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82752-99-6 | 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3h-1,2,4-triazol-3-one hydrochloride
CAS No: 82752-99-6 Catalog No: AG00582N MDL No:MFCD00935760
Product Description
Catalog Number:
AG00582N
Chemical Name:
2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3h-1,2,4-triazol-3-one hydrochloride
CAS Number:
82752-99-6
Molecular Formula:
C25H33Cl2N5O2
Molecular Weight:
506.4678
MDL Number:
MFCD00935760
IUPAC Name:
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one;hydrochloride
InChI:
InChI=1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H
InChI Key:
DYCKFEBIOUQECE-UHFFFAOYSA-N
SMILES:
CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl.Cl
UNII:
27X63J94GR
Properties
Complexity:
649
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
505.201g/mol
Formal Charge:
0
Heavy Atom Count:
34
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
506.472g/mol
Monoisotopic Mass:
505.201g/mol
Rotatable Bond Count:
10
Topological Polar Surface Area:
51.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
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| A randomized, double-blind controlled comparison of nefazodone and paroxetine in the treatment of depression: safety, tolerability and efficacy in continuation phase treatment. | Journal of psychopharmacology (Oxford, England) 20010901 |
| Treatment of somatization disorder with nefazodone: a prospective, open-label study. | Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20010901 |
| Opposite effects of nefazodone in two human models of anxiety. | Psychopharmacology 20010801 |
| Nefazodone may inhibit the metabolism of carbamazepine: three case reports. | European psychiatry : the journal of the Association of European Psychiatrists 20010801 |
| Bupropion and drug-induced parkinsonism. | Canadian journal of psychiatry. Revue canadienne de psychiatrie 20010801 |
| P-glycoprotein interactions of nefazodone and trazodone in cell culture. | Journal of clinical pharmacology 20010701 |
| Remission of SSRI-induced akathisia after switch to nefazodone. | The Journal of clinical psychiatry 20010701 |
| Open trial of nefazodone for combat veterans with posttraumatic stress disorder. | Journal of traumatic stress 20010701 |
| Antidepressants and ejaculation: a double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone. | Journal of clinical psychopharmacology 20010601 |
| The 'dalhousie serotonin cocktail' for treatment-resistant major depressive disorder. | Journal of psychopharmacology (Oxford, England) 20010601 |
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| Nefazodone for chronic daily headache prophylaxis: an open-label study. | Headache 20010501 |
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| Compounds with affinity for serotonergic receptors in the treatment of premenstrual dysphoria: a comparison of buspirone, nefazodone and placebo. | Psychopharmacology 20010501 |
| Effects of nefazodone on body weight: a pooled analysis of selective serotonin reuptake inhibitor- and imipramine-controlled trials. | The Journal of clinical psychiatry 20010401 |
| Quantitation of itraconazole in rat heparinized plasma by liquid chromatography-mass spectrometry. | Journal of chromatography. B, Biomedical sciences and applications 20010305 |
| Loratadine and terfenadine interaction with nefazodone: Both antihistamines are associated with QTc prolongation. | Clinical pharmacology and therapeutics 20010301 |
| Intermittent, luteal phase nefazodone treatment of premenstrual dysphoric disorder. | Journal of psychopharmacology (Oxford, England) 20010301 |
| Which depressed patients respond to nefazodone and when? | The Journal of clinical psychiatry 20010301 |
| Autonomic neurocardiac function in patients with major depression and effects of antidepressive treatment with nefazodone. | Journal of affective disorders 20010201 |
| Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. | The Journal of clinical psychiatry 20010101 |
| The effects of antidepressants on sexual functioning in depressed patients: a review. | The Journal of clinical psychiatry 20010101 |
| Clinical significance of monitoring early symptom change to predict outcome. | The Journal of clinical psychiatry 20010101 |
| Reemergence of sexual dysfunction in patients with major depressive disorder: double-blind comparison of nefazodone and sertraline. | The Journal of clinical psychiatry 20010101 |
| Response to nefazodone in a depressed patient with end-stage renal disease. | General hospital psychiatry 20010101 |
| Acute and maintenance treatment of chronic depression. | The Journal of clinical psychiatry 20010101 |
| Open trial of nefazodone among Hispanics with major depression: efficacy, tolerability, and adherence issues. | Depression and anxiety 20010101 |
| Increased throughput in quantitative bioanalysis using parallel-column liquid chromatography with mass spectrometric detection. | Rapid communications in mass spectrometry : RCM 20010101 |
| Long-term treatment of recurrent and chronic depression. | The Journal of clinical psychiatry 20010101 |
| Pharmacokinetically induced benzodiazepine withdrawal. | Psychopharmacology bulletin 20010101 |
| [Acute liver failure ascribed to nefazodone: importance of 'postmarketing surveillance' for recently introduced drugs]. | Nederlands tijdschrift voor geneeskunde 20001007 |
| Nefazodone-induced acute liver failure. | The American journal of gastroenterology 20000601 |
| Reversible nefazodone-induced liver failure. | Digestive diseases and sciences 20000501 |
| Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions. | Psychopharmacology 19990701 |
| Nefazodone-induced liver failure: report of three cases. | Annals of internal medicine 19990216 |
| Interaction between tacrolimus and nefazodone in a stable renal transplant recipient. | Pharmacotherapy 19980101 |
| Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. | The Journal of pharmacology and experimental therapeutics 19971201 |
| A comparison of nefazodone and fluoxetine on mood and on objective, subjective, and clinician-rated measures of sleep in depressed patients: a double-blind, 8-week clinical trial. | The Journal of clinical psychiatry 19970501 |
| Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. | Drugs 19970401 |
| Serotonin syndrome associated with nefazodone and paroxetine. | Annals of emergency medicine 19970201 |
| Myositis and rhabdomyolysis associated with concurrent use of simvastatin and nefazodone. | JAMA 19970101 |
| Probable nefazodone-induced mania in a patient with unreported bipolar disorder. | Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 19961201 |
| Nefazodone relief of alprazolam interdose dysphoria: a potential therapeutic benefit of 3A3/4 inhibition. | The Journal of clinical psychiatry 19960701 |
| The safety profile of nefazodone. | The Journal of clinical psychiatry 19960101 |
| Binding of antidepressants to human brain receptors: focus on newer generation compounds. | Psychopharmacology 19940501 |
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