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Home > Nitro Compounds > 865-40-7

865-40-7

865-40-7 | Methane, nitroso-(6CI,7CI,8CI,9CI)

CAS No: 865-40-7 Catalog No: AG004V49 MDL No:

Product Description

Catalog Number:
AG004V49
Chemical Name:
Methane, nitroso-(6CI,7CI,8CI,9CI)
CAS Number:
865-40-7
Molecular Formula:
CH3NO
Molecular Weight:
45.0406
IUPAC Name:
nitrosomethane
InChI:
InChI=1S/CH3NO/c1-2-3/h1H3
InChI Key:
IMHRONYAKYWGCC-UHFFFAOYSA-N
SMILES:
CN=O

Properties

Complexity:
12.3  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
45.021g/mol
Formal Charge:
0
Heavy Atom Count:
3  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
45.041g/mol
Monoisotopic Mass:
45.021g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
29.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.4  

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(3R,3aS,6aR)-2,5-Dimethyl-3-(5-phenyl-2-thien-yl)perhydro-pyrrolo[3,4-d][1,2]oxazole-4,6-dione. Acta crystallographica. Section E, Structure reports online 20080801
Efficient stereoselective nucleophilic addition of pyrroles to chiral nitrones. Organic & biomolecular chemistry 20080721
Identification of the aromatic tertiary N-oxide functionality in protonated analytes via ion/molecule reactions in mass spectrometers. The Journal of organic chemistry 20080704
Oxidative stress increases 6-nitronorepinephrine and 6-nitroepinephrine concentrations in rat brain. Biomedical chromatography : BMC 20080601
Evaluation of ketone-oxime method for developing therapeutic on-demand cleavable immunoconjugates. Bioconjugate chemistry 20080601
Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies. CNS & neurological disorders drug targets 20080601
2,5-Dimethyl-3-(3-methyl-thio-phen-2-yl)perhydro-pyrrolo[3,4-d]isoxazole-4,6-dione. Acta crystallographica. Section E, Structure reports online 20080601
Synthesis of maremycins A and D1 via cycloaddition of a nitrone with (E)-3-ethylidene-1-methylindolin-2-one. Organic letters 20080515
1-(4-Methoxy-phen-yl)-7-phenyl-3-(phenyl-selenylmeth-yl)perhydro-isoxazolo[2',3':1,2]pyrrolo[3,4-b]azetidine-6-spiro-2'-chroman-2,4'-dione. Acta crystallographica. Section E, Structure reports online 20080501
Mechanistic studies of the reactions of nitrone spin trap PBN with glutathiyl radical. The journal of physical chemistry. B 20080417
Synthesis and bioorthogonal coupling chemistry of a novel cyclopentenone-containing unnatural tyrosine analogue. Bioorganic chemistry 20080401
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides. Biochemical pharmacology 20080401
3-(4-Chloro-phen-yl)-4-(4-methoxyphen-yl)-6-(phenyl-selenylmeth-yl)-2,3,3a,3b,4,5,5a,6,1'',2'',3'',4''-do-deca-hydro-azeto[2',3':3,4]pyrrolo[1,2-b]isoxazole-2-spiro-2''-naphthalene-5,1''-dione. Acta crystallographica. Section E, Structure reports online 20080401
Nitrone cycloadditions to 1,2-diphenylcyclopropenes and subsequent transformations of the isoxazolidine cycloadducts. The Journal of organic chemistry 20080321
Reactivity of Pt- and Pd-bound nitriles towards nitrile oxides and nitrones: substitution vs. cycloaddition. Dalton transactions (Cambridge, England : 2003) 20080314
Quasienantiomeric levoglucosenone and isolevoglucosenone allow the parallel kinetic resolution of a racemic nitrone. The Journal of organic chemistry 20080307
Identifying the site of spin trapping in proteins by a combination of liquid chromatography, ELISA, and off-line tandem mass spectrometry. Free radical biology & medicine 20080301
(2Z)-2-Anilino-2-[oxido(phen-yl)iminio]-N-(2-pyrid-yl)acetamide methanol 0.425-solvate. Acta crystallographica. Section E, Structure reports online 20080301
The nitrone disodium 2,4-sulphophenyl-N-tert-butylnitrone is without cytoprotective effect on sodium nitroprusside-induced cell death in N1E-115 neuroblastoma cells in vitro. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080101
Metal-free and PdII-promoted [2+3] cycloadditions of a cyclic nitrone to phthalonitriles: syntheses of oxadiazolines as well as phthalamide-PdII and dihydropyrrolyl-iminoisoindolinone-PdII complexes with high catalytic activity in Suzuki-Miyaura cross-coupling reactions. Chemistry (Weinheim an der Bergstrasse, Germany) 20080101
(1R,4R,5R)-1,3,4-Triphenyl-7-[(R)-1-phenyl-ethyl]-2-oxa-3,7-diaza-spiro-[4.5]decan-10-one. Acta crystallographica. Section E, Structure reports online 20080101
Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea. Organic letters 20071206
Vasorelaxant activity of some oxime derivatives. European journal of pharmacology 20071201
Thermodynamic stability and reactivity of silylated bis(oxy)iminium ions. The Journal of organic chemistry 20071123
Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: dose-response and therapeutic window. Brain research 20071114
Asymmetric 1,3-dipolar cycloadditions of nitrones and methacrolein catalyzed by chiral bis-titanium lewis acid: a dramatic effect of N-substituent on nitrone. Organic letters 20071108
Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins: spin trapping analysis. Journal of the American Chemical Society 20071107
Design of new derivatives of nitrone DEPMPO functionalized at C-4 for further specific applications in superoxide radical detection. The Journal of organic chemistry 20071012
Determination of nitrocatecholamines in rat brain using high-performance liquid chromatography-peroxyoxalate chemiluminescence reaction detection. Journal of chromatography. A 20070914
Synthesis of oxepane ring containing monocyclic, conformationally restricted bicyclic and spirocyclic nucleosides from D-glucose: a cycloaddition approach. The Journal of organic chemistry 20070914
A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol. Organic & biomolecular chemistry 20070907
Orthogonal natural atomic orbitals form an appropriate one-electron basis for expanding CASSCF wave functions into localized bonding schemes and their weights. Journal of computational chemistry 20070901
Investigating the free radical trapping ability of NXY-059, S-PBN and PBN. Free radical research 20070901
Future therapeutic treatment of COPD: struggle between oxidants and cytokines. International journal of chronic obstructive pulmonary disease 20070901
A dual sensor spin trap for use with EPR spectroscopy. Organic letters 20070830
Fragmentation of nitrone triflates to 9-membered rings. Organic letters 20070816
Mixed unsymmetric oxadiazoline and/or imine platinum(II) complexes. Dalton transactions (Cambridge, England : 2003) 20070814
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. The Journal of biological chemistry 20070810
Phosphine-catalyzed synthesis of highly functionalized coumarins. Organic letters 20070802
Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemical research in toxicology 20070801
The element effect in nucleophilic aromatic photosubstitution (SN2Ar*). Organic letters 20070719
Reactivity of superoxide radical anion with cyclic nitrones: role of intramolecular H-bond and electrostatic effects. Journal of the American Chemical Society 20070704
Purification and partial characterization of N-hydroxy-l-phenylalanine decarboxylase/oxidase from Bacillus sp. strain OxB-1, an enzyme involved in aldoxime biosynthesis in the 'aldoxime-nitrile pathway'. Biochimica et biophysica acta 20070701
Detection, characterization, and decay kinetics of ROS and thiyl adducts of mito-DEPMPO spin trap. Chemical research in toxicology 20070701
The DNA-damaging potential of tamoxifen in breast cancer and normal cells. Archives of toxicology 20070701
Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation. Drug metabolism and disposition: the biological fate of chemicals 20070601
A ketone oximate based cyclic cationic [Ni(II)4] inverse metallacrown from simultaneous chelation and bridging of two ligands. Dalton transactions (Cambridge, England : 2003) 20070528
Regulation of S-thiolation and S-nitrosylation in the thiol/nitric oxide system by radical scavengers. Nitric oxide : biology and chemistry 20070501
Total synthesis of the putative structure of stemonidine: the definitive proof of misassignment. Organic letters 20070426
Synthesis of alpha,beta-unsaturated ketones as chalcone analogues via a S(RN)1 mechanism. Molecules (Basel, Switzerland) 20070418
An azomethine ylide approach to complex alkaloid-like heterocycles. The Journal of organic chemistry 20070413
Caspase-dependent and -independent suppression of apoptosis by monoHER in Doxorubicin treated cells. British journal of cancer 20070212
Conformers and photochemistry of propyl nitrites: a matrix isolation study. The journal of physical chemistry. A 20070125
Synthesis and ESR studies of a novel cyclic nitrone spin trap attached to a phosphonium group-a suitable trap for mitochondria-generated ROS? Free radical research 20070101
Immuno-spin trapping analyses of DNA radicals. Nature protocols 20070101
The use of silicon-based tethers for the Pauson-Khand reaction. Beilstein journal of organic chemistry 20070101
Alpha-phenyl-N-tert-butylnitrone-type derivatives bound to beta-cyclodextrins: syntheses, thermokinetics of self-inclusion and application to superoxide spin-trapping. Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
Half-sandwich rhodium (and iridium) complexes as enantioselective catalysts for the 1,3-dipolar cycloaddition of 3,4-dihydroisoquinoline N-oxide to methacrylonitrile. Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
Conformational preferences of methacrolein in Diels-Alder and 1,3-dipolar cycloaddition reactions. The Journal of organic chemistry 20061222
Hypokalemia, cardiac failure, and reporting NXY-059 safety for acute stroke. Journal of cardiovascular pharmacology and therapeutics 20061201
Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone. The Journal of organic chemistry 20061124
Probing the chemical steps of nitroalkane oxidation catalyzed by 2-nitropropane dioxygenase with solvent viscosity, pH, and substrate kinetic isotope effects. Biochemistry 20061121
Fluxional additives: a second generation control in enantioselective catalysis. Journal of the American Chemical Society 20061025
Effect of the phosphoryl substituent in the linear nitrone on the spin trapping of superoxide radical and the stability of the superoxide adduct: combined experimental and theoretical studies. The Journal of organic chemistry 20060929
Controlling a recognition-mediated reaction using a pH switch. Chemical communications (Cambridge, England) 20060921
Diastereoselective synthesis of novel iminosugar-containing UDP-Galf mimics: potential inhibitors of UDP-Gal mutase and UDP-Galf transferases. The Journal of organic chemistry 20060915
Synthesis of 1-homoaustraline. Carbohydrate research 20060904
The use of telomere biology to identify and develop superior nitrone based anti-oxidants. Biochemical and biophysical research communications 20060825
Synthesis and cytotoxic activity of polyamine analogues of camptothecin. Journal of medicinal chemistry 20060824
Efficient conversion of nitronate into nitrile oxide using cyanuric chloride. One-pot synthesis of bicyclic isoxazolines and isoxazoles from nitroalkenes. Organic & biomolecular chemistry 20060807
Sequential ring-closing metathesis and nitrone cycloaddition on glucose-derived substrates: a divergent approach to analogues of spiroannulated carbanucleosides and conformationally locked nucleosides. The Journal of organic chemistry 20060804
Effect of the metal fragment in the thermal cycloaddition between alkynyl metal(0) Fischer carbene complexes and nitrones. The Journal of organic chemistry 20060804
Experimental and theoretical study of the electronic spectrum of the methylene amidogen radical (H2CN): verification of the 2A1 <-- 2B2 assignment. The journal of physical chemistry. A 20060629
Further investigation of the N-demethylation of tertiary amine alkaloids using the non-classical Polonovski reaction. Bioorganic & medicinal chemistry letters 20060601
C-(2-chloroquinoline-3-yl)-N-phenyl nitrone: new synthetic antioxidant inhibits proliferation and induces apoptosis of breast carcinoma MCF-7 cells. Archiv der Pharmazie 20060501
An atypical approach identifies TYR234 as the key base catalyst in chondroitin AC lyase. Chembiochem : a European journal of chemical biology 20060401
Treating the acute stroke patient as an emergency: current practices and future opportunities. International journal of clinical practice 20060401
New nitronate sigma complexes and the mechanism of nucleophilic aromatic photosubstitution para to a nitro group. Organic letters 20060330
High static pressure alters spin trapping rates in solution. Dependence on the structure of nitrone spin traps. Organic & biomolecular chemistry 20060307
Antioxidant therapies in COPD. International journal of chronic obstructive pulmonary disease 20060301
CASPT2 study of the decomposition of nitrosomethane and its tautomerization reactions in the ground and low-lying excited states. The Journal of organic chemistry 20060203
Immuno-spin trapping of DNA radicals. Nature methods 20060201
Nitrones as therapeutics in age-related diseases. Aging cell 20060201
Reaction of nitrones with silyl ketene acetals: a DFT study. Journal of computational chemistry 20060130
Theoretical study of reactant activation in 1,3-dipolar cycloadditions of cyclic nitrones to free and Pt-bound nitriles. The Journal of organic chemistry 20060120
Stereoselective synthesis of chiral oxepanes and pyrans through intramolecular nitrone cycloaddition in organized aqueous media. The Journal of organic chemistry 20060106
Hydrazyl-nitrones, novel hybrid molecules in free radical research. Free radical research 20060101
Nitrone spin on cerebral ischemia. Current opinion in investigational drugs (London, England : 2000) 20060101
Melatonin in Alzheimer's disease and other neurodegenerative disorders. Behavioral and brain functions : BBF 20060101
Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics. Journal of biomedicine & biotechnology 20060101
Reduced neuronal injury after treatment with NG-nitro-L-arginine methyl ester (L-NAME) or 2-sulfo-phenyl-N-tert-butyl nitrone (S-PBN) following experimental brain contusion. Neurosurgery 20051201
tert-Butyl (phenylsulfonyl)alkyl-N-hydroxycarbamates: the first class of N-(Boc) nitrone equivalents. Organic letters 20051110
Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent. Journal of neurochemistry 20051101
Use of reversed-phase liquid chromatography for determining the lipophilicity of alpha-aryl-N-cyclopropylnitrones. Journal of pharmaceutical and biomedical analysis 20051004
Enantioselective 1,3-dipolar cycloaddition of nitrones to methacrolein catalyzed by (eta5-C5Me5)M{(R)-prophos} containing complexes (M = Rh, Ir; (R)-prophos = 1,2-bis(diphenylphosphino)propane): on the origin of the enantioselectivity. Journal of the American Chemical Society 20050928
Is there stereoselectivity in spin trapping superoxide by 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide? The Journal of organic chemistry 20050902
Asymmetric 1,3-dipolar cycloaddition reaction of nitrones and acrolein with a bis-titanium catalyst as chiral Lewis acid. Journal of the American Chemical Society 20050831
Diastereoselective intermolecular radical addition to nitrones. The Journal of organic chemistry 20050819
An improved approach to chiral cyclopentenone building blocks. Total synthesis of pentenomycin I and neplanocin A. The Journal of organic chemistry 20050819
Dramatically enhanced carbon acidity of the nitrobenzyl fragment in a nickel(II) scorpionate complex. Organic letters 20050804
Copper-catalyzed protein oxidation and its modulation by carbon dioxide: enhancement of protein radicals in cells. The Journal of biological chemistry 20050722
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline n-oxide (DMPO). 1. The thermodynamics of formation and its acidity. The journal of physical chemistry. A 20050714
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. The thermodynamics of decay and EPR spectral properties. The journal of physical chemistry. A 20050714
Kinetics of proton release after flash photolysis of 1-(2-nitrophenyl)ethyl sulfate (caged sulfate) in aqueous solution. Journal of the American Chemical Society 20050713
Open versus closed 1,3-dipolar additions of C60: a theoretical investigation on their mechanism and regioselectivity. The Journal of organic chemistry 20050708
Spin trapping of superoxide by diester-nitrones. Organic & biomolecular chemistry 20050707
Correlation of hippocampal morphological changes and morris water maze performance after cortical contusion injury in rats. Neurosurgery 20050701
An efficient and enantioselective approach to the azaspirocyclic core of alkaloids: formal synthesis of halichlorine and pinnaic acid. The Journal of organic chemistry 20050624
Nitrone derivatives of trolox as neuroprotective agents. Bioorganic & medicinal chemistry letters 20050615
Stereoselective syntheses of 4-hydroxy 4-substituted glutamic acids. The Journal of organic chemistry 20050610
Cis-stereoselective SmI2-promoted reductive coupling of keto-nitrones: first synthesis of 1-epitrehazolamine. Organic & biomolecular chemistry 20050607
Stilbazulenyl nitrone, a second-generation azulenyl nitrone antioxidant, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat: neurobehavior, histopathology, and pharmacokinetics. The Journal of pharmacology and experimental therapeutics 20050601
1,3-dipolar cycloaddition on solid supports: nitrone approach towards isoxazolidines and isoxazolines and subsequent transformations. Chemical Society reviews 20050601
Inclusion complexes of PBN-type nitrone spin traps and their superoxide spin adducts with cyclodextrin derivatives: parallel determination of the association constants by NMR titrations and 2D-EPR simulations. The journal of physical chemistry. B 20050526
Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition. The Journal of organic chemistry 20050513
Ketone-imide versus ketone-oxime reductive cross-coupling promoted by samarium diiodide: new mechanistic insight gained from a failed aminocyclopentitol synthesis. The Journal of organic chemistry 20050513
Highly stereoselective additions of tin enolates to nitroalkenes and subsequent conversion of the nitro group into a nitrile. Organic letters 20050428
Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes. Archives of biochemistry and biophysics 20050415
Imatinib (STI571) induces DNA damage in BCR/ABL-expressing leukemic cells but not in normal lymphocytes. Chemico-biological interactions 20050415
Identification of the myoglobin tyrosyl radical by immuno-spin trapping and its dimerization. Free radical biology & medicine 20050401
Enhancement in antimicrobial activity of 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine. Bioorganic & medicinal chemistry letters 20050401
1,3-Dipolar reactions involving corannulene: how does its rim and spoke addition vary? The Journal of organic chemistry 20050401
Reaction of morphinone reductase with 2-cyclohexen-1-one and 1-nitrocyclohexene: proton donation, ligand binding, and the role of residues Histidine 186 and Asparagine 189. The Journal of biological chemistry 20050318
Development of a new EPR spin trap, DOD-8C (N-[4-dodecyloxy-2-(7'-carboxyhept-1'-yloxy)benzylidene]-N-tert-butylamine N-oxide), for the trapping of lipid radicals at a predetermined depth within biological membranes. Archives of biochemistry and biophysics 20050315
A concise stereoselective route to the indoline spiroaminal framework of neoxaline and oxaline. Organic letters 20050303
Thiol oxidase activity of copper, zinc superoxide dismutase stimulates bicarbonate-dependent peroxidase activity via formation of a carbonate radical. Chemical research in toxicology 20050301
Interaction of amoxicillin with DNA in human lymphocytes and H. pylori-infected and non-infected gastric mucosa cells. Chemico-biological interactions 20050227
Assignment of the EPR spectrum of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) superoxide spin adduct. The Journal of organic chemistry 20050218
Total synthesis of (+)-hyacinthacine A2 based on SmI2-induced nitrone umpolung. The Journal of organic chemistry 20050218
Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitrone. Fundamental & clinical pharmacology 20050201
An electron transfer approach to the preparation of highly functionalized anthraquinones. Molecules (Basel, Switzerland) 20050131
Evidence of overestimation of rate constants for the superoxide trapping by nitrones in aqueous media. Physical chemistry chemical physics : PCCP 20050121
A novel protocol to identify and quantify all spin trapped free radicals from in vitro/in vivo interaction of HO(.-) and DMSO: LC/ESR, LC/MS, and dual spin trapping combinations. Free radical biology & medicine 20050101
A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities. Experimental neurology 20050101
A double-line sequential injection system for the spectrophotometric determination of copper, iron, manganese, and zinc in waters. Journal of AOAC International 20050101
Population pharmacokinetic modelling and estimation of dosing strategy for NXY-059, a nitrone being developed for stroke. Clinical pharmacokinetics 20050101
Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy. Respiratory research 20050101
Characterization of insulin-like-growth factor II (IGF II) mRNA positive hepatic altered foci and IGF II expression in hepatocellular carcinoma during diethylnitrosamine-induced hepatocarcinogenesis in rats. Journal of carcinogenesis 20050101
Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug. Nutrition & metabolism 20050101
A convenient synthesis of gamma-functionalized cyclopentenones. Beilstein journal of organic chemistry 20050101
Highly stereoselective grignard addition to cis-substituted C-cyclopropylaldonitrones. The bisected s-trans transition state can be stabilized effectively by the Lewis acid-coordination. The Journal of organic chemistry 20041224
Highly efficient chemoselective deprotection of O,O-acetals and O,O-ketals catalyzed by molecular iodine in acetone. The Journal of organic chemistry 20041210
Superoxide dismutase versus ferricytochrome C: determining rate constants for the spin trapping of superoxide by cyclic nitrones. The Journal of organic chemistry 20041126
Magnesium iodide promoted reactions of nitrones with cyclopropanes: a synthesis of tetrahydro-1,2-oxazines. The Journal of organic chemistry 20041126
Spin trapping by 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO): theoretical and experimental studies. The Journal of organic chemistry 20041112
Nucleophilicities of nitroalkyl anions. The Journal of organic chemistry 20041029
First asymmetric SmI2-induced cross-coupling of Cr(CO)3 aromatic nitrone complexes with carbonyl compounds. Chemical communications (Cambridge, England) 20041021
Intramolecular nitrone cycloaddition reaction on carbohydrate-based precursors: application in the synthesis of spironucleosides and spirobisnucleosides. The Journal of organic chemistry 20040917
Unprecedented single-pot synthesis of nitrile-derived ketoimino platinum(II) complexes by ring opening of Delta4-1,2,4-oxadiazolines. Dalton transactions (Cambridge, England : 2003) 20040907
A Weinreb nitrile oxide and nitrone for cycloaddition. Organic letters 20040902
Microdialysis sampling combined with electron spin resonance for superoxide radical detection in microliter samples. Analytical chemistry 20040815
Can the nitroso ene reaction proceed concertedly? Organic letters 20040805
[Development of radical reactions in water aimed at environmentally benign synthetic reactions]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040601
Effects of alpha-phenyl-N-tert-butyl nitrone (PBN)on brain cell membrane function and energy metabolism during transient global cerebral hypoxia-ischemia and reoxygenation-reperfusion in newborn piglets. Journal of Korean medical science 20040601
Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping. Free radical biology & medicine 20040515
A new kinetic approach to the evaluation of rate constants for the spin trapping of superoxide/hydroperoxyl radical by nitrones in aqueous media. Organic & biomolecular chemistry 20040507
Investigation of conjugate addition/intramolecular nitrone dipolar cycloadditions and their use in the synthesis of dendrobatid alkaloid precursors. Organic & biomolecular chemistry 20040421
Protein radical formation during lactoperoxidase-mediated oxidation of the suicide substrate glutathione: immunochemical detection of a lactoperoxidase radical-derived 5,5-dimethyl-1-pyrroline N-oxide nitrone adduct. The Journal of biological chemistry 20040326
ESR study of spin-trapping with two glycosylated analogues of PBN able to target cell membrane lectins. Organic & biomolecular chemistry 20040321
Imino-C-nucleoside synthesis: heteroaryl lithium carbanion additions to a carbohydrate cyclic imine and nitrone. The Journal of organic chemistry 20040319
Relaxant effect of oxime derivatives in isolated rat aorta: role of nitric oxide (NO) formation in smooth muscle. Biochemical pharmacology 20040315
Syntheses of (-)-funebrine and (-)-funebral, using sequential transesterification and intramolecular cycloaddition of a chiral nitrone. The Journal of organic chemistry 20040305
Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical. The Biochemical journal 20040301
Genotoxicity of streptozotocin in normal and cancer cells and its modulation by free radical scavengers. Cell biology and toxicology 20040301
Influence of conformation on the EPR spectrum of 5,5-dimethyl-1-hydroperoxy-1-pyrrolidinyloxyl: a spin trapped adduct of superoxide. The Journal of organic chemistry 20040220
Theoretical study of the spin trapping of hydroxyl radical by cyclic nitrones: a density functional theory approach. Journal of the American Chemical Society 20040218
A practical oxidative method for the cleavage of hydrazide N[bond]N bonds. Chemistry (Weinheim an der Bergstrasse, Germany) 20040206
Exo selective enantioselective nitrone cycloadditions. Journal of the American Chemical Society 20040128
Esterase-assisted accumulation of 3-carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl into lymphocytes. Organic & biomolecular chemistry 20040107
Ligand discrimination in the reaction of nitrones with [PtCl2(PhCN)2]. Selective formation of mono-oxadiazoline and mixed bis-oxadiazoline complexes under thermal and microwave conditions. Dalton transactions (Cambridge, England : 2003) 20040107
Vanadyl sulfate can differentially damage DNA in human lymphocytes and HeLa cells. Archives of toxicology 20040101
The outer membrane protein Omp35 affects the reduction of Fe(III), nitrate, and fumarate by Shewanella oneidensis MR-1. BMC microbiology 20040101
Nitrone-related therapeutics: potential of NXY-059 for the treatment of acute ischaemic stroke. CNS drugs 20040101
Diaphorase can metabolize some vasorelaxants to NO and eliminate NO scavenging effect of 2-phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide (PTIO). Physiological research 20040101
Alpha-oximono-esters as precursors to heterocycles--generation of oxazinone N-oxides and cycloaddition to alkene dipolarophiles. Organic & biomolecular chemistry 20031207
Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059. Pharmacology & therapeutics 20031201
NXY-059, a nitrone with free radical trapping properties inhibits release of cytochrome c after focal cerebral ischemia. Cellular and molecular biology (Noisy-le-Grand, France) 20031201
Synthesis and preliminary biological evaluations of ionic and nonionic amphiphilic alpha-phenyl-N-tert-butylnitrone derivatives. Journal of medicinal chemistry 20031120
Highly stereoselective synthesis of (-)-monatin, a high-intensity sweetener, using chelation-controlled nitrone cycloaddition. Chemical communications (Cambridge, England) 20031107
Comparative investigation of superoxide trapping by cyclic nitrone spin traps: the use of singular value decomposition and multiple linear regression analysis. Free radical biology & medicine 20031101
Free radical-dependent nuclear localization of Bcl-2 in the central nervous system of aged rats is not associated with Bcl-2-mediated protection from apoptosis. Journal of neurochemistry 20031101
Asymmetric total synthesis and stereochemical elucidation of the antitumor agent PM-94128. Organic letters 20031030
The kinetics and mechanism of the ferrate(VI) oxidation of hydroxylamines. Inorganic chemistry 20031020
Tandem double intramolecular [4+2]/[3+2] cycloadditions of nitroalkenes. The fused/bridged mode. The Journal of organic chemistry 20031017
Rearrangements of bicyclic nitrones to lactams: comparison of photochemical and modified Barton conditions. The Journal of organic chemistry 20031017
Water exclusion reaction in aqueous media: nitrone formation and cycloaddition in a single pot. Organic letters 20031016
Changes in tumor vascularization after irradiation, anthracyclin, or antiangiogenic treatment in nitrosomethyl ureas-induced rat mammary tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 20031001
The effects of PBN (phenyl-butyl-nitrone) on GLT-1 levels and on the extracellular levels of amino acids and energy metabolites in a model of iron-induced posttraumatic epilepsy. Epilepsy research 20031001
Neuroprotective effects of nitrone radical scavenger S-PBN on reperfusion nerve injury in rats. Brain research 20030829
A theoretical exploration of the 1,3-dipolar cycloadditions onto the sidewalls of (n,n) armchair single-wall carbon nanotubes. Journal of the American Chemical Society 20030827
Enantioselective syntheses and cytotoxicity of N,O-nucleosides. Journal of medicinal chemistry 20030814
Effects of Seocalcitol (EB1089) on nitrosomethyl urea-induced rat mammary tumors. Breast cancer research and treatment 20030801
Synthesis and EPR spin trapping properties of a new isoindole-based nitrone: 1,1,3-trimethylisoindole N-oxide (TMINO). Organic & biomolecular chemistry 20030721
Photolytic cleavage of 1-(2-nitrophenyl)ethyl ethers involves two parallel pathways and product release is rate-limited by decomposition of a common hemiacetal intermediate. Journal of the American Chemical Society 20030716
UVA-ketoprofen-induced hemoglobin radicals detected by immuno-spin trapping. Photochemistry and photobiology 20030601
Preparation and antibacterial evaluation of some nitrone derivatives with Ge(IV) and Sn(IV) chloride complexes. Bollettino chimico farmaceutico 20030601
Possible metabolic pathways of conversion of formaldoxime and glyceryl trinitrate to NO. General physiology and biophysics 20030601
Nitrone cycloadditions to isolevoglucosenone: ready access to a new class of directly linked (1-->3)-imino-C-disaccharides. Organic letters 20030501
Immunochemical detection of hemoglobin-derived radicals formed by reaction with hydrogen peroxide: involvement of a protein-tyrosyl radical. Free radical biology & medicine 20030401
Experimental and theoretical charge distribution in (Z)-N-methyl-C-phenylnitrone. Organic & biomolecular chemistry 20030321
Synthesis and characterization of EMPO-derived 5,5-disubstituted 1-pyrroline N-oxides as spin traps forming exceptionally stable superoxide spin adducts. Biological chemistry 20030301
The use of enantiomerically pure ketene dithioacetal bis(sulfoxides) in highly diastereoselective intramolecular nitrone cycloadditions. Application in the total synthesis of the beta-amino acid (-)-cispentacin and the first asymmetric synthesis of cis-(3R,4R)-4-amino-pyrrolidine-3-carboxylic acid. Organic & biomolecular chemistry 20030221
Evidence for the intermediacy of arylbenzylnitrenium ions in the thermal rearrangement of isoxazolidines derived from C,N-diarylnitrones and 2-morpholin-4-yl-acrylonitrile. Chemistry (Weinheim an der Bergstrasse, Germany) 20030217
Novel intermolecular carbon radical addition to a nitrone: asymmetric synthesis of alpha-amino acids. Chemical communications (Cambridge, England) 20030207
Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells. Mutation research 20030205
The importance of chromatographic separation in LC/MS/MS quantitation of drugs in biological fluids: detection, characterization, and synthesis of a previously unknown low-level nitrone metabolite of a substance P antagonist. Analytical chemistry 20030201
SmI(2)-promoted radical addition of nitrones to alpha,beta-unsaturated amides and esters: synthesis of gamma-amino acids via a nitrogen equivalent to the ketyl radical. Organic letters 20030123
Nonradical mechanism of (bi)sulfite reaction with DEPMPO: cautionary note for SO3*- radical spin trapping. Free radical biology & medicine 20030115
Free radical scavengers can modulate the DNA-damaging action of alloxan. Acta biochimica Polonica 20030101
NXY 059: CPI 22, NXY 059G. Drugs in R&D 20030101
Diastereo- and enantioselective synthesis of 1'-C-branched N,O-nucleosides. Nucleosides, nucleotides & nucleic acids 20030101
Nucleophilic addition of nitrones to ketones: development of a new catalytic asymmetric nitrone-aldol reaction. Chemistry (Weinheim an der Bergstrasse, Germany) 20021216
Chemoselective electrophilic oxidation of heteroatoms by hydroperoxy sultams. The Journal of organic chemistry 20021129
In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions. Brain research 20021115
Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective. Clinical and experimental pharmacology & physiology 20021101
Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. Journal of medicinal chemistry 20021024
A new route to coordination complexes of nitroxyl (HN=O) via insertion reactions of nitrosonium triflate with transition-metal hydrides. Journal of the American Chemical Society 20021016
Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats. Journal of neurotrauma 20021001
Novel synthesis of fused isoxazolidines via a palladium catalysed allene insertion-intramoleculer 1,3-dipolar cycloaddition cascade reaction. Chemical communications (Cambridge, England) 20020821
Immunological identification of the heart myoglobin radical formed by hydrogen peroxide. Free radical biology & medicine 20020801
Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine. Archives of biochemistry and biophysics 20020615
Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in rats. Journal of neurosurgery 20020601
A stereoselective intramolecular 1,3-dipolar nitrone cycloaddition for the synthesis of substituted chromanes. The Journal of organic chemistry 20020517
Asymmetric synthesis of epicylindrospermopsin via intramolecular nitrone cycloaddition. Assignment of absolute configuration. Journal of the American Chemical Society 20020508
Iron and ruthenium Lewis acid catalyzed asymmetric 1,3-dipolar cycloaddition reactions between nitrones and enals. Journal of the American Chemical Society 20020508
Stilbazulenyl nitrone (STAZN): a nitronyl-substituted hydrocarbon with the potency of classical phenolic chain-breaking antioxidants. Journal of the American Chemical Society 20020501
Spin adducts of superoxide, alkoxyl, and lipid-derived radicals with EMPO and its derivatives. Biological chemistry 20020501
Nitrones, their value as therapeutics and probes to understand aging. Mechanisms of ageing and development 20020430
Genotoxicity of idarubicin and its modulation by vitamins C and E and amifostine. Chemico-biological interactions 20020420
ESR analysis of spin adducts of alkoxyl and lipid-derived radicals with the spin trap Trazon. Biochemical pharmacology 20020415
Nucleophilic addition reaction of 2-trimethylsilyloxyfuran to N-gulosyl-C-alkoxymethylnitrones: synthetic approach to polyoxin C. Organic letters 20020404
Highly diastereoselective nitrone cycloaddition onto a chiral ketene equivalent: asymmetric synthesis of cispentacin. Organic letters 20020404
Nitrones as neuroprotectants and antiaging drugs. Annals of the New York Academy of Sciences 20020401
The nitrone spin trap PBN alters the cellular response to H(2)O(2): activation of the EGF receptor/ERK pathway. Free radical biology & medicine 20020315
Straightforward synthesis of enantiomerically pure (3S,4R)- and (3R,4S)-3,4-isopropylidenedioxypyrroline 1-oxide, precursors of functionalized cis-dihydroxy azaheterocycles, by a novel 'one-pot' procedure. The Journal of organic chemistry 20020308
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines. Bioorganic & medicinal chemistry letters 20020225
Nitrones are suitable ligands for heme models: X-ray crystal structure of the first metalloporphyrin nitrone complex. Chemical communications (Cambridge, England) 20020221
Detection and removal of contaminating hydroxylamines from the spin trap DEPMPO, and re-evaluation of its use to indicate nitrone radical cation formation and S(N)1 reactions. Free radical biology & medicine 20020201
Interdependent chemical-electrochemical steps in retrometabolism-based drug and safer chemical design. Die Pharmazie 20020201
Alternate substrates of human glutaryl-CoA dehydrogenase: structure and reactivity of substrates, and identification of a novel 2-enoyl-CoA product. Biochemistry 20020129
N-2-(2-ethoxycarbonyl-propyl) alpha-phenylnitrone: an efficacious lipophilic spin trap for superoxide detection. Archives of biochemistry and biophysics 20020101
Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis. Arthritis research 20020101
Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition. Molecular and cellular biochemistry 20020101
DNA damage in human colonic mucosa cells evoked by nickel and protective action of quercetin - involvement of free radicals? Cell biology and toxicology 20020101
Synthesis of polyhydroxyindolizidines from 5,6-dihydro-2H-pyran-2-one. Carbohydrate research 20011207
Effects of the nitrone radical scavengers PBN and S-PBN on in vivo trapping of reactive oxygen species after traumatic brain injury in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20011101
Free radical generation in the cochlea during combined exposure to noise and carbon monoxide: an electrophysiological and an EPR study. Hearing research 20011101
Formaldehyde oxime <--> nitrosomethane tautomerism. The Journal of organic chemistry 20011005
Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity. Journal of medicinal chemistry 20010927
Tandem double intramolecular [4 + 2]/[3 + 2] cycloadditions of nitroalkenes. Organic letters 20010906
Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals. Free radical biology & medicine 20010901
An ESR and HPLC-EC assay for the detection of alkyl radicals. Chemical research in toxicology 20010901
Principal component analysis of polarity and interaction parameters in inverse gas chromatography. Journal of chromatographic science 20010901
(1S)-(Z)-2-benzyloxy-N-(3-methyl-1-butylidene)-1-phenylethylamine N-oxide. Acta crystallographica. Section C, Crystal structure communications 20010901
NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat. Brain research 20010803
Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat. Journal of neurotrauma 20010801
Oxidation of nitrobenzylic carbanions with dimethyldioxirane. new synthesis of quinomethanes and nitrobenzylic carbinols. First examples of methylation of carbanions with dimethyldioxirane. The Journal of organic chemistry 20010727
Simultaneous discrimination of diastereotopic groups and faces: the first example in intramolecular [3+2] and [2+2+1] cycloaddition reactions. The Journal of organic chemistry 20010601
Inhibition of oxidized low-density lipoprotein-induced apoptosis in endothelial cells by nitric oxide. Peroxyl radical scavenging as an antiapoptotic mechanism. The Journal of biological chemistry 20010518
Tandem transesterification and intramolecular cycloaddition of alpha-methoxycarbonylnitrones with chiral acyclic allyl alcohols: systematic studies on the factors affecting diastereofacial selectivity of the cycloaddition. The Journal of organic chemistry 20010420
Modeling the 1,3-dipolar cycloaddition of nitrones to vinylboranes in competition with boration, cyclization, and oxidation reactions. The Journal of organic chemistry 20010406
Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059. Free radical research 20010401
A concise enantioselective synthesis of antimalarial febrifugine alkaloids. Organic letters 20010322
Transfer of stereochemical information in a minimal self-replicating system. Organic letters 20010308
Unique in vivo applications of spin traps. Free radical biology & medicine 20010301
Caloric restriction mimetics: metabolic interventions. The journals of gerontology. Series A, Biological sciences and medical sciences 20010301
Entropy-controlled selectivity in the vinylation of a cyclic chiral nitrone. An efficient route to enantiopure polyhydroxylated pyrrolidines. The Journal of organic chemistry 20010223
Carbon-to-carbon identity proton transfers from propyne, acetimide, thioacetaldehyde, and nitrosomethane to their respective conjugate anions in the gas phase. An ab initio study. The Journal of organic chemistry 20010209
Synthesis, analysis and reduction of 2-nitropropyl starch. Carbohydrate research 20010130
NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke 20010101
The guanylyl cyclase family at Y2K. Annual review of physiology 20010101
alpha-Phenyl-tert-N-butyl nitrone (PBN) improves functional and morphological outcome after cortical contusion injury in the rat. Acta neurochirurgica 20010101
Identical flow injection spectrophotometric manifold for determination of protein, phosphorus, calcium, chloride, copper, manganese, iron, and zinc in feeds or premixes. Journal of AOAC International 20010101
Preparation and antibacterial evaluation of some nitrone derivative and their zirconium (IV) chloride complexes. Bollettino chimico farmaceutico 20010101
Reactivity of 5-nitro-2-furaldehyde in alkaline and acidic solutions. Acta poloniae pharmaceutica 20010101

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