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884-68-4 | 8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one,9,10,11,11a-tetrahydro-, (6S,11aS,11bS)-
CAS No: 884-68-4 Catalog No: AG004C5A MDL No:
Product Description
Catalog Number:
AG004C5A
Chemical Name:
8H-6,11b-Methanofuro[2,3-c]pyrido[1,2-a]azepin-2(6H)-one,9,10,11,11a-tetrahydro-, (6S,11aS,11bS)-
CAS Number:
884-68-4
Molecular Formula:
C13H15NO2
Molecular Weight:
217.2637
IUPAC Name:
14-oxa-7-azatetracyclo[6.6.1.01,11.02,7]pentadeca-9,11-dien-13-one
InChI:
InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2
InChI Key:
SWZMSZQQJRKFBP-UHFFFAOYSA-N
SMILES:
O=C1C=C2C3(O1)CC(C=C2)N1C3CCCC1
Properties
Complexity:
426
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
217.11g/mol
Formal Charge:
0
Heavy Atom Count:
16
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
217.268g/mol
Monoisotopic Mass:
217.11g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
29.5A^2
Undefined Atom Stereocenter Count:
3
Undefined Bond Stereocenter Count:
0
XLogP3:
1.1
Literature
| Title | Journal |
|---|---|
| Proteomic and systems biology analysis of monocytes exposed to securinine, a GABA(A) receptor antagonist and immune adjuvant. | PloS one 20120101 |
| Toxoplasma gondii: inhibitory activity and encystation effect of securinine and pyrrolidine derivatives on Toxoplasma growth. | Experimental parasitology 20110201 |
| Securinine, a myeloid differentiation agent with therapeutic potential for AML. | PloS one 20110101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Enantioselective approach to Securinega alkaloids. Total synthesis of securinine and (-)-norsecurinine. | The Journal of organic chemistry 20090821 |
| Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists. | Journal of leukocyte biology 20071101 |
| Callus of Securinega suffruticosa, a cell line accumulates dextro Securinega alkaloids. | Natural product research 20070301 |
| Proposed biogenetic origin of secu'amamine A from allosecurinine: a model study to support the intermediacy of the putative aziridinium ion. | Organic letters 20060803 |
| Intracellular calcium involved in the long-term potentiation induced by securinine in dentate gyrus of anesthetized rats. | Planta medica 20020801 |
| An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine. | Organic letters 20010308 |
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