200,000+ products from a single source!
sales@angenechem.com
88218-12-6 | 2-Pyrrolidinecarboxaldehyde, (2S)-
CAS No: 88218-12-6 Catalog No: AG008BC1 MDL No:
Product Description
Catalog Number:
AG008BC1
Chemical Name:
2-Pyrrolidinecarboxaldehyde, (2S)-
CAS Number:
88218-12-6
Molecular Formula:
C5H9NO
Molecular Weight:
99.1311
IUPAC Name:
(2S)-pyrrolidine-2-carbaldehyde
InChI:
InChI=1S/C5H9NO/c7-4-5-2-1-3-6-5/h4-6H,1-3H2/t5-/m0/s1
InChI Key:
JIDDDPVQQUHACU-YFKPBYRVSA-N
SMILES:
O=C[C@@H]1CCCN1
Properties
Complexity:
72.5
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
99.068g/mol
Formal Charge:
0
Heavy Atom Count:
7
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
99.133g/mol
Monoisotopic Mass:
99.068g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
29.1A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.2
Literature
| Title | Journal |
|---|---|
| How does Pin1 catalyze the cis-trans prolyl peptide bond isomerization? A QM/MM and mean reaction force study. | The journal of physical chemistry. B 20121101 |
| 4-Methylpseudoproline derived from α-methylserine - synthesis and conformational studies. | Organic & biomolecular chemistry 20120907 |
| Energetics and mechanism of the normal-to-amyloidogenic isomerization of β2-microglobulin: on-the-fly string method calculations. | The journal of physical chemistry. B 20120809 |
| Conformational preferences of 4-chloroproline residues. | Biopolymers 20120801 |
| Are long-range structural correlations behind the aggregration phenomena of polyglutamine diseases? | PLoS computational biology 20120401 |
| Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate. | The Journal of biological chemistry 20120330 |
| Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. | Acta crystallographica. Section F, Structural biology and crystallization communications 20120201 |
| HIF-1 and c-Src mediate increased glucose uptake induced by endothelin-1 and connexin43 in astrocytes. | PloS one 20120101 |
| The oxidative function of diferric transferrin. | Biochemistry research international 20120101 |
| Novel intriguing strategies attenuating to sarcopenia. | Journal of aging research 20120101 |
| Prolyl cis/trans isomerase signalling pathways in cancer. | Current opinion in pharmacology 20110801 |
| FKBP immunophilins and Alzheimer's disease: a chaperoned affair. | Journal of biosciences 20110801 |
| Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway. | Carcinogenesis 20110501 |
| Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes. | Human molecular genetics 20110415 |
| Mutations in FKBP10 cause recessive osteogenesis imperfecta and Bruck syndrome. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110301 |
| Activation of colicin M by the FkpA prolyl cis-trans isomerase/chaperone. | The Journal of biological chemistry 20110225 |
| The common fetal development of the mammary fat pad and gubernaculum. | Journal of pediatric surgery 20110201 |
| Multi-timescale dynamics study of FKBP12 along the rapamycin-mTOR binding coordinate. | Journal of molecular biology 20110114 |
| Conformational preference and cis-trans isomerization of 4-methylproline residues. | Biopolymers 20110101 |
| Proteomic identification of OsCYP2, a rice cyclophilin that confers salt tolerance in rice (Oryza sativa L.) seedlings when overexpressed. | BMC plant biology 20110101 |
| Hypoxia-inducible factors and the prevention of acute organ injury. | Critical care (London, England) 20110101 |
| The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. | PloS one 20110101 |
| Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau. | PloS one 20110101 |
| The ATP-binding cassette transporters ABCB1 and ABCC1 are not regulated by hypoxia in immortalised human brain microvascular endothelial cells. | Experimental & translational stroke medicine 20110101 |
| Genome-wide scan identifies loci associated with classical BSE occurrence. | PloS one 20110101 |
| Protein disulfide isomerase and host-pathogen interaction. | TheScientificWorldJournal 20110101 |
| Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding. | PloS one 20110101 |
| Chronic deficiency of nitric oxide affects hypoxia inducible factor-1α (HIF-1α) stability and migration in human endothelial cells. | PloS one 20110101 |
| The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils. | Blood 20101223 |
| Conformational preferences of X-Pro sequences: Ala-Pro and Aib-Pro motifs. | The journal of physical chemistry. B 20101111 |
| Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs. | The Journal of biological chemistry 20101008 |
| The autoinducer-2 exporter superfamily. | Journal of molecular microbiology and biotechnology 20100801 |
| NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease. | Biochemical Society transactions 20100801 |
| Enzyme-linked enzyme-binding assay for Pin1 WW domain ligands. | Analytical biochemistry 20100701 |
| Tyrosine hydroxylase deficiency in three Greek patients with a common ancestral mutation. | Movement disorders : official journal of the Movement Disorder Society 20100615 |
| Streamlined, automated protocols for the production of milligram quantities of untagged recombinant human cyclophilin-A (hCypA) and untagged human proliferating cell nuclear antigen (hPCNA) using AKTAxpress. | Protein expression and purification 20100501 |
| Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. | Nature chemical biology 20100501 |
| Conformational preferences and prolyl cis-trans isomerization of phosphorylated Ser/Thr-Pro motifs. | Biopolymers 20100401 |
| Refinement of the GINGF3 locus for hereditary gingival fibromatosis. | European journal of pediatrics 20100301 |
| Interaction between ghrelin and the ghrelin receptor (GHS-R1a), a NMR study using living cells. | Bioorganic & medicinal chemistry 20100215 |
| Role of prolyl cis/trans isomers in cyclophilin-assisted Pseudomonas syringae AvrRpt2 protease activation. | Biochemistry 20100209 |
| Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis. | Arthritis research & therapy 20100101 |
| Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase. | Microbial cell factories 20100101 |
| The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding. | BMC structural biology 20100101 |
| Severe osteogenesis imperfecta in cyclophilin B-deficient mice. | PLoS genetics 20091201 |
| The prolyl cis/trans isomerase cyclophilin 18 interacts with the tumor suppressor p53 and modifies its functions in cell cycle regulation and apoptosis. | Oncogene 20091105 |
| RecA-mediated cleavage of lambda cI repressor accepts repressor dimers: probable role of prolyl cis-trans isomerization and catalytic involvement of H163, K177, and K232 of RecA. | Journal of biomolecular structure & dynamics 20091001 |
| Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases. | PLoS computational biology 20090801 |
| Molecular determinants of a native-state prolyl isomerization. | Journal of molecular biology 20090410 |
| Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain. | Journal of molecular biology 20090403 |
| Mechanism of action of cyclophilin a explored by metadynamics simulations. | PLoS computational biology 20090301 |
| Mechanistic insight into the role of transition-state stabilization in cyclophilin A. | Journal of the American Chemical Society 20090114 |
| Conformational preferences and cis-trans isomerization of L-3,4-dehydroproline residue. | Biopolymers 20090101 |
| Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. | Cell communication and signaling : CCS 20090101 |
| Strategies for successful recombinant expression of disulfide bond-dependent proteins in Escherichia coli. | Microbial cell factories 20090101 |
| N-alpha-PGP and PGP, potential biomarkers and therapeutic targets for COPD. | Respiratory research 20090101 |
| Regulatory elements in the 5'region of 16SrRNA gene of Bacillus sp. strain SJ-101. | Bioinformation 20090101 |
| Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art. | Fibrogenesis & tissue repair 20090101 |
| Cutaneous scarring: a clinical review. | Dermatology research and practice 20090101 |
| CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta. | Human mutation 20081201 |
| Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1. | Biochimica et biophysica acta 20080801 |
| Radiosynthesis and ex vivo evaluation of [11C]-SIB-1553A as a PET radiotracer for beta4 selective subtype nicotinic acetylcholine receptor. | Nuclear medicine and biology 20080401 |
| The rate enhancement for prolyl cis-to-trans isomerization of cyclic CPFC peptide is caused by an increase in the vibrational entropy of the transition state. | The journal of physical chemistry. B 20080320 |
| Binding of phosphatase inhibitor-2 to prolyl isomerase Pin1 modifies specificity for mitotic phosphoproteins. | Biochemistry 20080108 |
| Structure discrimination for the C-terminal domain of Escherichia coli trigger factor in solution. | Journal of biomolecular NMR 20080101 |
| Identification of protein secretion systems and novel secreted proteins in Rhizobium leguminosarum bv. viciae. | BMC genomics 20080101 |
| Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections. | BMC biotechnology 20080101 |
| Transcriptional responses of Arabidopsis thaliana plants to As (V) stress. | BMC plant biology 20080101 |
| Harnessing hypoxic adaptation to prevent, treat, and repair stroke. | Journal of molecular medicine (Berlin, Germany) 20071201 |
| Conformational preferences of pseudoproline residues. | The journal of physical chemistry. B 20071101 |
| Prolyl cis-trans isomerization as a molecular timer. | Nature chemical biology 20071001 |
| Molecular mechanisms of the phospho-dependent prolyl cis/trans isomerase Pin1. | The FEBS journal 20071001 |
| PIN-1 promoter polymorphisms in mild cognitive impairment and susceptibility to Alzheimer's disease: a preliminary report. | Aging clinical and experimental research 20071001 |
| Puckering transition of proline residue in water. | The journal of physical chemistry. B 20070906 |
| The Trypanosoma cruzi PIN1 gene encodes a parvulin peptidyl-prolyl cis/trans isomerase able to replace the essential ESS1 in Saccharomyces cerevisiae. | Molecular and biochemical parasitology 20070601 |
| Conformational preferences and cis-trans isomerization of azaproline residue. | The journal of physical chemistry. B 20070517 |
| Imidazole as a catalyst for in vitro refolding of enhanced green fluorescent protein. | Archives of biochemistry and biophysics 20070301 |
| Prolyl cis-trans Isomerization as a molecular timer in Crk signaling. | Molecular cell 20070223 |
| Proline cis-trans isomerization controls autoinhibition of a signaling protein. | Molecular cell 20070209 |
| Interaction mode of a symmetric Trp-rich undeca peptide PST11-RK with lipid bilayers. | FEBS letters 20070109 |
| Binding induced conformational changes of proteins correlate with their intrinsic fluctuations: a case study of antibodies. | BMC structural biology 20070101 |
| Role of the ubiquitin proteasome system in renal cell carcinoma. | BMC biochemistry 20070101 |
| Conformational preferences of non-prolyl and prolyl residues. | The journal of physical chemistry. B 20061026 |
| A fluorescence polarization-based assay for peptidyl prolyl cis/trans isomerase cyclophilin A. | Analytical biochemistry 20060901 |
| High Pin1 expression is associated with tumor progression in colorectal cancer. | Journal of surgical oncology 20060801 |
| Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. | Molecular cell 20060707 |
| Isothermal calorimetry as a tool to investigate slow conformational changes in proteins and peptides. | Analytical chemistry 20060701 |
| Topical application of epidermal growth factor accelerates wound healing by myofibroblast proliferation and collagen synthesis in rat. | Journal of veterinary science 20060601 |
| Exploring the molecular function of PIN1 by nuclear magnetic resonance. | Current protein & peptide science 20060601 |
| Conformational preference and cis-trans isomerization of 4(R)-substituted proline residues. | The journal of physical chemistry. B 20060202 |
| Cytoskeletal components of an invasion machine--the apical complex of Toxoplasma gondii. | PLoS pathogens 20060201 |
| Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis. | BMC evolutionary biology 20060101 |
| Protein kinases associated with the yeast phosphoproteome. | BMC bioinformatics 20060101 |
| A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins. | Acta neurochirurgica. Supplement 20060101 |
| Search for novel gene markers of traumatic brain injury by time differential microarray analysis. | Acta neurochirurgica. Supplement 20060101 |
| Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires. | BMC genomics 20060101 |
| Intrinsic dynamics of an enzyme underlies catalysis. | Nature 20051103 |
| Role of hensin in mediating the adaptation of the cortical collecting duct to metabolic acidosis. | Current opinion in nephrology and hypertension 20050701 |
| Ascorbate depletion: a critical step in nickel carcinogenesis? | Environmental health perspectives 20050501 |
| Effect of proline and glycine residues on dynamics and barriers of loop formation in polypeptide chains. | Journal of the American Chemical Society 20050316 |
| The cysteine residues of HIV-1 capsid regulate oligomerization and cyclophilin A-induced changes. | Biophysical journal 20050301 |
| Conservation of cis prolyl bonds in proteins during evolution. | Proteins 20050215 |
| Fibroblast-like synovial cells derived from synovial fluid. | The Journal of rheumatology 20050201 |
| Ab initio conformational study of N-acetyl-L-proline-N',N'-dimethylamide: a model for polyproline. | Biophysical chemistry 20050101 |
| Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers. | Bioorganic & medicinal chemistry letters 20041206 |
| Isotamarixen - a new antioxidant and prolyl endopeptidase-inhibiting triterpenoid from Tamarix hispida. | Planta medica 20040101 |
| N-tritylprolinal: an efficient building block for the stereoselective synthesis of proline-derived amino alcohols. | The Journal of organic chemistry 20031212 |
| A prolyl endopeptidase-inhibiting antioxidant from Phyllanthus ussurensis. | Archives of pharmacal research 20031201 |
| Proline replacements and the simplification of the complex, parallel channel folding mechanism for the alpha subunit of Trp synthase, a TIM barrel protein. | Journal of molecular biology 20030725 |
| Parallel channels and rate-limiting steps in complex protein folding reactions: prolyl isomerization and the alpha subunit of Trp synthase, a TIM barrel protein. | Journal of molecular biology 20021018 |
| Solution structure of the single-domain prolyl cis/trans isomerase PIN1At from Arabidopsis thaliana. | Journal of molecular biology 20020705 |
| Reductive unfolding and oxidative refolding of a Bowman-Birk inhibitor from horsegram seeds (Dolichos biflorus): evidence for 'hyperreactive' disulfide bonds and rate-limiting nature of disulfide isomerization in folding. | Biochimica et biophysica acta 20020603 |
| The hsp70 chaperone DnaK is a secondary amide peptide bond cis-trans isomerase. | Nature structural biology 20020601 |
| A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex. | Journal of natural products 20020101 |
| Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. | Nature cell biology 20010601 |
| Expression of proteinases and inflammatory cytokines in subchondral bone regions in the destructive joint of rheumatoid arthritis. | Rheumatology (Oxford, England) 20010301 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.