200,000+ products from a single source!
sales@angenechem.com
84226-06-2 | Benzamide,N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-3-iodo-6-methoxy-
CAS No: 84226-06-2 Catalog No: AG004RJN MDL No:
Product Description
Catalog Number:
AG004RJN
Chemical Name:
Benzamide,N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-3-iodo-6-methoxy-
CAS Number:
84226-06-2
Molecular Formula:
C15H21IN2O3
Molecular Weight:
404.2433
IUPAC Name:
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-3-iodo-6-methoxybenzamide
InChI:
InChI=1S/C15H21IN2O3/c1-3-18-8-4-5-10(18)9-17-15(20)13-12(21-2)7-6-11(16)14(13)19/h6-7,10,19H,3-5,8-9H2,1-2H3,(H,17,20)
InChI Key:
CANPFCFJURGKAX-UHFFFAOYSA-N
SMILES:
CCN1CCCC1CNC(=O)c1c(OC)ccc(c1O)I
Properties
Complexity:
356
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
404.06g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
404.248g/mol
Monoisotopic Mass:
404.06g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
61.8A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
2.3
Literature
| Title | Journal |
|---|---|
| Varenicline increases in vivo striatal dopamine D2/3 receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats. | Nuclear medicine and biology 20120701 |
| Dopaminergic neurotransmission in patients with schizophrenia in relation to positive and negative symptoms. | Pharmacopsychiatry 20120501 |
| Dual-isotope SPECT imaging of striatal dopamine: a comparative study between never-treated and haloperidol-treated first-episode schizophrenic patients. | European archives of psychiatry and clinical neuroscience 20120401 |
| The dopaminergic system in patients with functional dyspepsia analysed by single photon emission computed tomography (SPECT) and an alpha-methyl-para-tyrosine (AMPT) challenge test. | European journal of nuclear medicine and molecular imaging 20120401 |
| Dopaminergic mechanisms of target detection - P300 event related potential and striatal dopamine. | Psychiatry research 20111230 |
| Density of striatal D2 receptors in untreated first-episode psychosis: an I123-IBZM SPECT study. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20111201 |
| Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: an in vivo SPECT study. | Schizophrenia research 20110701 |
| Diagnostic accuracy of combined FP-CIT, IBZM, and MIBG scintigraphy in the differential diagnosis of degenerative parkinsonism: a multidimensional statistical approach. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110501 |
| Visual grasping in frontotemporal dementia and parkinsonism linked to chromosome 17 (microtubule-associated with protein tau): a comparison of N-Isopropyl-p-[(123)I]-iodoamphetamine brain perfusion single photon emission computed tomography analysis with progressive supranuclear palsy. | Movement disorders : official journal of the Movement Disorder Society 20110215 |
| Striatal dopamine function in a family with multiple SCA-3 phenotypes. | Journal of neurology 20110201 |
| Unexpected detection of nodular melanoma of the skin on the scalp by I-123 IBZM brain SPECT. | Clinical nuclear medicine 20110201 |
| Sunshine-exposure variation of human striatal dopamine D(2)/D(3) receptor availability in healthy volunteers. | Progress in neuro-psychopharmacology & biological psychiatry 20110115 |
| [Adrenergic and dopaminergic examinations in nuclear medicine. Presentation of the results of the French and Spanish surveys]. | Revista espanola de medicina nuclear 20110101 |
| Pharmacological challenge and synaptic response - assessing dopaminergic function in the rat striatum with small animal single-photon emission computed tomography (SPECT) and positron emission tomography (PET). | Reviews in the neurosciences 20110101 |
| Preliminary studies of differential impairments of the dopaminergic system in subtypes of progressive supranuclear palsy. | Nuclear medicine communications 20101101 |
| Striatal D₂ receptor binding in 22q11 deletion syndrome: an [¹²³I]IBZM SPECT study. | Journal of psychopharmacology (Oxford, England) 20101001 |
| Delusional infestation: neural correlates and antipsychotic therapy investigated by multimodal neuroimaging. | Progress in neuro-psychopharmacology & biological psychiatry 20101001 |
| Increased dopaminergic neurotransmission in therapy-naïve asymptomatic HIV patients is not associated with adaptive changes at the dopaminergic synapses. | Journal of neural transmission (Vienna, Austria : 1996) 20100601 |
| Impact of scatter correction on D2 receptor occupancy measurements using 123I-IBZM SPECT: comparison to 11C-Raclopride PET. | NeuroImage 20100501 |
| Dopamine D2 receptor SPECT with (123)I-IBZM: evaluation of collimator and post-filtering when using model-based compensation-a Monte Carlo study. | Physics in medicine and biology 20100407 |
| Involvement of nigrostriatal pathway in Japanese encephalitis with movement disorders: evidence from 99mTc-TRODAT-1 and 123I-IBZM SPECT imagings. | Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20100101 |
| Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance. | PloS one 20100101 |
| IBZM SPECT and FDG PET in the differential diagnosis of Parkinsonian syndromes: comparison with respect to inter-rater agreement. | Nuklearmedizin. Nuclear medicine 20100101 |
| Simultaneous 99mTc and 123I dual-isotope brain striatal phantom single photon emission computed tomography: validation of 99mTc-TRODAT-1 and 123I-IBZM simultaneous dopamine system brain imaging. | The Kaohsiung journal of medical sciences 20091101 |
| Neurotransmission SPECT and MR registration combining mutual and gradient information. | Medical physics 20091101 |
| Increase of striatal dopamine transmission in first episode drug-naive schizophrenic patients as demonstrated by [(123)I]IBZM SPECT. | Psychiatry research 20090930 |
| Targeting murine heart and brain: visualisation conditions for multi-pinhole SPECT with (99m)Tc- and (123)I-labelled probes. | European journal of nuclear medicine and molecular imaging 20090901 |
| Varenicline increases striatal dopamine D(2/3) receptor binding in rats. | Addiction biology 20090901 |
| Baseline and amphetamine-stimulated dopamine activity are related in drug-naïve schizophrenic subjects. | Biological psychiatry 20090615 |
| Within-subject comparison of striatal D2 receptor occupancy measurements using [123I]IBZM SPECT and [11C]Raclopride PET. | NeuroImage 20090601 |
| (99m)Tc-TRODAT-1 and (123)I-IBZM SPECT studies in a patient with extrapontine myelinolysis with parkinsonian features. | Annals of nuclear medicine 20090601 |
| Reduced striatal D2 receptor binding in myoclonus-dystonia. | European journal of nuclear medicine and molecular imaging 20090201 |
| Pharmacokinetics and time-course of D(2) receptor occupancy induced by atypical antipsychotics in stabilized schizophrenic patients. | Journal of psychopharmacology (Oxford, England) 20081101 |
| Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study. | Pharmacopsychiatry 20080901 |
| Kinetic analyses of [123I]IBZM SPECT for quantification of striatal dopamine D2 receptor binding: a critical evaluation of the single-scan approach. | NeuroImage 20080815 |
| AMPT-induced monoamine depletion in humans: evaluation of two alternative [123I]IBZM SPECT procedures. | European journal of nuclear medicine and molecular imaging 20080701 |
| Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up. | Journal of neurology 20080701 |
| Comparison of intravenous and intraperitoneal [123I]IBZM injection for dopamine D2 receptor imaging in mice. | Nuclear medicine and biology 20080701 |
| Cerebral kinetics of the dopamine D(2) receptor ligand [(123)I]IBZM in mice. | Nuclear medicine and biology 20080501 |
| Greater availability of dopamine transporters in patients with major depression--a dual-isotope SPECT study. | Psychiatry research 20080415 |
| Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080401 |
| Dual-isotope SPECT imaging of striatal dopamine: first episode, drug naïve schizophrenic patients. | Schizophrenia research 20080401 |
| Challenge by the murine brain: multi-pinhole SPECT of 123I-labelled pharmaceuticals. | Journal of neuroscience methods 20080315 |
| [99mTc]TRODAT-1/[123I]IBZM SPECT studies of the dopaminergic system in Tourette syndrome. | Psychiatry research 20080227 |
| Striatal dopamine D(2) receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings. | Depression and anxiety 20080101 |
| Decreased dopamine transporter availability in male smokers -- a dual isotope SPECT study. | Progress in neuro-psychopharmacology & biological psychiatry 20080101 |
| Test-retest variability and reliability of 123I-IBZM SPECT measurement of striatal dopamine D2 receptor availability in healthy volunteers and influence of iterative reconstruction algorithms. | Synapse (New York, N.Y.) 20080101 |
| Acute intravenous injection toxicity study of IBZM and BZM in rats. | Drug and chemical toxicology 20080101 |
| Acute prefrontal rTMS increases striatal dopamine to a similar degree as D-amphetamine. | Psychiatry research 20071215 |
| Diagnostic value of asymmetric striatal D2 receptor upregulation in Parkinson's disease: an [123I]IBZM and [123I]FP-CIT SPECT study. | European journal of nuclear medicine and molecular imaging 20070401 |
| Writer's cramp: restoration of striatal D2-binding after successful biofeedback-based sensorimotor training. | Parkinsonism & related disorders 20070401 |
| Diagnostic imaging of dopamine receptors in pituitary adenomas. | European journal of endocrinology 20070401 |
| Dopamine D2 receptor occupancy by risperidone: implications for the timing and magnitude of clinical response. | Psychiatry research 20061201 |
| Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration. | Movement disorders : official journal of the Movement Disorder Society 20061001 |
| Possible impact of dopamine SPECT on decision-making for drug treatment in Parkinsonian syndrome. | Journal of neural transmission (Vienna, Austria : 1996) 20060901 |
| Correlation between striatal dopamine D2/D3 receptor binding and cardiovascular activity in healthy subjects. | American journal of hypertension 20060901 |
| Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: preliminary results of a dynamic [123I] IBZM SPECT study. | Journal of psychiatric research 20060601 |
| Striatal dopamine D2/D3 receptor availability in male smokers. | Psychiatry research 20060130 |
| Striatal D2 receptor binding as a marker of prognosis and outcome in untreated first-episode psychosis. | NeuroImage 20060115 |
| Imaging of dopamine transporters and D2 receptors in vascular parkinsonism: a report of four cases. | Journal of neural transmission (Vienna, Austria : 1996) 20051001 |
| Dopaminergic function in a family with the PARK6 form of autosomal recessive Parkinson's syndrome. | Journal of neural transmission (Vienna, Austria : 1996) 20051001 |
| Subjective experiences during dopamine depletion. | The American journal of psychiatry 20050901 |
| Comfort, self-confidence, safety, and dopamine D2 receptor occupancy by antipsychotics. | The American journal of psychiatry 20050801 |
| Combined 123I-FP-CIT and 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients. | Journal of neural transmission (Vienna, Austria : 1996) 20050501 |
| Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats. | NeuroImage 20050201 |
| Diagnostic performance of a 3-D automated quantification method of dopamine D2 receptor SPECT studies in the differential diagnosis of parkinsonism. | Nuclear medicine communications 20050101 |
| Striatal dopaminergic D2 receptor occupancy and clinical efficacy in psychosis exacerbation: a 123I-IBZM study with ziprasidone and haloperidol. | Progress in neuro-psychopharmacology & biological psychiatry 20050101 |
| [SPECT with 123I-IBZM: utility in differential diagnosis of degenerative Parkinsonisms and establishment of quantification method]. | Revista espanola de medicina nuclear 20050101 |
| Comparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease. | Movement disorders : official journal of the Movement Disorder Society 20041201 |
| Abnormalities of dopaminergic neurotransmission in SCA2: a combined 123I-betaCIT and 123I-IBZM SPECT study. | Movement disorders : official journal of the Movement Disorder Society 20041101 |
| Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implications. | Psychopharmacology 20041001 |
| L-Dopa-responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings. | Movement disorders : official journal of the Movement Disorder Society 20041001 |
| Thiethylperazine-induced parkinsonism: in vivo demonstration of dopamine D2 receptors blockade. | European journal of neurology 20041001 |
| Association between cognitive performance and striatal dopamine binding is higher in timing and motor tasks in patients with schizophrenia. | Psychiatry research 20040915 |
| Associated alterations of striatal dopamine D2/D3 receptor and transporter binding in drug-naive patients with schizophrenia: a dual-isotope SPECT study. | The American journal of psychiatry 20040801 |
| Parkinson's disease-like presentation of multiple system atrophy with poor response to STN stimulation: a clinicopathological case report. | Movement disorders : official journal of the Movement Disorder Society 20040801 |
| Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide. | Biological psychiatry 20040515 |
| Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. | Biological psychiatry 20040515 |
| Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease. | Movement disorders : official journal of the Movement Disorder Society 20040501 |
| Is neuroleptic dysphoria a variant of drug-induced extrapyramidal side effects? | Canadian journal of psychiatry. Revue canadienne de psychiatrie 20040501 |
| Striatal dopamine D2 receptor density in neuroleptic-naive and in neuroleptic-free schizophrenic patients: an 123I-IBZM-SPECT study. | Psychopharmacology 20040301 |
| Lack of sex differences in striatal dopamine D2 receptor binding in drug-naive schizophrenic patients: an IBZM-SPECT study. | Psychiatry research 20040115 |
| A case of Cotard syndrome: (123)I-IBZM SPECT imaging of striatal D(2) receptor binding. | Psychiatry research 20040115 |
| Clinical and [99mTc]TRODAT-1/[123I]IBZM SPECT imaging findings in dopa-responsive dystonia. | European neurology 20040101 |
| Comparison between olanzapine and haloperidol on procedural learning and the relationship with striatal D2 receptor occupancy in schizophrenia. | The Journal of neuropsychiatry and clinical neurosciences 20040101 |
| Normal striatal D2 receptor binding in idiopathic restless legs syndrome with periodic leg movements in sleep. | Nuclear medicine communications 20040101 |
| [Study of the pre and post-synaptic dopaminergic system by DaTSCAN/IBZM SPECT in the differential diagnosis of parkinsonism in 75 patients]. | Neurologia (Barcelona, Spain) 20040101 |
| The prognostic value of dopamine receptor occupancy by [123I]IBZM-SPECT in schizophrenic patients treated with quetiapine. | Nuclear medicine review. Central & Eastern Europe 20040101 |
| Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naïve healthy volunteers: results from a large cohort. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20031201 |
| Synthesis and affinity of a possible byproduct of electrophilic radiolabeling of [123I]IBZM. | Bioorganic & medicinal chemistry letters 20031117 |
| Significance of non-presynaptic SPECT tracer methods in Parkinson's disease. | Movement disorders : official journal of the Movement Disorder Society 20031001 |
| Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in subclinical and clinically manifest idiopathic REM sleep behavior disorder, Parkinson's disease, and controls. | Sleep 20030801 |
| Correlation between fine motor activity and striatal dopamine D2 receptor density in patients with schizophrenia and healthy controls. | Psychiatry research 20030730 |
| Alteration of the striatal dopaminergic system in human narcolepsy. | Neurology 20030610 |
| Bilateral high-frequency stimulation of the subthalamic nucleus in patients with multiple system atrophy--parkinsonism. Report of four cases. | Journal of neurosurgery 20030401 |
| Dopaminergic response in Parkinsonian phenotype of Machado-Joseph disease. | Movement disorders : official journal of the Movement Disorder Society 20030201 |
| Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease. | AJNR. American journal of neuroradiology 20030201 |
| Different striatal dopamine D2 receptor occupancy in alcohol dependent patients with or without physical withdrawal symptoms --a study using IBZM-SPECT. | Journal of neural transmission (Vienna, Austria : 1996) 20020901 |
| Striatal dopamine D2 receptor binding of risperidone in schizophrenic patients as assessed by 123I-iodobenzamide SPECT: a comparative study with olanzapine. | Journal of psychopharmacology (Oxford, England) 20020901 |
| Normal IPT and IBZM SPECT in drug naive and levodopa-treated idiopathic restless legs syndrome. | Neurology 20020827 |
| Dual SPECT of dopamine system using [99mTc]TRODAT-1 and [123I]IBZM in normal and 6-OHDA-lesioned formosan rock monkeys. | Nuclear medicine and biology 20020701 |
| Steele-Richardson-Olszewski-syndrome: reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: (123)IBZM SPECT and MRI study. | Movement disorders : official journal of the Movement Disorder Society 20020501 |
| Cognitive and brain function in schizotypal personality disorder. | Schizophrenia research 20020301 |
| SPECT imaging of striatal pre- and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep. | Journal of neurology 20020201 |
| Downregulation of striatal dopamine D2 receptors in advanced Parkinson's disease contributes to the development of motor fluctuation. | European neurology 20020101 |
| Subjective effects of AMPT-induced dopamine depletion in schizophrenia: correlation between dysphoric responses and striatal D(2) binding ratios on SPECT imaging. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011101 |
| Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome. | Neurology 20011009 |
| Dopamine D(2) receptor availability and amphetamine-induced dopamine release in unipolar depression. | Biological psychiatry 20010901 |
| Double-blind olanzapine vs. haloperidol D2 dopamine receptor blockade in schizophrenic patients: a baseline-endpoint. | Psychiatry research 20010825 |
| Dopamine D(2) receptor blockade in schizophrenia. | The American journal of psychiatry 20010601 |
| Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights. | The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 20010601 |
| The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010501 |
| Comparison of in vivo dopamine D2 receptor binding of [(123)I]AIBZM and [(123)I]IBZM in rat brain. | Nuclear medicine and biology 20010501 |
| Peripheral neuropathy as the presenting feature of multiple system atrophy. | Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20010401 |
| Absolute activity quantitation in simultaneous 123I/99mTc brain SPECT. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010201 |
| In vivo measurement of haloperidol affinity to dopamine D2/D3 receptors by [123I]IBZM and single photon emission computed tomography. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010101 |
| Subjective experience and striatal dopamine D(2) receptor occupancy in patients with schizophrenia stabilized by olanzapine or risperidone. | The American journal of psychiatry 20000601 |
| D2 receptor occupancy under recommended and high doses of olanzapine: an iodine-123-iodobenzamide SPECT study. | Journal of psychopharmacology (Oxford, England) 20000101 |
| In vivo effects of olanzapine on striatal dopamine D(2)/D(3) receptor binding in schizophrenic patients: an iodine-123 iodobenzamide single-photon emission tomography study. | European journal of nuclear medicine 19990801 |
| In vivo determination of striatal dopamine D2 receptor occupancy in patients treated with olanzapine. | Psychiatry research 19990426 |
| Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels. | Psychiatry research 19970929 |
| Effects of the D2 receptor agonist bromocriptine on sleep bruxism: report of two single-patient clinical trials. | Journal of dental research 19970901 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.