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84878-61-5

84878-61-5 | Maduramicin Ammonium Salt

CAS No: 84878-61-5 Catalog No: AG004W9J MDL No:

Product Description

Catalog Number:
AG004W9J
Chemical Name:
Maduramicin Ammonium Salt
CAS Number:
84878-61-5
Molecular Formula:
C47H83NO17
Molecular Weight:
934.1584
IUPAC Name:
azane;2-[(2R,3S,4S,5R,6S)-6-[(1R)-1-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-[(2R,3S,5R)-3-[(2R,4S,5S,6S)-4,5-dimethoxy-6-methyloxan-2-yl]oxy-5-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyloxan-2-yl]oxolan-2-yl]-5-methyloxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]ethyl]-2-hydroxy-4,5-dimethoxy-3-methyloxan-2-yl]acetic acid
InChI:
InChI=1S/C47H80O17.H3N/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50;/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50);1H3/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+;/m0./s1
InChI Key:
WQGJEAMPBSZCIF-HKSLRPGUSA-N
SMILES:
CO[C@H]1C[C@H](O[C@H]([C@@H]1OC)C)O[C@H]1C[C@@H](OC1[C@]1(C)CCC(O1)[C@]1(C)CC[C@@]2(O1)C[C@H](O)[C@H]([C@H](O2)[C@H]([C@@H]1O[C@](O)(CC(=O)[O-])[C@H]([C@@H]([C@H]1OC)OC)C)C)C)C1O[C@](C)(O)[C@@H](C[C@@H]1C)C.[NH4+]

Properties

Complexity:
1610  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
24  
Defined Bond Stereocenter Count:
0
Exact Mass:
933.566g/mol
Formal Charge:
0
Heavy Atom Count:
65  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
934.171g/mol
Monoisotopic Mass:
933.566g/mol
Rotatable Bond Count:
13  
Topological Polar Surface Area:
210A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Maduramicin induces apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways. Toxicology in vitro : an international journal published in association with BIBRA 20180801
Transcriptome profile analysis reveals cardiotoxicity of maduramicin in primary chicken myocardial cells. Archives of toxicology 20180301
Maduramicin-activated protein phosphatase 2A results in extracellular signal-regulated kinase 1/2 inhibition, leading to cytotoxicity in myocardial H9c2 cells. Toxicology letters 20180301
Determination of narasin and monensin in bovine, swine, and chicken tissues by liquid chromatography with tandem mass spectrometry: first action 2011.24. Journal of AOAC International 20120101
Rapid method for the simultaneous determination of six ionophores in feed by liquid chromatography/mass spectrometry. Journal of AOAC International 20120101
Effects of ionophores on liver CYP1A and 3A in male broilers. Journal of veterinary pharmacology and therapeutics 20101201
Validation of the procedure for the determination of maduramicin in concentrates, premixes, and feeds by liquid chromatography. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090101
Eimeria tenella: analysis of differentially expressed genes in the monensin- and maduramicin-resistant lines using cDNA array. Experimental parasitology 20080601
Efficacy of decoquinate against drug sensitive laboratory strains of Eimeria tenella and field isolates of Eimeria spp. in broiler chickens in China. Veterinary parasitology 20070720
Isolation and selection of ionophore-tolerant Eimeria precocious lines: E. tenella, E. maxima and E. acervulina. Veterinary parasitology 20040206
Determination of maduramicin in feedingstuffs and premixtures by liquid chromatography: development, validation, and interlaboratory study. Journal of AOAC International 20040101
Study of resistance against some ionophores in Eimeria tenella field isolates. Veterinary parasitology 20011203
In vitro anticryptosporidial activity of dinitroaniline herbicides. FEMS microbiology letters 19960301
Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis. Antimicrobial agents and chemotherapy 19950401
Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines. Antimicrobial agents and chemotherapy 19910701

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