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86484-91-5 | 1,2-Benzenediol,4-[2-[[6-[(2-phenylethyl)amino]hexyl]amino]ethyl]-, hydrochloride (1:2)
CAS No: 86484-91-5 Catalog No: AG004VLU MDL No:
Product Description
Catalog Number:
AG004VLU
Chemical Name:
1,2-Benzenediol,4-[2-[[6-[(2-phenylethyl)amino]hexyl]amino]ethyl]-, hydrochloride (1:2)
CAS Number:
86484-91-5
Molecular Formula:
C22H34Cl2N2O2
Molecular Weight:
429.4236
IUPAC Name:
4-[2-[6-(2-phenylethylamino)hexylamino]ethyl]benzene-1,2-diol;dihydrochloride
InChI:
InChI=1S/C22H32N2O2.2ClH/c25-21-11-10-20(18-22(21)26)13-17-24-15-7-2-1-6-14-23-16-12-19-8-4-3-5-9-19;;/h3-5,8-11,18,23-26H,1-2,6-7,12-17H2;2*1H
InChI Key:
VPDULUNRSQWWJB-UHFFFAOYSA-N
SMILES:
Oc1cc(CCNCCCCCCNCCc2ccccc2)ccc1O.Cl.Cl
UNII:
0VN909S60Y
Properties
Complexity:
334
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
428.2g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
6
Isotope Atom Count:
0
Molecular Weight:
429.426g/mol
Monoisotopic Mass:
428.2g/mol
Rotatable Bond Count:
13
Topological Polar Surface Area:
64.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Epinephrine, norepinephrine, dobutamine, and dopexamine effects on free flap skin blood flow. | Plastic and reconstructive surgery 20120901 |
| Dopexamine has no additional benefit in high-risk patients receiving goal-directed fluid therapy undergoing major abdominal surgery. | Anesthesia and analgesia 20110101 |
| The effect of fenoldopam and dopexamine on cytokine and endotoxin release following on-pump coronary artery bypass grafting: a prospective randomized double-blind trial. | The heart surgery forum 20101201 |
| Dopexamine Test in septic shock with hyperlactatemia. | Annales francaises d'anesthesie et de reanimation 20101101 |
| Is dopexamine superior to dopamine in the treatment of multiple trauma patients--a prospective, double-blind, randomised study. | Injury 20100501 |
| Dopexamine after heart surgery: an uncommonly used, though useful inotropic agent. | Recent patents on cardiovascular drug discovery 20100101 |
| Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial. | Critical care (London, England) 20100101 |
| Dopexamine and survival: areas of consistency. | Anaesthesia 20091101 |
| Hemodynamic effects of dobutamine and dopexamine after cardiopulmonary bypass in pediatric cardiac surgery. | Paediatric anaesthesia 20090901 |
| The effect of fenoldopam and dopexamine on hepatic blood flow and hepatic function following coronary artery bypass grafting with hypothermic cardiopulmonary bypass. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20090601 |
| Meta-analyses of the effects of dopexamine in major surgery: do all roads lead to Rome? | Anaesthesia 20090601 |
| Meta-analysis on the effect of dopexamine on in-hospital mortality. | Anaesthesia 20090601 |
| Inotropic therapy for cardiac low output syndrome: comparison of hemodynamic effects of dopamine/dobutamine versus dopamine/dopexamine. | European journal of medical research 20081027 |
| Effect of dopexamine infusion on mortality following major surgery: individual patient data meta-regression analysis of published clinical trials. | Critical care medicine 20080401 |
| Inotropic therapy for cardiac low output syndrome: comparison of hemodynamic effects of dopamine/dobutamine versus dopamine/dopexamine. | European journal of medical research 20071105 |
| Synthetic inotropes inhibit the expression of adhesion molecules and augment the expression of L-selectin in polymorphonuclear neutrophils. | Resuscitation 20070801 |
| Splanchnic blood flow and oxygen consumption: effects of enteral nutrition and dopexamine in the elderly cardiac surgery patient. | Acta anaesthesiologica Scandinavica 20070501 |
| The effects of dopexamine in bupivacaine and ropivacaine induced cardiotoxicity in isolated rat heart. | Saudi medical journal 20060801 |
| Comparison of systemic and renal effects of dopexamine and dopamine in norepinephrine-treated septic shock. | Journal of cardiothoracic and vascular anesthesia 20060401 |
| Prevention of acute renal failure--first do no harm! | Acta anaesthesiologica Scandinavica 20060201 |
| Effects of dopexamine on regional blood flow and leukotriene production in multiple splanchnic sites in endotoxemic rats. | Hepato-gastroenterology 20060101 |
| Dopexamine and norepinephrine versus epinephrine on gastric perfusion in patients with septic shock: a randomized study [NCT00134212]. | Critical care (London, England) 20060101 |
| Effects of dopexamine in a rat model of supracoeliac aortic cross-clamping and declamping. | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20060101 |
| Catecholamines: physiological immunomodulators during health and illness. | Current medicinal chemistry 20060101 |
| Effects of dopexamine on the intestinal microvascular blood flow and leukocyte activation in a sepsis model in rats. | Critical care (London, England) 20060101 |
| Effects of dopexamine on lipid peroxidation during aortic surgery in pigs: comparison with dopamine. | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20051201 |
| Kidney dysfunction in the postoperative period. | British journal of anaesthesia 20050701 |
| Dopexamine and its role in the protection of hepatosplanchnic and renal perfusion in high-risk surgical and critically ill patients. | British journal of anaesthesia 20050401 |
| Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]. | Critical care (London, England) 20050101 |
| Dopexamine reverses the vasopressin-associated impairment in tissue oxygen supply but decreases systemic blood pressure in ovine endotoxemia. | Anesthesia and analgesia 20040901 |
| Adrenergic agents modify cerebral edema and microvessel ultrastructure in porcine sepsis. | Critical care medicine 20040901 |
| [How can one miss the correction local perfusion?]. | Der Anaesthesist 20040801 |
| Effects of dopexamine, dobutamine or dopamine on prolactin and thyreotropin serum concentrations in high-risk surgical patients. | Intensive care medicine 20040601 |
| Effects of dopamine, dobutamine, and dopexamine on microcirculatory blood flow in the gastrointestinal tract during sepsis and anesthesia. | Anesthesiology 20040501 |
| Effects of dopexamine in comparison with fenoterol on carbohydrate, fat and protein metabolism in healthy volunteers. | Intensive care medicine 20040401 |
| Effect of adding dopexamine to intraoperative volume expansion in patients undergoing major elective abdominal surgery. | British journal of anaesthesia 20040401 |
| Haemodynamic effects of dopexamine on postprandial splanchnic hyperaemia. | European journal of clinical investigation 20040401 |
| Local metabolic effects of dopexamine on the intestine during mesenteric hypoperfusion. | Shock (Augusta, Ga.) 20040301 |
| Effects of ephedrine, dobutamine and dopexamine on cerebral haemodynamics: transcranial Doppler studies in healthy volunteers. | British journal of anaesthesia 20040101 |
| Effects of dopexamine on rat cardiorenal functions during lipopolysaccharide-induced experimental sepsis. | The Journal of international medical research 20040101 |
| Dopexamine and cellular immune functions during systemic inflammation. | Immunobiology 20040101 |
| Dopexamine reverses colonic but not gastric mucosal perfusion defects in lethal endotoxin shock. | British journal of anaesthesia 20031201 |
| Should perioperative management target oxygen delivery? | British journal of anaesthesia 20031101 |
| Effect of adding dopexamine to intraoperative volume expansion in patients undergoing major elective abdominal surgery. | British journal of anaesthesia 20031101 |
| [The effect of dopexamine and iloprost on plasma disappearance rate of indocyanine green in patients in septic shock]. | Der Anaesthesist 20031101 |
| Dopexamine increases internal mammary artery blood flow following coronary artery bypass grafting. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20031001 |
| Effects of dopexamine and positive end-expiratory pressure on intestinal blood flow and oxygenation: the perfusion pressure perspective. | Chest 20030801 |
| Dopexamine, dobutamine, and dopamine increase splanchnic blood flow: what is the evidence? | Chest 20030501 |
| A review of anti-inflammatory strategies in cardiac surgery. | Perfusion 20030301 |
| Does dopexamine influence regional vascular tone and oxygenation during intestinal hypotension? | Acta anaesthesiologica Scandinavica 20021101 |
| Modulation of the inflammatory response to cardiopulmonary bypass by dopexamine and epidural anesthesia. | Acta anaesthesiologica Scandinavica 20021101 |
| The specific function of dopexamine: improvement of impaired oxygen delivery. | Critical care medicine 20020801 |
| A randomised controlled trial investigating the effects of dopexamine on gastrointestinal function and organ dysfunction in the critically ill. | Intensive care medicine 20020701 |
| Dopexamine attenuates microvascular perfusion injury of the small bowel in pigs induced by extracorporeal circulation. | British journal of anaesthesia 20020601 |
| Pre-operative optimisation employing dopexamine or adrenaline for patients undergoing major elective surgery: a cost-effectiveness analysis. | Intensive care medicine 20020501 |
| Dopexamine but not dopamine increases gastric mucosal oxygenation during mechanical ventilation in dogs. | Critical care medicine 20020401 |
| Extracorporeal circulation and intestinal microcirculation: pathophysiology and therapeutical options. An intravital microscopic study in a large animal model. | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20020101 |
| Endocrine effects of dopexamine vs. dopamine in high-risk surgical patients. | Intensive care medicine 20011201 |
| Attenuation of lung inflammation by adrenergic agonists in murine acute lung injury. | Anesthesiology 20011001 |
| Effects of dopexamine on acute necrotising pancreatitis in rats. | The European journal of surgery = Acta chirurgica 20011001 |
| Effect of dopexamine on hepatic metabolic activity in patients with septic shock. | Shock (Augusta, Ga.) 20010601 |
| A randomized study to evaluate the effect of a perioperative infusion of dopexamine on colonic mucosal ischemia after aortic surgery. | Journal of vascular surgery 20010401 |
| Dopexamine hydrochloride does not modify hemodynamic response or tissue oxygenation or gut permeability during abdominal aortic surgery. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010301 |
| Effects of dobutamine and dopexamine on hepatic micro- and macrocirculation during experimental endotoxemia: an intravital microscopic study in the rat. | Critical care medicine 20010301 |
| Impairment of renal function after cardiopulmonary bypass is not influenced by dopexamine. | Renal failure 20010301 |
| Differential effects of clonidine, dopamine, dobutamine, and dopexamine on basal and acid-stimulated mucosal blood flow in the rat stomach. | Critical care medicine 20010201 |
| Characterization of the mechanism involved in the relaxant response of dopexamine in the guinea pig pulmonary artery in vitro. | Journal of cardiovascular pharmacology 19990101 |
| A comparison of the efficacy of dopexamine and dobutamine for increasing oxygen delivery in high-risk surgical patients. | Anaesthesia and intensive care 19950801 |
| Organ blood flow and distribution of cardiac output in dopexamine- or dobutamine-treated endotoxemic rats. | Journal of critical care 19930601 |
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