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865854-05-3 | Tideglusib
CAS No: 865854-05-3 Catalog No: AG00365G MDL No:MFCD18633296
Product Description
Catalog Number:
AG00365G
Chemical Name:
Tideglusib
CAS Number:
865854-05-3
Molecular Formula:
C19H14N2O2S
Molecular Weight:
334.3917
MDL Number:
MFCD18633296
IUPAC Name:
4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione
InChI:
InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
InChI Key:
PMJIHLSCWIDGMD-UHFFFAOYSA-N
SMILES:
O=c1sn(c(=O)n1Cc1ccccc1)c1cccc2c1cccc2
UNII:
Q747Y6TT42
Properties
Complexity:
492
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
334.078g/mol
Formal Charge:
0
Heavy Atom Count:
24
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
334.393g/mol
Monoisotopic Mass:
334.078g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
65.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.3
Literature
| Title | Journal |
|---|---|
| Promotion of natural tooth repair by small molecule GSK3 antagonists. | Scientific reports 20170101 |
| Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study. | Journal of Alzheimer's disease : JAD 20130101 |
| Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib. | The Journal of biological chemistry 20120106 |
| Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities. | Journal of medicinal chemistry 20111222 |
| Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds. | Journal of medicinal chemistry 20110623 |
| Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment. | International journal of Alzheimer's disease 20110101 |
| A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo. | Neurobiology of disease 20090901 |
| NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070523 |
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