Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands. | Journal of medicinal chemistry 20050127 |
| Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors. | Bioorganic & medicinal chemistry letters 20050103 |
| [Effect of 1,2,3,4-tetrahydroimidazo[4,5-c]pyridine and 1,2,3,4-tetrahydroisoquinoline derivatives on the behavior and the brain receptor system in rats]. | Eksperimental'naia i klinicheskaia farmakologiia 20050101 |
| Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists. | Bioorganic & medicinal chemistry letters 20041206 |
| Alkaloidal constituents of Mucuna pruriens seeds. | Phytochemistry 20040901 |
| Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder. | Dialogues in clinical neuroscience 20040901 |
| New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of 'THIQ'. | Journal of medicinal chemistry 20040826 |
| Isolation and X-ray crystal structure of tetrahydroisoquinoline alkaloids from Calycotome villosa Subsp. intermedias. | Molecules (Basel, Switzerland) 20040731 |
| Synthesis of some novel 11b-substituted pyrimido[6,1-a]-isoquinoline derivatives. | Molecules (Basel, Switzerland) 20040731 |
| Stereoselective synthesis of atropisomeric korupensamines A and B utilizing planar chiral arene chromium complex. | The Journal of organic chemistry 20040611 |
| Enantioselective total syntheses of the Ipecacuanha alkaloid emetine, the Alangium alkaloid tubulosine and a novel benzoquinolizidine alkaloid by using a domino process. | Chemistry (Weinheim an der Bergstrasse, Germany) 20040607 |
| Pivotal role of an endogenous tetrahydroisoquinoline, salsolinol, in stress- and suckling-induced release of prolactin. | Annals of the New York Academy of Sciences 20040601 |
| Effect of 1,2,3,4,-tetrahydroisoquinoline administration under conditions of CYP2D inhibition on dopamine metabolism, level of tyrosine hydroxylase protein and the binding of [3H]GBR 12,935 to dopamine transporter in the rat nigrostriatal, dopaminergic system. | Brain research 20040529 |
| Structure of hydrated clusters of tetrahydroisoquinoline [THIQ-(H2O)(n=1,3)] investigated by jet spectroscopy. | The Journal of chemical physics 20040522 |
| Potential roles of NF-kappaB and ERK1/2 in cytoprotection against oxidative cell death induced by tetrahydropapaveroline. | Free radical biology & medicine 20040501 |
| Carbazates as potent inhibitors of hormone-sensitive lipase. | Bioorganic & medicinal chemistry letters 20040405 |
| Development of novel 1,2,3,4-tetrahydroisoquinoline derivatives and closely related compounds as potent and selective dopamine D3 receptor ligands. | Chembiochem : a European journal of chemical biology 20040402 |
| Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro. | Cancer chemotherapy and pharmacology 20040401 |
| In vivo bioconversion of tetrahydroisoquinoline by recombinant coclaurine N-methyltransferase. | Bioscience, biotechnology, and biochemistry 20040401 |
| Ruthenium-catalyzed anti-Markovnikov hydroamination of vinylarenes. | Journal of the American Chemical Society 20040310 |
| New imide 5-HT1A receptor ligands - modification of terminal fragment geometry. | Molecules (Basel, Switzerland) 20040227 |
| Disposition of 1,2,3,4,-tetrahydroisoquinoline in the brain of male Wistar and Dark Agouti rats. | Brain research 20040123 |
| Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. | Bioorganic & medicinal chemistry letters 20040105 |
| Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives. | Farmaco (Societa chimica italiana : 1989) 20040101 |
| Solid-phase synthesis of 1-substituted tetrahydroisoquinoline derivatives employing BOC-protected tetrahydroisoquinoline carboxylic acids. | Journal of combinatorial chemistry 20040101 |
| Solid-phase synthesis of 1,2,3,4-tetrahydroisoquinoline derivatives employing support-bound tyrosine esters in the Pictet-Spengler reaction. | Journal of combinatorial chemistry 20040101 |
| A new efficient synthetic methodology for tetrahydroisoquinoline and tetrahydro-beta-carboline derivatives using the Pictet-Spengler reaction. | Molecular diversity 20040101 |
| Inhibition of rodent brain monoamine oxidase and tyrosine hydroxylase by endogenous compounds - 1,2,3,4-tetrahydro-isoquinoline alkaloids. | Polish journal of pharmacology 20040101 |
| In vitro interaction between ecteinascidin 743 (ET-743) and radiation, in relation to its cell cycle effects. | British journal of cancer 20031215 |
| Synthetic studies on ecteinascidin 743: rapid access to the fully functionalized tetrahydroisoquinoline with a bridged 10-membered sulfur containing macrocycle. | Chemical communications (Cambridge, England) 20031207 |
| Structural specificity for the inhibitory effect of calmodulin on specific 125I-omega-conotoxin GVIA binding. | Neurochemical research 20031201 |
| Possible role of interleukin-6 in PC12 cell death induced by MPP+ and tetrahydroisoquinoline. | Journal of pharmacological sciences 20031201 |
| Intermolecular, markovnikov hydroamination of vinylarenes with alkylamines. | Journal of the American Chemical Society 20031126 |
| Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton. | Chemical & pharmaceutical bulletin 20031101 |
| The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice. | Journal of neural transmission (Vienna, Austria : 1996) 20031101 |
| The Pictet-Spengler reaction in solid-phase combinatorial chemistry. | Current opinion in drug discovery & development 20031101 |
| Synthesis and pharmacological evaluation of 1-oxo-2-(3-piperidyl)-1,2,3,4- tetrahydroisoquinolines and related analogues as a new class of specific bradycardic agents possessing I(f) channel inhibitory activity. | Journal of medicinal chemistry 20031023 |
| Organolathanide-catalyzed regioselective intermolecular hydroamination of alkenes, alkynes, vinylarenes, di- and trivinylarenes, and methylenecyclopropanes. Scope and mechanistic comparison to intramolecular cyclohydroaminations. | Journal of the American Chemical Society 20031015 |
| Debenzylation of tertiary amines using phosgene or triphosgene: an efficient and rapid procedure for the preparation of carbamoyl chlorides and unsymmetrical ureas. Application in carbon-11 chemistry. | The Journal of organic chemistry 20030919 |
| Presence of reticuline in rat brain: a pathway for morphine biosynthesis. | Brain research. Molecular brain research 20030910 |
| Renieramycin J, a highly cytotoxic tetrahydroisoquinoline alkaloid, from a marine sponge Neopetrosia sp. | Journal of natural products 20030801 |
| Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands. | Journal of medicinal chemistry 20030703 |
| Discovery of selective phosphonamide-based inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). | Bioorganic & medicinal chemistry letters 20030616 |
| New strategy for the synthesis of tetrahydroisoquinoline alkaloids. | Organic letters 20030612 |
| New scaffolds in the development of mu opioid-receptor ligands. | Bioorganic & medicinal chemistry letters 20030505 |
| Tetrahydroisoquinoline alkaloids and 2-deoxyribonolactones from Aristolochia arcuata. | Phytochemistry 20030401 |
| Synthesis and pharmacological evaluation of 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives as specific bradycardic agents. | Chemical & pharmaceutical bulletin 20030401 |
| The potent anticancer compound ecteinascidin-743 (ET-743) as its 2-propanol disolvate. | Acta crystallographica. Section C, Crystal structure communications 20030401 |
| Synthesis and pharmacological study of Rho-kinase inhibitors: pharmacomodulations on the lead compound Fasudil. | Journal of enzyme inhibition and medicinal chemistry 20030401 |
| A short diastereoselective synthesis of the putative alkaloid jamtine, using a tandem pummerer/mannich cyclization sequence. | The Journal of organic chemistry 20030207 |
| Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists. | Journal of chemical information and computer sciences 20030101 |
| A possible physiological role for cerebral tetrahydroisoquinolines. | Neurotoxicity research 20030101 |
| Tetrahydroisoquinoline and beta-carboline alkaloids from Haloxylon articulatum (Cav.) Bunge (Chenopodiaceae). | Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101 |
| Influence of acute and chronic 1,2,3,4-tetrahydroisoquinoline administration on the expression of proenkephalin mRNA in the rat striatum. | Polish journal of pharmacology 20030101 |
| A study of the influence of newly synthesized acyclonucleosides and 1,2,3,4-tetrahydroisoquinoline derivatives on deoxythymidine and deoxycytidine kinase activities in human neurofibrosarcoma and ovarian cancer. | Acta biochimica Polonica 20030101 |
| Cytotoxicity of dopamine-derived tetrahydroisoquinolines on melanoma cells. | Biochemical pharmacology 20021115 |
| Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: design, synthesis and structure-activity relationship. | Bioorganic & medicinal chemistry 20021101 |
| [Tetrahydroisoquinoline derivatives as possible Parkinson's disease-inducing substances]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20021101 |
| Alkaloids, alcohol and Parkinson's disease. | Parkinsonism & related disorders 20020901 |
| Two optically active isoquinoline derivatives. | Acta crystallographica. Section C, Crystal structure communications 20020801 |
| Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases. | Bioorganic & medicinal chemistry 20020601 |
| Tetrahydroisoquinoline derivatives of enkephalins: synthesis and properties. | Biochemical pharmacology 20020515 |
| 3-D-QSAR analysis of N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline and N-(3-acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thioureas analogues as potent vanilloid receptor ligands. | Bioorganic & medicinal chemistry 20020501 |
| Further characterization of the stimulus properties of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline. | Pharmacology, biochemistry, and behavior 20020501 |
| Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics. | Chemical reviews 20020501 |
| Active conformation of some arylpiperazine postsynaptic 5-HT(1A) receptor antagonists. | European journal of medicinal chemistry 20020401 |
| Total synthesis of (+/-)-jamtine using a thionium/N-acyliminium ion cascade. | Organic letters 20020307 |
| Relationship between lipophilicity and antitumor activity of molecule library of Mannich ketones determined by high-performance liquid chromatography, clogP calculation and cytotoxicity test. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020305 |
| Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter. | Biochemical pharmacology 20020301 |
| Application of a new chiral derivatizing agent to the enantioseparation of secondary amino acids. | Journal of chromatography. A 20020301 |
| A convenient synthesis of 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines via Pictet-Spengler reaction using titanium(IV) isopropoxide and acetic-formic anhydride. | Chemical & pharmaceutical bulletin 20020201 |
| Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay. | Biochemistry 20020122 |
| The influence of substitution at aromatic part of 1,2,3,4-tetrahydroisoquinoline on in vitro and in vivo 5-HT(1A)/5-HT(2A) receptor activities of its 1-adamantoyloaminoalkyl derivatives. | Bioorganic & medicinal chemistry 20020101 |
| Role of noradrenergic system in the mechanism of action of endogenous neurotoxin 1,2,3,4-tetrahydroisoquinoline: biochemical and functional studies. | Polish journal of pharmacology 20020101 |
| Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety. | Arzneimittel-Forschung 20020101 |
| N-methylation underlying Parkinson's disease. | Neurotoxicology and teratology 20020101 |
| Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquinolines. | Polish journal of pharmacology 20020101 |
| Synthesis and in vivo pharmacology of new derivatives of isothiazolo[5,4-b]pyridine of Mannich base type. | Farmaco (Societa chimica italiana : 1989) 20011201 |
| Synthesis of isoquinolines and pyridines by the palladium-catalyzed iminoannulation of internal alkynes. | The Journal of organic chemistry 20011130 |
| Total syntheses of conformationally constrained didemnin B analogues. replacements of N,O-dimethyltyrosine with L-1,2,3,4-tetrahydroisoquinoline and L-1,2,3,4-tetrahydro-7-methoxyisoquinoline. | The Journal of organic chemistry 20011116 |
| Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents. | Bioorganic & medicinal chemistry 20011101 |
| Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism-preventing effect of 1-MeTIQ by in vivo measurement of pre-synaptic dopamine transporters and post-synaptic dopamine D(2) receptors in the mouse striatum. | Journal of neurochemistry 20011101 |
| ET-743 (PharmaMar/NCI/Ortho Biotech). | Current opinion in investigational drugs (London, England : 2000) 20011101 |
| Advances in the chemistry and pharmacology of ecteinascidins, a promising new class of anti-cancer agents. | Current medicinal chemistry. Anti-cancer agents 20011101 |
| Intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins: a new method for the preparation of tetrahydroisoquinolines, tetrahydro-3-benzazepines, and hexahydro-3-benzazocines. | Organic letters 20011018 |
| Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand. | Bioorganic & medicinal chemistry 20011001 |
| Stress-related polyketide metabolism of Dioncophyllaceae and Ancistrocladaceae. | Journal of experimental botany 20011001 |
| Stereoselective effect of (R)- and (S)-1-methyl-1,2,3,4-tetrahydroisoquinolines on a mouse model of Parkinson's disease. | Brain research bulletin 20010901 |
| Effects of a 3-alkyl-, 4-hydroxy- and/or 8-aromatic-substituent on the phenylethanolamine N-methyltransferase inhibitor potency and alpha2-adrenoceptor affinity of 2,3,4,5-tetrahydro-1H-2-benzazepines. | Bioorganic & medicinal chemistry 20010801 |
| An unusual decarboxylative Maillard reaction between L-DOPA and D-glucose under biomimetic conditions: factors governing competition with Pictet-Spengler condensation. | The Journal of organic chemistry 20010727 |
| Different action on dopamine catabolic pathways of two endogenous 1,2,3,4-tetrahydroisoquinolines with similar antidopaminergic properties. | Journal of neurochemistry 20010701 |
| Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme. | Bioorganic & medicinal chemistry letters 20010618 |
| Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid. | Free radical biology & medicine 20010615 |
| Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine. | The Journal of organic chemistry 20010504 |
| Chromatographic separation and spectrometric identification of the oxidation products from a tetrahydro-isoquinoline alkaloid. | Journal of pharmaceutical and biomedical analysis 20010501 |
| Pictet-Spengler condensation of the antiparkinsonian drug L-DOPA with D-glyceraldehyde. Opposite kinetic effects of Fe3+ and Cu2+ ions and possible implications for the origin of therapeutic side effects. | Bioorganic & medicinal chemistry 20010401 |
| Salsolinol, a naturally occurring tetrahydroisoquinoline alkaloid, induces DNA damage and chromosomal aberrations in cultured Chinese hamster lung fibroblast cells. | Mutation research 20010301 |
| Synthesis and structure-activity relationships of potential anticonvulsants based on 2-piperidinecarboxylic acid and related pharmacophores. | European journal of medicinal chemistry 20010301 |
| Screening of beta-2 agonists and confirmation of fenoterol, orciprenaline, reproterol and terbutaline with gas chromatography-mass spectrometry as tetrahydroisoquinoline derivatives. | Journal of chromatography. B, Biomedical sciences and applications 20010210 |
| Reduction of rat brain levels of the endogenous dopaminergic proneurotoxins 1,2,3,4-tetrahydroisoquinoline and 1,2,3,4-tetrahydro-beta-carboline by cigarette smoke. | Neuroscience letters 20010209 |
| Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010201 |
| Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action. | European journal of cancer (Oxford, England : 1990) 20010101 |
| Benzolactam derivatives and their affinity for alpha 1- and alpha 2-adrenoreceptors. | Archiv der Pharmazie 20010101 |
| Opposite effect of simple tetrahydroisoquinolines on amphetamine- and morphine-stimulated locomotor activity in mice. | Journal of neural transmission (Vienna, Austria : 1996) 20010101 |
| Effects of single and repeated administration of 1,2,3,4-tetrahydroisoquinoline analogs on the binding of [11C]raclopride to dopamine D2 receptors in the mouse brain. | Journal of neural transmission (Vienna, Austria : 1996) 20010101 |
| Effect of acute administration of 1,2,3,4-tetrahydroisoquinoline on the levels of glutathione and reactive oxygen species, and on the enzymatic activity of gamma-glutamyl transpeptidase in dopaminergic structures of rat brain. | Neuroscience 20010101 |
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