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83654-05-1 | RHC-80267
CAS No: 83654-05-1 Catalog No: AG004Y2H MDL No:
Product Description
Catalog Number:
AG004Y2H
Chemical Name:
RHC-80267
CAS Number:
83654-05-1
Molecular Formula:
C20H34N4O4
Molecular Weight:
394.5084
IUPAC Name:
(cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate
InChI:
InChI=1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
InChI Key:
RXSVYGIGWRDVQC-UHFFFAOYSA-N
SMILES:
O=C(ON=C1CCCCC1)NCCCCCCNC(=O)ON=C1CCCCC1
Properties
Complexity:
484
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
394.258g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
394.516g/mol
Monoisotopic Mass:
394.258g/mol
Rotatable Bond Count:
11
Topological Polar Surface Area:
101A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.5
Literature
| Title | Journal |
|---|---|
| Brain phospholipase C, diacylglycerol lipase and monoacylglycerol lipase are involved in (±)-epibatidine-induced activation of central adrenomedullary outflow in rats. | European journal of pharmacology 20120915 |
| Assay and inhibition of diacylglycerol lipase activity. | Bioorganic & medicinal chemistry letters 20120715 |
| Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120711 |
| Polymodal activation of the endocannabinoid system in the extended amygdala. | Nature neuroscience 20111106 |
| Inhibitors of diacylglycerol metabolism reduce time to the onset of glutamate release potentation by mGlu7 receptors. | Neuroscience letters 20110815 |
| Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α. | Biochemical and biophysical research communications 20110812 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor. | Journal of neurophysiology 20101101 |
| Diacylglycerol lipase is not involved in depolarization-induced suppression of inhibition at unitary inhibitory connections in mouse hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217 |
| Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes. | Archives of biochemistry and biophysics 20090815 |
| Distinct functional and anatomical architecture of the endocannabinoid system in the auditory brainstem. | Journal of neurophysiology 20090501 |
| Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons. | Journal of neurochemistry 20090101 |
| L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity. | Journal of cellular physiology 20080701 |
| Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats. | European journal of pharmacology 20080317 |
| Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. | European journal of pharmacology 20071001 |
| Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries. | Pflugers Archiv : European journal of physiology 20070401 |
| Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability. | The Journal of physiology 20060415 |
| Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta. | American journal of physiology. Heart and circulatory physiology 20060101 |
| Characterization of the lipolytic pathways that mediate free fatty acid release during Fas/CD95-induced apoptosis. | Apoptosis : an international journal on programmed cell death 20051201 |
| The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action. | European journal of pharmacology 20050704 |
| Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats. | European journal of pharmacology 20050509 |
| Capsazepine, a vanilloid antagonist, abolishes tonic responses induced by 20-HETE on guinea pig airway smooth muscle. | American journal of physiology. Lung cellular and molecular physiology 20050301 |
| 2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion. | Cancer research 20041215 |
| Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats. | European journal of pharmacology 20040919 |
| Antimicrobial activity of clofazimine is not dependent on mycobacterial C-type phospholipases. | The Journal of antimicrobial chemotherapy 20040601 |
| Store operated Ca2+ influx by selective depletion of ryanodine sensitive Ca2+ pools in primary human skeletal muscle cells. | Naunyn-Schmiedeberg's archives of pharmacology 20030401 |
| Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum. | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20021201 |
| Endothelin-1-induced arachidonic acid release by cytosolic phospholipase A2 activation in rat vascular smooth muscle via extracellular signal-regulated kinases pathway. | Biochemical pharmacology 20020801 |
| Chlorpyrifos oxon potentiates diacylglycerol-induced extracellular signal-regulated kinase (ERK 44/42) activation, possibly by diacylglycerol lipase inhibition. | Toxicology and applied pharmacology 20020101 |
| Arachidonic acid mobilization by phospholipase D in the contraction induced by phenylephrine in rat aorta. | Proceedings of the Western Pharmacology Society 20020101 |
| In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries. | The Journal of physiology 20010715 |
| Melittin exerts multiple effects on the release of free fatty acids from L1210 cells: lack of selective activation of phospholipase A2 by melittin. | Archives of biochemistry and biophysics 20010501 |
| Signalling mechanisms underlying the myogenic response in human subcutaneous resistance arteries. | Cardiovascular research 20010301 |
| The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. | Circulation research 20010216 |
| 20-Hydroxyeicosatetraenoic acid mediates angiotensin ii-induced phospholipase d activation in vascular smooth muscle cells. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| Neurite outgrowth stimulated by neural cell adhesion molecules requires growth-associated protein-43 (GAP-43) function and is associated with GAP-43 phosphorylation in growth cones. | The Journal of neuroscience : the official journal of the Society for Neuroscience 19981215 |
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