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87-41-2

87-41-2 | Isobenzofuran-1(3H);-one

CAS No: 87-41-2 Catalog No: AG003TRL MDL No:MFCD00005906

Product Description

Catalog Number:
AG003TRL
Chemical Name:
Isobenzofuran-1(3H);-one
CAS Number:
87-41-2
Molecular Formula:
C8H6O2
Molecular Weight:
134.1320
MDL Number:
MFCD00005906
IUPAC Name:
3H-2-benzofuran-1-one
InChI:
InChI=1S/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2
InChI Key:
WNZQDUSMALZDQF-UHFFFAOYSA-N
SMILES:
O=C1OCc2c1cccc2
UNII:
8VV922U86J
NSC Number:
1469
FEMA Number:
4195

Properties

Complexity:
153  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
134.037g/mol
Formal Charge:
0
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
134.134g/mol
Monoisotopic Mass:
134.037g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
26.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.8  

Literature

Title Journal
Total synthesis of 7',8'-dihydroaigialospirol. Organic letters 20121005
Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists. Bioorganic & medicinal chemistry 20120815
C(Ar)-H···O hydrogen bonds in substituted isobenzofuranone derivatives: geometric, topological, and NMR characterization. The journal of physical chemistry. A 20120726
Metabolic conversion from co-existing ingredient leading to significant systemic exposure of Z-butylidenephthalide, a minor ingredient in Chuanxiong Rhizoma in rats. Current drug metabolism 20120601
Phthalide and isocoumarin derivatives produced by an Acremonium sp. isolated from a mangrove Rhizophora apiculata. Journal of natural products 20120525
Direct asymmetric Mannich reaction of phthalides: facile access to chiral substituted isoquinolines and isoquinolinones. Chemical communications (Cambridge, England) 20120516
CN-assisted oxidative cyclization of cyano cinnamates and styrene derivatives: a facile entry to 3-substituted chiral phthalides. Organic & biomolecular chemistry 20120514
Nucleophile- or light-induced synthesis of 3-substituted phthalides from 2-formylarylketones. Organic letters 20120504
Simultaneous determination of nine related substances in p-phthalic acid residue by RP-HPLC. Journal of chromatographic science 20120501
Copper(I) mediated facile synthesis of potent tubulin polymerization inhibitor, 9-amino-α-noscapine from natural α-noscapine. Bioorganic & medicinal chemistry letters 20120415
Stereoselective synthesis of hydroxy stilbenoids and styrenes by atom-efficient olefination with thiophthalides. Organic & biomolecular chemistry 20120414
A novel antioxidant isobenzofuranone derivative from fungus Cephalosporium sp.AL031. Molecules (Basel, Switzerland) 20120405
Highly stereoselective chemoenzymatic synthesis of the 3H-isobenzofuran skeleton. Access to enantiopure 3-methylphthalides. Organic letters 20120316
Anti-inflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways. Archives of pharmacal research 20120301
Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones. Bioorganic & medicinal chemistry 20120201
Two phthalide dimers from the radix of Angelica sinensis. Natural product research 20120101
Ligustilide: a novel TRPA1 modulator. Pflugers Archiv : European journal of physiology 20111201
Two new compounds from an endophytic fungus Pestalotiopsis heterocornis. Journal of Asian natural products research 20111201
The atmospheric photolysis of o-tolualdehyde. Environmental science & technology 20111115
Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae. The Journal of antibiotics 20111101
Ligusticum chuanxiong Hort: a review of chemistry and pharmacology. Pharmaceutical biology 20111101
Synthesis of biarylketones and phthalides from organoboronic acids and aldehydes catalyzed by cobalt complexes. Chemical communications (Cambridge, England) 20111007
Ruthenium-catalyzed oxidative C-H bond alkenylations in water: expedient synthesis of annulated lactones. Organic letters 20110819
Adulticidal activity of phthalides identified in Cnidium officinale rhizome to B- and Q-biotypes of Bemisia tabaci. Journal of agricultural and food chemistry 20110810
Phthalides and other constituents from Ligusticum porteri; sedative and spasmolytic activities of some natural products and derivatives. Natural product research 20110801
Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions. Bioorganic & medicinal chemistry letters 20110615
Benzannulation for the regiodefined synthesis of 2-alkyl/aryl-1-naphthols: total synthesis of arnottin I. The Journal of organic chemistry 20110506
Chemical composition of the essential oil from kelussia odoratissima Mozaff. and the evaluation of its sedative and anxiolytic effects in mice. Clinics (Sao Paulo, Brazil) 20110501
Correlative analysis of metabolite profiling of Danggui Buxue Tang in rat biological fluids by rapid resolution LC-TOF/MS. Journal of pharmaceutical and biomedical analysis 20110428
Metabolic profiling of GuanXin II prescription based on metabolic fingerprinting and chemical analysis. Journal of pharmaceutical and biomedical analysis 20110325
Cytotoxic bibenzyls, and germacrane- and pinguisane-type sesquiterpenoids from Indonesian, Tahitian and Japanese liverworts. Natural product communications 20110301
Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp. Journal of natural products 20110128
The use of endophytes to obtain bioactive compounds and their application in biotransformation process. Biotechnology research international 20110101
Identification of the major constituents in Xuebijing injection by HPLC-ESI-MS. Phytochemical analysis : PCA 20110101
Antimicrobial activities of hexane extract and decussatin from stembark extract of Ficus congensis. International journal of molecular sciences 20110101
Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway. Frontiers in microbiology 20110101
Bioactivities of major constituents isolated from Angelica sinensis (Danggui). Chinese medicine 20110101
Polyphasic analysis of intraspecific diversity in Epicoccum nigrum warrants reclassification into separate species. PloS one 20110101
Antibacterial activity of new dibenzoxepinone oximes with fluorine and trifluoromethyl group substituents. International journal of molecular sciences 20110101
Synthesis and Antimicrobial Evaluation of Dibenzo[b,e]oxepin-11(6H)-one O-Benzoyloxime Derivatives. Scientia pharmaceutica 20110101
Marilones A-C, phthalides from the sponge-derived fungus Stachylidium sp. Beilstein journal of organic chemistry 20110101
A practical total synthesis of (+)-spirolaxine methyl ether. The Journal of organic chemistry 20101203
New isocourmarin and phthalide derivatives from the rhizomes of Matteuccia orientalis. Chemical & pharmaceutical bulletin 20101201
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehyde to access 3-aryl- and alkenylphthalides. The Journal of organic chemistry 20100903
Synthesis of demethylated nidulol via an intramolecular Michael reaction. Natural product research 20100801
3-Acetyl-benzoic acid. Acta crystallographica. Section E, Structure reports online 20100701
Rhodium-catalyzed cascade reaction: aryl addition/intramolecular esterification to access 3-aryl and 3-alkenyl phthalides. Angewandte Chemie (International ed. in English) 20100510
Transition metal-catalyzed addition reactions of arylboronic acids with alkyl 2-formylbenzoates: efficient access to chiral 3-substituted phthalides. Chemical communications (Cambridge, England) 20100507
Pesticide residues in coastal waters affected by rice paddy effluents temporarily stored in a wastewater reservoir in southern Japan. Archives of environmental contamination and toxicology 20100201
Synthesis of chiral 3-substituted phthalides by a sequential organocatalytic enantioselective aldol-lactonization reaction. Three-step synthesis of (S)-(-)-3-butylphthalide. The Journal of organic chemistry 20100115
Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong. Molecules (Basel, Switzerland) 20100115
Novel phthalide compounds from Sparassis crispa (Hanabiratake), Hanabiratakelide A-C, exhibiting anti-cancer related activity. Biological & pharmaceutical bulletin 20100101
Efficient synthesis of 3-arylphthalides using palladium-catalyzed arylation of aldehydes with organoboronic acids. The Journal of organic chemistry 20091204
Evaluation of the in vivo antimalarial activity of ethanolic leaf and stembark extracts of Anthocleista djalonensis. Indian journal of pharmacology 20091201
Phthalides by rhodium-catalyzed ketone hydroacylation. Journal of the American Chemical Society 20091104
Catalytic enantioselective synthesis of chiral phthalides by efficient reductive cyclization of 2-acylarylcarboxylates under aqueous transfer hydrogenation conditions. Organic letters 20091015
3,3'-Oxybi[isobenzofuran-1(3H)-one]. Acta crystallographica. Section E, Structure reports online 20091001
Two new compounds from the roots of Ligusticum chuanxiong. Journal of Asian natural products research 20090901
A novel compound from celery seed with a bactericidal effect against Helicobacter pylori. The Journal of pharmacy and pharmacology 20090801
Identification of metabolites of Danggui Buxue Tang in rat urine by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM 20090701
Biomimetic studies towards the cardinalins: synthesis of (+)-ventiloquinone L and an unusual dimerisation. Organic & biomolecular chemistry 20090621
Daily variation of pesticides in surface water of a small river flowing through paddy field area. Bulletin of environmental contamination and toxicology 20090601
Preparative isolation and purification of isobenzofuranone derivatives and saponins from seeds of Nigella glandulifera Freyn by high-speed counter-current chromatography combined with gel filtration. Journal of chromatography. A 20090508
2-(3-Oxo-1,3-dihydro-isobenzofuran-1-yl)-phthalazin-1(2H)-one. Acta crystallographica. Section E, Structure reports online 20090501
Occurence and bioactivities of funicone-related compounds. International journal of molecular sciences 20090401
New phthalide glycosides from Helichrysum arenarium (L.) Moench. Journal of Asian natural products research 20090101
Simultaneous determination of phenolic acids and phthalide compounds by liquid chromatography for quality assessment of Rhizoma cnidii. Journal of AOAC International 20090101
New antitumour fungal metabolites from Alternaria porri. Natural product research 20090101
Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes. Parasitology research 20081201
[Analysis of principal composition of ethyl acetate part in Huangqi Danggui decoction by HPLC-ESI-TOF-MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101
Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells. Journal of ethnopharmacology 20081030
Decrease of 4,5,6,7-tetrachlorophthalide in paddy field soil after aerial application. Bulletin of environmental contamination and toxicology 20081001
Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils. Journal of natural products 20081001
Dynamic nature of the ligustilide complex. Journal of natural products 20080901
3-(5,6,7,8-Tetra-hydro-2-naphth-yl)iso-benzofuran-1(3H)-one. Acta crystallographica. Section E, Structure reports online 20080901
Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography/diode-array detection coupled with time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM 20080801
Anti-Helicobacter pylori activity of derivatives of the phthalide-containing antibacterial agents spirolaxine methyl ether, CJ-12,954, CJ-13,013, CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015. Bioorganic & medicinal chemistry 20080601
Variation of 4,5,6,7-tetrachlorophthalide in water after aerial application to rice cultivation area. Bulletin of environmental contamination and toxicology 20080501
3-(4-Methyl-piperazin-1-yl)isobenzofuran-1(3H)-one. Acta crystallographica. Section E, Structure reports online 20080501
3-(2-Hydr-oxy-5-methyl-anilino)isobenzo-furan-1(3H)-one. Acta crystallographica. Section E, Structure reports online 20080501
High-performance liquid chromatographic assay with ultraviolet spectrometric detection for the evaluation of inhibitors of phosphatidylinositol-specific phospholipase C. Analytical biochemistry 20080415
2-(3-Oxo-1,3-dihydro-isobenzofuran-1-ylamino)benzoic acid. Acta crystallographica. Section E, Structure reports online 20080401
3-(2-Chloro-anilino)isobenzofuran-1(3H)-one. Acta crystallographica. Section E, Structure reports online 20080401
3-(2,4-Dichloro-anilino)iso-benzo-furan-1(3H)-one. Acta crystallographica. Section E, Structure reports online 20080401
[GC-MS analysis of essential oil from rhizomes of Ligusticum chuanxiong cultivated in GAP base for Chinese medicinal materials of China]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201
Flavor enhancement of chicken broth from boiled celery constituents. Journal of agricultural and food chemistry 20080123
Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. Pharmacology, biochemistry, and behavior 20080101
Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales. Planta medica 20080101
Chemical markers for the quality control of herbal medicines: an overview. Chinese medicine 20080101
Reductive dechlorination of chloroethenes by Dehalococcoides-containing cultures enriched from a polychlorinated-dioxin-contaminated microcosm. The ISME journal 20071001
Synthesis, resolution, and antiplatelet activity of 3-substituted 1(3H)-isobenzofuranone. Bioorganic & medicinal chemistry letters 20070915
Importance of interaction between C1 domain and lipids in protein kinase C alpha activation: hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level. ChemMedChem 20070701
Direct access to 1,4-dihydroxyanthraquinones: the Hauser annulation reexamined with p-quinones. The Journal of organic chemistry 20070622
Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells. Planta medica 20070601
The structural diversity of phthalides from the Apiaceae. Journal of natural products 20070501
Comparative analysis of Ligusticum chuanxiong and related umbelliferous medicinal plants by high performance liquid chromatography-electrospray ionization mass spectrometry. Planta medica 20070401
Rhodium-catalyzed asymmetric one-pot transesterification and [2 + 2 + 2] cycloaddition leading to enantioenriched 3,3-disubstituted phthalides. Organic letters 20070329
Highly efficient cyclization of o-iodobenzoates with aldehydes catalyzed by cobalt bidentate phosphine complexes: a novel entry to chiral phthalides. Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
An alkyne strategy for the asymmetric synthesis of natural products: application to (+)-spirolaxine methyl ether. Angewandte Chemie (International ed. in English) 20070101
Absolute configuration of sporotricale and structure of 6-hydroxysporotricale. Journal of natural products 20061201
Regiocontrolled intramolecular cyclizations of carboxylic acids to carbon-carbon triple bonds promoted by acid or base catalyst. Organic letters 20061123
The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo. Journal of neurochemistry 20061101
[High performance liquid chromatography-mass spectrometry analysis of radix Angelica sciensis]. Yao xue xue bao = Acta pharmaceutica Sinica 20061101
Runoff of aerially applied phthalide from paddy fields. Bulletin of environmental contamination and toxicology 20061001
Kinetics and products of photolysis and reaction with OH radicals of a series of aromatic carbonyl compounds. Environmental science & technology 20060901
Synthesis of (+)-spirolaxine methyl ether. The Journal of organic chemistry 20060804
Uptake and UV-photooxidation of gas-phase PAHs on the surface of atmospheric water films. 1. Naphthalene. The journal of physical chemistry. A 20060727
Antiproliferative effect of Baylis-Hillman adducts and a new phthalide derivative on human tumor cell lines. European journal of medicinal chemistry 20060601
Two new phthalides from Ligusticum chuanxiong. Planta medica 20060601
Determination of volatile flavor components in danggui cultivars by solvent free injection and hydrodistillation followed by gas chromatographic-mass spectrometric analysis. Journal of chromatography. A 20060526
Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: versatile intermediates for the design and synthesis of topoisomerase I inhibitors. Bioorganic & medicinal chemistry letters 20060401
Potent odorants characterize the aroma quality of leaves and stalks in raw and boiled celery. Bioscience, biotechnology, and biochemistry 20060401
Total synthesis and biological evaluation of 22-hydroxyacuminatine. Journal of medicinal chemistry 20060223
Simultaneous qualitative and quantitative analyses of the major constituents in the rhizome of Ligusticum Chuanxiong using HPLC-DAD-MS. Chemical & pharmaceutical bulletin 20060201
Sulfated mesoporous alumina: a highly effective solid strong base catalyst for the Tishchenko reaction in supercritical carbon dioxide. The journal of physical chemistry. B 20060126
Total syntheses of oxygenated brazanquinones via regioselective homologous anionic Fries rearrangement of benzylic O-carbamates. Beilstein journal of organic chemistry 20060101
GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels. Phytochemical analysis : PCA 20060101
A brief and convergent synthetic route to defucogilvocarcin M chromophore: the formal synthesis of WS-5995 A and C. The Journal of organic chemistry 20051028
Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation. Planta medica 20050901
Anxiolytic effects of benzalphthalides. Bioorganic & medicinal chemistry letters 20050801
Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster. Journal of agricultural and food chemistry 20050713
Synthesis of enantiopure phthalides including 3-butylphthalide, a fragrance component of celery oil, and determination of their absolute configurations. Chirality 20050505
[Protective effect of ligusticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050301
Enantiomerical excess determination, purification and biological evaluation of (3S) and (3R) alpha,beta-butenolide analogues of isobenzofuranone. Bioorganic & medicinal chemistry letters 20050201
[New dimeric phthalide derivative from Angelica sinensis]. Yao xue xue bao = Acta pharmaceutica Sinica 20050201
HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong. Molecular diversity 20050101
Efficient synthesis of isobenzofuran-1(3H)-ones (phthalides) and selected biological evaluations. Arzneimittel-Forschung 20050101
A phthalide with in vitro growth inhibitory activity from an oidiodendron strain. Journal of natural products 20041201
Insecticidal effect of phthalides and furanocoumarins from Angelica acutiloba against Drosophila melanogaster. Journal of agricultural and food chemistry 20040714
Synthesis of phthalide derivatives using nickel-catalyzed cyclization of o-haloesters with aldehydes. Chemistry (Weinheim an der Bergstrasse, Germany) 20040621
Design, synthesis, and structure-activity relationship of new isobenzofuranone ligands of protein kinase C. Bioorganic & medicinal chemistry letters 20040607
Evaluation of series of isobenzofuranone dimers as PKCalpha ligands: implication for the distance between the two ligand binding sites. Bioorganic & medicinal chemistry letters 20040607
Polar constituents of celery seed. Phytochemistry 20031101
A new regiospecific preparation of xanthones. Organic letters 20031002
Synthesis and absolute configuration of (-)-3-butyl-7-hydroxyphthalide, a cytotoxic metabolite of Penicillium vulpinum. Bioscience, biotechnology, and biochemistry 20031001
Characterization of phthalides in Ligusticum chuanxiong by liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometry. Journal of chromatographic science 20030901
A new antioxidant isobenzofuranone derivative from the algicolous marine fungus Epicoccum sp. Planta medica 20030901
Total synthesis of (+/-)-O-methyl PD 116740. Organic letters 20020627
Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities. Phytochemistry 20020501
Application of microgels as polymer supports for organic synthesis: preparation of a small phthalide library, a scavenger, and a borohydride reagent. Journal of combinatorial chemistry 20020101
Efficient heterogeneous catalytic intramolecular Tishchenko reaction of o-phthalaldehyde to phthalide with alkaline earth oxides. Chemical communications (Cambridge, England) 20011207
A new alternative synthesis of 5-cyanophthalide, a versatile intermediate in the preparation of the antidepressant drug citalopram. Farmaco (Societa chimica italiana : 1989) 20010901
Characterization of an unknown component in Noscapine using liquid chromatography-mass spectrometry and proton nuclear magnetic resonance spectroscopy. Journal of chromatography. A 20010824
Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis. Structure (London, England : 1993) 20010110
Solid-phase directed ortho-lithiation and the preparation of a phthalide library. Journal of combinatorial chemistry 20010101
Sedanolide, a natural phthalide from celery seed oil: effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines. In vitro & molecular toxicology 20010101

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