200,000+ products from a single source!
sales@angenechem.com
Home > Other Building Blocks > 872993-05-0
872993-05-0 | Resolvin D1
CAS No: 872993-05-0 Catalog No: AG004LII MDL No:MFCD11045851
Product Description
Catalog Number:
AG004LII
Chemical Name:
Resolvin D1
CAS Number:
872993-05-0
Molecular Formula:
C22H32O5
Molecular Weight:
376.4865
MDL Number:
MFCD11045851
IUPAC Name:
(4Z,7S,8R,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
InChI:
InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20+,21-/m0/s1
InChI Key:
OIWTWACQMDFHJG-CCFUIAGSSA-N
SMILES:
CCC=CCC(C=CC=CC=CC=CC(C(CC=CCCC(=O)O)O)O)O
Properties
Complexity:
555
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
3
Defined Bond Stereocenter Count:
6
Exact Mass:
376.225g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
376.493g/mol
Monoisotopic Mass:
376.225g/mol
Rotatable Bond Count:
14
Topological Polar Surface Area:
98A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.1
Literature
| Title | Journal |
|---|---|
| Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection. | Mucosal immunology 20180101 |
| Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. | Blood 20121011 |
| Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation. | Clinical chemistry 20121001 |
| Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. | Journal of immunology (Baltimore, Md. : 1950) 20120901 |
| Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. | Journal of immunology (Baltimore, Md. : 1950) 20120815 |
| Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. | Arteriosclerosis, thrombosis, and vascular biology 20120801 |
| Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. | The American journal of pathology 20120501 |
| Infection regulates pro-resolving mediators that lower antibiotic requirements. | Nature 20120426 |
| 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. | British journal of pharmacology 20120201 |
| Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. | PloS one 20120101 |
| Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20111214 |
| Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype. | Journal of immunology (Baltimore, Md. : 1950) 20111115 |
| Emerging roles of resolvins in the resolution of inflammation and pain. | Trends in neurosciences 20111101 |
| The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. | British journal of pharmacology 20110901 |
| Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. | Journal of immunology (Baltimore, Md. : 1950) 20110815 |
| Resolvin D1 protects mice from LPS-induced acute lung injury. | Pulmonary pharmacology & therapeutics 20110801 |
| Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution. | The Biochemical journal 20110715 |
| Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110701 |
| Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. | Journal of immunology (Baltimore, Md. : 1950) 20110515 |
| Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. | Journal of immunology (Baltimore, Md. : 1950) 20110401 |
| Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids. | European journal of immunology 20110201 |
| Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. | British journal of pharmacology 20101001 |
| The effects of polyunsaturated fatty acids and their metabolites on osteoclastogenesis in vitro. | Prostaglandins & other lipid mediators 20100601 |
| Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. | Nature medicine 20100501 |
| Fighting off pain with resolvins. | Nature medicine 20100501 |
| Resolvin D1 binds human phagocytes with evidence for proresolving receptors. | Proceedings of the National Academy of Sciences of the United States of America 20100126 |
| Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. | Prostaglandins, leukotrienes, and essential fatty acids 20100101 |
| Resolvins and protectins: natural pharmacophores for resolution biology. | Prostaglandins, leukotrienes, and essential fatty acids 20100101 |
| NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD). | Experimental gerontology 20091101 |
| Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators. | Investigative ophthalmology & visual science 20091001 |
| Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress. | British journal of pharmacology 20091001 |
| Lipid mediator interplay: resolvin D1 attenuates inflammation evoked by glutathione-conjugated lipid peroxidation products. | British journal of pharmacology 20091001 |
| Resolvins: Current understanding and future potential in the control of inflammation. | Current opinion in drug discovery & development 20090901 |
| Resolvins E1 and D1 in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions. | Investigative ophthalmology & visual science 20090801 |
| Anticancer actions of omega-3 fatty acids--current state and future perspectives. | Anti-cancer agents in medicinal chemistry 20090501 |
| Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. | Journal of immunology (Baltimore, Md. : 1950) 20081215 |
| Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081001 |
| Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. | Journal of periodontology 20080801 |
| Endogenous lipid mediators in the resolution of airway inflammation. | The European respiratory journal 20071101 |
| Lipoxins and resolvins in inflammatory bowel disease. | Inflammatory bowel diseases 20070601 |
| Resolvins and protectins in the termination program of acute inflammation. | Trends in immunology 20070401 |
| [Novel chemical mediators in the resolution of inflammation]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20070401 |
| Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. | The Journal of biological chemistry 20070330 |
| Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. | Journal of the American Society for Mass Spectrometry 20070101 |
| Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. | Prostaglandins & other lipid mediators 20040401 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.