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88903-69-9 | Xestospongin C
CAS No: 88903-69-9 Catalog No: AG00491B MDL No:MFCD01862629
Product Description
Catalog Number:
AG00491B
Chemical Name:
Xestospongin C
CAS Number:
88903-69-9
Molecular Formula:
C28H50N2O2
Molecular Weight:
446.7088
MDL Number:
MFCD01862629
IUPAC Name:
(1R,8S,10R,15S,22S,29R)-9,30-dioxa-11,25-diazapentacyclo[20.6.2.28,11.010,15.025,29]dotriacontane
InChI:
InChI=1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m0/s1
InChI Key:
PQYOPBRFUUEHRC-MUJQFDPKSA-N
SMILES:
C1CCCC2CCCN3C2OC(CCCCCCC2C4OC(CC1)CCN4CCC2)CC3
Properties
Complexity:
510
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
6
Defined Bond Stereocenter Count:
0
Exact Mass:
446.387g/mol
Formal Charge:
0
Heavy Atom Count:
32
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
446.72g/mol
Monoisotopic Mass:
446.387g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
24.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
7.4
Literature
| Title | Journal |
|---|---|
| Xestospongin C induces monocytic differentiation of HL60 cells through activation of the ERK pathway. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130501 |
| Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats. | American journal of physiology. Lung cellular and molecular physiology 20121101 |
| Hydrogen sulfide prevents hypoxia-induced apoptosis via inhibition of an H2O2-activated calcium signaling pathway in mouse hippocampal neurons. | Biochemical and biophysical research communications 20120824 |
| Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstriction. | Antioxidants & redox signaling 20120801 |
| Ca2+ responses of pulmonary arterial myocytes to acute hypoxia require release from ryanodine and inositol trisphosphate receptors in sarcoplasmic reticulum. | American journal of physiology. Lung cellular and molecular physiology 20120715 |
| Interleukin-13 enhanced Ca2+ oscillations in airway smooth muscle cells. | Cytokine 20120101 |
| Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). | PloS one 20120101 |
| Intracellular angiotensin II activates rat myometrium. | American journal of physiology. Cell physiology 20110901 |
| Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores. | American journal of physiology. Cell physiology 20110901 |
| Essential role for calcium waves in migration of human vascular smooth muscle cells. | American journal of physiology. Heart and circulatory physiology 20110801 |
| VEGF-induced retinal angiogenic signaling is critically dependent on Ca²⁺ signaling by Ca²⁺/calmodulin-dependent protein kinase II. | Investigative ophthalmology & visual science 20110511 |
| A fundamental role for NO-PLC signaling pathway in mediating intracellular Ca2+ oscillation in pancreatic acini. | Nitric oxide : biology and chemistry 20110430 |
| The common inhaled anesthetic isoflurane increases aggregation of huntingtin and alters calcium homeostasis in a cell model of Huntington's disease. | Toxicology and applied pharmacology 20110201 |
| Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110119 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Frequent calcium oscillations lead to NFAT activation in human immature dendritic cells. | The Journal of biological chemistry 20100521 |
| Spontaneous ryanodine-receptor-dependent Ca2+-activated K+ currents and hyperpolarizations in rat medial preoptic neurons. | Journal of neurophysiology 20100501 |
| Characterization of spontaneous inhibitory postsynaptic currents in cultured rat retinal amacrine cells. | Neuroscience 20100120 |
| A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI. | PloS one 20100101 |
| Acetylcholine rescues two-cell block through activation of IP3 receptors and Ca2+/calmodulin-dependent kinase II in an ICR mouse strain. | Pflugers Archiv : European journal of physiology 20091001 |
| Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. | The Journal of biological chemistry 20090807 |
| Effect of low level laser therapy on bronchial hyper-responsiveness. | Lasers in medical science 20090701 |
| Vascular endothelial cells and smooth muscle cells mediate carbachol-induced hepatocyte proliferation via muscarinic receptors and IP3/PKC signaling cascades. | Cell biology international 20090401 |
| Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death. | Diabetes 20090201 |
| MK801 blocks hypoxic blood-brain-barrier disruption and leukocyte adhesion. | Neuroscience letters 20090116 |
| Enhanced pulsatile pressure accelerates vascular smooth muscle migration: implications for atherogenesis of hypertension. | Cardiovascular research 20081201 |
| An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown. | Neuropharmacology 20081201 |
| Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain. | Journal of neurochemistry 20081201 |
| Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries. | American journal of physiology. Cell physiology 20081101 |
| Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors. | Progress in neuro-psychopharmacology & biological psychiatry 20081001 |
| Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells. | Cell death and differentiation 20080801 |
| Inhibition of mGluR1 and IP3Rs impairs long-term memory formation in young chicks. | Neurobiology of learning and memory 20080701 |
| Calcium release via activation of presynaptic IP3 receptors contributes to kainate-induced IPSC facilitation in rat neocortex. | Neuropharmacology 20080701 |
| A requirement for calcium in the caspase-independent killing of Burkitt lymphoma cell lines by Rituximab. | British journal of haematology 20080701 |
| Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T cell activation. | The Journal of biological chemistry 20080502 |
| A novel Ca2+ influx pathway activated by mechanical stretch in human airway smooth muscle cells. | American journal of respiratory cell and molecular biology 20080401 |
| Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory. | Learning & memory (Cold Spring Harbor, N.Y.) 20080301 |
| Sub-plasmalemmal [Ca2+]i upstroke in myocytes of the guinea-pig small intestine evoked by muscarinic stimulation: IP3R-mediated Ca2+ release induced by voltage-gated Ca2+ entry. | Cell calcium 20080201 |
| Effect of inhalational anesthetics on cytotoxicity and intracellular calcium differently in rat pheochromocytoma cells (PC12). | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080201 |
| Potentiation of N-methyl-D-aspartate receptor-mediated neuronal injury during methamphetamine withdrawal in vitro requires co-activation of IP3 receptors. | Brain research 20080102 |
| Role of InsP3 and ryanodine receptors in the activation of capacitative Ca2+ entry by store depletion or hypoxia in canine pulmonary arterial smooth muscle cells. | British journal of pharmacology 20070901 |
| Purinergic receptor-stimulated IP3-mediated Ca2+ release enhances neuroprotection by increasing astrocyte mitochondrial metabolism during aging. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070613 |
| R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. | Nature cell biology 20070401 |
| Differential contribution of extracellular and intracellular calcium sources to basal transmission and long-term potentiation in the sympathetic ganglion of the rat. | Developmental neurobiology 20070401 |
| Two distinct signaling pathways for regulation of spontaneous local Ca2+ release by phospholipase C in airway smooth muscle cells. | Pflugers Archiv : European journal of physiology 20070101 |
| Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium release. | Journal of neurochemistry 20070101 |
| A store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia. | Journal of neurophysiology 20061101 |
| Involvement of calcium-mediated apoptotic signals in H2O2-induced MIN6N8a cell death. | European journal of pharmacology 20061010 |
| Role of inositol 1,4,5-trisphosphate receptors in alpha1-adrenergic receptor-induced cardiomyocyte hypertrophy. | Acta pharmacologica Sinica 20060701 |
| Localized Ca2+ uncaging induces Ca2+ release through IP3R in smooth muscle. | Acta pharmacologica Sinica 20060701 |
| Role of phospholipase C-gamma in NGF-stimulated differentiation and gene induction. | Acta biologica Hungarica 20060601 |
| Morphine mimics the antiapoptotic effect of preconditioning via an Ins(1,4,5)P3 signaling pathway in rat ventricular myocytes. | American journal of physiology. Heart and circulatory physiology 20050101 |
| Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice. | American journal of physiology. Cell physiology 20041001 |
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