200,000+ products from a single source!
sales@angenechem.com
83409-32-9 | Desethylamiodarone
CAS No: 83409-32-9 Catalog No: AG00G29K MDL No:
Product Description
Catalog Number:
AG00G29K
Chemical Name:
Desethylamiodarone
CAS Number:
83409-32-9
IUPAC Name:
(2-butyl-1-benzofuran-3-yl)-[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]methanone
InChI:
InChI=1S/C23H25I2NO3/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3
InChI Key:
VXOKDLACQICQFA-UHFFFAOYSA-N
UNII:
M31FU99E3Y
Properties
Complexity:
508
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
616.992g/mol
Formal Charge:
0
Heavy Atom Count:
29
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
617.266g/mol
Monoisotopic Mass:
616.992g/mol
Rotatable Bond Count:
10
Topological Polar Surface Area:
51.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.7
Literature
| Title | Journal |
|---|---|
| Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates. | Archives of toxicology 20170301 |
| Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells. | Chemico-biological interactions 20130825 |
| A liquid chromatography-electrospray tandem mass spectrometry method for the determination of antiarrhythmic drugs and their metabolites in forensic whole blood samples. | Journal of analytical toxicology 20120301 |
| Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. | Toxicological sciences : an official journal of the Society of Toxicology 20120101 |
| Stimulation of human monocytic THP-1 cells by metabolic activation of hepatotoxic drugs. | Drug metabolism and pharmacokinetics 20120101 |
| Preparation and determination of desethylamiodarone in dog lung by HPLC-MS. | Die Pharmazie 20111101 |
| Epicardial application of an amiodarone-releasing hydrogel to suppress atrial tachyarrhythmias. | International journal of cardiology 20110616 |
| Identification of amiodarone metabolites in human bile by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry. | Drug metabolism and disposition: the biological fate of chemicals 20110601 |
| Pharmacokinetics of intravenous amiodarone and its electrocardiographic effects on healthy Japanese subjects. | Heart and vessels 20110501 |
| Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells. | The Journal of pharmacology and experimental therapeutics 20110201 |
| A randomized, controlled study of amiodarone for prevention of atrial fibrillation after transthoracic esophagectomy. | The Journal of thoracic and cardiovascular surgery 20100701 |
| The effect of beta-naphthoflavone on the metabolism of amiodarone by hepatic and extra-hepatic microsomes. | Toxicology letters 20100602 |
| Simultaneous measurement of amiodarone and desethylamiodarone in human plasma and serum by stable isotope dilution liquid chromatography-tandem mass spectrometry assay. | Journal of pharmaceutical and biomedical analysis 20100105 |
| The effect of CYP1A induction on amiodarone disposition in the rat. | Journal of pharmaceutical sciences 20100101 |
| Assessment of the inactivation potential of desethylamiodarone on human CYP1A1. | Drug metabolism letters 20100101 |
| Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone. | Journal of electrocardiology 20100101 |
| Amiodarone and its putative metabolites fail to activate wild type hTAAR1. | Bioorganic & medicinal chemistry letters 20091015 |
| Cocktail-substrate assay system for mechanism-based inhibition of CYP2C9, CYP2D6, and CYP3A using human liver microsomes at an early stage of drug development. | Xenobiotica; the fate of foreign compounds in biological systems 20090601 |
| Benzofuran derivatives and the thyroid. | Clinical endocrinology 20090101 |
| Experimental hyperlipidemia causes an increase in the electrocardiographic changes associated with amiodarone. | Journal of cardiovascular pharmacology 20090101 |
| Amiodarone inhibits arterial thrombus formation and tissue factor translation. | Arteriosclerosis, thrombosis, and vascular biology 20081201 |
| Effects of intestinal constituents and lipids on intestinal formation and pharmacokinetics of desethylamiodarone formed from amiodarone. | The Journal of pharmacy and pharmacology 20081201 |
| Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites. | Bioorganic & medicinal chemistry letters 20081115 |
| The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat. | International journal of pharmaceutics 20080901 |
| Simultaneous determination of amiodarone and its metabolite desethylamiodarone by high-performance liquid chromatography with chemiluminescent detection. | Analytica chimica acta 20080808 |
| Amiodarone increases the accumulation of DEA in a human alveolar epithelium-derived cell line. | Biological & pharmaceutical bulletin 20080701 |
| Pharmacokinetics of desethylamiodarone in the rat after its administration as the preformed metabolite, and after administration of amiodarone. | Biopharmaceutics & drug disposition 20080401 |
| Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells. | Toxicology and applied pharmacology 20080315 |
| Efflux transport of N-monodesethylamiodarone by the human intestinal cell-line Caco-2 cells. | Drug metabolism and pharmacokinetics 20070801 |
| The influence of hyperlipoproteinemia on in vitro distribution of amiodarone and desethylamiodarone in human and rat plasma. | Pharmaceutical research 20070401 |
| A liquid chromatography-mass spectrometry assay method for simultaneous determination of amiodarone and desethylamiodarone in rat specimens. | Biomedical chromatography : BMC 20070301 |
| Amiodarone induces angiotensinogen gene expression in lung alveolar epithelial cells through activation protein-1. | Basic & clinical pharmacology & toxicology 20070101 |
| Effect of amiodarone on the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia. | Drug metabolism and pharmacokinetics 20061201 |
| Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles. | Drug metabolism and disposition: the biological fate of chemicals 20061001 |
| Serum amiodarone and desethylamiodarone concentrations following nasogastric versus oral administration. | Journal of clinical pharmacy and therapeutics 20060601 |
| Determination of amiodarone and desethylamiodarone in horse plasma and urine by high-performance liquid chromatography combined with UV detection and electrospray ionization mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060519 |
| Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. | Drug metabolism and disposition: the biological fate of chemicals 20060101 |
| Amiodarone and N-desethylamiodarone enhance endothelial nitric oxide production in human endothelial cells. | International heart journal 20060101 |
| Uptake of amiodarone by thyroidal and non-thyroidal cell lines. | Journal of endocrinological investigation 20060101 |
| Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation. | The Journal of pharmacology and experimental therapeutics 20041201 |
| Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. | Circulation 20041109 |
| A pharmacokinetic study of the combined administration of amiodarone and ximelagatran, an oral direct thrombin inhibitor. | Journal of clinical pharmacology 20040901 |
| A rapid procedure for the monitoring of amiodarone and N-desethylamiodarone by HPLC-UV detection. | Journal of analytical toxicology 20040101 |
| Protective effect of amiodarone but not N-desethylamiodarone on postischemic hearts through the inhibition of mitochondrial permeability transition. | The Journal of pharmacology and experimental therapeutics 20031101 |
| Silymarin and vitamin E reduce amiodarone-induced lysosomal phospholipidosis in rats. | Toxicology 20030828 |
| [Analysis of increased hepatic density during chronic amiodarone therapy]. | Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 20030501 |
| Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. | Endocrinology 20030201 |
| Pharmacological cardioversion of recent onset atrial fibrillation with intravenous amiodarone in patients receiving long-term amiodarone therapy: is it reasonable? | Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20030201 |
| Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction. | The Journal of pharmacology and experimental therapeutics 20030101 |
| Amiodarone N-deethylation by CYP2C8 and its variants, CYP2C8*3 and CYP2C8 P404A. | Pharmacology & toxicology 20021001 |
| Amiodarone and desethylamiodarone bind to barrier gels in serum separator blood collection tubes. | Clinical chemistry and laboratory medicine 20020801 |
| Determination of amiodarone and desethylamiodarone in human plasma by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry with an ion trap detector. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020125 |
| Amiodarone-Induced thyroid dysfunction and ventricular tachyarrhythmias during long-term therapy in Japan. | Japanese circulation journal 20011101 |
| Altered metabolite concentrations with amiodarone generic substitution cannot be observed without monitoring. | The Canadian journal of cardiology 20011101 |
| Role of desethylamiodarone in the anticoagulant effect of concurrent amiodarone and warfarin therapy. | Journal of cardiovascular pharmacology and therapeutics 20011001 |
| Effects of vitamin E on cytotoxicity of amiodarone and N-desethylamiodarone in isolated hamster lung cells. | Toxicology 20010925 |
| Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity. | The Journal of pharmacology and experimental therapeutics 20010901 |
| Desethylamiodarone antagonizes the effect of thyroid hormone at the molecular level. | European journal of endocrinology 20010701 |
| Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone. | British journal of pharmacology 20010701 |
| Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone. | Xenobiotica; the fate of foreign compounds in biological systems 20010501 |
| Metabolism of amiodarone (part I): identification of a new hydroxylated metabolite of amiodarone. | Drug metabolism and disposition: the biological fate of chemicals 20010201 |
| Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010201 |
| Desethylamiodarone interferes with the binding of co-activator GRIP-1 to the beta 1-thyroid hormone receptor. | FEBS letters 20000922 |
| Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro. | American journal of physiology. Lung cellular and molecular physiology 20000501 |
| Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene. | Biochemical and biophysical research communications 19980819 |
| Cellular electropharmacology of amiodarone. | Cardiovascular research 19970701 |
| Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone alpha 1-receptor protein. | Molecular and cellular endocrinology 19950701 |
| Amiodarone decreases Na,K-ATPase alpha 2 and beta 2 expression specifically in cardiac ventricle. | Journal of molecular and cellular cardiology 19940401 |
| Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein. | Endocrinology 19940401 |
| Amiodarone N-deethylation in human liver microsomes: involvement of cytochrome P450 3A enzymes (first report). | Life sciences 19930101 |
| Peripheral neuropathy during longterm high-dose amiodarone therapy. | Journal of neurology, neurosurgery, and psychiatry 19850601 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.