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83435-66-9 | Delapril
CAS No: 83435-66-9 Catalog No: AG0053ZS MDL No:
Product Description
Catalog Number:
AG0053ZS
Chemical Name:
Delapril
CAS Number:
83435-66-9
Molecular Formula:
C26H32N2O5
Molecular Weight:
452.5427
IUPAC Name:
2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid
InChI:
InChI=1S/C26H32N2O5/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30)/t18-,23-/m0/s1
InChI Key:
WOUOLAUOZXOLJQ-MBSDFSHPSA-N
SMILES:
CCOC(=O)[C@@H](N[C@H](C(=O)N(C1Cc2c(C1)cccc2)CC(=O)O)C)CCc1ccccc1
UNII:
W77UAL9THI
Properties
Complexity:
649
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
452.231g/mol
Formal Charge:
0
Heavy Atom Count:
33
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
452.551g/mol
Monoisotopic Mass:
452.231g/mol
Rotatable Bond Count:
12
Topological Polar Surface Area:
95.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7
Literature
| Title | Journal |
|---|---|
| Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial. | Hypertension (Dallas, Tex. : 1979) 20111101 |
| Optimal treatment strategies for patients with hypertension and diabetes: are effects on metabolism important? | Hypertension (Dallas, Tex. : 1979) 20111101 |
| Combination delapril/manidipine as antihypertensive therapy in high-risk patients. | Clinical drug investigation 20110101 |
| Delapril and manidipine measurements by liquid chromatography-tandem mass spectrometry in a pharmaceutical formulation. | European journal of mass spectrometry (Chichester, England) 20110101 |
| Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria. | Advances in therapy 20090301 |
| Efficacy of manidipine/delapril versus losartan/hydrochlorothiazide fixed combinations in patients with hypertension and diabetes. | Journal of hypertension 20080401 |
| Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients. | Internal medicine (Tokyo, Japan) 20080101 |
| Effects of manidipine/delapril versus olmesartan/hydrochlorothiazide combination therapy in elderly hypertensive patients with type 2 diabetes mellitus. | Hypertension research : official journal of the Japanese Society of Hypertension 20080101 |
| Manidipine-delapril combination in the management of hypertension. | Vascular health and risk management 20070601 |
| Manidipine plus delapril in patients with Type 2 diabetes and hypertension: reducing cardiovascular risk and end-organ damage. | Expert review of cardiovascular therapy 20070301 |
| Effect on the development of ankle edema of adding delapril to manidipine in patients with mild to moderate essential hypertension: a three-way crossover study. | Clinical therapeutics 20070301 |
| Delapril plus indapamide: a review of the combination in the treatment of hypertension. | Clinical drug investigation 20070101 |
| Effects of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker on ventricular defibrillation threshold. | Pacing and clinical electrophysiology : PACE 20060701 |
| Delapril/manidipine. | Drugs 20060101 |
| Delapril/manidipine: viewpoints. | Drugs 20060101 |
| Fixed combination of manidipine and delapril in the treatment of mild to moderate essential hypertension: evaluation by 24-hour ambulatory blood pressure monitoring. | Blood pressure. Supplement 20050701 |
| Effect of delapril-manidipine combination vs irbesartan-hydrochlorothiazide combination on fibrinolytic function in hypertensive patients with type II diabetes mellitus. | Journal of human hypertension 20041001 |
| Efficacy and safety of delapril plus manidipine compared with enalapril plus hydrochlorothiazide in mild to moderate essential hypertension: results of a randomized trial. | Clinical therapeutics 20040901 |
| Different effects of losartan and delapril on plasma PAI-1 levels in patients with mild to moderate hypertension. | International journal of cardiology 20031201 |
| Beneficial effects of angiotensin-converting enzyme inhibitor and nitrate association on left ventricular remodeling in patients with large acute myocardial infarction: the Delapril Remodeling after Acute Myocardial Infarction (DRAMI) trial. | American heart journal 20030701 |
| Effect of an ACE inhibitor and an AT1 receptor antagonist on cardiac hypertrophy. | Molecular and cellular biochemistry 20030601 |
| Evaluation of the efficacy and tolerability of the combination delapril plus indapamide in the treatment of mild to moderate essential hypertension: a randomised, multicentre, controlled study. | Journal of human hypertension 20030201 |
| Pharmacokinetics and tolerability of a new manidipine and delapril fixed oral combination in young and elderly subjects. | Arzneimittel-Forschung 20030101 |
| Single oral dose pharmacokinetic interaction study of manidipine and delapril in healthy volunteers. | Arzneimittel-Forschung 20030101 |
| Dose-dependent prevention of fibrosis in aorta of salt-loaded stroke-prone spontaneously hypertensive rats by combined delapril and indapamide treatment. | Journal of cardiovascular pharmacology 20020901 |
| Interaction of digoxin with antihypertensive drugs via MDR1. | Life sciences 20020215 |
| Fixed combinations of delapril plus indapamide vs fosinopril plus hydrochlorothiazide in mild to moderate essential hypertension. | Advances in therapy 20020101 |
| Temporary treatment of prepubescent rats with angiotensin inhibitors suppresses the development of hypertensive nephrosclerosis. | Journal of the American Society of Nephrology : JASN 20010401 |
| Effects on urinary albumin excretion and renal function changes by delapril and manidipine in normotensive type 2 diabetic patients with microalbuminuria. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20010201 |
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