CAS 84477-87-2 | Isoquinoline,5-[(2-methyl-1-piperazinyl)sulfonyl]- | CAS Number 84477-87-2

Title	Journal
An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens.	Toxicology in vitro : an international journal published in association with BIBRA 20170401
Novel Nrf2/ARE activator, trans-Coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38α/MAPKAPK-2 and PK-N3 signaling pathway.	Chemical research in toxicology 20150921
Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice.	Molecular vision 20150101
Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis.	Journal of cellular physiology 20140301
Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs.	The Journal of surgical research 20121101
Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.	Hypertension (Dallas, Tex. : 1979) 20121101
Fasudil ameliorates disease progression in experimental autoimmune encephalomyelitis, acting possibly through antiinflammatory effect.	CNS neuroscience & therapeutics 20121101
RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism.	Toxicology and industrial health 20121001
Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain.	Cellular and molecular neurobiology 20121001
Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma.	The Journal of pharmacology and experimental therapeutics 20121001
Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat.	Pharmacological research 20121001
A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator.	Neuroscience 20120918
Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats.	European journal of pharmacology 20120915
Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome.	American journal of physiology. Endocrinology and metabolism 20120915
Calcium/calmodulin-dependent protein kinase II regulates IL-10 production by human T lymphocytes: a distinct target in the calcium dependent pathway.	Molecular immunology 20120901
Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.	Naunyn-Schmiedeberg's archives of pharmacology 20120901
Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat.	European journal of pharmacology 20120815
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.	Cell 20120803
Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats.	European journal of applied physiology 20120801
NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers.	American journal of physiology. Cell physiology 20120801
Evaluation of clinical efficacy of fasudil for the treatment of pulmonary arterial hypertension.	Recent patents on cardiovascular drug discovery 20120801
[Effect of Fasudil on the phenotype conversion of LPS-stimulated BV-2 microglia].	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120801
Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy.	Biochemical and biophysical research communications 20120727
ROCK1 feedback regulation of the upstream small GTPase RhoA.	Cellular signalling 20120701
Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon.	Arthritis care & research 20120601
Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells.	Neurochemical research 20120601
Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601
Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1.	Toxicology letters 20120601
The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells.	Cancer chemotherapy and pharmacology 20120601
Tumor necrosis factor α decreases nitric oxide synthase type 3 expression primarily via Rho/Rho kinase in the thick ascending limb.	Hypertension (Dallas, Tex. : 1979) 20120601
Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation.	The American journal of pathology 20120601
Aorta-derived mesoangioblasts differentiate into the oligodendrocytes by inhibition of the Rho kinase signaling pathway.	Stem cells and development 20120501
Fasudil inhibits lung carcinoma-conditioned endothelial cell viability and migration.	Oncology reports 20120501
Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice.	Lupus 20120501
Hydroxyfasudil ameliorates bladder dysfunction in male spontaneously hypertensive rats.	Urology 20120501
Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats.	Atherosclerosis 20120501
Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels.	Investigative ophthalmology & visual science 20120501
Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction.	American journal of physiology. Renal physiology 20120415
Cytoskeletal drugs prevent posterior capsular opacification in human lens capsule in vitro.	Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20120401
ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation.	Glia 20120401
The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer.	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120401
Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses.	Journal of cellular physiology 20120301
Inhibition of Rho kinases increases directional motility of microvascular endothelial cells.	Biochemical pharmacology 20120301
[Progress in pharmacotherapy of pulmonary arterial hypertension in children].	Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20120301
Activation of corticotropin releasing factor receptor type 2 in the heart by corticotropin releasing factor offers cytoprotection against ischemic injury via PKA and PKC dependent signaling.	Regulatory peptides 20120210
Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage.	European journal of clinical pharmacology 20120201
Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.	Stroke 20120201
Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats.	Neurochemistry international 20120201
Effects of fasudil in patients with high-altitude pulmonary hypertension.	The European respiratory journal 20120201
Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride.	Neuroscience 20120103
Intracranial hemorrhage after intra-arterial administration of fasudil for treatment of cerebral vasospasm following subarachnoid hemorrhage: a serious adverse event.	Neuroradiology 20120101
Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver.	Journal of hepatology 20120101
Purinergic P2X7 receptors participate in disturbed intracellular calcium homeostasis in peripheral blood mononuclear cells of patients with chronic kidney disease.	Kidney & blood pressure research 20120101
Cardioprotective effect of a combination of Rho-kinase inhibitor and p38 MAPK inhibitor on cardiovascular remodeling and oxidative stress in Dahl rats.	Journal of atherosclerosis and thrombosis 20120101
Antivasospastic effects of hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage.	Journal of pharmacological sciences 20120101
Enhancement of endothelial progenitor cell numbers and migration by H1152, a Rho kinase specific inhibitor.	Bioscience, biotechnology, and biochemistry 20120101
[Fasudil improves erectile function of hypertensive rats].	Zhonghua nan ke xue = National journal of andrology 20120101
Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells.	Cancer biology & therapy 20120101
Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.	BMC medicine 20120101
High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.	Cardiovascular diabetology 20120101
Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta.	Swiss medical weekly 20120101
Involvement of protein kinase C in reduction of aggregated protein and phosphorylation of CREB in glomeruli.	Experimental animals 20120101
ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion.	Cardiovascular diabetology 20120101
The affinity of histamine for Gq protein-coupled histamine H(1)-receptors is predominantly regulated by their internalization in human astrocytoma cells.	Journal of pharmacological sciences 20120101
Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.	Asian Pacific journal of cancer prevention : APJCP 20120101
Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.	International journal of molecular sciences 20120101
Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways.	PloS one 20120101
Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions.	Molecular and cellular biochemistry 20111201
Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.	American journal of physiology. Lung cellular and molecular physiology 20111201
Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.	The Journal of clinical endocrinology and metabolism 20111201
Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice.	The Journal of surgical research 20111201
Adipocyte P2X7 receptors expression: a role in modulating inflammatory response in subjects with metabolic syndrome?	Atherosclerosis 20111201
Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.	Biochemistry and cell biology = Biochimie et biologie cellulaire 20111201
Neuroprotective effects of NEP1-40 and fasudil on Nogo-A expression in neonatal rats with hypoxic-ischemic brain damage.	Genetics and molecular research : GMR 20111129
CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth.	The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116
Preventive effects of fasudil on adriamycin-induced cardiomyopathy: possible involvement of inhibition of RhoA/ROCK pathway.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101
Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene.	American journal of physiology. Lung cellular and molecular physiology 20111101
Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase.	Plastic and reconstructive surgery 20111101
[Mechanism of diabetes-induced microvascular damage and therapeutic potential of ROCK inhibition].	Nippon Ganka Gakkai zasshi 20111101
[Fasudil(Rho-kinase inhibitor)].	Nihon rinsho. Japanese journal of clinical medicine 20111101
The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.	Journal of neuroimmunology 20111028
Immunoliposomal drug-delivery system targeting lectin-like oxidized low-density lipoprotein receptor-1 for carotid plaque lesions in rats.	Journal of neurosurgery 20111001
Rho kinase inhibition by fasudil exerts antioxidant effects in hypercholesterolemic rats.	Clinical and experimental pharmacology & physiology 20111001
Rho-associated kinase activity, endothelial function, and cardiovascular risk factors.	Arteriosclerosis, thrombosis, and vascular biology 20111001
Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip¹ via the ERK signal pathway.	Chinese medical journal 20111001
Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901
Pharmacological properties of the rhesus macaque monkey P2X7 receptor.	British journal of pharmacology 20110901
The Rho kinase inhibitor fasudil augments the number of functional endothelial progenitor cells in ex vivo cultures.	International journal of molecular medicine 20110901
Rho-kinase inhibition attenuates calcium-induced contraction in β-escin but not Triton X-100 permeabilized rabbit femoral artery.	Journal of muscle research and cell motility 20110901
[Rho-kinase inhibitors].	Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110901
Rho kinase as a therapeutic target in cardiovascular disease.	Future cardiology 20110901
Subdose of fasudil suppresses myocardial fibrosis in aldosterone-salt-treated uninephrectomized rats.	Die Pharmazie 20110901
Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells.	Biochemical and biophysical research communications 20110812
Agonist-induced periodic vasomotion in rat isolated pulmonary artery.	Fundamental & clinical pharmacology 20110801
Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery.	The Journal of thoracic and cardiovascular surgery 20110801
Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats.	International journal of molecular medicine 20110801
Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts.	Arteriosclerosis, thrombosis, and vascular biology 20110801
Involvement of subtypes γ and ε of protein kinase C in colon pain induced by formalin injection.	Neuro-Signals 20110801
Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis.	Journal of the neurological sciences 20110715
Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells.	American journal of physiology. Cell physiology 20110701
Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses isoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways.	Journal of cellular biochemistry 20110701
Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury.	The Journal of pharmacology and experimental therapeutics 20110701
Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.	The Journal of pharmacology and experimental therapeutics 20110701
Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor.	Mycopathologia 20110701
[The effect of fasudil via Rho/ROCK signaling pathway on the inflammation and fibrosis in human mesangial cells in high glucose medium].	Zhonghua nei ke za zhi 20110701
Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549.	Medical oncology (Northwood, London, England) 20110601
The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes.	British journal of pharmacology 20110601
Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity.	Cellular & molecular biology letters 20110601
Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses high glucose-induced proliferation and collagen synthesis in rat cardiac fibroblasts.	Clinical and experimental pharmacology & physiology 20110601
Rho-kinase in sea urchin eggs and embryos.	Development, growth & differentiation 20110601
[Anti-hepatofibrosis effect of fasudil hydrochloride on Schistosoma japonicum-infected mice].	Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20110601
NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.	Behavioural brain research 20110516
TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts.	Biochemical and biophysical research communications 20110506
Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway.	American journal of physiology. Cell physiology 20110501
ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase.	Microvascular research 20110501
Involvement of Rho-kinase in collar-induced vasoconstriction and vascular hypersensitivity to serotonin in rat carotid.	International journal of cardiology 20110414
Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling.	Biochemical and biophysical research communications 20110408
On the role of RhoA/ROCK signaling in contact guidance of bone-forming cells on anisotropic Ti6Al4V surfaces.	Acta biomaterialia 20110401
Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.	Journal of applied physiology (Bethesda, Md. : 1985) 20110401
Active tension adaptation at a shortened arterial muscle length: inhibition by cytochalasin-D.	American journal of physiology. Heart and circulatory physiology 20110401
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.	American journal of physiology. Heart and circulatory physiology 20110401
Obesity abrogates the concentration-dependent effect of leptin on endogenous cholesterol synthesis in human monocytes.	Immunobiology 20110301
In vitro activation of murine peritoneal macrophages by recombinant YopJ: production of nitric oxide, proinflammatory cytokines and chemokines.	Immunobiology 20110301
Fasudil mesylate protects PC12 cells from oxidative stress injury via the Bax-mediated pathway.	Cellular and molecular neurobiology 20110301
Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK.	International journal of oncology 20110301
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.	Bioorganic & medicinal chemistry letters 20110215
Chronic treatment with an oral rho-kinase inhibitor restores erectile function by suppressing corporal apoptosis in diabetic rats.	The journal of sexual medicine 20110201
Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure.	Kidney international 20110201
Fasudil protects cultured N1E-115 cells against lysophosphatidic acid-induced neurite retraction through inhibition of Rho-kinase.	Brain research bulletin 20110201
LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression.	Journal of neurochemistry 20110201
HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways.	Cancer science 20110201
Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.	Science signaling 20110125
Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits.	Investigative ophthalmology & visual science 20110105
Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion.	Life sciences 20110103
Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil.	Pediatric pulmonology 20110101
Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation.	American journal of physiology. Renal physiology 20110101
Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.	Toxicology and applied pharmacology 20110101
Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma.	The Journal of endocrinology 20110101
Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.	Atherosclerosis 20110101
Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.	Urologia internationalis 20110101
Rho kinase inhibition in diabetic nephropathy.	Current opinion in nephrology and hypertension 20110101
Aberrant ROCK activation promotes the development of type I diabetes in NOD mice.	Cellular immunology 20110101
Advances in treatment of cerebral vasospasm: an update.	Acta neurochirurgica. Supplement 20110101
Hydrogel tissue construct-based high-content compound screening.	Journal of biomolecular screening 20110101
Clinical trial of nicardipine prolonged-release implants for preventing cerebral vasospasm: multicenter cooperative study in Tokyo.	Acta neurochirurgica. Supplement 20110101
Intra-arterial Administration of Fasudil Hydrochloride for Vasospasm Following Subarachnoid Haemorrhage: Experience of 90 Cases.	Acta neurochirurgica. Supplement 20110101
DNA intercalator stimulates influenza transcription and virus replication.	Virology journal 20110101
Continuous intravertebral artery injection of fasudil hydrochloride in the treatment of cerebral vasospasm.	Neurology India 20110101
Continuous intravertebral injection of fasudil hydrochloride in the treatment of cerebral vasospasm.	Neurology India 20110101
Role of rho kinase in microvascular damage following cerebral ischemia reperfusion in rats.	International journal of molecular sciences 20110101
Potassium-induced intermittent vasomotion in rat isolated pulmonary artery.	Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20110101
Vasodilatation produced by fasudil mesylate in vivo and in vitro.	Vascular pharmacology 20110101
Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis.	Renal failure 20110101
4-aminopyridine induces apoptosis of human acute myeloid leukemia cells via increasing [Ca2+]i through P2X7 receptor pathway.	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101
Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.	PloS one 20110101
Comparison of ROCK and EGFR activation pathways in the progression of glomerular injuries in AngII-infused rats.	Renal failure 20110101
Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine.	Neurologia medico-chirurgica 20110101
Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury.	PloS one 20110101
Rho kinase inhibition by fasudil has anti-inflammatory effects in hypercholesterolemic rats.	Biological & pharmaceutical bulletin 20110101
Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes.	Cell biology international 20101201
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.	American journal of physiology. Heart and circulatory physiology 20101201
Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow.	American journal of physiology. Cell physiology 20101201
Effect of H-7 on secondary cataract after phacoemulsification in the live rabbit eye.	Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20101201
Follicle-stimulating hormone promotes proliferation of cultured chicken ovarian germ cells through protein kinases A and C activation.	Journal of Zhejiang University. Science. B 20101201
Oily fraction of Semecarpus anacardium Linn nuts involves protein kinase C activation for its pro-inflammatory response.	Indian journal of experimental biology 20101201
TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes.	Biochimica et biophysica acta 20101101
Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase.	Journal of molecular and cellular cardiology 20101101
Urotensin II alters vascular reactivity in animals subjected to volume overload.	Peptides 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.	Bioorganic & medicinal chemistry letters 20101101
Identification of small molecules enhancing autophagic function from drug network analysis.	Autophagy 20101101
[Molecular mechanisms of preretinal membrane contraction in proliferative vitreoretinal diseases and ROCK as a therapeutic target].	Nippon Ganka Gakkai zasshi 20101101
PKC plays a crucial roles in c-mpl gene expression in megakaryoblastic cells.	Okajimas folia anatomica Japonica 20101101
[Effect of notch signaling on differentiation of rat marrow mesenchymal stem cells into neurons induced by fasudil hydrochloride].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20101101
Characterization of Fasudil in preclinical models of pain.	The journal of pain : official journal of the American Pain Society 20101001
Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil.	The European respiratory journal 20101001
Effect of tongxinluo on vasoconstriction induced by the chronic injury of the adventitia in the rat carotid artery.	Journal of ethnopharmacology 20100915
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.	The Biochemical journal 20100915
Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis.	The Journal of pharmacology and experimental therapeutics 20100901
Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction.	Hypertension research : official journal of the Japanese Society of Hypertension 20100901
Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice.	Journal of neurochemistry 20100901
Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro.	Canadian journal of physiology and pharmacology 20100901
Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152.	Neuroscience 20100825
NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice.	American journal of physiology. Heart and circulatory physiology 20100801
Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels.	Bulletin of experimental biology and medicine 20100801
Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.	Brain research 20100716
Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.	Journal of applied physiology (Bethesda, Md. : 1985) 20100701
The role of protein kinase C in the opening of blood-brain barrier induced by electromagnetic pulse.	Toxicology 20100629
Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry.	Journal of pharmaceutical and biomedical analysis 20100605
Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury.	Neuropathology : official journal of the Japanese Society of Neuropathology 20100601
Therapeutic potential of experimental autoimmune encephalomyelitis by Fasudil, a Rho kinase inhibitor.	Journal of neuroscience research 20100601
Modulation of cerebral malaria by fasudil and other immune-modifying compounds.	Experimental parasitology 20100601
Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.	Cancer biology & therapy 20100601
Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.	Synapse (New York, N.Y.) 20100501
Up-regulation of the RhoA/Rho-kinase signaling pathway in corpus cavernosum from endothelial nitric-oxide synthase (NOS), but not neuronal NOS, null mice.	The Journal of pharmacology and experimental therapeutics 20100401
Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management.	Current opinion in critical care 20100401
Rho-kinase limits FGF-2-stimulated VEGF release in osteoblasts.	Bone 20100401
Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats.	British journal of pharmacology 20100401
Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway.	Medical science monitor : international medical journal of experimental and clinical research 20100401
Increased RhoA/ROK mRNA expression and function in diabetic vein grafts compared with nondiabetic vein grafts and diabetic arterial grafts.	The Thoracic and cardiovascular surgeon 20100401
Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation.	American journal of physiology. Cell physiology 20100301
Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries.	Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20100301
Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging.	Stem cell reviews 20100301
ROCK inhibition facilitates tissue reconstitution from embryonic kidney cell suspensions.	Kidney international 20100301
Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension.	Heart and vessels 20100301
Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice.	Regulatory peptides 20100225
Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: experimental study in rats using vascular corrosion casts.	Neuroscience letters 20100205
Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.	Pediatric research 20100201
Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice.	Molecular and cellular neurosciences 20100201
Radiosynthesis of N-[(11)C]-methyl-hydroxyfasudil as a new potential PET radiotracer for rho-kinases (ROCKs).	Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20100201
The influence of fasudil on the epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells from diabetic rats.	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100201
Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits.	Journal of vascular surgery 20100201
Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage.	Brain research bulletin 20100115
Delayed intrinsic activation of an NMDA-independent CaM-kinase II in a critical time window is necessary for late consolidation of an associative memory.	The Journal of neuroscience : the official journal of the Society for Neuroscience 20100106
Rebound bursts in GABAergic neurons of the thalamic reticular nucleus in postnatal mice.	Physiological research 20100101
The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100101
Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis.	Arthritis and rheumatism 20100101
Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.	Neurologia medico-chirurgica 20100101
Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression.	Endocrine journal 20100101
Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium.	PloS one 20100101
HA1077 enhances the cytokeratin expression of mesenchymal stem cells.	Journal of burn care & research : official publication of the American Burn Association 20100101
The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes.	Experimental diabetes research 20100101
Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration.	Journal of Alzheimer's disease : JAD 20100101
Modification of the detrimental effect of TNF-α on human endothelial progenitor cells by fasudil and Y27632.	Journal of biochemical and molecular toxicology 20100101
Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype.	PloS one 20100101
Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria.	PloS one 20100101
Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes.	BMC systems biology 20100101
Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipients.	Atherosclerosis 20091201
Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium.	International journal of urology : official journal of the Japanese Urological Association 20091201
Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells.	International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20091201
Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat.	Canadian journal of physiology and pharmacology 20091201
A Rho-kinase inhibitor, fasudil, attenuates progressive glomerulosclerosis induced by daunorubicin in rats.	Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20091201
Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.	Neurochemistry international 20091101
Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF.	Brain, behavior, and immunity 20091101
Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice.	Atherosclerosis 20091101
Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.	Prostaglandins & other lipid mediators 20091101
Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling.	American journal of physiology. Heart and circulatory physiology 20091101
Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation.	Brain research 20091027
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.	The Biochemical journal 20091023
Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase.	Journal of viral hepatitis 20091001
Acetylcholine rescues two-cell block through activation of IP3 receptors and Ca2+/calmodulin-dependent kinase II in an ICR mouse strain.	Pflugers Archiv : European journal of physiology 20091001
Current status of rho-associated kinases (ROCKs) in coronary atherosclerosis and vasospasm.	Cardiovascular & hematological agents in medicinal chemistry 20091001
Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model.	International journal of urology : official journal of the Japanese Urological Association 20091001
Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction.	Acta pharmacologica Sinica 20091001
Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells.	The Journal of membrane biology 20091001
A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.	American journal of physiology. Endocrinology and metabolism 20090901
A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory.	The European journal of neuroscience 20090901
[Experimental study on rho-kinase inhibitor by intravenous injection inhibiting intimal hyperplasia in vein grafts].	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20090901
[Fasudil promotes migration and vasculogenesis of endothelial cells differentiated from rat bone marrow mesenchymal stem cells in vitro].	Sheng li xue bao : [Acta physiologica Sinica] 20090825
P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy.	The Journal of biological chemistry 20090821
Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery.	Canadian journal of physiology and pharmacology 20090801
Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.	International journal of molecular medicine 20090701
Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P.	FEBS letters 20090618
Expression of the dominant-negative tail of myosin Va enhances exocytosis of large dense core vesicles in neurons.	Cellular and molecular neurobiology 20090601
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.	Journal of biochemistry 20090601
Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function.	Endocrinology 20090501
Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta.	The Journal of pharmacology and experimental therapeutics 20090501
Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.	American journal of physiology. Renal physiology 20090501
Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.	American journal of physiology. Heart and circulatory physiology 20090501
Vascular dysfunction in septic shock--any ROCKing news?	Critical care medicine 20090501
The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent.	Acta biochimica et biophysica Sinica 20090501
Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands.	Glia 20090415
Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease.	Pediatric cardiology 20090401
Rho GTPases in hepatocellular carcinoma.	Biochimica et biophysica acta 20090401
Rho-kinase-mediated suppression of KDR current in cerebral arteries requires an intact actin cytoskeleton.	American journal of physiology. Heart and circulatory physiology 20090401
The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes.	Current eye research 20090401
Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats.	Cellular and molecular neurobiology 20090301
A role for Rho-kinase in Ca-independent contractions induced by phorbol-12,13-dibutyrate.	Clinical and experimental pharmacology & physiology 20090301
Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation.	Clinica chimica acta; international journal of clinical chemistry 20090301
Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis.	American journal of physiology. Heart and circulatory physiology 20090301
Increased leukocyte ROCK activity in patients after acute ischemic stroke.	Brain research 20090227
Nonlinear optical microscopy reveals invading endothelial cells anisotropically alter three-dimensional collagen matrices.	Experimental cell research 20090201
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.	Circulation journal : official journal of the Japanese Circulation Society 20090201
Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists.	Bioorganic & medicinal chemistry letters 20090201
Peripheral delivery of a ROCK inhibitor improves learning and working memory.	Behavioral neuroscience 20090201
Boundary conditions for the maintenance of memory by PKMzeta in neocortex.	Learning & memory (Cold Spring Harbor, N.Y.) 20090201
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.	Brain : a journal of neurology 20090201
Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.	Archives of pharmacal research 20090201
Effect of RhoA signaling transduction on expression of Ezrin in breast cancer cell lines.	Ai zheng = Aizheng = Chinese journal of cancer 20090201
Rho-kinase inhibitors decrease TGF-beta-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.	Biochemical pharmacology 20090115
Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons.	European journal of pharmacology 20090114
Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes.	FEBS letters 20090105
Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina.	Investigative ophthalmology & visual science 20090101
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.	Diabetes 20090101
Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression.	American journal of physiology. Endocrinology and metabolism 20090101
Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway.	Pharmacology 20090101
In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat.	Neonatology 20090101
The effect of the Rho-associated protein kinase inhibitor, HA-1077, in the rabbit ocular hypertension model induced by water loading.	Current eye research 20090101
Protein kinase C is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in human bladder cancer cells.	Urologia internationalis 20090101
Signaling through Rho GTPase pathway as viable drug target.	Current medicinal chemistry 20090101
Therapeutic approach against intimal hyperplasia of vein grafts through endothelial nitric oxide synthase/nitric oxide (eNOS/NO) and the Rho/Rho-kinase pathway.	Surgery today 20090101
Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats.	Cardiovascular diabetology 20090101
RhoA/ROK pathway related to the mechanism of higher susceptibility to spasm in RA than in IMA.	Journal of cardiac surgery 20090101
Rho kinase (ROCK) inhibitors and their application to inflammatory disorders.	Current topics in medicinal chemistry 20090101
Characterisation of K+ currents in the C8-B4 microglial cell line and their regulation by microglia activating stimuli.	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101
Evaluation of monkey intraocular pressure by rebound tonometer.	Molecular vision 20090101
The role of the key enzymes of the phosphoinositide signaling pathway in the effect of oxidized glutathione and glutoxim on intracellular Ca2+ concentration in macrophages.	Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20090101
Significance of the nongenomic, inflammatory pathway in mediating the toxic action of TCDD to induce rapid and long-term cellular responses in 3T3-L1 adipocytes.	Biochemistry 20081230
Initial and extended inflammatory messages of the nongenomic signaling pathway of the TCDD-activated Ah receptor in U937 macrophages.	Archives of biochemistry and biophysics 20081215
Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity.	Neuron 20081210
A Rho-kinase inhibitor improves cardiac function after 24-hour heart preservation.	The Journal of thoracic and cardiovascular surgery 20081201
A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation.	Journal of computer-aided molecular design 20081101
Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.	British journal of pharmacology 20081101
Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.	American journal of physiology. Lung cellular and molecular physiology 20081101
Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis.	Arthritis and rheumatism 20081101
CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes.	Cell metabolism 20081101
Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction.	European journal of pharmacology 20081010
Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes.	Biophysical journal 20081001
Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.	The Journal of pharmacology and experimental therapeutics 20081001
Fasudil inhibits the myogenic response in the fetal pulmonary circulation.	American journal of physiology. Heart and circulatory physiology 20081001
[Role of coil embolization and arterial injection in elderly subarachnoid hemorrhage patients: preliminary report].	No shinkei geka. Neurological surgery 20081001
Involvement of Rho-kinase in prostaglandin F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.	Molecular and cellular endocrinology 20080910
G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.	Cardiovascular research 20080901
Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.	British journal of pharmacology 20080901
Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation.	American journal of physiology. Cell physiology 20080901
P2X7 receptor-Pannexin1 complex: pharmacology and signaling.	American journal of physiology. Cell physiology 20080901
Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.	Journal of hypertension 20080901
Chronic stable angina pectoris.	Disease-a-month : DM 20080901
Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes.	Arthritis and rheumatism 20080901
Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase.	Cellular and molecular neurobiology 20080801
Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.	Cardiovascular drugs and therapy 20080801
Silencing-induced metaplasticity in hippocampal cultured neurons.	Journal of neurophysiology 20080801
Activated RHOA and peripheral axon regeneration.	Experimental neurology 20080801
Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy.	The British journal of surgery 20080801
H-1152 effects on intraocular pressure and trabecular meshwork morphology of rat eyes.	Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080801
Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.	Blood 20080701
Constitutive activity of inwardly rectifying K+ channel at physiological [Ca]i is mediated by Ca2+/CaMK II pathway in opossum kidney proximal tubule cells.	The journal of physiological sciences : JPS 20080601
Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.	Anesthesia and analgesia 20080601
[Effects of chronic hypoxia on the expression of calmodulin and calcicum/calmodulin-dependent protein kinase II and the calcium activity in myocardial cells in young rats].	Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080601
Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.	Molecular cancer therapeutics 20080601
Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.	Neurologia medico-chirurgica 20080601
Rho-kinase inhibitor and nicotinamide adenine dinucleotide phosphate oxidase inhibitor prevent impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rats.	Journal of the renin-angiotensin-aldosterone system : JRAAS 20080601
Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501
Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.	American journal of physiology. Lung cellular and molecular physiology 20080401
Toxoplasma gondii induces prostaglandin E2 synthesis in macrophages via signal pathways for calcium-dependent arachidonic acid production and PKC-dependent induction of cyclooxygenase-2.	Parasitology research 20080401
Central role of rho kinase in lipopolysaccharide-induced platelet capture on venous endothelium.	Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20080401
Rho kinase inhibition in severe malaria: thwarting parasite-induced collateral damage to endothelia.	The Journal of infectious diseases 20080401
Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.	Brain research 20080327
Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control.	Diabetes 20080301
Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.	Hepatology (Baltimore, Md.) 20080301
Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle.	American journal of physiology. Gastrointestinal and liver physiology 20080301
Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration.	The American journal of pathology 20080301
Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina.	Coronary artery disease 20080301
Rho kinase inhibition: a new approach for treating diabetic nephropathy?	Diabetes 20080301
Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats.	Journal of cardiovascular pharmacology 20080301
Purkinje cell survival in organotypic cultures: implication of Rho and its downstream effector ROCK.	Journal of neuroscience research 20080215
A plant Ca2+ pump, ACA2, relieves salt hypersensitivity in yeast. Modulation of cytosolic calcium signature and activation of adaptive Na+ homeostasis.	The Journal of biological chemistry 20080208
Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.	Brain research 20080208
Role for calcium in the development of ovarial patency in Heliothis virescens.	Journal of insect physiology 20080201
Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue.	British journal of pharmacology 20080201
Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.	Experimental and molecular pathology 20080201
Negative and positive allosteric modulators of the P2X(7) receptor.	British journal of pharmacology 20080201
[Basic research and treatment for cerebral vasospasm after subarachnoid hemorrhage: the present and future prospects].	No shinkei geka. Neurological surgery 20080201
Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells.	Journal of cardiovascular pharmacology 20080201
Increased static pressure promotes migration of vascular smooth muscle cells: involvement of the Rho-kinase pathway.	Journal of cardiovascular pharmacology 20080101
Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor.	Japanese journal of ophthalmology 20080101
In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis.	Methods in enzymology 20080101
Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.	Prostaglandins, leukotrienes, and essential fatty acids 20080101
Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors.	The Journal of biological chemistry 20071228
Protein kinase inhibitors reduce GABA but not glutamate release in the nucleus accumbens.	Neuropharmacology 20071201
Nitrergic modulation of an oviposition digging rhythm in locusts.	The Journal of experimental biology 20071201
Erythropoietin reduces cisplatin-induced apoptosis in renal carcinoma cells via a PKC dependent pathway.	Cancer biology & therapy 20071201
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.	Neoplasia (New York, N.Y.) 20071201
Rho kinase and Ca2+ entry mediate increased pulmonary and systemic vascular resistance in L-NAME-treated rats.	American journal of physiology. Lung cellular and molecular physiology 20071101
Contraction of tubulointerstitial fibrosis tissue in diabetic nephropathy, as demonstrated in an in vitro fibrosis model.	Virchows Archiv : an international journal of pathology 20071101
Functional expression of ionotropic purinergic receptors on mouse taste bud cells.	The Journal of physiology 20071015
Behavioral modulation of neuronal calcium/calmodulin-dependent protein kinase II activity: differential effects on nicotine-induced spinal and supraspinal antinociception in mice.	Biochemical pharmacology 20071015
Activation of protein kinases A and C promoted proliferation of chicken primordial germ cells.	Animal reproduction science 20071001
Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo.	Journal of neurochemistry 20071001
Contribution of two ionotropic purinergic receptors to ATP responses in submandibular gland ductal cells.	Cellular signalling 20071001
Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.	American journal of physiology. Gastrointestinal and liver physiology 20071001
Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.	Hypertension (Dallas, Tex. : 1979) 20071001
[Advances in the study of Rho kinase and its inhibitors].	Yao xue xue bao = Acta pharmaceutica Sinica 20071001
[Exercise-induced vasospastic angina].	Nihon rinsho. Japanese journal of clinical medicine 20070928
Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats.	Life sciences 20070922
Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL).	Journal of cellular physiology 20070901
Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.	British journal of pharmacology 20070901
Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis.	Spine 20070901
Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells.	Peptides 20070901
A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry.	Journal of immunological methods 20070831
Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase.	European journal of pharmacology 20070827
Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.	Journal of neuroscience research 20070815
Photobleaching reveals complex effects of inhibitors on transcribing RNA polymerase II in living cells.	Experimental cell research 20070815
Hepatocyte growth factor-induced enhancement of dendritic branching is blocked by inhibitors of N-methyl-D-aspartate receptors and calcium/calmodulin-dependent kinases.	Journal of neuroscience research 20070815
Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.	Biochemical pharmacology 20070815
The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.	Leukemia 20070801
A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage.	Surgical neurology 20070801
Role of calcium messenger systems in ACTH-induced cortisol production in bovine adrenal fasciculo-reticularis cells.	Endocrine journal 20070801
Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.	Nature reviews. Drug discovery 20070801
Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats.	Journal of cardiovascular pharmacology 20070801
Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats.	Journal of cardiovascular pharmacology 20070801
[Effects of fasudil on neuropathic pain-like state in mice].	Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20070801
The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats.	European journal of pharmacology 20070730
From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.	Journal of medicinal chemistry 20070726
Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide.	American journal of physiology. Heart and circulatory physiology 20070701
Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats.	Cardiovascular research 20070701
Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.	Brain research 20070618
Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.	American journal of physiology. Heart and circulatory physiology 20070601
The RISK of ROCK.	American journal of physiology. Heart and circulatory physiology 20070601
Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats.	Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070601
Combined effects of H7 and pilocarpine on anterior segment physiology in monkey eyes.	Current eye research 20070601
KN-62 analogues as potent differentiating agents of HL-60 cells.	Leukemia research 20070501
Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070501
Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation.	Journal of cellular physiology 20070501
Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4.	American journal of physiology. Renal physiology 20070501
Effects of monocarboxylic acid-derived Cl- channel blockers on depolarization-activated potassium currents in rat ventricular myocytes.	Experimental physiology 20070501
Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts.	International journal of molecular medicine 20070501
Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats.	Journal of hypertension 20070501
Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells.	Investigative ophthalmology & visual science 20070501
The Rho-kinase inhibitor H-1152P suppresses the wound-healing activities of human Tenon's capsule fibroblasts in vitro.	Investigative ophthalmology & visual science 20070501
Corticotropin-releasing hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter.	The Journal of endocrinology 20070501
Contribution of Ca(2+) -dependent protein kinase C in the spinal cord to the development of mechanical allodynia in diabetic mice.	Biological & pharmaceutical bulletin 20070501
Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.	Molecular cancer therapeutics 20070501
Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression.	Biological chemistry 20070501
Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.	Circulation 20070403
Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin.	American journal of physiology. Heart and circulatory physiology 20070401
Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitors.	The Tohoku journal of experimental medicine 20070401
Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges.	Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070401
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.	Circulation research 20070330
RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.	The Journal of biological chemistry 20070316
Progress of the study of rho-kinase and future perspective of the inhibitor.	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070301
A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats.	The Journal of endocrinology 20070301
Activity-dependent initiation of a prolonged depolarization in aplysia bag cell neurons: role for a cation channel.	Journal of neurophysiology 20070301
Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.	Journal of cardiovascular pharmacology 20070301
Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.	Journal of the American College of Cardiology 20070213
The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function.	Neuroscience 20070209
Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.	American journal of physiology. Gastrointestinal and liver physiology 20070201
The Rho-associated kinase inhibitor fasudil hydrochloride enhances neural regeneration after axotomy in the peripheral nervous system.	Plastic and reconstructive surgery 20070201
Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide.	Biological & pharmaceutical bulletin 20070201
Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.	Journal of cardiovascular pharmacology 20070201
Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.	Brain research 20070112
Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats.	Chinese medical journal 20070105
Crosstalk of sterol-dependent and non-sterol-dependent signaling in human monocytes after in vitro addition of LDL.	Cell biochemistry and function 20070101
Post-translational synaptic protein modification as substrate for long-lasting, remote memory: an initial test.	Hippocampus 20070101
Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats.	Pharmacological research 20070101
Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor.	Diabetes 20070101
Systemic availability of the active metabolite hydroxy-fasudil after administration of fasudil to different sites of the human gastrointestinal tract.	Journal of clinical pharmacology 20070101
Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK.	The FEBS journal 20070101
The role of p38 mitogen-activated protein kinase in regulating interleukin-10 gene expression in Burkitt's lymphoma cell lines.	Microbiology and immunology 20070101
Fasudil: a potential addition to the anti-arthritis weaponry.	Medical hypotheses 20070101
Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation.	The Journal of veterinary medical science 20070101
RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.	Neurourology and urodynamics 20070101
Life and death in bovine monocytes: the fate of Mycobacterium avium subsp. paratuberculosis.	Microbial pathogenesis 20070101
The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.	Clinical & experimental metastasis 20070101
The retinoic acid receptor/CaMKII interaction: pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells.	Blood cells, molecules & diseases 20070101
Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina.	Japanese journal of ophthalmology 20070101
Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease.	Circulation research 20061208
Androgens potentiate renal vascular responses to angiotensin II via amplification of the Rho kinase signaling pathway.	Cardiovascular research 20061201
Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.	Journal of cardiovascular pharmacology 20061201
[Effects of intervention with Rho kinase inhibitor fasudil on rats with hypoxic pulmonary hypertension].	Zhonghua er ke za zhi = Chinese journal of pediatrics 20061201
Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.	American journal of physiology. Lung cellular and molecular physiology 20061101
Presynaptic inhibition by kainate receptors converges mechanistically with presynaptic inhibition by adenosine and GABAB receptors.	Neuropharmacology 20061101
The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.	Journal of neuroimmunology 20061101
Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model.	The journal of sexual medicine 20061101
[Fasudil inhibits HSC adhesion, migration and proliferation via Rho/ROCK pathway].	Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20061101
ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling.	Circulation research 20061013
Role of kinases and G-proteins in the hyposmotic stimulation of cardiac IKs.	Biochimica et biophysica acta 20061001
Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury.	Journal of the peripheral nervous system : JPNS 20060901
[Role of the Rho/Rho-kinase pathway in the development of hypertensive glomerulosclerosis: renoprotective effect of Rho-kinase inhibitor in hypertensive glomerulosclerosis and its molecular mechanism].	Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060901
The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models.	Molecular cancer therapeutics 20060901
Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.	Neurologia medico-chirurgica 20060901
Fasudil, a Rho-kinase inhibitor, inhibits leukocyte adhesion in inflamed large blood vessels in vivo.	Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060901
Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats.	Experimental neurology 20060801
Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury.	Journal of the American Society of Nephrology : JASN 20060801
In vivo X-ray angiography in the mouse brain using synchrotron radiation.	Stroke 20060701
Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy.	Journal of cardiovascular pharmacology 20060701
Monkey organ-cultured anterior segments: technique and response to H-7.	Experimental eye research 20060601
Modulation by LL-37 of the responses of salivary glands to purinergic agonists.	Molecular pharmacology 20060601
Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats.	Hypertension (Dallas, Tex. : 1979) 20060601
Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+ -dependent, PKC-mediated mechanism: protective effect of PKA.	Free radical biology & medicine 20060601
Regulation of acrosome reaction of fowl spermatozoa: evidence for the involvement of protein kinase C and protein phosphatase-type 1 and/or -type 2A.	Reproduction (Cambridge, England) 20060601
Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits.	Journal of vascular surgery 20060601
[Mechanism of signal transduction of differentiation of mesenchymal stem cells into cytokeratin-expressing epidermoid cells].	Zhonghua yi xue za zhi 20060516
Determination of the enantiomeric excess of an M3 antagonist drug substance by chemometric analysis of the IR spectra of different guest-host complexes.	Chirality 20060515
Effects of calcitonin on the function of human osteoclast-like cells formed from CD14-positive monocytes.	Cellular and molecular biology (Noisy-le-Grand, France) 20060515
Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A.	Toxicological sciences : an official journal of the Society of Toxicology 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa.	Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.	Journal of leukocyte biology 20060501
Topical application of drugs influencing cytoskeleton and cell contractility affects alveolar bone loss in rats.	Journal of periodontology 20060501
Effect of H-7 and Lat-B on retinal physiology.	Current eye research 20060501
Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.	Autonomic & autacoid pharmacology 20060401
Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris.	Circulation journal : official journal of the Japanese Circulation Society 20060401
Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts.	European journal of pharmacology 20060318
Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells.	The Journal of physiology 20060315
Differential effect of kinase A and C blockers on lordosis facilitation by progesterone and its metabolites in ovariectomized estrogen-primed rats.	Hormones and behavior 20060301
Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.	Journal of applied physiology (Bethesda, Md. : 1985) 20060301
Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.	Biological & pharmaceutical bulletin 20060301
Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil.	Structure (London, England : 1993) 20060301
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.	American journal of physiology. Lung cellular and molecular physiology 20060201
Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage.	American journal of physiology. Heart and circulatory physiology 20060201
M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder.	The Journal of pharmacology and experimental therapeutics 20060201
M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. II. Denervated rat bladder.	The Journal of pharmacology and experimental therapeutics 20060201
Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.	Cardiovascular research 20060201
Internalization and desensitization of a green fluorescent protein-tagged P2Y nucleotide receptor are differently controlled by inhibition of calmodulin-dependent protein kinase II.	Journal of neurochemistry 20060201
Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension.	Circulation journal : official journal of the Japanese Circulation Society 20060201
Involvement of Rho-kinase in experimental vascular endothelial dysfunction.	Molecular and cellular biochemistry 20060201
The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.	The Journal of biological chemistry 20060106
Rho kinase regulates fragmentation and phagocytosis of apoptotic cells.	Experimental cell research 20060101
Rho-kinase as a molecular target for insulin resistance and hypertension.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101
Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101
Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury.	Journal of pharmacological sciences 20060101

Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.

Hypertension (Dallas, Tex. : 1979) 20121101

Fasudil ameliorates disease progression in experimental autoimmune encephalomyelitis, acting possibly through antiinflammatory effect.

CNS neuroscience & therapeutics 20121101

RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism.

Toxicology and industrial health 20121001

Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain.

Cellular and molecular neurobiology 20121001

Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma.

The Journal of pharmacology and experimental therapeutics 20121001

Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat.

Pharmacological research 20121001

A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator.

Neuroscience 20120918

Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats.

European journal of pharmacology 20120915

Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome.

American journal of physiology. Endocrinology and metabolism 20120915

Calcium/calmodulin-dependent protein kinase II regulates IL-10 production by human T lymphocytes: a distinct target in the calcium dependent pathway.

Molecular immunology 20120901

Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.

Naunyn-Schmiedeberg's archives of pharmacology 20120901

Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat.

European journal of pharmacology 20120815

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.

Cell 20120803

Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats.

European journal of applied physiology 20120801

NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers.

American journal of physiology. Cell physiology 20120801

Evaluation of clinical efficacy of fasudil for the treatment of pulmonary arterial hypertension.

Recent patents on cardiovascular drug discovery 20120801

[Effect of Fasudil on the phenotype conversion of LPS-stimulated BV-2 microglia].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120801

Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy.

Biochemical and biophysical research communications 20120727

ROCK1 feedback regulation of the upstream small GTPase RhoA.

Cellular signalling 20120701

Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon.

Arthritis care & research 20120601

Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells.

Neurochemical research 20120601

Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601

Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1.

Toxicology letters 20120601

The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells.

Cancer chemotherapy and pharmacology 20120601

Tumor necrosis factor α decreases nitric oxide synthase type 3 expression primarily via Rho/Rho kinase in the thick ascending limb.

Hypertension (Dallas, Tex. : 1979) 20120601

Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation.

The American journal of pathology 20120601

Aorta-derived mesoangioblasts differentiate into the oligodendrocytes by inhibition of the Rho kinase signaling pathway.

Stem cells and development 20120501

Fasudil inhibits lung carcinoma-conditioned endothelial cell viability and migration.

Oncology reports 20120501

Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice.

Lupus 20120501

Hydroxyfasudil ameliorates bladder dysfunction in male spontaneously hypertensive rats.

Urology 20120501

Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats.

Atherosclerosis 20120501

Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels.

Investigative ophthalmology & visual science 20120501

Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction.

American journal of physiology. Renal physiology 20120415

Cytoskeletal drugs prevent posterior capsular opacification in human lens capsule in vitro.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20120401

ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation.

Glia 20120401

The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120401

Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses.

Journal of cellular physiology 20120301

Inhibition of Rho kinases increases directional motility of microvascular endothelial cells.

Biochemical pharmacology 20120301

[Progress in pharmacotherapy of pulmonary arterial hypertension in children].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20120301

Activation of corticotropin releasing factor receptor type 2 in the heart by corticotropin releasing factor offers cytoprotection against ischemic injury via PKA and PKC dependent signaling.

Regulatory peptides 20120210

Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage.

European journal of clinical pharmacology 20120201

Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.

Stroke 20120201

Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats.

Neurochemistry international 20120201

Effects of fasudil in patients with high-altitude pulmonary hypertension.

The European respiratory journal 20120201

Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride.

Neuroscience 20120103

Intracranial hemorrhage after intra-arterial administration of fasudil for treatment of cerebral vasospasm following subarachnoid hemorrhage: a serious adverse event.

Neuroradiology 20120101

Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver.

Journal of hepatology 20120101

Purinergic P2X7 receptors participate in disturbed intracellular calcium homeostasis in peripheral blood mononuclear cells of patients with chronic kidney disease.

Kidney & blood pressure research 20120101

Cardioprotective effect of a combination of Rho-kinase inhibitor and p38 MAPK inhibitor on cardiovascular remodeling and oxidative stress in Dahl rats.

Journal of atherosclerosis and thrombosis 20120101

Antivasospastic effects of hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage.

Journal of pharmacological sciences 20120101

Enhancement of endothelial progenitor cell numbers and migration by H1152, a Rho kinase specific inhibitor.

Bioscience, biotechnology, and biochemistry 20120101

[Fasudil improves erectile function of hypertensive rats].

Zhonghua nan ke xue = National journal of andrology 20120101

Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells.

Cancer biology & therapy 20120101

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.

BMC medicine 20120101

High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.

Cardiovascular diabetology 20120101

Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta.

Swiss medical weekly 20120101

Involvement of protein kinase C in reduction of aggregated protein and phosphorylation of CREB in glomeruli.

Experimental animals 20120101

ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion.

Cardiovascular diabetology 20120101

The affinity of histamine for Gq protein-coupled histamine H(1)-receptors is predominantly regulated by their internalization in human astrocytoma cells.

Journal of pharmacological sciences 20120101

Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.

Asian Pacific journal of cancer prevention : APJCP 20120101

Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.

International journal of molecular sciences 20120101

Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways.

PloS one 20120101

Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions.

Molecular and cellular biochemistry 20111201

Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.

American journal of physiology. Lung cellular and molecular physiology 20111201

Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.

The Journal of clinical endocrinology and metabolism 20111201

Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice.

The Journal of surgical research 20111201

Adipocyte P2X7 receptors expression: a role in modulating inflammatory response in subjects with metabolic syndrome?

Atherosclerosis 20111201

Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.

Biochemistry and cell biology = Biochimie et biologie cellulaire 20111201

Neuroprotective effects of NEP1-40 and fasudil on Nogo-A expression in neonatal rats with hypoxic-ischemic brain damage.

Genetics and molecular research : GMR 20111129

CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116

Preventive effects of fasudil on adriamycin-induced cardiomyopathy: possible involvement of inhibition of RhoA/ROCK pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101

Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene.

American journal of physiology. Lung cellular and molecular physiology 20111101

Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase.

Plastic and reconstructive surgery 20111101

[Mechanism of diabetes-induced microvascular damage and therapeutic potential of ROCK inhibition].

Nippon Ganka Gakkai zasshi 20111101

[Fasudil(Rho-kinase inhibitor)].

Nihon rinsho. Japanese journal of clinical medicine 20111101

The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.

Journal of neuroimmunology 20111028

Immunoliposomal drug-delivery system targeting lectin-like oxidized low-density lipoprotein receptor-1 for carotid plaque lesions in rats.

Journal of neurosurgery 20111001

Rho kinase inhibition by fasudil exerts antioxidant effects in hypercholesterolemic rats.

Clinical and experimental pharmacology & physiology 20111001

Rho-associated kinase activity, endothelial function, and cardiovascular risk factors.

Arteriosclerosis, thrombosis, and vascular biology 20111001

Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip¹ via the ERK signal pathway.

Chinese medical journal 20111001

Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901

Pharmacological properties of the rhesus macaque monkey P2X7 receptor.

British journal of pharmacology 20110901

The Rho kinase inhibitor fasudil augments the number of functional endothelial progenitor cells in ex vivo cultures.

International journal of molecular medicine 20110901

Rho-kinase inhibition attenuates calcium-induced contraction in β-escin but not Triton X-100 permeabilized rabbit femoral artery.

Journal of muscle research and cell motility 20110901

[Rho-kinase inhibitors].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110901

Rho kinase as a therapeutic target in cardiovascular disease.

Future cardiology 20110901

Subdose of fasudil suppresses myocardial fibrosis in aldosterone-salt-treated uninephrectomized rats.

Die Pharmazie 20110901

Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells.

Biochemical and biophysical research communications 20110812

Agonist-induced periodic vasomotion in rat isolated pulmonary artery.

Fundamental & clinical pharmacology 20110801

Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery.

The Journal of thoracic and cardiovascular surgery 20110801

Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats.

International journal of molecular medicine 20110801

Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts.

Arteriosclerosis, thrombosis, and vascular biology 20110801

Involvement of subtypes γ and ε of protein kinase C in colon pain induced by formalin injection.

Neuro-Signals 20110801

Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis.

Journal of the neurological sciences 20110715

Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells.

American journal of physiology. Cell physiology 20110701

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses isoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways.

Journal of cellular biochemistry 20110701

Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury.

The Journal of pharmacology and experimental therapeutics 20110701

Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.

The Journal of pharmacology and experimental therapeutics 20110701

Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor.

Mycopathologia 20110701

[The effect of fasudil via Rho/ROCK signaling pathway on the inflammation and fibrosis in human mesangial cells in high glucose medium].

Zhonghua nei ke za zhi 20110701

Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549.

Medical oncology (Northwood, London, England) 20110601

The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes.

British journal of pharmacology 20110601

Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity.

Cellular & molecular biology letters 20110601

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses high glucose-induced proliferation and collagen synthesis in rat cardiac fibroblasts.

Clinical and experimental pharmacology & physiology 20110601

Rho-kinase in sea urchin eggs and embryos.

Development, growth & differentiation 20110601

[Anti-hepatofibrosis effect of fasudil hydrochloride on Schistosoma japonicum-infected mice].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20110601

NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.

Behavioural brain research 20110516

TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts.

Biochemical and biophysical research communications 20110506

Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway.

American journal of physiology. Cell physiology 20110501

ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase.

Microvascular research 20110501

Involvement of Rho-kinase in collar-induced vasoconstriction and vascular hypersensitivity to serotonin in rat carotid.

International journal of cardiology 20110414

Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling.

Biochemical and biophysical research communications 20110408

On the role of RhoA/ROCK signaling in contact guidance of bone-forming cells on anisotropic Ti6Al4V surfaces.

Acta biomaterialia 20110401

Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.

Journal of applied physiology (Bethesda, Md. : 1985) 20110401

Active tension adaptation at a shortened arterial muscle length: inhibition by cytochalasin-D.

American journal of physiology. Heart and circulatory physiology 20110401

Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.

American journal of physiology. Heart and circulatory physiology 20110401

Obesity abrogates the concentration-dependent effect of leptin on endogenous cholesterol synthesis in human monocytes.

Immunobiology 20110301

In vitro activation of murine peritoneal macrophages by recombinant YopJ: production of nitric oxide, proinflammatory cytokines and chemokines.

Immunobiology 20110301

Fasudil mesylate protects PC12 cells from oxidative stress injury via the Bax-mediated pathway.

Cellular and molecular neurobiology 20110301

Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK.

International journal of oncology 20110301

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Bioorganic & medicinal chemistry letters 20110215

Chronic treatment with an oral rho-kinase inhibitor restores erectile function by suppressing corporal apoptosis in diabetic rats.

The journal of sexual medicine 20110201

Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure.

Kidney international 20110201

Fasudil protects cultured N1E-115 cells against lysophosphatidic acid-induced neurite retraction through inhibition of Rho-kinase.

Brain research bulletin 20110201

LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression.

Journal of neurochemistry 20110201

HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways.

Cancer science 20110201

Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.

Science signaling 20110125

Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits.

Investigative ophthalmology & visual science 20110105

Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion.

Life sciences 20110103

Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil.

Pediatric pulmonology 20110101

Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation.

American journal of physiology. Renal physiology 20110101

Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.

Toxicology and applied pharmacology 20110101

Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma.

The Journal of endocrinology 20110101

Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.

Atherosclerosis 20110101

Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.

Urologia internationalis 20110101

Rho kinase inhibition in diabetic nephropathy.

Current opinion in nephrology and hypertension 20110101

Aberrant ROCK activation promotes the development of type I diabetes in NOD mice.

Cellular immunology 20110101

Advances in treatment of cerebral vasospasm: an update.

Acta neurochirurgica. Supplement 20110101

Hydrogel tissue construct-based high-content compound screening.

Journal of biomolecular screening 20110101

Clinical trial of nicardipine prolonged-release implants for preventing cerebral vasospasm: multicenter cooperative study in Tokyo.

Acta neurochirurgica. Supplement 20110101

Intra-arterial Administration of Fasudil Hydrochloride for Vasospasm Following Subarachnoid Haemorrhage: Experience of 90 Cases.

Acta neurochirurgica. Supplement 20110101

DNA intercalator stimulates influenza transcription and virus replication.

Virology journal 20110101

Continuous intravertebral artery injection of fasudil hydrochloride in the treatment of cerebral vasospasm.

Neurology India 20110101

Continuous intravertebral injection of fasudil hydrochloride in the treatment of cerebral vasospasm.

Neurology India 20110101

Role of rho kinase in microvascular damage following cerebral ischemia reperfusion in rats.

International journal of molecular sciences 20110101

Potassium-induced intermittent vasomotion in rat isolated pulmonary artery.

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20110101

Vasodilatation produced by fasudil mesylate in vivo and in vitro.

Vascular pharmacology 20110101

Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis.

Renal failure 20110101

4-aminopyridine induces apoptosis of human acute myeloid leukemia cells via increasing [Ca2+]i through P2X7 receptor pathway.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.

PloS one 20110101

Comparison of ROCK and EGFR activation pathways in the progression of glomerular injuries in AngII-infused rats.

Renal failure 20110101

Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine.

Neurologia medico-chirurgica 20110101

Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury.

PloS one 20110101

Rho kinase inhibition by fasudil has anti-inflammatory effects in hypercholesterolemic rats.

Biological & pharmaceutical bulletin 20110101

Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes.

Cell biology international 20101201

Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.

American journal of physiology. Heart and circulatory physiology 20101201

Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow.

American journal of physiology. Cell physiology 20101201

Effect of H-7 on secondary cataract after phacoemulsification in the live rabbit eye.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20101201

Follicle-stimulating hormone promotes proliferation of cultured chicken ovarian germ cells through protein kinases A and C activation.

Journal of Zhejiang University. Science. B 20101201

Oily fraction of Semecarpus anacardium Linn nuts involves protein kinase C activation for its pro-inflammatory response.

Indian journal of experimental biology 20101201

TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes.

Biochimica et biophysica acta 20101101

Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase.

Journal of molecular and cellular cardiology 20101101

Urotensin II alters vascular reactivity in animals subjected to volume overload.

Peptides 20101101

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Identification of small molecules enhancing autophagic function from drug network analysis.

Autophagy 20101101

[Molecular mechanisms of preretinal membrane contraction in proliferative vitreoretinal diseases and ROCK as a therapeutic target].

Nippon Ganka Gakkai zasshi 20101101

PKC plays a crucial roles in c-mpl gene expression in megakaryoblastic cells.

Okajimas folia anatomica Japonica 20101101

[Effect of notch signaling on differentiation of rat marrow mesenchymal stem cells into neurons induced by fasudil hydrochloride].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20101101

Characterization of Fasudil in preclinical models of pain.

The journal of pain : official journal of the American Pain Society 20101001

Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil.

The European respiratory journal 20101001

Effect of tongxinluo on vasoconstriction induced by the chronic injury of the adventitia in the rat carotid artery.

Journal of ethnopharmacology 20100915

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.

The Biochemical journal 20100915

Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis.

The Journal of pharmacology and experimental therapeutics 20100901

Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction.

Hypertension research : official journal of the Japanese Society of Hypertension 20100901

Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice.

Journal of neurochemistry 20100901

Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro.

Canadian journal of physiology and pharmacology 20100901

Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152.

Neuroscience 20100825

NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice.

American journal of physiology. Heart and circulatory physiology 20100801

Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels.

Bulletin of experimental biology and medicine 20100801

Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.

Brain research 20100716

Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.

Journal of applied physiology (Bethesda, Md. : 1985) 20100701

The role of protein kinase C in the opening of blood-brain barrier induced by electromagnetic pulse.

Toxicology 20100629

Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20100605

Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury.

Neuropathology : official journal of the Japanese Society of Neuropathology 20100601

Therapeutic potential of experimental autoimmune encephalomyelitis by Fasudil, a Rho kinase inhibitor.

Journal of neuroscience research 20100601

Modulation of cerebral malaria by fasudil and other immune-modifying compounds.

Experimental parasitology 20100601

Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.

Cancer biology & therapy 20100601

Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.

Synapse (New York, N.Y.) 20100501

Up-regulation of the RhoA/Rho-kinase signaling pathway in corpus cavernosum from endothelial nitric-oxide synthase (NOS), but not neuronal NOS, null mice.

The Journal of pharmacology and experimental therapeutics 20100401

Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management.

Current opinion in critical care 20100401

Rho-kinase limits FGF-2-stimulated VEGF release in osteoblasts.

Bone 20100401

Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats.

British journal of pharmacology 20100401

Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway.

Medical science monitor : international medical journal of experimental and clinical research 20100401

Increased RhoA/ROK mRNA expression and function in diabetic vein grafts compared with nondiabetic vein grafts and diabetic arterial grafts.

The Thoracic and cardiovascular surgeon 20100401

Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation.

American journal of physiology. Cell physiology 20100301

Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20100301

Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging.

Stem cell reviews 20100301

ROCK inhibition facilitates tissue reconstitution from embryonic kidney cell suspensions.

Kidney international 20100301

Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension.

Heart and vessels 20100301

Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice.

Regulatory peptides 20100225

Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: experimental study in rats using vascular corrosion casts.

Neuroscience letters 20100205

Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.

Pediatric research 20100201

Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice.

Molecular and cellular neurosciences 20100201

Radiosynthesis of N-[(11)C]-methyl-hydroxyfasudil as a new potential PET radiotracer for rho-kinases (ROCKs).

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20100201

The influence of fasudil on the epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells from diabetic rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100201

Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits.

Journal of vascular surgery 20100201

Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage.

Brain research bulletin 20100115

Delayed intrinsic activation of an NMDA-independent CaM-kinase II in a critical time window is necessary for late consolidation of an associative memory.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100106

Rebound bursts in GABAergic neurons of the thalamic reticular nucleus in postnatal mice.

Physiological research 20100101

The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100101

Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis.

Arthritis and rheumatism 20100101

Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.

Neurologia medico-chirurgica 20100101

Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression.

Endocrine journal 20100101

Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium.

PloS one 20100101

HA1077 enhances the cytokeratin expression of mesenchymal stem cells.

Journal of burn care & research : official publication of the American Burn Association 20100101

The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes.

Experimental diabetes research 20100101

Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration.

Journal of Alzheimer's disease : JAD 20100101

Modification of the detrimental effect of TNF-α on human endothelial progenitor cells by fasudil and Y27632.

Journal of biochemical and molecular toxicology 20100101

Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype.

PloS one 20100101

Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria.

PloS one 20100101

Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes.

BMC systems biology 20100101

Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipients.

Atherosclerosis 20091201

Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium.

International journal of urology : official journal of the Japanese Urological Association 20091201

Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20091201

Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat.

Canadian journal of physiology and pharmacology 20091201

A Rho-kinase inhibitor, fasudil, attenuates progressive glomerulosclerosis induced by daunorubicin in rats.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20091201

Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.

Neurochemistry international 20091101

Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF.

Brain, behavior, and immunity 20091101

Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice.

Atherosclerosis 20091101

Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.

Prostaglandins & other lipid mediators 20091101

Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling.

American journal of physiology. Heart and circulatory physiology 20091101

Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation.

Brain research 20091027

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.

The Biochemical journal 20091023

Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase.

Journal of viral hepatitis 20091001

Acetylcholine rescues two-cell block through activation of IP3 receptors and Ca2+/calmodulin-dependent kinase II in an ICR mouse strain.

Pflugers Archiv : European journal of physiology 20091001

Current status of rho-associated kinases (ROCKs) in coronary atherosclerosis and vasospasm.

Cardiovascular & hematological agents in medicinal chemistry 20091001

Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model.

International journal of urology : official journal of the Japanese Urological Association 20091001

Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction.

Acta pharmacologica Sinica 20091001

Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells.

The Journal of membrane biology 20091001

A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.

American journal of physiology. Endocrinology and metabolism 20090901

A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory.

The European journal of neuroscience 20090901

[Experimental study on rho-kinase inhibitor by intravenous injection inhibiting intimal hyperplasia in vein grafts].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20090901

[Fasudil promotes migration and vasculogenesis of endothelial cells differentiated from rat bone marrow mesenchymal stem cells in vitro].

Sheng li xue bao : [Acta physiologica Sinica] 20090825

P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy.

The Journal of biological chemistry 20090821

Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery.

Canadian journal of physiology and pharmacology 20090801

Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.

International journal of molecular medicine 20090701

Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P.

FEBS letters 20090618

Expression of the dominant-negative tail of myosin Va enhances exocytosis of large dense core vesicles in neurons.

Cellular and molecular neurobiology 20090601

Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.

Journal of biochemistry 20090601

Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function.

Endocrinology 20090501

Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta.

The Journal of pharmacology and experimental therapeutics 20090501

Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.

American journal of physiology. Renal physiology 20090501

Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.

American journal of physiology. Heart and circulatory physiology 20090501

Vascular dysfunction in septic shock--any ROCKing news?

Critical care medicine 20090501

The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent.

Acta biochimica et biophysica Sinica 20090501

Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands.

Glia 20090415

Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease.

Pediatric cardiology 20090401

Rho GTPases in hepatocellular carcinoma.

Biochimica et biophysica acta 20090401

Rho-kinase-mediated suppression of KDR current in cerebral arteries requires an intact actin cytoskeleton.

American journal of physiology. Heart and circulatory physiology 20090401

The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes.

Current eye research 20090401

Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats.

Cellular and molecular neurobiology 20090301

A role for Rho-kinase in Ca-independent contractions induced by phorbol-12,13-dibutyrate.

Clinical and experimental pharmacology & physiology 20090301

Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation.

Clinica chimica acta; international journal of clinical chemistry 20090301

Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis.

American journal of physiology. Heart and circulatory physiology 20090301

Increased leukocyte ROCK activity in patients after acute ischemic stroke.

Brain research 20090227

Nonlinear optical microscopy reveals invading endothelial cells anisotropically alter three-dimensional collagen matrices.

Experimental cell research 20090201

Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.

Circulation journal : official journal of the Japanese Circulation Society 20090201

Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists.

Bioorganic & medicinal chemistry letters 20090201

Peripheral delivery of a ROCK inhibitor improves learning and working memory.

Behavioral neuroscience 20090201

Boundary conditions for the maintenance of memory by PKMzeta in neocortex.

Learning & memory (Cold Spring Harbor, N.Y.) 20090201

Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.

Brain : a journal of neurology 20090201

Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.

Archives of pharmacal research 20090201

Effect of RhoA signaling transduction on expression of Ezrin in breast cancer cell lines.

Ai zheng = Aizheng = Chinese journal of cancer 20090201

Rho-kinase inhibitors decrease TGF-beta-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.

Biochemical pharmacology 20090115

Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons.

European journal of pharmacology 20090114

Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes.

FEBS letters 20090105

Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina.

Investigative ophthalmology & visual science 20090101

Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.

Diabetes 20090101

Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression.

American journal of physiology. Endocrinology and metabolism 20090101

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway.

Pharmacology 20090101

In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat.

Neonatology 20090101

The effect of the Rho-associated protein kinase inhibitor, HA-1077, in the rabbit ocular hypertension model induced by water loading.

Current eye research 20090101

Protein kinase C is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in human bladder cancer cells.

Urologia internationalis 20090101

Signaling through Rho GTPase pathway as viable drug target.

Current medicinal chemistry 20090101

Therapeutic approach against intimal hyperplasia of vein grafts through endothelial nitric oxide synthase/nitric oxide (eNOS/NO) and the Rho/Rho-kinase pathway.

Surgery today 20090101

Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats.

Cardiovascular diabetology 20090101

RhoA/ROK pathway related to the mechanism of higher susceptibility to spasm in RA than in IMA.

Journal of cardiac surgery 20090101

Rho kinase (ROCK) inhibitors and their application to inflammatory disorders.

Current topics in medicinal chemistry 20090101

Characterisation of K+ currents in the C8-B4 microglial cell line and their regulation by microglia activating stimuli.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101

Evaluation of monkey intraocular pressure by rebound tonometer.

Molecular vision 20090101

The role of the key enzymes of the phosphoinositide signaling pathway in the effect of oxidized glutathione and glutoxim on intracellular Ca2+ concentration in macrophages.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20090101

Significance of the nongenomic, inflammatory pathway in mediating the toxic action of TCDD to induce rapid and long-term cellular responses in 3T3-L1 adipocytes.

Biochemistry 20081230

Initial and extended inflammatory messages of the nongenomic signaling pathway of the TCDD-activated Ah receptor in U937 macrophages.

Archives of biochemistry and biophysics 20081215

Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity.

Neuron 20081210

A Rho-kinase inhibitor improves cardiac function after 24-hour heart preservation.

The Journal of thoracic and cardiovascular surgery 20081201

A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation.

Journal of computer-aided molecular design 20081101

Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.

British journal of pharmacology 20081101

Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.

American journal of physiology. Lung cellular and molecular physiology 20081101

Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis.

Arthritis and rheumatism 20081101

CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes.

Cell metabolism 20081101

Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction.

European journal of pharmacology 20081010

Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes.

Biophysical journal 20081001

Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.

The Journal of pharmacology and experimental therapeutics 20081001

Fasudil inhibits the myogenic response in the fetal pulmonary circulation.

American journal of physiology. Heart and circulatory physiology 20081001

[Role of coil embolization and arterial injection in elderly subarachnoid hemorrhage patients: preliminary report].

No shinkei geka. Neurological surgery 20081001

Involvement of Rho-kinase in prostaglandin F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.

Molecular and cellular endocrinology 20080910

G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.

Cardiovascular research 20080901

Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.

British journal of pharmacology 20080901

Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation.

American journal of physiology. Cell physiology 20080901

P2X7 receptor-Pannexin1 complex: pharmacology and signaling.

American journal of physiology. Cell physiology 20080901

Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.

Journal of hypertension 20080901

Chronic stable angina pectoris.

Disease-a-month : DM 20080901

Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes.

Arthritis and rheumatism 20080901

Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase.

Cellular and molecular neurobiology 20080801

Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.

Cardiovascular drugs and therapy 20080801

Silencing-induced metaplasticity in hippocampal cultured neurons.

Journal of neurophysiology 20080801

Activated RHOA and peripheral axon regeneration.

Experimental neurology 20080801

Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy.

The British journal of surgery 20080801

H-1152 effects on intraocular pressure and trabecular meshwork morphology of rat eyes.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080801

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

Blood 20080701

Constitutive activity of inwardly rectifying K+ channel at physiological [Ca]i is mediated by Ca2+/CaMK II pathway in opossum kidney proximal tubule cells.

The journal of physiological sciences : JPS 20080601

Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.

Anesthesia and analgesia 20080601

[Effects of chronic hypoxia on the expression of calmodulin and calcicum/calmodulin-dependent protein kinase II and the calcium activity in myocardial cells in young rats].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080601

Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.

Molecular cancer therapeutics 20080601

Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.

Neurologia medico-chirurgica 20080601

Rho-kinase inhibitor and nicotinamide adenine dinucleotide phosphate oxidase inhibitor prevent impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rats.

Journal of the renin-angiotensin-aldosterone system : JRAAS 20080601

Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501

Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.

American journal of physiology. Lung cellular and molecular physiology 20080401

Toxoplasma gondii induces prostaglandin E2 synthesis in macrophages via signal pathways for calcium-dependent arachidonic acid production and PKC-dependent induction of cyclooxygenase-2.

Parasitology research 20080401

Central role of rho kinase in lipopolysaccharide-induced platelet capture on venous endothelium.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20080401

Rho kinase inhibition in severe malaria: thwarting parasite-induced collateral damage to endothelia.

The Journal of infectious diseases 20080401

Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.

Brain research 20080327

Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control.

Diabetes 20080301

Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.

Hepatology (Baltimore, Md.) 20080301

Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle.

American journal of physiology. Gastrointestinal and liver physiology 20080301

Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration.

The American journal of pathology 20080301

Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina.

Coronary artery disease 20080301

Rho kinase inhibition: a new approach for treating diabetic nephropathy?

Diabetes 20080301

Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats.

Journal of cardiovascular pharmacology 20080301

Purkinje cell survival in organotypic cultures: implication of Rho and its downstream effector ROCK.

Journal of neuroscience research 20080215

A plant Ca2+ pump, ACA2, relieves salt hypersensitivity in yeast. Modulation of cytosolic calcium signature and activation of adaptive Na+ homeostasis.

The Journal of biological chemistry 20080208

Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.

Brain research 20080208

Role for calcium in the development of ovarial patency in Heliothis virescens.

Journal of insect physiology 20080201

Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue.

British journal of pharmacology 20080201

Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.

Experimental and molecular pathology 20080201

Negative and positive allosteric modulators of the P2X(7) receptor.

British journal of pharmacology 20080201

[Basic research and treatment for cerebral vasospasm after subarachnoid hemorrhage: the present and future prospects].

No shinkei geka. Neurological surgery 20080201

Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells.

Journal of cardiovascular pharmacology 20080201

Increased static pressure promotes migration of vascular smooth muscle cells: involvement of the Rho-kinase pathway.

Journal of cardiovascular pharmacology 20080101

Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor.

Japanese journal of ophthalmology 20080101

In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis.

Methods in enzymology 20080101

Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.

Prostaglandins, leukotrienes, and essential fatty acids 20080101

Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors.

The Journal of biological chemistry 20071228

Protein kinase inhibitors reduce GABA but not glutamate release in the nucleus accumbens.

Neuropharmacology 20071201

Nitrergic modulation of an oviposition digging rhythm in locusts.

The Journal of experimental biology 20071201

Erythropoietin reduces cisplatin-induced apoptosis in renal carcinoma cells via a PKC dependent pathway.

Cancer biology & therapy 20071201

Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.

Neoplasia (New York, N.Y.) 20071201

Rho kinase and Ca2+ entry mediate increased pulmonary and systemic vascular resistance in L-NAME-treated rats.

American journal of physiology. Lung cellular and molecular physiology 20071101

Contraction of tubulointerstitial fibrosis tissue in diabetic nephropathy, as demonstrated in an in vitro fibrosis model.

Virchows Archiv : an international journal of pathology 20071101

Functional expression of ionotropic purinergic receptors on mouse taste bud cells.

The Journal of physiology 20071015

Behavioral modulation of neuronal calcium/calmodulin-dependent protein kinase II activity: differential effects on nicotine-induced spinal and supraspinal antinociception in mice.

Biochemical pharmacology 20071015

Activation of protein kinases A and C promoted proliferation of chicken primordial germ cells.

Animal reproduction science 20071001

Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo.

Journal of neurochemistry 20071001

Contribution of two ionotropic purinergic receptors to ATP responses in submandibular gland ductal cells.

Cellular signalling 20071001

Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.

American journal of physiology. Gastrointestinal and liver physiology 20071001

Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.

Hypertension (Dallas, Tex. : 1979) 20071001

[Advances in the study of Rho kinase and its inhibitors].

Yao xue xue bao = Acta pharmaceutica Sinica 20071001

[Exercise-induced vasospastic angina].

Nihon rinsho. Japanese journal of clinical medicine 20070928

Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats.

Life sciences 20070922

Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL).

Journal of cellular physiology 20070901

Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.

British journal of pharmacology 20070901

Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis.

Spine 20070901

Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells.

Peptides 20070901

A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry.

Journal of immunological methods 20070831

Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase.

European journal of pharmacology 20070827

Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.

Journal of neuroscience research 20070815

Photobleaching reveals complex effects of inhibitors on transcribing RNA polymerase II in living cells.

Experimental cell research 20070815

Hepatocyte growth factor-induced enhancement of dendritic branching is blocked by inhibitors of N-methyl-D-aspartate receptors and calcium/calmodulin-dependent kinases.

Journal of neuroscience research 20070815

Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.

Biochemical pharmacology 20070815

The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.

Leukemia 20070801

A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage.

Surgical neurology 20070801

Role of calcium messenger systems in ACTH-induced cortisol production in bovine adrenal fasciculo-reticularis cells.

Endocrine journal 20070801

Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.

Nature reviews. Drug discovery 20070801

Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats.

Journal of cardiovascular pharmacology 20070801

Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats.

Journal of cardiovascular pharmacology 20070801

[Effects of fasudil on neuropathic pain-like state in mice].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20070801

The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats.

European journal of pharmacology 20070730

From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.

Journal of medicinal chemistry 20070726

Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide.

American journal of physiology. Heart and circulatory physiology 20070701

Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats.

Cardiovascular research 20070701

Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.

Brain research 20070618

Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.

American journal of physiology. Heart and circulatory physiology 20070601

The RISK of ROCK.

American journal of physiology. Heart and circulatory physiology 20070601

Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070601

Combined effects of H7 and pilocarpine on anterior segment physiology in monkey eyes.

Current eye research 20070601

KN-62 analogues as potent differentiating agents of HL-60 cells.

Leukemia research 20070501

Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070501

Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation.

Journal of cellular physiology 20070501

Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4.

American journal of physiology. Renal physiology 20070501

Effects of monocarboxylic acid-derived Cl- channel blockers on depolarization-activated potassium currents in rat ventricular myocytes.

Experimental physiology 20070501

Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts.

International journal of molecular medicine 20070501

Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats.

Journal of hypertension 20070501

Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells.

Investigative ophthalmology & visual science 20070501

The Rho-kinase inhibitor H-1152P suppresses the wound-healing activities of human Tenon's capsule fibroblasts in vitro.

Investigative ophthalmology & visual science 20070501

Corticotropin-releasing hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter.

The Journal of endocrinology 20070501

Contribution of Ca(2+) -dependent protein kinase C in the spinal cord to the development of mechanical allodynia in diabetic mice.

Biological & pharmaceutical bulletin 20070501

Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.

Molecular cancer therapeutics 20070501

Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression.

Biological chemistry 20070501

Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.

Circulation 20070403

Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin.

American journal of physiology. Heart and circulatory physiology 20070401

Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitors.

The Tohoku journal of experimental medicine 20070401

Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070401

Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.

Circulation research 20070330

RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.

The Journal of biological chemistry 20070316

Progress of the study of rho-kinase and future perspective of the inhibitor.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070301

A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats.

The Journal of endocrinology 20070301

Activity-dependent initiation of a prolonged depolarization in aplysia bag cell neurons: role for a cation channel.

Journal of neurophysiology 20070301

Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.

Journal of cardiovascular pharmacology 20070301

Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.

Journal of the American College of Cardiology 20070213

The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function.

Neuroscience 20070209

Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.

American journal of physiology. Gastrointestinal and liver physiology 20070201

The Rho-associated kinase inhibitor fasudil hydrochloride enhances neural regeneration after axotomy in the peripheral nervous system.

Plastic and reconstructive surgery 20070201

Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide.

Biological & pharmaceutical bulletin 20070201

Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.

Journal of cardiovascular pharmacology 20070201

Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.

Brain research 20070112

Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats.

Chinese medical journal 20070105

Crosstalk of sterol-dependent and non-sterol-dependent signaling in human monocytes after in vitro addition of LDL.

Cell biochemistry and function 20070101

Post-translational synaptic protein modification as substrate for long-lasting, remote memory: an initial test.

Hippocampus 20070101

Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats.

Pharmacological research 20070101

Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor.

Diabetes 20070101

Systemic availability of the active metabolite hydroxy-fasudil after administration of fasudil to different sites of the human gastrointestinal tract.

Journal of clinical pharmacology 20070101

Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK.

The FEBS journal 20070101

The role of p38 mitogen-activated protein kinase in regulating interleukin-10 gene expression in Burkitt's lymphoma cell lines.

Microbiology and immunology 20070101

Fasudil: a potential addition to the anti-arthritis weaponry.

Medical hypotheses 20070101

Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation.

The Journal of veterinary medical science 20070101

RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.

Neurourology and urodynamics 20070101

Life and death in bovine monocytes: the fate of Mycobacterium avium subsp. paratuberculosis.

Microbial pathogenesis 20070101

The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2.

Clinical & experimental metastasis 20070101

The retinoic acid receptor/CaMKII interaction: pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells.

Blood cells, molecules & diseases 20070101

Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina.

Japanese journal of ophthalmology 20070101

Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease.

Circulation research 20061208

Androgens potentiate renal vascular responses to angiotensin II via amplification of the Rho kinase signaling pathway.

Cardiovascular research 20061201

Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.

Journal of cardiovascular pharmacology 20061201

[Effects of intervention with Rho kinase inhibitor fasudil on rats with hypoxic pulmonary hypertension].

Zhonghua er ke za zhi = Chinese journal of pediatrics 20061201

Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.

American journal of physiology. Lung cellular and molecular physiology 20061101

Presynaptic inhibition by kainate receptors converges mechanistically with presynaptic inhibition by adenosine and GABAB receptors.

Neuropharmacology 20061101

The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.

Journal of neuroimmunology 20061101

Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model.

The journal of sexual medicine 20061101

[Fasudil inhibits HSC adhesion, migration and proliferation via Rho/ROCK pathway].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20061101

ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling.

Circulation research 20061013

Role of kinases and G-proteins in the hyposmotic stimulation of cardiac IKs.

Biochimica et biophysica acta 20061001

Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury.

Journal of the peripheral nervous system : JPNS 20060901

[Role of the Rho/Rho-kinase pathway in the development of hypertensive glomerulosclerosis: renoprotective effect of Rho-kinase inhibitor in hypertensive glomerulosclerosis and its molecular mechanism].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060901

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models.

Molecular cancer therapeutics 20060901

Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.

Neurologia medico-chirurgica 20060901

Fasudil, a Rho-kinase inhibitor, inhibits leukocyte adhesion in inflamed large blood vessels in vivo.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060901

Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats.

Experimental neurology 20060801

Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury.

Journal of the American Society of Nephrology : JASN 20060801

In vivo X-ray angiography in the mouse brain using synchrotron radiation.

Stroke 20060701

Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy.

Journal of cardiovascular pharmacology 20060701

Monkey organ-cultured anterior segments: technique and response to H-7.

Experimental eye research 20060601

Modulation by LL-37 of the responses of salivary glands to purinergic agonists.

Molecular pharmacology 20060601

Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats.

Hypertension (Dallas, Tex. : 1979) 20060601

Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+ -dependent, PKC-mediated mechanism: protective effect of PKA.

Free radical biology & medicine 20060601

Regulation of acrosome reaction of fowl spermatozoa: evidence for the involvement of protein kinase C and protein phosphatase-type 1 and/or -type 2A.

Reproduction (Cambridge, England) 20060601

Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits.

Journal of vascular surgery 20060601

[Mechanism of signal transduction of differentiation of mesenchymal stem cells into cytokeratin-expressing epidermoid cells].

Zhonghua yi xue za zhi 20060516

Determination of the enantiomeric excess of an M3 antagonist drug substance by chemometric analysis of the IR spectra of different guest-host complexes.

Chirality 20060515

Effects of calcitonin on the function of human osteoclast-like cells formed from CD14-positive monocytes.

Cellular and molecular biology (Noisy-le-Grand, France) 20060515

Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A.

Toxicological sciences : an official journal of the Society of Toxicology 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.

Journal of leukocyte biology 20060501

Topical application of drugs influencing cytoskeleton and cell contractility affects alveolar bone loss in rats.

Journal of periodontology 20060501

Effect of H-7 and Lat-B on retinal physiology.

Current eye research 20060501

Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.

Autonomic & autacoid pharmacology 20060401

Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris.

Circulation journal : official journal of the Japanese Circulation Society 20060401

Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts.

European journal of pharmacology 20060318

Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells.

The Journal of physiology 20060315

Differential effect of kinase A and C blockers on lordosis facilitation by progesterone and its metabolites in ovariectomized estrogen-primed rats.

Hormones and behavior 20060301

Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.

Journal of applied physiology (Bethesda, Md. : 1985) 20060301

Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.

Biological & pharmaceutical bulletin 20060301

Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil.

Structure (London, England : 1993) 20060301

Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.

American journal of physiology. Lung cellular and molecular physiology 20060201

Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage.

American journal of physiology. Heart and circulatory physiology 20060201

M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder.

The Journal of pharmacology and experimental therapeutics 20060201

M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. II. Denervated rat bladder.

The Journal of pharmacology and experimental therapeutics 20060201

Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.

Cardiovascular research 20060201

Internalization and desensitization of a green fluorescent protein-tagged P2Y nucleotide receptor are differently controlled by inhibition of calmodulin-dependent protein kinase II.

Journal of neurochemistry 20060201

Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension.

Circulation journal : official journal of the Japanese Circulation Society 20060201

Involvement of Rho-kinase in experimental vascular endothelial dysfunction.

Molecular and cellular biochemistry 20060201

The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.

The Journal of biological chemistry 20060106

Rho kinase regulates fragmentation and phagocytosis of apoptotic cells.

Experimental cell research 20060101

Rho-kinase as a molecular target for insulin resistance and hypertension.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101

Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101

Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury.

Journal of pharmacological sciences 20060101

Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effect of rho-kinase inhibitor in hypertensive glomerulosclerosis.

Journal of pharmacological sciences 20060101

Cardioprotective effect of hydroxyfasudil as a specific Rho-kinase inhibitor, on ischemia-reperfusion injury in canine coronary microvessels in vivo.

Clinical hemorheology and microcirculation 20060101

Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.

Protein and peptide letters 20060101

ProFace: a server for the analysis of the physicochemical features of protein-protein interfaces.

BMC structural biology 20060101

Direct Rho-associated kinase inhibition [correction of inhibiton] induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells.

Cellular & molecular biology letters 20060101

Differential role of rho-kinase in pathological and physiological cardiac hypertrophy in rats.

Pharmacology 20060101

Effect of fasudil on macrovascular disorder-induced endothelial dysfunction.

Canadian journal of physiology and pharmacology 20060101

Development of specific Rho-kinase inhibitors and their clinical application.

Biochimica et biophysica acta 20051230

Effects of fasudil, a Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats.

European journal of pharmacology 20051219

5-Hydroxytryptamine as a potent migration enhancer of human aortic endothelial cells.

FEBS letters 20051219

Modulation of intracellular Ca2+ release and capacitative Ca2+ entry by CaMKII inhibitors in bovine vascular endothelial cells.

American journal of physiology. Cell physiology 20051201

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension.

British journal of pharmacology 20051201

Smoking, endothelial function, and Rho-kinase in humans.

Arteriosclerosis, thrombosis, and vascular biology 20051201

N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts.

Journal of biomedical science 20051201

Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial.

Journal of the neurological sciences 20051115

Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial.

Journal of the American College of Cardiology 20051115

Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.

American journal of physiology. Heart and circulatory physiology 20051101

Probing the control elements of the CYP1A1 switching module in H4IIE hepatoma cells.

Toxicological sciences : an official journal of the Society of Toxicology 20051101

Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice.

The Journal of pharmacology and experimental therapeutics 20051101

Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.

British journal of pharmacology 20051101

Inhibition of rho-kinase by hydroxyfasudil prevents vasopressin-induced myocardial ischemia in Donryu rats by attenuating coronary vasoconstriction.

Pharmacology 20051101

Modulation of ICa-L by alpha1-adrenergic stimulation in rat ventricular myocytes.

Canadian journal of physiology and pharmacology 20051101

Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.

Brain research. Molecular brain research 20051031

Proerectile effects of the Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the rat penis.

The Journal of pharmacology and experimental therapeutics 20051001

Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.

Stroke 20051001

Gonadotropin-releasing hormone induction of extracellular-signal regulated kinase is blocked by inhibition of calmodulin.

Molecular endocrinology (Baltimore, Md.) 20050901

Human melanomas express functional P2 X(7) receptors.

Cell and tissue research 20050901

Human epidermal and monocyte-derived langerhans cells express functional P2X receptors.

The Journal of investigative dermatology 20050901

[Cerebral circulation dynamics following fasudil intravenous infusion: a CT perfusion study].

No to shinkei = Brain and nerve 20050901

Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells.

Liver international : official journal of the International Association for the Study of the Liver 20050801

Inhibition of protein kinases C prevents murine cytomegalovirus replication.

The Journal of general virology 20050801

Protective effect of a protein kinase inhibitor on cellular injury induced by cephaloridine in the porcine kidney cell line LLC-PK(1).

The Journal of toxicological sciences 20050801

Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713

Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes.

Arteriosclerosis, thrombosis, and vascular biology 20050701

Effects of 17beta-estradiol on chemically induced long-term depression.

Neuropharmacology 20050701

Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia.

Learning & memory (Cold Spring Harbor, N.Y.) 20050701

Role of protein kinase C in the monocyte-derived macrophage-mediated biodegradation of polycarbonate-based polyurethanes.

Journal of biomedical materials research. Part A 20050701

Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation.

The Journal of biological chemistry 20050610

Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide in the Brunner's gland of the rat duodenum.

American journal of physiology. Gastrointestinal and liver physiology 20050601

Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage.

American journal of physiology. Heart and circulatory physiology 20050601

Fasudil prevents KATP channel-induced improvement in postischemic functional recovery.

American journal of physiology. Heart and circulatory physiology 20050601

The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes.

British journal of pharmacology 20050601

Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure.

Circulation 20050531

Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.

Neuron 20050519

Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis.

Circulation 20050503

Induction of CD69 antigen expression in peripheral blood mononuclear cells on exposure to silica, but not by asbestos/chrysotile-A.

Immunology letters 20050415

Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.

European journal of pharmacology 20050411

Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice.

European journal of pharmacology 20050411

Role of protein kinase C beta in phorbol ester-induced c-fos gene expression in neurons of normotensive and spontaneously hypertensive rat brains.

Brain research 20050408

Dual effects of bryostatin-1 on spatial memory and depression.

European journal of pharmacology 20050404

Does cyclic AMP mediate rat urinary bladder relaxation by isoproterenol?

The Journal of pharmacology and experimental therapeutics 20050401

Role of Rho-kinase and p27 in angiotensin II-induced vascular injury.

Hypertension (Dallas, Tex. : 1979) 20050401

Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells.

Molecular and cellular biology 20050401

Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.

Regulatory peptides 20050330

Regulation of corticotropin-releasing factor receptor type 2beta mRNA by mitogen-activated protein kinases in aortic smooth muscle cells.

Regulatory peptides 20050330

Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone.

European journal of pharmacology 20050328

Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.

American journal of respiratory and critical care medicine 20050301

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension.

Heart (British Cardiac Society) 20050301

Small guanine nucleotide-binding protein Rho and myocardial function.

Acta pharmacologica Sinica 20050301

Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216

Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo.

Journal of the American College of Cardiology 20050215

Prostaglandins differently regulate FGF-2 and FGF receptor expression and induce nuclear translocation in osteoblasts via MAPK kinase.

Cell and tissue research 20050201

Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility.

Experimental eye research 20050201

Rho-kinase and myosin II activities are required for cell type and environment specific migration.

Genes to cells : devoted to molecular & cellular mechanisms 20050201

Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms.

The Journal of endocrinology 20050201

[Intra-arterial administration of fasudil hydrochloride: duration of action].

No shinkei geka. Neurological surgery 20050201

Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases.

The European journal of neuroscience 20050201

A cGMP-dependent cascade enhances an L-type-like Ca2+ current in identified snail neurons.

Brain research 20050125

Heterologous desensitization of insulin secretion by GIP (glucose-dependent insulinotropic peptide) in INS-1 cells: the significance of Galphai2 and investigations on the mechanism involved.

Cell biochemistry and function 20050101

Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS).

Neuroscience 20050101

Effects of hydroxyfasudil administered to the nucleus tractus solitarii on blood pressure and heart rate in spontaneously hypertensive rats.

Clinical and experimental hypertension (New York, N.Y. : 1993) 20050101

5-HT2 receptor mediated the potentiation of GABA-activated current in the membrane of the dorsal root ganglion neurons of rat.

Yao xue xue bao = Acta pharmaceutica Sinica 20050101

[The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil].

Zhonghua xin xue guan bing za zhi 20050101

Induction of expression of bovine leukemia virus (BLV) in blood taken from BLV-infected cows without removal of plasma.

Microbes and infection 20050101

Transcriptional upregulation of the human MRP2 gene expression by serine/threonine protein kinase inhibitors.

Journal of biological regulators and homeostatic agents 20050101

AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions.

Diabetes 20041201

Chlamydophila pneumoniae induces p44/p42 mitogen-activated protein kinase activation in human fibroblasts through Toll-like receptor 4.

Journal of medical microbiology 20041201

Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.

Molecular cancer research : MCR 20041201

Regulation of transmitter release by synapsin II in mouse motor terminals.

The Journal of physiology 20041115

NMDA receptor-dependent long-term potentiation in the telencephalon of the zebrafish.

Neuroscience letters 20041111

Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta.

Naunyn-Schmiedeberg's archives of pharmacology 20041101

Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptor.

The Journal of biological chemistry 20041022

Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.

British journal of pharmacology 20041001

Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.

British journal of pharmacology 20041001

[Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report].

Journal of cardiology 20041001

Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP.

European journal of pharmacology 20040913

Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats.

Journal of hypertension 20040901

Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.

Journal of cardiovascular pharmacology 20040901

Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.

Brain research 20040820

Gene- and cell-type-specific effects of signal transduction cascades on metal-regulated gene transcription appear to be independent of changes in the phosphorylation of metal-response-element-binding transcription factor-1.

The Biochemical journal 20040815

H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys.

Investigative ophthalmology & visual science 20040801

[Development of drug delivery system for intrathecal administration and its therapeutic effect on cerebral vasospasm and ischemia].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801

Effects of topical H-7 on outflow facility, intraocular pressure, and corneal thickness in monkeys.

Archives of ophthalmology (Chicago, Ill. : 1960) 20040801

Acquired dendritic channelopathy in temporal lobe epilepsy.

Science (New York, N.Y.) 20040723

Fibroblast growth and H-7 protein kinase inhibitor response monitored in microimpedance sensor arrays.

Biotechnology and bioengineering 20040720

Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.

Arteriosclerosis, thrombosis, and vascular biology 20040701

Pharmacologic disruption of Schlemm's canal cells and outflow facility in anterior segments of human eyes.

Investigative ophthalmology & visual science 20040701

Augmented release of matrix metalloproteinase-9 by PKC activation in organotypic cultures of human breast cancer and adjacent normal breast tissue and fibroadenoma.

The Chinese journal of physiology 20040630

KN-62, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase II, inhibits the lysozyme pre-mRNA splicing in myelomonocytic HD11 cells.

Biochemical and biophysical research communications 20040625

Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.

Neurochemistry international 20040601

Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.

Circulation 20040511

Presynaptic inhibition of spontaneous acetylcholine release induced by adenosine at the mouse neuromuscular junction.

British journal of pharmacology 20040501

Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.

Acta pharmacologica Sinica 20040501

Modulatory effect of substance P on GABA-activated currents from rat dorsal root ganglion.

Acta pharmacologica Sinica 20040501

The cytosolic II-III loop of Cav2.3 provides an essential determinant for the phorbol ester-mediated stimulation of E-type Ca2+ channel activity.

The European journal of neuroscience 20040501

A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release.

Journal of immunology (Baltimore, Md. : 1950) 20040415

Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040401

Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.

Journal of cellular biochemistry 20040401

PknH, a transmembrane Hank's type serine/threonine kinase from Mycobacterium tuberculosis is differentially expressed under stress conditions.

FEMS microbiology letters 20040401

Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040331

Rho kinase inhibition initiates apoptosis in human airway epithelial cells.

American journal of respiratory cell and molecular biology 20040301

Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability.

American journal of physiology. Heart and circulatory physiology 20040301

[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].

Nihon rinsho. Japanese journal of clinical medicine 20040301

Mechanism of activation of ADP-induced platelet aggregation under the influence of oxidatively modified fibrinogen.

Bulletin of experimental biology and medicine 20040301

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.

Circulation research 20040220

Copper-inducible transcription: regulation by metal- and oxidative stress-responsive pathways.

American journal of physiology. Cell physiology 20040201

Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions.

Diabetes 20040201

Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells.

Journal of molecular endocrinology 20040201

Competitive binding of postsynaptic density 95 and Ca2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain.

Acta pharmacologica Sinica 20040201

[Rho-kinase inhibitor].

Nihon rinsho. Japanese journal of clinical medicine 20040201

Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice.

Circulation research 20040109

A role for calcium/calmodulin kinase in insulin stimulated glucose transport.

Life sciences 20040102

Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms.

Arteriosclerosis, thrombosis, and vascular biology 20040101

Functional and structural reversibility of H-7 effects on the conventional aqueous outflow pathway in monkeys.

Experimental eye research 20040101

NMDA receptor-mediated immediate Ser831 phosphorylation of GluR1 through CaMKIIalpha in rat hippocampus during early global ischemia.

Neuroscience research 20040101

Differential effects of Rho-kinase inhibition on artery wall mass and remodeling.

Journal of vascular surgery 20040101

The Rho-ROCK system as a new therapeutic target for preventing interstitial fibrosis.

Drug news & perspectives 20040101

Effects of HA-1077 and Y-27632, two rho-kinase inhibitors, in the human umbilical artery.

Cell biochemistry and biophysics 20040101

Nicotinamide relaxes vascular smooth muscle by inhibiting myosin light chain kinase-dependent signaling pathways: implications for anticancer efficacy.

Oncology research 20040101

Agonists and antagonists acting at P2X7 receptor.

Current topics in medicinal chemistry 20040101

Dissecting individual current components of co-expressed human P2X1 and P2X7 receptors.

Current topics in medicinal chemistry 20040101

Pretreatment with PKC inhibitor triggers TNF-alpha induced apoptosis in TNF-alpha-resistant B16 melanoma BL6 cells.

Life sciences 20031226

Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide.

European journal of pharmacology 20031215

Possible mechanisms underlying the mitogenic action of heptachlor in rat hepatocytes.

Toxicology and applied pharmacology 20031215

Effects of kinase inhibitors on TGF-beta induced upregulation of Kv1.3 K+ channels in brain macrophages.

Pflugers Archiv : European journal of physiology 20031201

Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.

The Journal of physiology 20031201

Rho kinase inhibitors block activation of pancreatic stellate cells.

British journal of pharmacology 20031201

Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm.

Arteriosclerosis, thrombosis, and vascular biology 20031201

Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats.

Kidney international 20031201

Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.

Structure (London, England : 1993) 20031201

Oxidative and adhesive responses of human neutrophils to nitrovasodilators in vitro: the role of protein kinases.

Mediators of inflammation 20031201

Paradoxical actions of hydrogen peroxide on long-term potentiation in transgenic superoxide dismutase-1 mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20031112

Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi.

The Biochemical journal 20031101

Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways.

The Journal of pharmacology and experimental therapeutics 20031101

Induction of cortical cataracts in cultured mouse lenses with H-89, an inhibitor of protein kinase A.

Current eye research 20031101

A novel interaction between protein kinase D and TNF receptor-associated factor molecules regulates B cell receptor-CD40 synergy.

Journal of immunology (Baltimore, Md. : 1950) 20031101

Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system.

Circulation research 20031017

Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.

Neuroscience letters 20031009

Ca(2+)-inactivated K+ current is modulated by endothelin-1 in B-16 murine melanoma cells.

Pigment cell research 20031001

Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.

British journal of pharmacology 20031001

Protein phosphorylation in neutrophils monitored with phosphospecific antibodies.

Journal of immunological methods 20031001

Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.

British journal of pharmacology 20030901

Beta-adrenergic stimulation induces cardiac ankyrin repeat protein expression: involvement of protein kinase A and calmodulin-dependent kinase.

Cardiovascular research 20030901

Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1.

The Journal of biological chemistry 20030822

Three kinds of current in response to substance P in bullfrog DRG neurons.

Brain research 20030815

Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.

Brain research. Molecular brain research 20030723

Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice.

European journal of pharmacology 20030711

Regulation of CO production in cerebral microvessels of newborn pigs.

American journal of physiology. Heart and circulatory physiology 20030701

Mechanisms underlying the contractile response to endothelin-1 in the rat renal artery.

Pharmacology 20030701

Protein kinase C and protein tyrosine kinase mediate lipopolysaccharide- and cytokine-induced nitric oxide formation in vascular smooth muscle cells of rats.

Sheng li xue bao : [Acta physiologica Sinica] 20030625

Astrocyte stellation induced by Rho kinase inhibitors in culture.

Brain research. Developmental brain research 20030612

Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.

Kidney international 20030601

P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.

Journal of immunology (Baltimore, Md. : 1950) 20030601

Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20030601

Activation of the Epstein-Barr virus lytic cycle by the latex of the plant Euphorbia tirucalli.

British journal of cancer 20030519

Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans.

Hypertension (Dallas, Tex. : 1979) 20030501

Regulation of ERK phosphorylation by ethanol in fetal cortical neurons.

Neurochemical research 20030501

NF-kappaB is involved in regulation of CD40 ligand expression on Mycobacterium bovis bacillus Calmette-Guérin-activated human T cells.

Clinical and diagnostic laboratory immunology 20030501

Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes.

Chemical research in toxicology 20030501

Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by alpha2-adrenoceptor agonists.

European journal of pharmacology 20030425

Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.

Circulation research 20030418

Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons.

Journal of neuroscience research 20030415

Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.

Biochemical and biophysical research communications 20030411

Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.

Journal of medicinal chemistry 20030410

Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.

American journal of physiology. Gastrointestinal and liver physiology 20030401

Role of PKC and calcium in modulation of effects of angiotensin II on sodium transport in proximal tubule.

American journal of physiology. Renal physiology 20030401

Synthesis and pharmacological study of Rho-kinase inhibitors: pharmacomodulations on the lead compound Fasudil.

Journal of enzyme inhibition and medicinal chemistry 20030401

Insulin-stimulated cyclic guanosine monophosphate inhibits vascular smooth muscle cell migration by inhibiting Ca/calmodulin-dependent protein kinase II.

Circulation 20030325

Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.

The Journal of physiology 20030315

Effect of unsaturated fatty acid on muscarinic current in guinea pig gastric antral circular myocytes.

Acta pharmacologica Sinica 20030301

Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze.

Neuropharmacology 20030301

Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation.

Carcinogenesis 20030301

Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells.

World journal of gastroenterology 20030215

Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization.

Brain research 20030207

Role of arachidonic acid and protein kinase C during maturation-inducing hormone-dependent meiotic resumption and ovulation in ovarian follicles of Atlantic croaker.

Biology of reproduction 20030201

Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae.

The Journal of physiology 20030201

Effect of gamma-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation.

Nutrition (Burbank, Los Angeles County, Calif.) 20030201

Concurrent exposure to heat shock and H7 synergizes to trigger breast cancer cell apoptosis while sparing normal cells.

Breast cancer research and treatment 20030201

A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.

Brain research 20030103

Regulation of corticotropin-releasing factor receptor type 2beta mRNA via cyclic AMP pathway in A7r5 aortic smooth muscle cells.

Cellular signalling 20030101

Regulation of glutamatergic neurotransmission in the striatum by presynaptic adenylyl cyclase-dependent processes.

Neurochemistry international 20030101

The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.

Archives of biochemistry and biophysics 20030101

Role of protein kinase C in central muscarinic inhibitory mechanisms regulating voiding in rats.

Neuroscience 20030101

Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm.

Journal of the American College of Cardiology 20030101

Formation of AP-1 transcription factors during learning in Helix.

Neuroscience and behavioral physiology 20030101

Components of the intracellular cAMP system supporting the olfactory reception of amyl alcohol.

Neuroscience and behavioral physiology 20030101

A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.

Neuroscience 20030101

Vessel- and vasoconstrictor-dependent role of rho/rho-kinase in renal microvascular tone.

Journal of vascular research 20030101

Pituitary adenylate cyclase-activating polypeptide (PACAP)-evoked increase in cyclic AMP production in chick cerebral cortex: lack of a role of the protein kinase C pathway.

Polish journal of pharmacology 20030101

c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis.

Anticancer research 20030101

Differential regulation by Ca(2+) of calmodulin- and PKC-dependent contractile pathways in cat lower oesophageal sphincter.

Autonomic & autacoid pharmacology 20030101

Role of the flocculus in mediating vestibular nucleus neuron plasticity during vestibular compensation in the rat.

The Journal of physiology 20021215

RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.

British journal of pharmacology 20021201

Levamisole receptor phosphorylation: effects of kinase antagonists on membrane potential responses in Ascaris suum suggest that CaM kinase and tyrosine kinase regulate sensitivity to levamisole.

The Journal of experimental biology 20021201

[Basic and clinical studies on coronary vasospasm].

Masui. The Japanese journal of anesthesiology 20021201

Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction.

European journal of pharmacology 20021129

Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.

The Journal of biological chemistry 20021122

Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats.

Life sciences 20021122

[Regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by protein kinase C].

Zhonghua yi xue za zhi 20021110

3',5'-cyclic adenosine monophosphate augments intracellular Ca2+ concentration and gonadotropin-releasing hormone (GnRH) release in immortalized GnRH neurons in an Na+ -dependent manner.

Endocrinology 20021101

Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study.

Journal of cardiovascular pharmacology 20021101

The mechanism of excitation-contraction coupling in phenylephrine-stimulated human saphenous vein.

American journal of physiology. Heart and circulatory physiology 20021001

Estradiol feedback alters potassium currents and firing properties of gonadotropin-releasing hormone neurons.

Molecular endocrinology (Baltimore, Md.) 20021001

Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line.

European journal of biochemistry 20021001

Molecular basis of the synergistic production of IL-1 receptor antagonist by human neutrophils stimulated with IL-4 and IL-10.

International immunology 20021001

Postsynaptic kinase signaling underlies inhibitory synaptic plasticity in the lateral superior olive.

Journal of neurobiology 20021001

Modulation by oxytocin of ATP-activated currents in rat dorsal root ganglion neurons.

Neuropharmacology 20021001

KN-62 enhances Chlamydia pneumoniae-induced p44/p42 mitogen-activated protein kinase activation in murine fibroblasts and attenuates in vitro infection.

FEMS microbiology letters 20020924

Inhibition of transforming growth factor-beta signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF beta type I receptor kinase.

Biochemistry 20020910

Nitric oxide-induced motility in aortic smooth muscle cells: role of protein tyrosine phosphatase SHP-2 and GTP-binding protein Rho.

Circulation research 20020906

Activity of protein kinase C modulates the apoptosis induced by polychlorinated biphenyls in human leukemic HL-60 cells.

Toxicology letters 20020905

The signal transduction of endothelin-1-induced circular smooth muscle cell contraction in cat esophagus.

The Journal of pharmacology and experimental therapeutics 20020901

Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity.

Hepatology (Baltimore, Md.) 20020901

Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway.

Prostaglandins & other lipid mediators 20020901

Okadaic acid induces epileptic seizures and hyperphosphorylation of the NR2B subunit of the NMDA receptor in rat hippocampus in vivo.

Experimental neurology 20020901

Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.

The Journal of endocrinology 20020801

[Involvement of Rho-kinase in hypertensive vascular disease--a novel therapeutic target in hypertension].

Fukuoka igaku zasshi = Hukuoka acta medica 20020801

Time-dependent involvement of PKA/PKC in contextual memory consolidation.

Behavioural brain research 20020718

Angiotensin II and cAMP regulate AT(1)-mRNA expression in rat cardiomyocytes by transcriptional mechanism.

European journal of pharmacology 20020712

Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase.

Circulation 20020702

Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways.

Gut 20020701

Ca(2+)/calmodulin-dependent protein kinase (CaM-kinase) inhibitor KN-62 suppresses the activity of mitogen-activated protein kinase (MAPK), c-myc activation and human keratinocyte proliferation.

Archives of dermatological research 20020701

Hyperosmotic stimuli inhibit VCAM-1 expression in cultured endothelial cells via effects on interferon regulatory factor-1 expression and activity.

European journal of immunology 20020701

CaMKII regulates amphetamine-induced ERK1/2 phosphorylation in striatal neurons.

Neuroreport 20020612

Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes.

Biochimica et biophysica acta 20020612

Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.

The Biochemical journal 20020601

Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures.

Journal of periodontal research 20020601

Activation and inactivation of signal transducers and activators of transcription by ciliary neurotrophic factor in neuroblastoma cells.

Cellular signalling 20020501

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

Enhanced contractile mechanisms in vasospasm: is endothelial dysfunction the whole story?

Circulation 20020402

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.

Circulation 20020402

Inhibition of spontaneous acetylcholine secretion by 2-chloroadenosine as revealed by a protein kinase inhibitor at the mouse neuromuscular junction.

British journal of pharmacology 20020401

Characteristics of ATP-induced current through P2X7 receptor in NG108-15 cells: unique antagonist sensitivity and lack of pore formation.

Japanese journal of pharmacology 20020401

Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

Journal of neurochemistry 20020401

Receptor-mediated modulation of avian caecal muscle contraction by melatonin: role of tyrosine protein kinase.

Journal of pineal research 20020401

Protein kinases--the major drug targets of the twenty-first century?

Nature reviews. Drug discovery 20020401

Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.

Life sciences 20020322

Nucleo-cytoplasmic localization of influenza virus nucleoprotein depends on cell density and phosphorylation.

Virus research 20020320

Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.

Journal of cardiovascular pharmacology 20020301

Involvement of protein kinase C and arachidonic acid pathways in the gonadotropin-releasing hormone regulation of oocyte meiosis and follicular steroidogenesis in the goldfish ovary.

Biology of reproduction 20020301

Cell cycle-dependent regulation of telomerase activity by auxin, abscisic acid and protein phosphorylation in tobacco BY-2 suspension culture cells.

The Plant journal : for cell and molecular biology 20020301

Human macrophage adhesion on fibronectin: the role of substratum and intracellular signalling kinases.

Cellular signalling 20020201

CaMKII is activated and translocated to the secretory apical membrane during cholinergically conveyed gastric acid secretion.

Cellular signalling 20020201

Estrogen inhibition of PTH-stimulated osteoclast formation and attachment in vitro: involvement of both PKA and PKC.

Endocrinology 20020201

Pharmacological characterization of the P2X(7) receptor on human macrophages using the patch-clamp technique.

Naunyn-Schmiedeberg's archives of pharmacology 20020201

Nucleotide-evoked relaxation of rat vas deferens: possible mechanisms.

European journal of pharmacology 20020201

Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries.

Arteriosclerosis, thrombosis, and vascular biology 20020201

Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.

International journal of pharmaceutics 20020131

The transcriptional co-activators CBP and p300 are activated via phenylephrine through the p42/p44 MAPK cascade.

The Journal of biological chemistry 20020125

The signalling pathway for BCG-induced interleukin-6 production in human bladder cancer cells.

Biochemical pharmacology 20020115

Protein kinase C increases 11beta-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells.

Journal of andrology 20020101

Involvement of protein kinase C and tyrosin kinase in tumoricidal activation of macrophage induced by Streptococcus pneumoniae type II capsular polysaccharide.

International immunopharmacology 20020101

Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety.

Arzneimittel-Forschung 20020101

Dysregulation of the granulocyte-macrophage colony-stimulating factor receptor is one of the causes of defective expression of CD80 antigen in systemic lupus erythematosus.

Lupus 20020101

The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway.

Pharmacology & therapeutics 20020101

A protein kinase inhibitor as an antimycobacterial agent.

FEMS microbiology letters 20011218

Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity.

Molecular endocrinology (Baltimore, Md.) 20011201

Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina.

British journal of pharmacology 20011201

Effects of calcium, calmodulin, protein kinase C and protein tyrosine kinases on volume-activated taurine efflux in human erythroleukemia cells.

Journal of cellular physiology 20011201

Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.

Hypertension (Dallas, Tex. : 1979) 20011201

Effects of anti-myosin drugs on anaphase chromosome movement and cytokinesis in crane-fly primary spermatocytes.

Cell motility and the cytoskeleton 20011201

Investigation of the inhibitory effects of HA-1077 and Y-32885 on the translocation of PKCbetaI, PKCbetaII and PKCzeta in human neutrophils.

Mediators of inflammation 20011201

Protein kinase inhibitors and the dynamics of tight junction opening and closing in A6 cell monolayers.

The Journal of membrane biology 20011115

Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions.

The Journal of biological chemistry 20011109

Morphine inhibits indolactam V-induced U937 cell adhesion and gelatinase secretion.

Journal of cellular physiology 20011101

Induction of manganese superoxide dismutase by tumour necrosis factor-alpha in human endometrial stromal cells.

Molecular human reproduction 20011101

Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20011101

Regulation of matrix metalloproteinase-2 production by cytokines and pharmacological agents in human pulp cell cultures.

Journal of endodontics 20011101

Calmodulin and a cyclic nucleotide-dependent protein kinase facilitate the prolactin-induced increase in tyrosine hydroxylase activity in tuberoinfundibular dopaminergic neurons.

Endocrine 20011101

Stimulation of cardiac glucose transport by inhibitors of oxidative phosphorylation.

Life sciences 20011005

Role of Na(+)/H(+) exchanger during O(2) deprivation in mouse CA1 neurons.

American journal of physiology. Cell physiology 20011001

Role of protein kinase C in myogenic calcium-contraction coupling of rat cannulated mesenteric small arteries.

Clinical and experimental pharmacology & physiology 20011001

Regulation of the rat NHE3 gene promoter by sodium butyrate.

American journal of physiology. Gastrointestinal and liver physiology 20011001

Effect of Leishmania donovani lipophosphoglycan on ornithine decarboxylase activity in macrophages.

The Journal of parasitology 20011001

Differential influence of cAMP on the expression of the three subtypes (ATA1, ATA2, and ATA3) of the amino acid transport system A.

FEBS letters 20010914

Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.

European journal of pharmacology 20010907

Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats.

European journal of pharmacology 20010907

Functional characterization of P2Y and P2X receptors in human eosinophils.

Journal of cellular physiology 20010901

Effects of second messengers on gap junctional intercellular communication of ovine luteal cells throughout the estrous cycle.

Biology of reproduction 20010901

Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.

British journal of pharmacology 20010901

PP1 inhibitors depolarize Hermissenda photoreceptors and reduce K+ currents.

Journal of neurophysiology 20010901

Novel protein kinase C delta isoform insensitive to caspase-3.

Biological & pharmaceutical bulletin 20010901

Antiischemic properties of fasudil in experimental models of vasospastic angina.

Japanese journal of pharmacology 20010901

P2Y(11) receptor expression by human lymphocytes: evidence for two cAMP-linked purinoceptors.

European journal of pharmacology 20010831

Effect of oleoresin capsicum (OC) and ortho-chlorobenzylidene malononitrile (CS) on ciliary beat frequency.

Toxicology 20010828

Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation.

The Journal of biological chemistry 20010824

Sea urchin sperm cation-selective channels directly modulated by cAMP.

FEBS letters 20010810

Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.

Life sciences 20010810

Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.

Archives of ophthalmology (Chicago, Ill. : 1960) 20010801

Spl phosphorylation induced by serum stimulates the human alpha2(I) collagen gene expression.

The Journal of investigative dermatology 20010801

H-7 and fetal calf serum (FCS) act synergistically to increase apoptosis in the KB line of human oral carcinoma cells.

Tissue & cell 20010801

Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells.

Journal of cellular physiology 20010701

Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo.

Cardiovascular research 20010701

Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons).

Molecular pharmacology 20010701

Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010701

Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids.

Journal of gastroenterology and hepatology 20010701

Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling.

Journal of neurochemistry 20010701

Modulation of GABA-augmented norepinephrine release in female rat brain slices by opioids and adenosine.

Neurochemical research 20010701

Effect of H-7 on cultured human trabecular meshwork cells.

Molecular vision 20010627

Histamine production by cultured microglial cells of the mouse.

Neuroscience letters 20010615

The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.

Oncogene 20010614

Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).

Experimental cell research 20010610

Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.

Brain research 20010608

Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C.

Gut 20010601

Angiotensin II type 1 receptor modulation of L-type calcium currents in guinea-pig ventricular cells.

Chinese medical journal 20010601

Follicle-stimulating hormone promotes the growth of human epithelial ovarian cancer cells through the protein kinase C-mediated system.

Cancer letters 20010526

Capsaicin potentiates 1,25-dihydoxyvitamin D3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells.

European journal of pharmacology 20010525

CAMKII inhibition in the parabrachial nuclei elicits conditioned taste aversion in rats.

Neurobiology of learning and memory 20010501

Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors.

Experimental hematology 20010501

Regulation of SERCA Ca2+ pump expression by cytoplasmic Ca2+ in vascular smooth muscle cells.

American journal of physiology. Cell physiology 20010401

Intracellular calcium reduces light-induced excitatory post-synaptic responses in salamander retinal ganglion cells.

The Journal of physiology 20010401

Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells.

The Journal of physiology 20010401

Efficacy of intrathecal liposomal fasudil for experimental cerebral vasospasm after subarachnoid hemorrhage.

Neurosurgery 20010401

Stimulation of hyaluronan synthesis by interleukin-1beta involves activation of protein kinase C betaII in fibroblasts from patients with Graves' ophthalmopathy.

Journal of cellular biochemistry 20010401

Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.

FEBS letters 20010330

Interleukin-1beta enhances retinoic acid-mediated expression of bone-type alkaline phosphatase in rat IEC-6 cells.

American journal of physiology. Gastrointestinal and liver physiology 20010301

Complexities of measuring antagonist potency at P2X(7) receptor orthologs.

The Journal of pharmacology and experimental therapeutics 20010301

Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.

Journal of neurochemistry 20010301

Hydrogen peroxide and hydroxyl radical involvement in the activation of caspase-3 in chemically induced apoptosis of HL-60 cells.

Cellular and molecular life sciences : CMLS 20010301

Involvement of intracellular Ca2+ in the regulation of bovine leukemia virus expression.

Biological chemistry 20010301

Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia.

Neurologia medico-chirurgica 20010301

The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium.

Molecular and cellular endocrinology 20010227

Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.

FEBS letters 20010209

Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010201

Inhibition of oxotremorine-induced desensitization of guinea-pig ileal longitudinal muscle in Ca2+-free conditions.

The Journal of pharmacy and pharmacology 20010201

Gastrin inhibits cholangiocarcinoma growth through increased apoptosis by activation of Ca2+-dependent protein kinase C-alpha.

Journal of hepatology 20010201

Acute effects of H-7 on ciliary epithelium and corneal endothelium in monkey eyes.

Current eye research 20010201

Rho-associated kinase phosphorylates MARCKS in human neuronal cells.

Biochemical and biophysical research communications 20010126

Three-dimensional collagen regulates collagen gene expression by a mechanism that requires serine/threonine kinases and is independent of mechanical contraction.

Biochemical and biophysical research communications 20010112

The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.

Oncogene 20010111

Bombesin and gastrin releasing peptide increase tyrosine phosphorylation of focal adhesion kinase and paxillin in non-small cell lung cancer cells.

Cancer letters 20010110

Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.

Neurochemistry international 20010101

Hypoglycemia-induced VEGF expression is mediated by intracellular Ca2+ and protein kinase C signaling pathway in HepG2 human hepatoblastoma cells.

International journal of molecular medicine 20010101

Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells.

American journal of physiology. Cell physiology 20010101

A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol.

American journal of physiology. Cell physiology 20010101

Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin-dependent enzymes.

Biochemical pharmacology 20010101

Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors.

Naunyn-Schmiedeberg's archives of pharmacology 20010101

Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1.

Molecular and cellular biochemistry 20010101

Modulation by cyclic AMP and phorbol myristate acetate of cephaloridine-induced injury in rat renal cortical slices.

Japanese journal of pharmacology 20010101

Effects of PKC inhibitors on suppression of thermotolerance development in tsAF8 cells.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20010101

Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.

Journal of muscle research and cell motility 20010101

Effect of Fasudil HCl, a protein kinase inhibitor, on cerebral vasospasm.

Acta neurochirurgica. Supplement 20010101

Combined administration of Fasudil hydrochloride and nitroglycerin for treatment of cerebral vasospasm.

Acta neurochirurgica. Supplement 20010101

A novel drug delivery system as prophylaxis for cerebral vasospasm.

Acta neurochirurgica. Supplement 20010101

Antioxidants may contribute in the fight against ageing: an in vitro model.

Mechanisms of ageing and development 20001220

Regulation of Na/K-ATPase beta1-subunit gene expression by ouabain and other hypertrophic stimuli in neonatal rat cardiac myocytes.

Molecular and cellular biochemistry 20001201

Specificity and mechanism of action of some commonly used protein kinase inhibitors.

The Biochemical journal 20001001

Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.

Antiviral research 20001001

Immediate early gene expression in PC12 cells exposed to lead: requirement for protein kinase C.

Journal of neurochemistry 20000301

Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase.

Experimental cell research 20000201

Autocrine regulation of TPA-induced apoptosis in monoblastic cell-line U-937: role for TNF-alpha, MnSOD and IL-6.

Anticancer research 20000101

Isoquinolinesulphonamide derivatives inhibit transcriptional elongation of human immunodeficiency virus type 1 RNA in a promyelocytic model of latency.

Antiviral chemistry & chemotherapy 19990901

MAP kinase-independent induction of proto-oncogene c-fos mRNA by hemin in human cells.

Biochemical and biophysical research communications 19990624

Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy.

Cardiovascular research 19980901

Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrochloride.

AIDS research and human retroviruses 19980301

Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture.

Biochemical and biophysical research communications 19971229

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro.

Genes & development 19971015

Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mouse.

The Journal of pharmacology and experimental therapeutics 19970801

Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937.

Molecular pharmacology 19970601

The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes.

British journal of pharmacology 19970401

cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expression.

The Journal of biological chemistry 19970207

Transcriptional regulation by transforming growth factor beta of the expression of retinoic acid and retinoid X receptor genes in osteoblastic cells is mediated through AP-1.

The Journal of biological chemistry 19961206

Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal.

The European journal of neuroscience 19961201

Growth regulation by peroxisome proliferators: opposing activities in early and late G1.

Cancer research 19960715

Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.

The Journal of pharmacology and experimental therapeutics 19960401

Naphthalenesulphonamides block neutrophil superoxide production by intact cells and in a cell-free system: is myosin light chain kinase responsible for these effects?

The Biochemical journal 19951001

Cadmium-induced expression of immediate early genes in LLC-PK1 cells.

Kidney international 19950801

The effects of various kinase and phosphatase inhibitors on the transmission of the prolactin and extracellular matrix signals to rabbit alpha S1-casein and transferrin genes.

The international journal of biochemistry & cell biology 19950701

Angiotensin II induces transcription and expression of alpha 1-adrenergic receptors in vascular smooth muscle cells.

The American journal of physiology 19950301

Pentoxifylline and other protein kinase C inhibitors down-regulate HIV-LTR NF-kappa B induced gene expression.

Molecular medicine (Cambridge, Mass.) 19941101

Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.

Journal of cellular biochemistry 19940901

Pretreatment of transient focal cerebral ischemia in rats with the calcium antagonist AT877.

Stroke 19940601

Acetaldehyde induces c-fos and c-jun proto-oncogenes in fat-storing cell cultures through protein kinase C activation.

Alcohol and alcoholism (Oxford, Oxfordshire) 19940501

Blockade of neurotensin-induced motor activity by inhibition of protein kinase.

Psychopharmacology 19940201

Novel indolocarbazole protein kinase C inhibitors prevent reactivation of HIV-1 in latently infected cells.

Antiviral research 19931201

[Treatment of cerebral vasospasm by a protein kinase inhibitor AT 877].

No to shinkei = Brain and nerve 19930901

Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.

Molecular and cellular endocrinology 19930301

Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro.

Biochemical pharmacology 19911009

Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells.

The Journal of biological chemistry 19901005

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

The Journal of biological chemistry 19900315

Phorbol ester-mediated induction of HIV-1 from a chronically infected promonocyte clone: blockade by protein kinase inhibitors and relationship to tat-directed trans-activation.

Biochemical and biophysical research communications 19900115

Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase.

British journal of pharmacology 19891201

Comparison of effects of protein kinase C inhibitors on phorbol ester-induced CD4 down-regulation and augmentation of human immunodeficiency virus replication in human T cell lines.

Biochemical and biophysical research communications 19891016

Human immunodeficiency virus induces phosphorylation of its cell surface receptor.

Nature 19880519

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

Biochemistry 19841009