200,000+ products from a single source!
sales@angenechem.com
Home > Quinoline > 898562-94-2
898562-94-2 | Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-
CAS No: 898562-94-2 Catalog No: AG00H0HG MDL No:MFCD09743765
Product Description
Catalog Number:
AG00H0HG
Chemical Name:
Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-
CAS Number:
898562-94-2
MDL Number:
MFCD09743765
IUPAC Name:
2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline
InChI:
InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3
InChI Key:
AZEXWHKOMMASPA-UHFFFAOYSA-N
UNII:
R9Y8EY0G42
Properties
Complexity:
531
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
392.164g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
392.462g/mol
Monoisotopic Mass:
392.164g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
52.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.2
Literature
| Title | Journal |
|---|---|
| Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington's Disease Models. | Neuron 20161221 |
| A novel thermoregulatory role for PDE10A in mouse and human adipocytes. | EMBO molecular medicine 20160701 |
| Phosphodiesterase 2 inhibitors promote axonal outgrowth in organotypic slice co-cultures. | Neuro-Signals 20130101 |
| Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer. | Journal of medicinal chemistry 20120524 |
| Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A. | European journal of medicinal chemistry 20110901 |
| Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging. | Journal of medicinal chemistry 20110825 |
| Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A. | Nuclear medicine and biology 20110801 |
| Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors. | Bioorganic & medicinal chemistry letters 20110615 |
| Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain. | Bioorganic & medicinal chemistry 20110301 |
| The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. | Journal of neural transmission (Vienna, Austria : 1996) 20101101 |
| Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats. | Acta neurobiologiae experimentalis 20100101 |
| Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease. | PloS one 20100101 |
| Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. | The Journal of pharmacology and experimental therapeutics 20091101 |
| Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. | Journal of medicinal chemistry 20090827 |
| Preclinical characterization of selective phosphodiesterase 10A inhibitors: a new therapeutic approach to the treatment of schizophrenia. | The Journal of pharmacology and experimental therapeutics 20080501 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.