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88899-55-2 | (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
CAS No: 88899-55-2 Catalog No: AG0039AQ MDL No:MFCD06795130
Product Description
Catalog Number:
AG0039AQ
Chemical Name:
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
CAS Number:
88899-55-2
Molecular Formula:
C35H58O9
Molecular Weight:
622.8296
MDL Number:
MFCD06795130
IUPAC Name:
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
InChI:
InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChI Key:
XDHNQDDQEHDUTM-JQWOJBOSSA-N
SMILES:
CO[C@H]1/C=C/C=C(\C)/C[C@H](C)[C@H](O)[C@@H](/C=C(/C=C(/C(=O)O[C@@H]1[C@H]([C@H]([C@@H]([C@@]1(O)C[C@@H](O)[C@@H]([C@H](O1)C(C)C)C)C)O)C)\OC)\C)C
Properties
Complexity:
1060
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
12
Defined Bond Stereocenter Count:
4
Exact Mass:
622.408g/mol
Formal Charge:
0
Heavy Atom Count:
44
Hydrogen Bond Acceptor Count:
9
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
622.84g/mol
Monoisotopic Mass:
622.408g/mol
Rotatable Bond Count:
7
Topological Polar Surface Area:
135A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6
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| Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation. | American journal of physiology. Cell physiology 20080801 |
| Receptor-independent, vacuolar ATPase-mediated cellular uptake of histamine receptor-1 ligands: possible origin of pharmacological distortions and side effects. | Toxicology and applied pharmacology 20080615 |
| A determination of the steady state lysosomal pH of bloodstream stage African trypanosomes. | Molecular and biochemical parasitology 20080601 |
| Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod. | Molecular immunology 20080601 |
| Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2. | The Biochemical journal 20080501 |
| Intense pseudotransport of a cationic drug mediated by vacuolar ATPase: procainamide-induced autophagic cell vacuolization. | Toxicology and applied pharmacology 20080501 |
| An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection. | Biomaterials 20080501 |
| Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts. | Histochemistry and cell biology 20080501 |
| Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. | Nature chemical biology 20080501 |
| A mathematical model of the proton balance in the outer mantle epithelium of Anodonta cygnea L. | The Journal of membrane biology 20080501 |
| A method to measure cardiac autophagic flux in vivo. | Autophagy 20080401 |
| Analysis of the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection: aminopeptidase N is not important and a process of acidification of the endosome is necessary. | The Journal of general virology 20080401 |
| Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase. | The Journal of experimental biology 20080401 |
| Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms. | American journal of physiology. Renal physiology 20080301 |
| Vesicular release of glutamate from hippocampal neurons in culture: an immunocytochemical assay. | Experimental brain research 20080201 |
| Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. | Traffic (Copenhagen, Denmark) 20080201 |
| The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells. | The FEBS journal 20080201 |
| Acute effectors of GLUT1 glucose transporter subcellular targeting in CIT3 mouse mammary epithelial cells. | Pediatric research 20080101 |
| Phagocytosis-induced apoptosis of macrophages is linked to uptake, killing and degradation of bacteria. | European journal of immunology 20080101 |
| Induction of apoptosis by epigallocatechin gallate and autophagy inhibitors in a mouse macrophage-like cell line. | Anticancer research 20080101 |
| Low-affinity transport of FITC-albumin in alveolar type II epithelial cell line RLE-6TN. | Drug metabolism and pharmacokinetics 20080101 |
| Methods to investigate autophagy during starvation and regeneration in hydra. | Methods in enzymology 20080101 |
| Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. | ACS nano 20080101 |
| Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells. | Endocrinology 20071201 |
| Involvement of vesicular H+-ATPase in insulin-stimulated glucose transport in 3T3-F442A adipocytes. | Endocrine journal 20071201 |
| Depolarization of isolated horizontal cells of fish acidifies their immediate surrounding by activating V-ATPase. | The Journal of physiology 20071201 |
| Involvement of Na+/H+ exchangers in induction of cyclooxygenase-2 by vacuolar-type (H+)-ATPase inhibitors in RAW 264 cells. | FEBS letters 20071002 |
| A dimethylmaleic acid-melittin-polylysine conjugate with reduced toxicity, pH-triggered endosomolytic activity and enhanced gene transfer potential. | The journal of gene medicine 20070901 |
| Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins. | Journal of virology 20070801 |
| Bafilomycin A1 is a potassium ionophore that impairs mitochondrial functions. | Journal of bioenergetics and biomembranes 20070801 |
| NAADP mobilizes calcium from the endoplasmic reticular Ca(2+) store in T-lymphocytes. | The Journal of biological chemistry 20070629 |
| Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies. | The Journal of biological chemistry 20070622 |
| Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. | The Journal of biological chemistry 20070420 |
| An envelope-determined endocytic route of viral entry allows HIV-1 to escape from secreted phospholipase A2 entry blockade. | Journal of molecular biology 20070330 |
| Angiotensin II increases chloride absorption in the cortical collecting duct in mice through a pendrin-dependent mechanism. | American journal of physiology. Renal physiology 20070301 |
| ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1. | Molecular pharmacology 20070301 |
| Vacuolar-type H+-ATPase-mediated acidosis promotes in vitro osteoclastogenesis via modulation of cell migration. | International journal of molecular medicine 20070301 |
| Vesicular release of glutamate from unmyelinated axons in white matter. | Nature neuroscience 20070301 |
| Chitosan-graft-polyethylenimine as a gene carrier. | Journal of controlled release : official journal of the Controlled Release Society 20070212 |
| Inhibition of bone resorption in cultures of mouse calvariae by apicularen A. | Planta medica 20070201 |
| Estrogen decrease in tight junctional resistance involves matrix-metalloproteinase-7-mediated remodeling of occludin. | Endocrinology 20070101 |
| Biosynthetic origin of the methoxyl extender unit in bafilomycin and concanamycin using stereospecifically labeled precursors. | The Journal of antibiotics 20070101 |
| Conjugated polythiophene probes target lysosome-related acidic vacuoles in cultured primary cells. | Molecular and cellular probes 20070101 |
| Inhibition of betanodavirus infection by inhibitors of endosomal acidification. | Archives of virology 20070101 |
| The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20061201 |
| Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha. | Molecular pharmacology 20061201 |
| Cell entry and cAMP imaging of anthrax edema toxin. | The EMBO journal 20061115 |
| Osteoclasts play a part in pain due to the inflammation adjacent to bone. | Bone 20061101 |
| Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells. | The Journal of pharmacology and experimental therapeutics 20061101 |
| Suppression of proinflammatory cytokine production in macrophages by lansoprazole. | Pediatric surgery international 20061101 |
| pH dependence and inhibition by extracellular calcium of proton currents via plasmalemmal vacuolar-type H+-ATPase in murine osteoclasts. | The Journal of physiology 20061015 |
| Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator. | Biochimica et biophysica acta 20061001 |
| CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. | Biochemical and biophysical research communications 20060714 |
| Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1). | Diabetes research and clinical practice 20060601 |
| Role of urease in megasome formation and Helicobacter pylori survival in macrophages. | Journal of leukocyte biology 20060601 |
| Dynamic life and death interactions between Mycobacterium smegmatis and J774 macrophages. | Cellular microbiology 20060601 |
| Effects of bafilomycin A1, a vacuolar type H+ ATPase inhibitor, on the thermosensitivity of a human pancreatic cancer cell line. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20060601 |
| Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing. | Experimental cell research 20060515 |
| Inhibition of vacuolar-type (H+)-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells. | FEBS letters 20060515 |
| Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition. | The Journal of biological chemistry 20060421 |
| Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation. | The Journal of biological chemistry 20060421 |
| FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus. | The Journal of biological chemistry 20060421 |
| Ca2+ release triggered by NAADP in hepatocyte microsomes. | The Biochemical journal 20060415 |
| Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. | Molecular pharmacology 20060401 |
| Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM. | Organic letters 20060316 |
| Cathepsin B-mediated yolk protein degradation during killifish oocyte maturation is blocked by an H+-ATPase inhibitor: effects on the hydration mechanism. | American journal of physiology. Regulatory, integrative and comparative physiology 20060201 |
| Proton pump-rich cell secretes acid in skin of zebrafish larvae. | American journal of physiology. Cell physiology 20060201 |
| Calcium mobilization by nicotinic acid adenine dinucleotide phosphate (NAADP) in rat astrocytes. | Cell calcium 20060201 |
| Glia re-sealed particles freshly prepared from adult rat brain are competent for exocytotic release of glutamate. | Journal of neurochemistry 20060201 |
| Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum. | Journal of immunology (Baltimore, Md. : 1950) 20060201 |
| GTP uptake into rat brain synaptic vesicles. | Brain research 20060127 |
| Intragranular pH rapidly modulates exocytosis in adrenal chromaffin cells. | Journal of neurochemistry 20060101 |
| H+-ATPase activity in selective disruption of H+-K+-ATPase alpha 1 gene of mice under normal and K-depleted conditions. | The Journal of laboratory and clinical medicine 20060101 |
| Autophagy, bafilomycin and cell death: the 'a-B-cs' of plecomacrolide-induced neuroprotection. | Autophagy 20060101 |
| Subunit a of the yeast V-ATPase participates in binding of bafilomycin. | The Journal of biological chemistry 20051209 |
| Inhibition of the vacuolar H(+)-pump with bafilomycin A1 does not induce acrosome reaction or activate proacrosin in mouse spermatozoa. | Biochemical and biophysical research communications 20051202 |
| Proteolytic processing of the ovine prion protein in cell cultures. | Biochemical and biophysical research communications 20051111 |
| Nano neodymium oxide induces massive vacuolization and autophagic cell death in non-small cell lung cancer NCI-H460 cells. | Biochemical and biophysical research communications 20051111 |
| Neuronal zinc stores are modulated by non-steroidal anti-inflammatory drugs: an optical analysis in cultured hippocampal neurons. | Brain research 20051102 |
| Gene delivery with low molecular weight linear polyethylenimines. | The journal of gene medicine 20051001 |
| A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050901 |
| Ca2+ accumulation into acidic organelles mediated by Ca2+- and vacuolar H+-ATPases in human platelets. | The Biochemical journal 20050815 |
| Mechanisms behind Pb-induced disruption of Na+ and Cl- balance in rainbow trout (Oncorhynchus mykiss). | American journal of physiology. Regulatory, integrative and comparative physiology 20050801 |
| Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica. | Plant physiology 20050801 |
| Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes. | Journal of controlled release : official journal of the Controlled Release Society 20050720 |
| V-ATPase expression during development of Artemia franciscana embryos: potential role for proton gradients in anoxia signaling. | The Journal of experimental biology 20050701 |
| V-ATPase inhibition prevents recovery from anoxia in Artemia franciscana embryos: quiescence signaling through dissipation of proton gradients. | The Journal of experimental biology 20050701 |
| Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. | The journal of gene medicine 20050501 |
| Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. | International journal of oncology 20050501 |
| Direct measurement of acid efflux from isolated guinea pig pancreatic ducts. | Pancreas 20050501 |
| Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells. | Journal of cell science 20050501 |
| pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells. | The Journal of biological chemistry 20050429 |
| Glycosaminoglycans modulate activation, activity, and stability of tripeptidyl-peptidase I in vitro and in vivo. | The Journal of biological chemistry 20050304 |
| Insertion of targeting domains into the envelope glycoprotein of Moloney murine leukemia virus (MoMLV)-based vectors modulates the route of mCAT-1-mediated viral entry. | Virus research 20050301 |
| Nicotinic acid adenine dinucleotide phosphate potentiates neurite outgrowth. | The Journal of biological chemistry 20050218 |
| Role of H+-ATPase-mediated acidification in sorting and release of the regulated secretory protein chromogranin A: evidence for a vesiculogenic function. | The Journal of biological chemistry 20050204 |
| In vitro gene delivery using polyamidoamine dendrimers with a trimesyl core. | Biomacromolecules 20050101 |
| Lysosome-sarcoplasmic reticulum junctions. A trigger zone for calcium signaling by nicotinic acid adenine dinucleotide phosphate and endothelin-1. | The Journal of biological chemistry 20041224 |
| Burkholderia cepacia complex isolates survive intracellularly without replication within acidic vacuoles of Acanthamoeba polyphaga. | Cellular microbiology 20041201 |
| H+-ATPase of crude homogenate of the outer mantle epithelium of Anodonta cygnea. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20041201 |
| A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism. | The Journal of biological chemistry 20041119 |
| Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules. | American journal of physiology. Renal physiology 20041101 |
| The ability of chloroquine to prevent tat-induced cytokine secretion by monocytes is implicated in its in vivo anti-human immunodeficiency virus type 1 activity. | Journal of virology 20041101 |
| Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. | The Journal of biological chemistry 20041022 |
| Distinct profiles of refilling of inhibitory neurotransmitters into presynaptic terminals projecting to spinal neurones in immature rats. | The Journal of physiology 20041015 |
| Inhibition of bicarbonate reabsorption in the rat proximal tubule by activation of luminal P2Y1 receptors. | American journal of physiology. Renal physiology 20041001 |
| Identification and characterization of the Pasteurella multocida toxin translocation domain. | Molecular microbiology 20041001 |
| Mobilization and fusion of a non-recycling pool of synaptic vesicles under conditions of endocytic blockade. | Neuropharmacology 20041001 |
| Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A. | The Journal of antibiotics 20041001 |
| Molecular mechanisms of TNF-alpha-induced ceramide formation in human glioma cells: P53-mediated oxidant stress-dependent and -independent pathways. | Cell death and differentiation 20040901 |
| V-type ATPase is involved in biogenesis of GLUT4 vesicles. | American journal of physiology. Endocrinology and metabolism 20040901 |
| Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the phosphatidylinositol 3-kinase and Akt pathway. | The Journal of biological chemistry 20040827 |
| The bafilomycin/concanamycin binding site in subunit c of the V-ATPases from Neurospora crassa and Saccharomyces cerevisiae. | The Journal of biological chemistry 20040806 |
| Transmembrane reorientation of the substrate-binding site in vesicular acetylcholine transporter. | Biochemistry 20040713 |
| Up-regulation of low-density lipoprotein receptor in human hepatocytes is induced by sequestration of free cholesterol in the endosomal/lysosomal compartment. | Biochemical pharmacology 20040615 |
| Mild heat shock induces autophagic growth arrest, but not apoptosis in U251-MG and U87-MG human malignant glioma cells. | Journal of neuro-oncology 20040601 |
| Proteinases participating in the processing and activation of prolegumain in primary cultured rat macrophages. | Biological chemistry 20040601 |
| Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1. | The Journal of biological chemistry 20040507 |
| Important role for the V-type H(+)-ATPase and the Golgi apparatus in the recycling of PTH/PTHrP receptor. | American journal of physiology. Endocrinology and metabolism 20040501 |
| Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing autosomal dominant osteopetrosis type II. | The American journal of pathology 20040501 |
| Processing and activation of latent heparanase occurs in lysosomes. | Journal of cell science 20040501 |
| Release of intact and fragmented osteocalcin molecules from bone matrix during bone resorption in vitro. | The Journal of biological chemistry 20040430 |
| Involvement of membrane GABA transporter in alpha-latrotoxin-stimulated [3H]GABA release. | Neurochemistry international 20040401 |
| Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. | Cell death and differentiation 20040401 |
| The membrane potential of the intraerythrocytic malaria parasite Plasmodium falciparum. | The Journal of biological chemistry 20040319 |
| Lactosylated polyethylenimine for gene transfer into airway epithelial cells: role of the sugar moiety in cell delivery and intracellular trafficking of the complexes. | The journal of gene medicine 20040301 |
| Endocytic trafficking in actively resorbing osteoclasts. | Journal of cell science 20040227 |
| Inhibitory effect of Toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages. | Journal of immunology (Baltimore, Md. : 1950) 20040215 |
| Synergism in gene delivery by small PEIs and three different nonviral vectors. | International journal of pharmaceutics 20040211 |
| Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells. | The international journal of biochemistry & cell biology 20040201 |
| Correction of defective early tyrosinase processing by bafilomycin A1 and monensin in pink-eyed dilution melanocytes. | Pigment cell research 20040201 |
| Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL. | The Journal of biological chemistry 20040116 |
| Sodium and chloride transport in soft water and hard water acclimated zebrafish (Danio rerio). | Biochimica et biophysica acta 20031230 |
| Synthesis of the c14-c25 subunit of bafilomycin A1. | The Journal of organic chemistry 20031226 |
| Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation. | The Journal of biological chemistry 20031128 |
| Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases. | The Journal of biological chemistry 20031107 |
| Characterization of the functional coupling of bovine brain vacuolar-type H(+)-translocating ATPase. Effect of divalent cations, phospholipids, and subunit H (SFD). | The Journal of biological chemistry 20031107 |
| Profibrillin-1 maturation by human dermal fibroblasts: proteolytic processing and molecular chaperones. | Journal of cellular biochemistry 20031015 |
| Wortmannin alters the intracellular trafficking of the bradykinin B2 receptor: role of phosphoinositide 3-kinase and Rab5. | The Biochemical journal 20031001 |
| Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1. | Journal of biochemistry 20030901 |
| The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol. | The Journal of biological chemistry 20030822 |
| Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. | The Journal of biological chemistry 20030815 |
| Cell alkalosis elevates cytosolic Ca2+ in rabbit resident alveolar macrophages. | Clinical science (London, England : 1979) 20030701 |
| Amyloid-beta increases acetylcholinesterase expression in neuroblastoma cells by reducing enzyme degradation. | Journal of neurochemistry 20030701 |
| Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. | Oncogene 20030619 |
| Distribution and serotonin-induced activation of vacuolar-type H+-ATPase in the salivary glands of the blowfly Calliphora vicina. | The Journal of experimental biology 20030601 |
| Channel formation by the binding component of Clostridium botulinum C2 toxin: glutamate 307 of C2II affects channel properties in vitro and pH-dependent C2I translocation in vivo. | Biochemistry 20030513 |
| Increase in secretion of glial cell line-derived neurotrophic factor from glial cell lines by inhibitors of vacuolar ATPase. | Neurochemistry international 20030501 |
| Secretion of acid and base equivalents by intact distal airways. | American journal of physiology. Lung cellular and molecular physiology 20030501 |
| Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. | Cancer research 20030501 |
| Phosphocitrate inhibits calcium hydroxyapatite induced mitogenesis and upregulation of matrix metalloproteinase-1, interleukin-1beta and cyclooxygenase-2 mRNA in human breast cancer cell lines. | Breast cancer research and treatment 20030501 |
| Proton pump inhibitors control osteoclastic resorption of calcium phosphate implants and stimulate increased local reparative bone growth. | The Journal of craniofacial surgery 20030501 |
| An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway. | The Journal of biological chemistry 20030418 |
| Effects of Bafilomycin A1: an inhibitor of vacuolar H (+)-ATPases on endocytosis and apoptosis in RAW cells and RAW cell-derived osteoclasts. | Journal of cellular biochemistry 20030415 |
| Presentation by recycling MHC class II molecules of an influenza hemagglutinin-derived epitope that is revealed in the early endosome by acidification. | Journal of immunology (Baltimore, Md. : 1950) 20030401 |
| Isolation of small agranular synaptic vesicles of rat brain by gel filtration chromatography. | Journal of biochemistry 20030401 |
| Remodeling of endosomes during lysosome biogenesis involves 'kiss and run' fusion events regulated by rab5. | Journal of cell science 20030301 |
| Increased tumour extracellular pH induced by Bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics. | European journal of cancer (Oxford, England : 1990) 20030301 |
| In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis. | FEBS letters 20030227 |
| Different synergistic roles of small polyethylenimine and Dosper in gene delivery. | Journal of controlled release : official journal of the Controlled Release Society 20030214 |
| Localization and characterization of phenamil-sensitive Na+ influx in isolated rainbow trout gill epithelial cells. | The Journal of experimental biology 20030201 |
| Specific biological functions of vacuolar-type H(+)-ATPase and lysosomal cysteine proteinase, cathepsin K, in osteoclasts. | The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 20030201 |
| Inhibition of the yeast V-type ATPase by cytosolic ADP. | FEBS letters 20030130 |
| Receptor occupancy limits synaptic depression at climbing fiber synapses. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030115 |
| Storage and release of ATP from astrocytes in culture. | The Journal of biological chemistry 20030110 |
| Intracellular pH regulation in U937 human monocytes: roles of V-ATPase and Na+/H+ exchange. | Immunobiology 20030101 |
| Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes. | American journal of physiology. Endocrinology and metabolism 20021201 |
| Activation of D2-like receptors causes recruitment of tyrosine-phosphorylated NKA alpha 1-subunits in kidney. | American journal of physiology. Renal physiology 20021201 |
| Rapid trafficking of membrane type 1-matrix metalloproteinase to the cell surface regulates progelatinase a activation. | Laboratory investigation; a journal of technical methods and pathology 20021201 |
| Clostridium perfringens iota toxin. Mapping of the Ia domain involved in docking with Ib and cellular internalization. | The Journal of biological chemistry 20021115 |
| Hydralazine reduces the quantal size of secretory events by displacement of catecholamines from adrenomedullary chromaffin secretory vesicles. | Circulation research 20021101 |
| The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function. | The Journal of biological chemistry 20021011 |
| Inhibition of vacuolation toxin activity of Helicobacter pylori by iodine, nitrite and potentiation by sodium chloride, sterigmatocystin and fluoride. | Toxicology in vitro : an international journal published in association with BIBRA 20021001 |
| Inhibition of weak-base amine-induced lysis of lysosomes by cytosol. | Journal of biochemistry 20021001 |
| In-vitro characterisation of the phagocytosis and fate of anthrax spores in macrophages and the effects of anti-PA antibody. | Journal of medical microbiology 20021001 |
| Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents. | The Journal of biological chemistry 20020927 |
| Vesicle transmembrane potential is required for translocation to the cytosol of externally added FGF-1. | The EMBO journal 20020902 |
| Plasmalemmal H+ extruders in mammalian alveolar macrophages. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20020901 |
| Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein. | Journal of experimental botany 20020901 |
| Mechanisms of acid secretion in pseudobranch cells of rainbow trout (Oncorhynchus mykiss). | The Journal of experimental biology 20020901 |
| Properties of the V-type ATPase from the excretory system of the usherhopper, Poekilocerus bufonius. | Insect biochemistry and molecular biology 20020901 |
| Influence of ANG II on cytoplasmic sodium in cultured rabbit nonpigmented ciliary epithelium. | American journal of physiology. Cell physiology 20020801 |
| The internal pH of synaptic-like microvesicles in rat pinealocytes in culture. | Journal of neurochemistry 20020801 |
| Analysis of the infectious entry pathway of human papillomavirus type 33 pseudovirions. | Virology 20020801 |
| The Vibrio cholerae haemolysin anion channel is required for cell vacuolation and death. | Cellular microbiology 20020701 |
| Total synthesis of (-)-bafilomycin A(1). | Journal of the American Chemical Society 20020619 |
| Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment. | The Journal of organic chemistry 20020614 |
| V-type H+-ATPase in the human eccrine sweat duct: immunolocalization and functional demonstration. | American journal of physiology. Cell physiology 20020601 |
| Environmental factors in the etiology of type 1 diabetes. | American journal of medical genetics 20020530 |
| Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway. | The Journal of biological chemistry 20020426 |
| Copper uptake across rainbow trout gills: mechanisms of apical entry. | The Journal of experimental biology 20020401 |
| Acidocalcisomes are functionally linked to the contractile vacuole of Dictyostelium discoideum. | The Journal of biological chemistry 20020308 |
| Mutations in subunit C of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site. | The Journal of biological chemistry 20020208 |
| Inhibition of protein phosphatase-1 is linked to phosphorylation of p53 and apoptosis. | Apoptosis : an international journal on programmed cell death 20020201 |
| Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts. | Journal of lipid research 20020201 |
| pH-dependent regulation of lysosomal calcium in macrophages. | Journal of cell science 20020201 |
| Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments. | Pharmaceutical research 20020201 |
| Transcytosis of iota-toxin across polarized CaCo-2 cells. | Molecular microbiology 20020201 |
| Hippocampal astrocytes in situ exhibit calcium oscillations that occur independent of neuronal activity. | Journal of neurophysiology 20020101 |
| Physiological and morphological evidences for the presence acidocalcisomes in Trypanosoma evansi: single cell fluorescence and 31P NMR studies. | Molecular and biochemical parasitology 20020101 |
| [Effect of an vacuolar proton pump inhibitor bafilomycin A1 on the intracellular processing of markers for receptor-mediated and liquid phase endocytosis]. | Tsitologiia 20020101 |
| Internalization and stepwise degradation of heparan sulfate proteoglycans in rat hepatocytes. | Biochimica et biophysica acta 20011219 |
| On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes. | Biochimica et biophysica acta 20011101 |
| Multiple virulence factors of Cryptococcus neoformans are dependent on VPH1. | Molecular microbiology 20011101 |
| Total synthesis of bafilomycin A(1) relying on iterative 1,2-induction in acyclic precursors. | Journal of the American Chemical Society 20011024 |
| Inverse correlation between pink-eyed dilution protein expression and induction of melanogenesis by bafilomycin A1. | Pigment cell research 20011001 |
| Potential tumor-targeting peptide vector of histidylated oligolysine conjugated to a tumor-homing RGD motif. | Cancer gene therapy 20011001 |
| Ca(2+) and H+ homeostasis in fission yeast: a role of Ca(2+)/H+ exchange and distinct V-H+-ATPases of the secretory pathway organelles. | FEBS letters 20010914 |
| Dietary microbial toxins and type 1 diabetes--a new meaning for seed and soil. | Diabetologia 20010901 |
| Na(+)-dependent pH regulation by the amitochondriate protozoan parasite Giardia intestinalis. | The Journal of biological chemistry 20010803 |
| Endocytosed SP-A and surfactant lipids are sorted to different organelles in rat type II pneumocytes. | American journal of physiology. Lung cellular and molecular physiology 20010801 |
| Melanosomal pH controls rate of melanogenesis, eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells. | Experimental cell research 20010801 |
| Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins. | Glycobiology 20010801 |
| Bafilomycin A1 inhibits proteolytic cleavage and hydration but not yolk crystal disassembly or meiosis during maturation of sea bass oocytes. | The Journal of experimental zoology 20010801 |
| Bafilomycin A1 at nanomolar concentrations saturably inhibits a portion of turtle bladder acidification current. | The Journal of experimental biology 20010801 |
| Ca(2+) transport into an intracellular acidic compartment of Candida parapsilosis. | FEBS letters 20010629 |
| Bafilomycin A(1) inhibits rhinovirus infection in human airway epithelium: effects on endosome and ICAM-1. | American journal of physiology. Lung cellular and molecular physiology 20010601 |
| Ca2+-dependent exocytosis of L-glutamate by alphaTC6, clonal mouse pancreatic alpha-cells. | Diabetes 20010501 |
| Increasing the intra-Golgi pH of cultured LS174T goblet-differentiated cells mimics the decreased mucin sulfation and increased Thomsen-Friedenreich antigen (Gal beta1-3GalNac alpha-) expression seen in colon cancer. | Glycobiology 20010501 |
| Functional analysis of the sheep Wilson disease protein (sATP7B) in CHO cells. | European journal of cell biology 20010501 |
| Release of dopamine and ATP from PC12 cells treated with dexamethasone, reserpine and bafilomycin A1. | The Journal of veterinary medical science 20010401 |
| Chloroquine antagonizes the proinflammatory cytokine response to opportunistic fungi by alkalizing the fungal phagolysosome. | The Journal of infectious diseases 20010315 |
| Effect of bafilomycin A1, a specific inhibitor of vacuolar (V-type) proton ATPases, on the capacitation of rabbit spermatozoa. | Andrologia 20010301 |
| Plasma-membrane H+-ATPases are expressed in pitchers of the carnivorous plant Nepenthes alata Blanco. | Planta 20010301 |
| Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy. | Biochimica et biophysica acta 20010209 |
| Brief treatments with forskolin enhance s-phase entry in balance epithelia from the ears of rats. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010201 |
| Mechanisms of iron transport into rat erythroid cells. | Journal of cellular physiology 20010201 |
| In situ analysis of pH gradients in mosquito larvae using non-invasive, self-referencing, pH-sensitive microelectrodes. | The Journal of experimental biology 20010201 |
| Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films. | Bone 20010201 |
| Glycolipid antigen processing for presentation by CD1d molecules. | Science (New York, N.Y.) 20010126 |
| Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. | Chemistry & biology 20010101 |
| Involvement of vacuolar proton ATPase in Junin virus multiplication. | Archives of virology 20010101 |
| Polyethylenimine-mediated gene delivery: a mechanistic study. | The journal of gene medicine 20010101 |
| Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. | Antimicrobial agents and chemotherapy 20000301 |
| Characterization of iron uptake from transferrin by murine endothelial cells. | Endothelium : journal of endothelial cell research 20000101 |
| Calcineurin and vacuolar-type H+-ATPase modulate macrophage effector functions. | Proceedings of the National Academy of Sciences of the United States of America 19990525 |
| In vitro activities of free and liposomal drugs against Mycobacterium avium-M. intracellulare complex and M. tuberculosis. | Antimicrobial agents and chemotherapy 19931201 |
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