200,000+ products from a single source!
sales@angenechem.com
Home > Other Building Blocks > 81938-43-4
81938-43-4 | zofenopril calcium
CAS No: 81938-43-4 Catalog No: AG0055W0 MDL No:MFCD08704648
Product Description
Catalog Number:
AG0055W0
Chemical Name:
zofenopril calcium
CAS Number:
81938-43-4
Molecular Formula:
C44H44CaN2O8S4
Molecular Weight:
897.1668
MDL Number:
MFCD08704648
IUPAC Name:
calcium;(2S,4S)-1-[(2S)-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylate
InChI:
InChI=1S/2C22H23NO4S2.Ca/c2*1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17;/h2*2-11,15,18-19H,12-14H2,1H3,(H,25,26);/q;;+2/p-2/t2*15-,18+,19+;/m11./s1
InChI Key:
NSYUKKYYVFVMST-LETVYOFWSA-L
SMILES:
O=C(N1C[C@H](C[C@H]1C(=O)[O-])Sc1ccccc1)[C@@H](CSC(=O)c1ccccc1)C.O=C(N1C[C@H](C[C@H]1C(=O)[O-])Sc1ccccc1)[C@@H](CSC(=O)c1ccccc1)C.[Ca+2]
UNII:
88ZQ329PU2
Properties
Complexity:
582
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3
Defined Atom Stereocenter Count:
6
Defined Bond Stereocenter Count:
0
Exact Mass:
896.161g/mol
Formal Charge:
0
Heavy Atom Count:
59
Hydrogen Bond Acceptor Count:
12
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
897.16g/mol
Monoisotopic Mass:
896.161g/mol
Rotatable Bond Count:
14
Topological Polar Surface Area:
256A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| [Efficacy of ACE-inhibitors in patients with recent myocardial infarction. Studies with zofenopril]. | Giornale italiano di cardiologia (2006) 20121001 |
| Long-term clinical experience with zofenopril. | Expert review of cardiovascular therapy 20120801 |
| Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice. | Pharmacological research 20120301 |
| Cardioprotective effects of zofenopril, enalapril and valsartan against ischaemia/reperfusion injury as well as doxorubicin cardiotoxicity. | Acta cardiologica 20120201 |
| The anti-oxidant and anti-apoptotic effects of nebivolol and zofenopril in a model of cerebral ischemia/reperfusion in rats. | Progress in neuro-psychopharmacology & biological psychiatry 20120110 |
| Comparison between zofenopril and ramipril in combination with acetylsalicylic acid in patients with left ventricular systolic dysfunction after acute myocardial infarction: results of a randomized, double-blind, parallel-group, multicenter, European study (SMILE-4). | Clinical cardiology 20120101 |
| Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients. | European journal of clinical pharmacology 20110901 |
| Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of zofenopril and its active metabolite zofenoprilat in human plasma. | Journal of pharmaceutical and biomedical analysis 20110601 |
| Protective effects of zofenopril on testicular torsion and detorsion injury in rats. | Urology journal 20110101 |
| Aliskiren, a renin inhibitor, downregulates TNF-α-induced tissue factor expression in HUVECS. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20101201 |
| Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2. | Naunyn-Schmiedeberg's archives of pharmacology 20101201 |
| Effects of zofenopril and ramipril on cough reflex responses in anesthetized and awake rabbits. | Journal of cardiovascular pharmacology and therapeutics 20101201 |
| HPLC-DAD method for the simultaneous determination of zofenopril and hydrochlorothiazide in oral pharmaceutical formulations. | Journal of separation science 20100601 |
| Cardiovascular changes in spontaneously hypertensive rats are improved by chronic treatment with zofenopril. | British journal of pharmacology 20091201 |
| Serum cholesterol levels on admission and survival in patients with acute myocardial infarction treated with zofenopril: a post hoc analysis of the Survival of Myocardial Infarction Long-term Evaluation trial. | Fundamental & clinical pharmacology 20091001 |
| ACE inhibition and protection from doxorubicin-induced cardiotoxicity in the rat. | Vascular pharmacology 20090101 |
| Zofenopril plus hydrochlorothiazide fixed combination in the treatment of hypertension and associated clinical conditions. | Cardiovascular therapeutics 20090101 |
| Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima-media thickening and improves the nitric oxide/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension. | American heart journal 20081201 |
| Effects of early treatment with zofenopril in patients with myocardial infarction and metabolic syndrome: the SMILE Study. | Vascular health and risk management 20080601 |
| ACE-inhibition ameliorates vascular reactivity and delays diabetes outcome in NOD mice. | Vascular pharmacology 20080101 |
| Comparison of home and office blood pressure in hypertensive patients treated with zofenopril or losartan. | Blood pressure. Supplement 20071001 |
| An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension. | Blood pressure. Supplement 20071001 |
| Blood pressure control and response rates with zofenopril compared with amlodipine in hypertensive patients. | Blood pressure. Supplement 20071001 |
| Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension. | Blood pressure. Supplement 20071001 |
| [ACE inhibitors after myocardial infarction: close-up on zofenopril]. | Annales de cardiologie et d'angeiologie 20070601 |
| Effect of sulfhydryl and non-sulfhydryl angiotensin-converting enzyme inhibitors on endothelial function in essential hypertensive patients. | American journal of hypertension 20070401 |
| Antihypertensive efficacy of zofenopril plus hydrochlorothiazide fixed combination for treatment in metabolic syndrome. | Advances in therapy 20070101 |
| Fixed combination of zofenopril plus hydrochlorothiazide in the management of hypertension: a review of available data. | Vascular health and risk management 20061201 |
| Effects of angiotensin-converting-enzyme inhibitors in combination with diuretics on blood pressure and renal injury in nitric oxide-deficiency-induced hypertension in rats. | Clinical science (London, England : 1979) 20060201 |
| The role of zofenopril in myocardial protection during cardioplegia arrest: an isolated rat heart model. | Journal of cardiac surgery 20060101 |
| An Angiotensin-converting enzyme inhibitor, zofenopril, prevents renal ischemia/reperfusion injury in rats. | Annals of clinical and laboratory science 20060101 |
| Hydrochlorothiazide increases plasma or tissue angiotensin-converting enzyme-inhibitor drug levels in rats with myocardial infarction: differential effects on lisinopril and zofenopril. | European journal of pharmacology 20051219 |
| Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension. | American heart journal 20040701 |
| Cardioprotective effect of zofenopril in perfused rat heart subjected to ischemia and reperfusion. | Journal of cardiovascular pharmacology 20040201 |
| 11C-Radiosynthesis and preliminary human evaluation of the disposition of the ACE inhibitor [11C]zofenoprilat. | Bioorganic & medicinal chemistry 20040201 |
| Effects of the early ACE inhibition in diabetic nonthrombolyzed patients with anterior acute myocardial infarction. | Diabetes care 20030601 |
| Double-blind comparison between zofenopril and lisinopril in patients with acute myocardial infarction: results of the Survival of Myocardial Infarction Long-term Evaluation-2 (SMILE-2) study. | American heart journal 20030101 |
| An unusual rearrangement of Zofenopril, a new ACE inhibitor drug: mass spectrometric and conformational studies. | Journal of mass spectrometry : JMS 20021201 |
| Zofenopril inhibits the expression of adhesion molecules on endothelial cells by reducing reactive oxygen species. | American journal of hypertension 20021001 |
| Pharmacokinetic and pharmacodynamic comparative study of zofenopril and enalapril in healthy volunteers. | Arzneimittel-Forschung 20020101 |
| Chronic treatment with sulfhydryl angiotensin-converting enzyme inhibitors reduce susceptibility of plasma LDL to in vitro oxidation, formation of oxidation-specific epitopes in the arterial wall, and atherogenesis in apolipoprotein E knockout mice. | International journal of cardiology 20011201 |
| Cardioprotective effects of zofenopril, a new angiotensin-converting enzyme inhibitor, on doxorubicin-induced cardiotoxicity in the rat. | European journal of pharmacology 20010223 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.