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86-94-2 | 1-hydroxyisoquinolin-3(2h)-one
CAS No: 86-94-2 Catalog No: AG004HMC MDL No:
Product Description
Catalog Number:
AG004HMC
Chemical Name:
1-hydroxyisoquinolin-3(2h)-one
CAS Number:
86-94-2
Molecular Formula:
C9H7NO2
Molecular Weight:
161.1574
IUPAC Name:
1-hydroxy-2H-isoquinolin-3-one
InChI:
InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)9(12)10-8/h1-5H,(H2,10,11,12)
InChI Key:
QFNFXYPFSYJCDF-UHFFFAOYSA-N
SMILES:
O=c1cc2ccccc2c([nH]1)O
Properties
Complexity:
359
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
161.048g/mol
Formal Charge:
0
Heavy Atom Count:
12
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
161.16g/mol
Monoisotopic Mass:
161.048g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
49.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.4
Literature
| Title | Journal |
|---|---|
| Ethyl 4-methyl-1,3-dioxo-1,2,3,4-tetra-hydro-isoquinoline-4-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20120301 |
| Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia. | Journal of neuroinflammation 20120101 |
| Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line. | Journal of inflammation (London, England) 20110101 |
| Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. | Human molecular genetics 20101201 |
| NF-kappaB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening. | Bioorganic & medicinal chemistry letters 20100801 |
| Photoinduced tandem reactions of isoquinoline-1,3,4-trione with alkynes to build aza-polycycles. | The Journal of organic chemistry 20100507 |
| The catalytic and protein-protein interaction domains are required for APM1 function. | Plant physiology 20100401 |
| 4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione. | Acta crystallographica. Section E, Structure reports online 20100401 |
| 2'-Methyl-3,5-diphenyl-spiro-[4,6-dioxa-2-aza-bicyclo-[3.2.0]hept-2-ene-7,4'-iso-quinoline]-1',3'(2'H,4'H)-dione. | Acta crystallographica. Section E, Structure reports online 20100401 |
| 4-[(2,4-Dimethyl-thia-zol-5-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione. | Acta crystallographica. Section E, Structure reports online 20100401 |
| 4-[(2,5-Dimethyl-1,3-thia-zol-4-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione. | Acta crystallographica. Section E, Structure reports online 20100401 |
| Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4. | Journal of medicinal chemistry 20090423 |
| Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. | Bioorganic & medicinal chemistry letters 20090101 |
| Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. | Molecular pharmacology 20081201 |
| 4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4 (CDK4). | Journal of medicinal chemistry 20080626 |
| Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. | Bioorganic & medicinal chemistry letters 20080615 |
| Role of glycolysis inhibition and poly(ADP-ribose) polymerase activation in necrotic-like cell death caused by ascorbate/menadione-induced oxidative stress in K562 human chronic myelogenous leukemic cells. | International journal of cancer 20070315 |
| Synthesis and biological evaluation of caulibugulones A-E. | Organic & biomolecular chemistry 20040807 |
| Determination of a new isoquinolinedione derivative, 7-anilino-5,8-isoquinolinedione, in plasma, urine and tissue homogenates by high-performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20021015 |
| Discovery of novel inhibitors of inducible nitric oxide synthase. | The Journal of pharmacy and pharmacology 20020801 |
| Thymidine phosphorylase inhibitors with a homophthalimide skeleton. | Biological & pharmaceutical bulletin 20010701 |
| Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure-activity relationship study. | Bioorganic & medicinal chemistry 20010101 |
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