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890842-28-1 | GSK 650394
CAS No: 890842-28-1 Catalog No: AG00408H MDL No:MFCD12828779
Product Description
Catalog Number:
AG00408H
Chemical Name:
GSK 650394
CAS Number:
890842-28-1
Molecular Formula:
C25H22N2O2
Molecular Weight:
382.4544
MDL Number:
MFCD12828779
IUPAC Name:
2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
InChI:
InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
InChI Key:
WVSBGSNVCDAMCF-UHFFFAOYSA-N
SMILES:
OC(=O)c1ccc(cc1C1CCCC1)c1c[nH]c2c1cc(cn2)c1ccccc1
UNII:
56887611DJ
Properties
Complexity:
569
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
382.168g/mol
Formal Charge:
0
Heavy Atom Count:
29
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
382.463g/mol
Monoisotopic Mass:
382.168g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
66A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.1
Literature
| Title | Journal |
|---|---|
| Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport. | The Journal of biological chemistry 20160902 |
| Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening. | Bioorganic & medicinal chemistry letters 20120901 |
| Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1. | The Journal of biological chemistry 20110916 |
| Selectivity of kinase inhibitor fragments. | Journal of medicinal chemistry 20110728 |
| Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption. | British journal of pharmacology 20101001 |
| Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors. | Bioorganic & medicinal chemistry letters 20090801 |
| Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. | Cancer research 20080915 |
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