CAS 84478-11-5 | 5-Isoquinolinesulfonamide,N-[2-(methylamino)ethyl]- | CAS Number 84478-11-5

200,000+ products from a single source!

sales@angenechem.com

Product Categories

Home > Amines > 84478-11-5

84478-11-5 | 5-Isoquinolinesulfonamide,N-[2-(methylamino)ethyl]-

CAS No: 84478-11-5 Catalog No: AG00550B MDL No:

Product Description

Catalog Number:

AG00550B

Chemical Name:

5-Isoquinolinesulfonamide,N-[2-(methylamino)ethyl]-

CAS Number:

84478-11-5

Molecular Formula:

C12H15N3O2S

Molecular Weight:

265.3314

IUPAC Name:

N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide

InChI:

InChI=1S/C12H15N3O2S/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12/h2-6,9,13,15H,7-8H2,1H3

InChI Key:

PJWUXKNZVMEPPH-UHFFFAOYSA-N

SMILES:

CNCCNS(=O)(=O)c1cccc2c1ccnc2

EC Number:

617-573-3

Properties

Complexity:

353

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

265.088g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

265.331g/mol

Monoisotopic Mass:

265.088g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

79.5A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

0.6

Literature

Title	Journal
Intermittent PTH(1-34) signals through protein kinase A to regulate osteoprotegerin production in human periodontal ligament cells in vitro.	Clinical oral investigations 20120401
Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro.	Investigative ophthalmology & visual science 20120401
Intermittent administration of PTH(1-34) regulates the osteoblastic differentiation of human periodontal ligament cells via protein kinase C- and protein kinase A-dependent pathways in vitro.	Journal of periodontal research 20110601
Effects of sarcolemmal Ca(2+) entry, ryanodine function, and kinase inhibitors on a rabbit model of heart failure.	International heart journal 20100701
Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt).	Journal of medicinal chemistry 20100311
Blocking L-type calcium channels reduced the threshold of cAMP-induced steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells.	The Journal of endocrinology 20100101
Aquaporin 2 expression increased by glucagon in normal rat inner medullary collecting ducts.	American journal of physiology. Renal physiology 20090101
Role of gap junctions and protein kinase A during the development of oocyte maturational competence in Ayu (Plecoglossus altivelis).	General and comparative endocrinology 20080201
Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.	Experimental and molecular pathology 20080201
Deoxycholic acid induces the overexpression of intestinal mucin, MUC2, via NF-kB signaling pathway in human esophageal adenocarcinoma cells.	BMC cancer 20080101
The selectivity of protein kinase inhibitors: a further update.	The Biochemical journal 20071215
Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk.	Bioorganic & medicinal chemistry letters 20070901
Role of kinases and G-proteins in the hyposmotic stimulation of cardiac IKs.	Biochimica et biophysica acta 20061001
Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation.	The Journal of steroid biochemistry and molecular biology 20060701
Involvement of cyclic GMP-dependent protein kinase in nitrous oxide-induced anxiolytic-like behavior in the mouse light/dark exploration test.	Brain research 20050315
Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms.	The Journal of endocrinology 20050201
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.	The Journal of physiology 20031201
Role of alpha2-adrenergic receptors and cyclic adenosine monophosphate-dependent protein kinase in the regulation of norepinephrine release in the central nervous system of spontaneously hypertensive rats.	Journal of cardiovascular pharmacology 20031201
Physiological Ca2+ level and Ca2+-induced Permeability Transition Pore control protein phosphorylation in rat brain mitochondria.	Cell calcium 20030901
Flagellar adhesion between mating type plus and mating type minus gametes activates a flagellar protein-tyrosine kinase during fertilization in Chlamydomonas.	The Journal of biological chemistry 20030829
Mechanism of H-8 inhibition of cyclin-dependent kinase 9: study using inhibitor-immobilized matrices.	Genes to cells : devoted to molecular & cellular mechanisms 20030301
Evidence for involvement of protein kinases in the regulation of serotonin synthesis and turnover in the mouse brain in vivo.	Journal of neural transmission (Vienna, Austria : 1996) 20021101
Hormonal regulation of DNA polymerase beta activity and expression in rat adrenal glands and testes.	Molecular and cellular endocrinology 20020628
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.	The Journal of biological chemistry 20020419
Protein kinases--the major drug targets of the twenty-first century?	Nature reviews. Drug discovery 20020401
Stimulation of cardiac glucose transport by inhibitors of oxidative phosphorylation.	Life sciences 20011005
Synergistic effects of highly unsaturated fatty acid-containing phosphatidyl-ethanolamine on differentiation of human leukemia HL-60 cells by dibutyryl cyclic adenosine monophosphate.	Japanese journal of cancer research : Gann 20010601
Forskolin modulation of desensitization at GABA(A) and glycine receptors is not mediated by cAMP-dependent protein kinase in isolated carp amacrine-like cells.	Pflugers Archiv : European journal of physiology 20010301
Steroidogenic acute regulatory protein expression is dependent upon post-translational effects of cAMP-dependent protein kinase A.	Molecular and cellular endocrinology 20010227
Isoquinolinesulphonamide derivatives inhibit transcriptional elongation of human immunodeficiency virus type 1 RNA in a promyelocytic model of latency.	Antiviral chemistry & chemotherapy 19990901
Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrochloride.	AIDS research and human retroviruses 19980301
Direct blockade of both cloned rat rod photoreceptor cyclic nucleotide-gated non-selective cation (CNG) channel alpha-subunit and native CNG channels from Xenopus rod outer segments by H-8, a non-specific cyclic nucleotide-dependent protein kinase inhibitor.	Neuroscience letters 19970912
cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expression.	The Journal of biological chemistry 19970207
Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal.	The European journal of neuroscience 19961201
Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.	The Journal of pharmacology and experimental therapeutics 19960401
Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase.	The Journal of neuroscience : the official journal of the Society for Neuroscience 19950801
Multiple second messenger systems act sequentially to mediate rolipram-induced prolongation of prostaglandin E2-induced mechanical hyperalgesia in the rat.	Neuroscience 19950201
Phosphorylation of the RNA polymerase II largest subunit during heat shock and inhibition of transcription in HeLa cells.	Journal of cellular physiology 19940301
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.	Biochemistry 19841009