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Home > Pyridines > 848591-89-9
848591-89-9 | Pyrrolo[3,4-c]pyrrole, octahydro-2-Methyl-5-(6-phenyl-3-pyridazinyl)-
CAS No: 848591-89-9 Catalog No: AG00GAOX MDL No:MFCD22572950
Product Description
Catalog Number:
AG00GAOX
Chemical Name:
Pyrrolo[3,4-c]pyrrole, octahydro-2-Methyl-5-(6-phenyl-3-pyridazinyl)-
CAS Number:
848591-89-9
Molecular Formula:
C17H20N4
Molecular Weight:
280.3675
MDL Number:
MFCD22572950
IUPAC Name:
2-methyl-5-(6-phenylpyridazin-3-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole
InChI:
InChI=1S/C17H20N4/c1-20-9-14-11-21(12-15(14)10-20)17-8-7-16(18-19-17)13-5-3-2-4-6-13/h2-8,14-15H,9-12H2,1H3
InChI Key:
GTMRUYCIJSNXGB-UHFFFAOYSA-N
SMILES:
CN1CC2C(C1)CN(C2)c1ccc(nn1)c1ccccc1
Properties
Complexity:
341
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
280.169g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
280.375g/mol
Monoisotopic Mass:
280.169g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
32.3A^2
Undefined Atom Stereocenter Count:
2
Undefined Bond Stereocenter Count:
0
XLogP3:
2.1
Literature
| Title | Journal |
|---|---|
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. | Journal of medicinal chemistry 20111208 |
| Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats. | PloS one 20110101 |
| Repeated administration of alpha7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases alpha7 nAChR levels in the brain. | Journal of neurochemistry 20100801 |
| In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys. | PloS one 20100101 |
| Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors. | British journal of pharmacology 20091101 |
| Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo. | Brain research 20090410 |
| Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice. | European journal of pharmacology 20090105 |
| The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat. | Neuroscience 20080623 |
| Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. | CNS neuroscience & therapeutics 20080101 |
| Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys. | Biochemical pharmacology 20071015 |
| Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070926 |
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