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89687-39-8 | 1,2-Propanedione,1-(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-
CAS No: 89687-39-8 Catalog No: AG0044B6 MDL No:
Product Description
Catalog Number:
AG0044B6
Chemical Name:
1,2-Propanedione,1-(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-
CAS Number:
89687-39-8
Molecular Formula:
C9H11N5O3
Molecular Weight:
237.2153
IUPAC Name:
1-(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)propane-1,2-dione
InChI:
InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h4,12H,2H2,1H3,(H4,10,11,13,14,17)
InChI Key:
WBJZXBUVECZHCE-UHFFFAOYSA-N
SMILES:
Nc1nc(O)c2c(n1)NCC(N2)C(=O)C(=O)C
Properties
Complexity:
479
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
237.086g/mol
Formal Charge:
0
Heavy Atom Count:
17
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
237.219g/mol
Monoisotopic Mass:
237.086g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
126A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.7
Literature
| Title | Journal |
|---|---|
| Cloning, expression and enzymatic properties analysis of dihydrofolate reductase gene from the silkworm, Bombyx mori. | Molecular biology reports 20121201 |
| An international survey of patients with tetrahydrobiopterin deficiencies presenting with hyperphenylalaninaemia. | Journal of inherited metabolic disease 20121101 |
| Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation. | Molecular pharmacology 20120901 |
| Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension. | American journal of physiology. Heart and circulatory physiology 20120601 |
| Advanced glycation end products-mediated hypertrophy is negatively regulated by tetrahydrobiopterin in renal tubular cells. | Molecular and cellular endocrinology 20120515 |
| Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase. | The Biochemical journal 20120401 |
| Effect of advanced glycation end products on oxidative stress and senescence of trabecular meshwork cells. | Korean journal of ophthalmology : KJO 20120401 |
| Sepiapterin reductase deficiency: a treatable mimic of cerebral palsy. | Annals of neurology 20120401 |
| Dicarbonyl reduction by single enzyme for the preparation of chiral diols. | Chemical Society reviews 20120307 |
| A homozygous frameshift mutation of sepiapterin reductase gene causing parkinsonism with onset in childhood. | Parkinsonism & related disorders 20120201 |
| Analgesia by inhibiting tetrahydrobiopterin synthesis. | Current opinion in pharmacology 20120201 |
| Child neurology: paroxysmal stiffening, upward gaze, and hypotonia: hallmarks of sepiapterin reductase deficiency. | Neurology 20120131 |
| Mutagenesis by imprecise excision of the piggyBac transposon in Drosophila melanogaster. | Biochemical and biophysical research communications 20120106 |
| HemaMax™, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates. | PloS one 20120101 |
| Transcriptome analysis in tardigrade species reveals specific molecular pathways for stress adaptations. | Bioinformatics and biology insights 20120101 |
| Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing. | International journal of vascular medicine 20120101 |
| NAD(P)H oxidase and eNOS play differential roles in cytomegalovirus infection-induced microvascular dysfunction. | Free radical biology & medicine 20111215 |
| Whole-genome sequencing informs treatment: personalized medicine takes another step forward. | Clinical chemistry 20111201 |
| C-reactive protein induces release of both endothelial microparticles and circulating endothelial cells in vitro and in vivo: further evidence of endothelial dysfunction. | Clinical chemistry 20111201 |
| Asymmetric uptake of sepiapterin and 7,8-dihydrobiopterin as a gateway of the salvage pathway of tetrahydrobiopterin biosynthesis from the lumenal surface of rat endothelial cells. | Molecular genetics and metabolism 20111101 |
| Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease. | Neurobiology of aging 20111101 |
| Autophagy induction by tetrahydrobiopterin deficiency. | Autophagy 20111101 |
| Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus Mortierella alpina. | Microbiology (Reading, England) 20111101 |
| Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction. | American journal of physiology. Heart and circulatory physiology 20111101 |
| Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning. | American journal of physiology. Heart and circulatory physiology 20111101 |
| Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. | Oncology reports 20111001 |
| Tetrahydrobiopterin: biochemistry and pathophysiology. | The Biochemical journal 20110915 |
| Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo. | American journal of physiology. Heart and circulatory physiology 20110901 |
| Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase. | American journal of physiology. Lung cellular and molecular physiology 20110901 |
| Role of sepiapterin on endothelial nitric oxide synthase in acute kidney injury: an enigmatic story. | Journal of cardiovascular pharmacology 20110901 |
| Inhibitory effects of sepiapterin on vascular endothelial growth factor-A-induced proliferation and adhesion in human umbilical vein endothelial cells. | Archives of pharmacal research 20110901 |
| Impairment of nitrergic system and delayed gastric emptying in low density lipoprotein receptor deficient female mice. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110801 |
| Genotype-phenotype correlations in sepiapterin reductase deficiency. A splicing defect accounts for a new phenotypic variant. | Neurogenetics 20110801 |
| Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. | Nitric oxide : biology and chemistry 20110801 |
| Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice. | Clinical and experimental pharmacology & physiology 20110801 |
| Effects of sepiapterin infusion on renal oxygenation and early acute renal injury after suprarenal aortic clamping in rats. | Journal of cardiovascular pharmacology 20110801 |
| Non-conventional hydrogen bonds: pterins-metal anions. | Physical chemistry chemical physics : PCCP 20110728 |
| Whole-genome sequencing for optimized patient management. | Science translational medicine 20110615 |
| Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging. | Aging cell 20110601 |
| Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency. | Free radical biology & medicine 20110601 |
| Emission properties of dihydropterins in aqueous solutions. | Physical chemistry chemical physics : PCCP 20110428 |
| Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1. | American journal of physiology. Heart and circulatory physiology 20110301 |
| eNOS-uncoupling in age-related erectile dysfunction. | International journal of impotence research 20110301 |
| Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain. | The Journal of biological chemistry 20110114 |
| Mechanisms of diesel-induced endothelial nitric oxide synthase dysfunction in coronary arterioles. | Environmental health perspectives 20110101 |
| Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis. | Molecular genetics and metabolism 20110101 |
| Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments. | Frontiers in neuroanatomy 20110101 |
| The eukaryotic-type serine/threonine protein kinase Stk is required for biofilm formation and virulence in Staphylococcus epidermidis. | PloS one 20110101 |
| Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism. | PloS one 20110101 |
| The evolution of metabolic networks of E. coli. | BMC systems biology 20110101 |
| Sepiapterin reverses the changes in gastric nNOS dimerization and function in diabetic gastroparesis. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20101201 |
| Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study. | The Lancet. Neurology 20101126 |
| Roles of tetrahydrobiopterin in promoting tumor angiogenesis. | The American journal of pathology 20101101 |
| The role of proteomics in depression research. | European archives of psychiatry and clinical neuroscience 20100901 |
| Alterations in dopamine and glutamate neurotransmission in tetrahydrobiopterin deficient spr-/- mice: relevance to schizophrenia. | BMB reports 20100901 |
| Fluorine-18-FDG PET findings of focal eosinophilic liver disease: correlation with CT and/or MRI, laboratory, and pathologic findings. | Abdominal imaging 20100801 |
| Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets. | Current hypertension reports 20100801 |
| Dystonia-plus syndromes. | European journal of neurology 20100701 |
| Identification of genes influencing skeletal phenotypes in congenic P/NP rats. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100601 |
| The role of cyanopterin in UV/blue light signal transduction of cyanobacterium Synechocystis sp. PCC 6803 phototaxis. | Plant & cell physiology 20100601 |
| Sepiapterin reductase deficiency: two Indian siblings with unusual clinical features. | Movement disorders : official journal of the Movement Disorder Society 20100515 |
| Effects of sepiapterin supplementation and NOS inhibition on glucocorticoid-induced hypertension. | American journal of hypertension 20100501 |
| Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice. | Heart and vessels 20100501 |
| Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms. | Anesthesiology 20100301 |
| Sleep and rhythm consequences of a genetically induced loss of serotonin. | Sleep 20100301 |
| The tetrahydrobiopterin pathway and pain. | Current opinion in investigational drugs (London, England : 2000) 20100101 |
| Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents. | PloS one 20100101 |
| Central tetrahydrobiopterin concentration in neurodevelopmental disorders. | Frontiers in neuroscience 20100101 |
| Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. | Molecular systems biology 20100101 |
| Is tetrahydrobiopterin a therapeutic option in diabetic hypertensive patients? | Integrated blood pressure control 20100101 |
| Sepiapterin reductase deficiency in a 2-year-old girl with incomplete response to treatment during short-term follow-up. | Journal of inherited metabolic disease 20091201 |
| Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson's Disease: a HuGE review and meta-analysis. | American journal of epidemiology 20091201 |
| Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats. | American journal of physiology. Heart and circulatory physiology 20091101 |
| Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels. | Proteomics 20091101 |
| eNOS uncoupling and endothelial dysfunction in aged vessels. | American journal of physiology. Heart and circulatory physiology 20091101 |
| Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain. | Annals of neurology 20090901 |
| Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues. | Journal of biochemistry 20090701 |
| Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. | American journal of physiology. Heart and circulatory physiology 20090701 |
| Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia. | Brain : a journal of neurology 20090701 |
| Disorders of biopterin metabolism. | Journal of inherited metabolic disease 20090601 |
| Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization. | The Journal of pharmacology and experimental therapeutics 20090601 |
| Neuroimaging findings in children with paediatric neurotransmitter diseases. | Journal of inherited metabolic disease 20090601 |
| Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. | Pharmacogenetics and genomics 20090501 |
| The silkworm mutant lemon (lemon lethal) is a potential insect model for human sepiapterin reductase deficiency. | The Journal of biological chemistry 20090424 |
| Certain progestins prevent the enhancing effect of 17beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20090401 |
| [Mutational analysis of patients with 6-pyruvoyltetrahydrobiopterin synthesis deficiency]. | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20090401 |
| Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase. | Biochemistry 20090324 |
| Tetrahydrobiopterin in intestinal lumen: its absorption and secretion in the small intestine and the elimination in the large intestine. | Journal of inherited metabolic disease 20090201 |
| [Biopterin and child neurologic disease]. | No to hattatsu = Brain and development 20090101 |
| Nitric oxide and vascular insulin resistance. | BioFactors (Oxford, England) 20090101 |
| Prevention of atherosclerosis by interference with the vascular nitric oxide system. | Current pharmaceutical design 20090101 |
| Pigmentation pathway evolution after whole-genome duplication in fish. | Genome biology and evolution 20090101 |
| Production and Peripheral Roles of 5-HTP, a Precursor of Serotonin. | International journal of tryptophan research : IJTR 20090101 |
| Neopterin: Biomarker of cell-mediated immunity and potent usage as biomarker in silicosis and other occupational diseases. | Indian journal of occupational and environmental medicine 20081201 |
| Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. | American journal of physiology. Heart and circulatory physiology 20081101 |
| Leptin-induced endothelial dysfunction in obesity. | American journal of physiology. Heart and circulatory physiology 20081001 |
| Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure. | Hypertension (Dallas, Tex. : 1979) 20080901 |
| Two Greek siblings with sepiapterin reductase deficiency. | Molecular genetics and metabolism 20080801 |
| Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin. | Molecular genetics and metabolism 20080801 |
| Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures. | Extremophiles : life under extreme conditions 20080701 |
| Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin. | Acta biochimica et biophysica Sinica 20080601 |
| A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease. | Biochemical and biophysical research communications 20080321 |
| Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles. | The Journal of physiology 20080215 |
| Proteomic analysis of embryonic stem cell-derived neural cells exposed to the antidepressant paroxetine. | Journal of neuroscience research 20080201 |
| Nitration of soluble proteins in organotypic culture models of Parkinson's disease. | Neurochemistry international 20080201 |
| An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites. | Molecular microbiology 20080201 |
| Effect of beta-blockers on endothelial function during biological aging: a nanotechnological approach. | Journal of cardiovascular pharmacology 20080201 |
| 2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner. | Biochimica et biophysica acta 20080101 |
| Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease. | BMC molecular biology 20080101 |
| Targeting retinal dopaminergic neurons in tyrosine hydroxylase-driven green fluorescent protein transgenic zebrafish. | Molecular vision 20080101 |
| C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling. | Journal of molecular and cellular cardiology 20071201 |
| Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. | PLoS genetics 20071201 |
| Tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2. | FEBS letters 20071127 |
| 4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation. | Arteriosclerosis, thrombosis, and vascular biology 20071101 |
| Regulation of tetrahydrobiopterin biosynthesis by shear stress. | Circulation research 20071012 |
| Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells. | Journal of cellular physiology 20070901 |
| Causation, prevention and reversal of vascular endothelial dysfunction. | The Journal of the Association of Physicians of India 20070901 |
| Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. | Cancer research 20070801 |
| Inactivity of nitric oxide synthase gene in the atherosclerotic human carotid artery. | Basic research in cardiology 20070701 |
| Singlet oxygen (O2(1Deltag)) quenching by dihydropterins. | The journal of physical chemistry. A 20070524 |
| The pediatric neurotransmitter disorders. | Journal of child neurology 20070501 |
| Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. | Brain research 20070330 |
| Molecular genetics of tetrahydrobiopterin (BH4) deficiency in the Maltese population. | Molecular genetics and metabolism 20070301 |
| Insulin enhances nitric oxide production in trabecular meshwork cells via de novo pathway for tetrahydrobiopterin synthesis. | Korean journal of ophthalmology : KJO 20070301 |
| Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans. | Molecular pain 20070101 |
| Evolution of pigment synthesis pathways by gene and genome duplication in fish. | BMC evolutionary biology 20070101 |
| Dopa-responsive hypersomnia and mixed movement disorder due to sepiapterin reductase deficiency. | Neurology 20061212 |
| The zebrafish mutation m865 affects formation of dopaminergic neurons and neuronal survival, and maps to a genetic interval containing the sepiapterin reductase locus. | Anatomy and embryology 20061201 |
| GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. | Nature medicine 20061101 |
| Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo. | Diabetes 20061101 |
| Sepiapterin reductase deficiency: clinical presentation and evaluation of long-term therapy. | Pediatric neurology 20061101 |
| Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase. | Human mutation 20060901 |
| Pigment pattern formation in the quail mutant of the silkworm, Bombyx mori: parallel increase of pteridine biosynthesis and pigmentation of melanin and ommochromes. | Pigment cell research 20060801 |
| eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. | Circulation research 20060707 |
| The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations. | Journal of medical genetics 20060701 |
| Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2. | Biochimica et biophysica acta 20060601 |
| Developmental regulation of GTP-CH1 in the porcine lung and its relationship to pulmonary vascular relaxation. | Pediatric research 20060601 |
| Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction. | Free radical biology & medicine 20060415 |
| A murine model for human sepiapterin-reductase deficiency. | American journal of human genetics 20060401 |
| Familial dopa-responsive cervical dystonia. | Neurology 20060227 |
| Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency. | Movement disorders : official journal of the Movement Disorder Society 20060201 |
| Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin. | The Journal of biological chemistry 20060127 |
| Sepiapterin reductase deficiency an autosomal recessive DOPA-responsive dystonia. | Molecular genetics and metabolism 20060101 |
| Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase. | Brain research. Molecular brain research 20051207 |
| Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta. | The Journal of pharmacology and experimental therapeutics 20051201 |
| Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. | Arteriosclerosis, thrombosis, and vascular biology 20051201 |
| Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4. | Molecular genetics and metabolism 20051201 |
| Enhanced oxidative stress impairs cAMP-mediated dilation by reducing Kv channel function in small coronary arteries of diabetic rats. | American journal of physiology. Heart and circulatory physiology 20051101 |
| DAF-FM (4-amino-5-methylamino-2',7'-difluorofluorescein) diacetate detects impairment of agonist-stimulated nitric oxide synthesis by elevated glucose in human vascular endothelial cells: reversal by vitamin C and L-sepiapterin. | The Journal of pharmacology and experimental therapeutics 20051101 |
| Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation. | Free radical biology & medicine 20051015 |
| Sepiapterin reductase deficiency: a congenital dopa-responsive motor and cognitive disorder. | Brain : a journal of neurology 20051001 |
| Neuroprotective therapy in Parkinson's disease: current status and new directions from experimental and genetic clues. | Journal of clinical neurology (Seoul, Korea) 20051001 |
| Antioxidant effects of N-acetylserotonin: possible mechanisms and clinical implications. | Annals of the New York Academy of Sciences 20050801 |
| N-acetyldopamine inhibits rat brain lipid peroxidation induced by lipopolysaccharide. | Annals of the New York Academy of Sciences 20050801 |
| D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum Ax2. | FEBS letters 20050606 |
| Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants. | Vascular health and risk management 20050601 |
| Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase. | Critical care medicine 20050501 |
| Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products. | British journal of pharmacology 20050401 |
| Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum. | Acta crystallographica. Section F, Structural biology and crystallization communications 20050201 |
| Esrom, an ortholog of PAM (protein associated with c-myc), regulates pteridine synthesis in the zebrafish. | Developmental biology 20050115 |
| Sepiapterin reductases from Chlorobium tepidum and Chlorobium limicola catalyze the synthesis of L-threo-tetrahydrobiopterin from 6-pyruvoyltetrahydropterin. | FEMS microbiology letters 20050101 |
| Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells. | Pharmacogenetics 20041201 |
| Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process. | Journal of pharmacological sciences 20041001 |
| Heterozygous mutation in 5'-untranslated region of sepiapterin reductase gene (SPR) in a patient with dopa-responsive dystonia. | Neurogenetics 20040901 |
| Moderate hyperhomocysteinemia decreases endothelial-dependent vasorelaxation in pregnant but not nonpregnant mice. | Hypertension (Dallas, Tex. : 1979) 20040901 |
| Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4). | American journal of physiology. Heart and circulatory physiology 20040801 |
| Tetrahydropteridines suppress gene expression and induce apoptosis of activated RAW264.7 cells via formation of hydrogen peroxide. | Free radical biology & medicine 20040801 |
| Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. | Experimental neurology 20040801 |
| Functional tetrahydrobiopterin synthesis in human platelets. | Circulation 20040713 |
| Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin. | Free radical biology & medicine 20040615 |
| Cyclic AMP-mediated upregulation of the expression of neuronal NO synthase in human A673 neuroepithelioma cells results in a decrease in the level of bioactive NO production: analysis of the signaling mechanisms that are involved. | Biochemistry 20040608 |
| Suppression of cytokine-inducible nitric oxide synthesis during intraperitoneal Meth A tumor growth. | The Journal of veterinary medical science 20040501 |
| 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. | The Journal of biological chemistry 20040430 |
| Nuclear localization of tetrahydrobiopterin biosynthetic enzymes. | Biochimica et biophysica acta 20040105 |
| Activity of synthetic enzymes of tetrahydrobiopterin in the human placenta. | International journal of molecular medicine 20040101 |
| Glucocorticoids decrease GTP cyclohydrolase and tetrahydrobiopterin-dependent vasorelaxation through glucocorticoid receptors. | Journal of cardiovascular pharmacology 20040101 |
| Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension. | Journal of cardiovascular pharmacology 20040101 |
| Tetrahydrobiopterin, a critical factor in the production and role of nitric oxide in mast cells. | The Journal of biological chemistry 20031212 |
| A haplotype at the PARK3 locus influences onset age for Parkinson's disease: the GenePD study. | Neurology 20031209 |
| Peroxisome proliferator-activated receptor agonists inhibit interleukin-1beta-mediated nitric oxide production in cultured lacrimal gland acinar cells. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201 |
| GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats. | American journal of physiology. Heart and circulatory physiology 20031101 |
| Ascorbate enhances iNOS activity by increasing tetrahydrobiopterin in RAW 264.7 cells. | Free radical biology & medicine 20031015 |
| Sepiapterin reduces postischemic injury in the rat heart. | Pflugers Archiv : European journal of physiology 20031001 |
| Localization of sepiapterin reductase in pigment cells of Oryzias latipes. | Pigment cell research 20031001 |
| Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide. | Molecular pharmacology 20031001 |
| Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice. | British journal of pharmacology 20031001 |
| Genetic engineering of Escherichia coli for production of tetrahydrobiopterin. | Metabolic engineering 20031001 |
| Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members. | Archives of biochemistry and biophysics 20030815 |
| Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. | Arteriosclerosis, thrombosis, and vascular biology 20030801 |
| Exogenous biopterins requirement for iNOS function in vascular smooth muscle cells. | Journal of cardiovascular pharmacology 20030801 |
| Overexpression of V-1 prevents nitric oxide-induced cell death: involvement of enhanced tetrahydrobiopterin biosynthesis. | Journal of neuroscience research 20030615 |
| The pteridine pathway in zebrafish: regulation and specification during the determination of neural crest cell-fate. | Pigment cell research 20030601 |
| Mycophenolic acid inhibits activation of inducible nitric oxide synthase in rodent fibroblasts. | Clinical and experimental immunology 20030501 |
| Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines. | Journal of neurochemistry 20030501 |
| Possible impact of tetrahydrobiopterin and sepiapterin on endothelial dysfunction. | Arteriosclerosis, thrombosis, and vascular biology 20030501 |
| Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures. | Journal of neurochemistry 20030401 |
| GTP cyclohydrolase 1 downregulation contributes to glucocorticoid hypertension in rats. | Hypertension (Dallas, Tex. : 1979) 20030301 |
| Effect of antisense oligodeoxynucleotide for sepiapterin reductase on the viability of PC12 cells in the presence of exogenous carbonyl compounds. | Chemico-biological interactions 20030201 |
| Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin. | Hypertension (Dallas, Tex. : 1979) 20030101 |
| Peripheral administration of lipopolysaccharide enhances the expression of guanosine triphosphate cyclohydrolase I mRNA in murine locus coeruleus. | Neuroscience 20030101 |
| Lack of nitric oxide mediation of flow-dependent arteriolar dilation in type I diabetes is restored by sepiapterin. | Journal of vascular research 20030101 |
| Nitric oxide production by decidual endothelial cells is not reduced in preeclampsia. | Hypertension in pregnancy 20030101 |
| Recent segmental and gene duplications in the mouse genome. | Genome biology 20030101 |
| Age estimation of Mexican fruit fly (Diptera: Tephritidae) based on accumulation of pterins. | Journal of economic entomology 20021201 |
| Localization of sepiapterin reductase in the human brain. | Brain research 20021108 |
| Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20021101 |
| Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants. | Arteriosclerosis, thrombosis, and vascular biology 20021001 |
| Mycophenolic acid downregulates inducible nitric oxide synthase induction in astrocytes. | Glia 20020901 |
| Escherichia coli 6-pyruvoyltetrahydropterin synthase ortholog encoded by ygcM has a new catalytic activity for conversion of sepiapterin to 7,8-dihydropterin. | FEBS letters 20020717 |
| Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: modulation of inducible nitric oxide synthase. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701 |
| Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function. | American journal of physiology. Heart and circulatory physiology 20020601 |
| Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells. | Biochemical and biophysical research communications 20020510 |
| Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin. | Brain research 20020510 |
| Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability. | British journal of pharmacology 20020501 |
| Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin. | Cytokine 20020421 |
| Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid. | Biochemical and biophysical research communications 20020412 |
| Disorders of tetrahydrobiopterin metabolism and their treatment. | Current drug metabolism 20020401 |
| The enzymes with benzil reductase activity conserved from bacteria to mammals. | Journal of biotechnology 20020328 |
| Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein. | The Journal of biological chemistry 20020322 |
| The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. | The Biochemical journal 20020315 |
| Analysis of xanthophore and pterinosome biogenesis in zebrafish using methylene blue and pteridine autofluorescence. | Pigment cell research 20020201 |
| Detection of sepiapterin in CSF of patients with sepiapterin reductase deficiency. | Molecular genetics and metabolism 20020201 |
| Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II. | Biochimica et biophysica acta 20020131 |
| Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors. | The Journal of biological chemistry 20020104 |
| Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency. | Journal of neurochemistry 20020101 |
| Isolation and expression of a Bacillus cereus gene encoding benzil reductase. | Biotechnology and bioengineering 20011220 |
| [Perspectives on tetrahydrobiopterin research]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20011201 |
| Cloning and developmental expression of zebrafish GTP cyclohydrolase I. | Mechanisms of development 20011101 |
| Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. | European journal of human genetics : EJHG 20010901 |
| Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells. | Japanese journal of pharmacology 20010901 |
| Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. | American journal of human genetics 20010801 |
| Tetrahydrobiopterin levels regulate endothelial cell proliferation. | American journal of physiology. Heart and circulatory physiology 20010801 |
| Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010801 |
| Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction? | American journal of physiology. Heart and circulatory physiology 20010601 |
| Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA. | The Journal of laboratory and clinical medicine 20010501 |
| Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase. | Nitric oxide : biology and chemistry 20010401 |
| Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. | Circulation 20010306 |
| The cytotoxic effects of diesel exhaust particles on human pulmonary artery endothelial cells in vitro: role of active oxygen species. | Free radical biology & medicine 20010301 |
| Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts. | Clinical chemistry 20010301 |
| Effect of vitamin C on the availability of tetrahydrobiopterin in human endothelial cells. | Journal of cardiovascular pharmacology 20010301 |
| Paracrine neuroprotective effect of nitric oxide in the developing retina. | Journal of neurochemistry 20010201 |
| Role of the conserved Ser-Tyr-Lys triad of the SDR family in sepiapterin reductase. | Chemico-biological interactions 20010130 |
| L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. | The Journal of biological chemistry 20010105 |
| Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension. | American journal of physiology. Heart and circulatory physiology 20010101 |
| Sequence-specific DNA damage induced by UVA radiation in the presence of endogenous and exogenous photosensitizers. | Current problems in dermatology 20010101 |
| Glucocorticoids inhibit tetrahydrobiopterin-dependent endothelial function. | Experimental biology and medicine (Maywood, N.J.) 20010101 |
| Tetrahydrobiopterin deficiencies without hyperphenylalaninemia: diagnosis and genetics of dopa-responsive dystonia and sepiapterin reductase deficiency. | Molecular genetics and metabolism 20010101 |
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