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CAS No: 82768-44-3 Catalog No: AG004TFT MDL No:
Title | Journal |
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Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues. | The Biochemical journal 20120701 |
Antitumor effects of oncolytic adenovirus armed with Drosophila melanogaster deoxyribonucleoside kinase in colorectal cancer. | Oncology reports 20120501 |
Antivirals for management of herpes zoster including ophthalmicus: a systematic review of high-quality randomized controlled trials. | Antiviral therapy 20120101 |
Potent anticancer effects of lentivirus encoding a Drosophila melanogaster deoxyribonucleoside kinase mutant combined with brivudine. | Asian Pacific journal of cancer prevention : APJCP 20120101 |
RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients. | Journal of cancer research and clinical oncology 20110901 |
Phenotypic and genetic characterization of varicella-zoster virus mutants resistant to acyclovir, brivudine and/or foscarnet. | Medical microbiology and immunology 20110801 |
Expression of herpes simplex virus type 1 recombinant thymidine kinase and its application to a rapid antiviral sensitivity assay. | Antiviral research 20110801 |
Emergence of herpes simplex virus-1 syncytial variants with altered virulence for mice after selection with a natural carrageenan. | Sexually transmitted diseases 20110601 |
Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine. | Investigational new drugs 20110401 |
Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2. | Antiviral therapy 20110101 |
Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A. | BMC bioinformatics 20110101 |
[64-year-old patient with efflorescences on the upper and lower legs]. | Deutsche medizinische Wochenschrift (1946) 20100901 |
New trends in nucleoside biotechnology. | Acta naturae 20100701 |
Epstein-Barr virus encephalitis after kidney transplantation and successful treatment with brivudine. | Transplant international : official journal of the European Society for Organ Transplantation 20100601 |
Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus. | Antiviral research 20100601 |
[Varicella and herpes zoster. Part 2: therapy and prevention]. | Medizinische Klinik (Munich, Germany : 1983) 20100601 |
[Skin involvement in zoster]. | Klinische Monatsblatter fur Augenheilkunde 20100501 |
Interaction between capecitabine and brivudin in a patient with breast cancer. | Nature reviews. Clinical oncology 20100101 |
Disseminated cutaneous herpes zoster complicated by acyclovir nephrotoxicity and successfully treated with brivudin. | European journal of dermatology : EJD 20100101 |
Early detection of Varicella-Zoster virus (VZV)-specific T-cells before seroconversion in primary varicella infection: case report. | Virology journal 20100101 |
Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts. | Nucleosides, nucleotides & nucleic acids 20100101 |
Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. | The Cochrane database of systematic reviews 20100101 |
Herpes zoster oticus: A rare clinical entity. | Contemporary clinical dentistry 20100101 |
Acute hepatitis due to brivudin: a case report. | Journal of hepatology 20091101 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20091001 |
All-oral combination of oral vinorelbine and capecitabine as first-line chemotherapy in HER2-negative metastatic breast cancer: an International Phase II Trial. | British journal of cancer 20090721 |
Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells. | Mutation research 20090512 |
Fatal drug-drug interaction of brivudine and capecitabine. | Acta oncologica (Stockholm, Sweden) 20090101 |
Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. | Drugs 20090101 |
Synthesis and antimicrobial evaluation of 5-iodopyrimidine analogs. | Indian journal of pharmaceutical sciences 20090101 |
Synthesis of nucleoside-based antiviral drugs in ionic liquids. | Bioorganic & medicinal chemistry letters 20081015 |
Substrate specificity of feline and canine herpesvirus thymidine kinase. | Antiviral research 20080801 |
5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts. | Nucleosides, nucleotides & nucleic acids 20080601 |
[Case report: again just an idiopathic facial nerve palsy?]. | MMW Fortschritte der Medizin 20080522 |
Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase. | The FEBS journal 20080501 |
Synthesis and antitumor activity of a heterodinucleotide of BVDU and gemcitabine. | Nucleosides, nucleotides & nucleic acids 20080501 |
6-Azathymidine-4'-thionucleosides: synthesis and antiviral evaluation. | Journal of enzyme inhibition and medicinal chemistry 20080201 |
Perineal muco-cutaneous herpes zoster treated with brivudin. | The Journal of dermatological treatment 20080101 |
Susceptibility of Autographa californica multiple nucleopolyhedrovirus to inhibitors of DNA replication. | Journal of virological methods 20071201 |
Recommendations for the management of herpes zoster. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070101 |
Molecular modelling studies on the binding of some protides to the putative human phosphoramidase Hint1. | Nucleosides, nucleotides & nucleic acids 20070101 |
RP101 improves the efficacy of chemotherapy in pancreas carcinoma cell lines and pancreatic cancer patients. | Anti-cancer drugs 20061001 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060901 |
Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts. | Biochemical and biophysical research communications 20060526 |
Antiviral activity of cyclosaligenyl prodrugs of the nucleoside analogue bromovinyldeoxyuridine against herpes viruses. | International journal of antimicrobial agents 20060501 |
New antiviral agents. | Indian journal of pediatrics 20060401 |
[Update in the treatment of herpes zoster]. | Actas dermo-sifiliograficas 20060301 |
Linear Darier disease with herpes zoster superinfection treated successfully by brivudine. | The British journal of dermatology 20060201 |
Inhibitory efficacy of cyclosal-nucleoside monophosphates of aciclovir and brivudin on DNA synthesis of orthopoxvi ruses. | Antiviral chemistry & chemotherapy 20060101 |
[Varicella-zoster virus infections--2: Zoster pain -- therapy and prevention]. | MMW Fortschritte der Medizin 20060101 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060101 |
Insecticidal activity of the pyrimidine nucleoside analogue (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU). | Pest management science 20050801 |
Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster. | The FEBS journal 20050801 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20050401 |
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides. | Antimicrobial agents and chemotherapy 20050301 |
(E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU). | Medicinal research reviews 20050101 |
Brivudin compared with famciclovir in the treatment of herpes zoster: effects in acute disease and chronic pain in immunocompetent patients. A randomized, double-blind, multinational study. | Journal of the European Academy of Dermatology and Venereology : JEADV 20050101 |
[On the mailing list: use of acyclovir in patients on hemodialysis]. | Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20050101 |
Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells. | BMC cancer 20050101 |
[Antiherpetic therapy]. | Oftalmologia (Bucharest, Romania : 1990) 20050101 |
Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20050101 |
Naphthyl phosphoramidate derivatives of BVdU as potential anticancer agents: design, synthesis and biological evaluation. | Nucleosides, nucleotides & nucleic acids 20050101 |
Current management of herpes zoster: the European view. | American journal of clinical dermatology 20050101 |
Acute retinal necrosis. | Seminars in ophthalmology 20050101 |
Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster. | Biochemical pharmacology 20041215 |
Functional expression of thymidine kinase in human leukaemic and colorectal cells, delivered as EGFP fusion protein by herpesvirus saimiri-based vector. | Cancer gene therapy 20040901 |
First regioselective enzymatic alkoxycarbonylation of primary amines. Synthesis of novel 5'- and 3'-carbamates of pyrimidine 3',5'-diaminonucleoside derivatives including BVDU analogues. | The Journal of organic chemistry 20040305 |
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir? | Antiviral research 20040301 |
Brivudin (bromovinyl deoxyuridine). | Drugs 20040101 |
Lipid-mediated protein delivery of suicide nucleoside kinases. | Cancer research 20031015 |
Comparison of HSV-1 thymidine kinase-dependent and -independent inhibition of replication-competent adenoviral vectors by a panel of drugs. | Cancer gene therapy 20031001 |
[Brivudine as an alternative systemic therapy to aciclovir and ganciclovir in acute retinal necrosis syndrome due to varicella-zoster virus]. | Klinische Monatsblatter fur Augenheilkunde 20031001 |
Synthesis, protonation behavior, conformational analysis, and regioselective enzymatic acylation of the novel diamino analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU). | Nucleosides, nucleotides & nucleic acids 20031001 |
Inhibition of induced chemoresistance by cotreatment with (E)-5-(2-bromovinyl)-2'-deoxyuridine (RP101). | Cancer research 20030915 |
Herpes zoster guidelines of the German Dermatological Society. | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20030801 |
Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy. | Biochemical pharmacology 20030801 |
Crystal structure of varicella zoster virus thymidine kinase. | The Journal of biological chemistry 20030704 |
NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint. | Anti-cancer drugs 20030701 |
Oral brivudin in comparison with acyclovir for improved therapy of herpes zoster in immunocompetent patients: results of a randomized, double-blind, multicentered study. | Antiviral research 20030601 |
Oral brivudin in comparison with acyclovir for herpes zoster: a survey study on postherpetic neuralgia. | Antiviral research 20030601 |
Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. | Drugs of today (Barcelona, Spain : 1998) 20030501 |
Herpes zoster guideline of the German Dermatology Society (DDG). | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20030401 |
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase. | European journal of medicinal chemistry 20030401 |
Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8. | Molecular pharmacology 20030201 |
The role of antivirals in the management of neuropathic pain in the older patient with herpes zoster. | Drugs & aging 20030101 |
CycloSal-BVDUMP pronucleotides: how to convert an antiviral-inactive nucleoside analogue into a bioactive compound against EBV. | Journal of medicinal chemistry 20021107 |
Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication. | The Journal of antimicrobial chemotherapy 20020701 |
Establishment and use of a cell line expressing HSV-1 thymidine kinase to characterize viral thymidine kinase-dependent drug-resistance. | Antiviral research 20020601 |
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase. | Molecular pharmacology 20020501 |
Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. | Molecular cancer therapeutics 20020401 |
Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol. | Biochemical and biophysical research communications 20011123 |
Hamao Umezawa Memorial Award Lecture: 'An Odyssey in the Viral Chemotherapy Field'. | International journal of antimicrobial agents 20011001 |
Synthesis and antiviral evaluation of phosphoramidate derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine. | Antiviral chemistry & chemotherapy 20010901 |
Bystander effects of cancer cell lines transduced with the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster and synergistic enhancement by hydroxyurea. | Molecular pharmacology 20010801 |
[Controlling herpes zoster. End end to bullae]. | MMW Fortschritte der Medizin 20010531 |
(E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells. | Cancer gene therapy 20010501 |
cycloSaligenyl-5-[(E)-2-bromovinyl]-2'-deoxyuridine monophosphate (cycloSal-BVDUMP) pronucleotides active against Epstein-Barr virus. | Chembiochem : a European journal of chemical biology 20010402 |
A novel approach to thymidylate synthase as a target for cancer chemotherapy. | Molecular pharmacology 20010301 |
Recent developments in herpesvirus therapy. | Herpes : the journal of the IHMF 20010301 |
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase. | Molecular pharmacology 20010201 |
Genetic risks of antiviral nucleoside analogues--a survey. | Antiviral research 20010201 |
Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase. | Biochemical pharmacology 20010115 |
Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude mice. | Neoplasma 20010101 |
Antiviral activity of ganciclovir elaidic acid ester against herpesviruses. | Antiviral research 20000301 |
Antiviral efficacies of famciclovir, valaciclovir, and brivudin in disseminated herpes simplex virus type 1 infection in mice. | Intervirology 19970101 |
Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU. | Antiviral research 19940801 |
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication. | Journal of medicinal chemistry 19910801 |
Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors. | Antiviral research 19900301 |
(E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity. | Biochemical pharmacology 19890615 |
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity. | Journal of medicinal chemistry 19880901 |
Comparison of two bromovinyl nucleoside analogs, 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and E-5-(2-bromovinyl)-2'-deoxyuridine, with acyclovir in inhibition of Epstein-Barr virus replication. | Antimicrobial agents and chemotherapy 19880701 |
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity. | Journal of medicinal chemistry 19870701 |
Effect of antiviral agents on replication of herpes simplex virus type 1 in brain cultures. | Antimicrobial agents and chemotherapy 19861201 |
Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. | Journal of medicinal chemistry 19860201 |
5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue. | Journal of medicinal chemistry 19851101 |
Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents. | Journal of medicinal chemistry 19850601 |
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines. | Journal of medicinal chemistry 19850501 |
Inhibition of human and woodchuck hepatitis virus DNA polymerase by the triphosphates of acyclovir, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and E-5-(2-bromovinyl)-2'-deoxyuridine. | Antiviral research 19840801 |
Oral antiviral drugs in experimental herpes simplex keratitis. | Antimicrobial agents and chemotherapy 19831201 |
Synergistic antiviral activity of acyclovir and interferon on human cytomegalovirus. | Antimicrobial agents and chemotherapy 19830901 |
Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine against different herpes simplex virus strains in cell culture and against experimental herpes encephalitis in mice. | Antiviral research 19821001 |
Inhibitory effect of E-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on herpes simplex virus replication and DNA synthesis. | Journal of virology 19820701 |
Efficiency and selectivity of (E)-5-(2-bromovinyl)-2'-deoxyuridine and some other 5-substituted 2'-deoxypyrimidine nucleosides as anti-herpes agents. | Antiviral research 19820501 |
In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds. | Antimicrobial agents and chemotherapy 19820101 |
Selective inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2'-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2'-deoxyuridine. | Antimicrobial agents and chemotherapy 19810501 |
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